Rho GTPases and cell migration

Journal of Cell Science

Volumn 114, Issue 15, 2001, Pages 2713-2722

  Ridley, A J ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

Actin; Cell adhesion; Cytoskeleton; Migration; Rho GTPases

Indexed keywords

ACTIN; GUANOSINE TRIPHOSPHATASE; INTEGRIN; MYOSIN; RHO FACTOR;

ACTIN POLYMERIZATION; ANIMAL CELL; ARTICLE; CAENORHABDITIS ELEGANS; CELL ACTIVITY; CELL ADHESION; CELL MIGRATION; CLINICAL RESEARCH; CONTROLLED STUDY; CYTOSKELETON; DEPOLYMERIZATION; DICTYOSTELIUM; DROSOPHILA; HUMAN; HUMAN CELL; INTERMEDIATE FILAMENT; MICROTUBULE ASSEMBLY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; SIGNAL TRANSDUCTION;

ANIMALS; CELL ADHESION; CELL MOVEMENT; CYTOSKELETON; RHO GTP-BINDING PROTEINS;

ANIMALIA; CAENORHABDITIS ELEGANS; DICTYOSTELIUM; NEMATODA; PROTOZOA;

EID: 0034865456     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (144)

1. Stimulation of fascin spikes by thrombospondin-1 is mediated by the GTPases Rac and Cdc42
2. Overexpression of cofilin stimulates bundling of actin filaments, membrane ruffling, and cell movement in Dictyostelium
3. Rho, Rac and Cdc42 regulate actin organization and cell adhesion in macrophages
4. A role for Cdc42 in macrophage chemotaxis
5. Regulation and functions of Rho-associated kinase
6. Platelet-derived growth factor and fibronectin-stimulated migration are differentially regulated by the Rac and extracellular signal-regulated kinase pathways
7. Epidermal growth factor receptor distribution during chemotactic responses
8. Actin-dependent lamellipodia formation and microtubule-dependent tail retraction control-directed cell migration
9. Motility and invasion are differentially modulated by Rho family GTPases
10. Evidence that beta3 integrin-induced Rac activation involves the calpain-dependent formation of integrin clusters that are distinct from the focal complexes and focal adhesions that form as Rac and RhoA become active
11. Control of cell migration during Caenorhabditis elegans development
12. EGF induces recycling membrane to form ruffles
13. Lipid kinases are novel effectors of the GTPase Rac1
14. Role of cofilin in epidermal growth factor-stimulated actin polymerization and lamellipod protrusion
15. Rnd proteins: A new family of Rho-related proteins that interfere with the assembly of filamentous actin structures and cell adhesion
16. Cofilin/ADF is required for cell motility during Drosophila ovary development and oogenesis
17. Regulation of cell contraction and membrane ruffling by distinct signals in migratory cells
18. Role of Rac in controlling the actin cytoskeleton and chemotaxis in motile cells
19. Rho guanosine triphosphatase mediates the selective stabilization of microtubules induced by lysophosphatidic acid
20. Regulation of integrin-mediated adhesion during cell migration
21. Integrin-mediated adhesion regulates cell polarity and membrane protrusion through the Rho family of GTPases
22. p21-activated protein kinase: A crucial component of morphological signaling?
23. Control of intramolecular interactions between the pleckstrin homology and Dbl homology domains of Vav and Sos1 regulates Rac binding
24. Rac/Cdc42 and p65PAK regulate the microtubule-destabilizing protein stathmin through phosphorylation at serine 16
25. Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK
26. Rho GTPases in growth cone guidance
27. Rac1 GTPases control filopodia formation, cell motility, endocytosis, cytokinesis and development in Dictyostelium
28. Impaired mechanical stability, migration and contractile capacity in vimentin-deficient fibroblasts
29. Impaired wound healing in embryonic and adult mice lacking vimentin
30. Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics
31. Mammalian Cdc42 is a brefeldin A-sensitive component of the Golgi apparatus
32. Tools of the trade: Use of dominant-inhibitory mutants of Ras-family GTPases
33. Regulation of the Rac1-specific exchange factor Tiam1 involves both phosphoinositide 3-kinase-dependent and -independent components
34. Rho small G-protein-dependent binding of mDia to an Src homology 3 domain-containing IRSp53/BAIAP2
35. The tail domain of myosin M catalyses nucleotide exchange on Rac1 GTPases and can induce actin-driven surface protrusions
36. Epidermal growth factor receptor activation of calpain is required for fibroblast motility and occurs via an ERK/MAP kinase signaling pathway
37. The Dbl-related protein, Lfc, localizes to microtubules and mediates the activation of Rac signaling pathways in cells
38. Phosphorylation of vimentin by Rho-associated kinase at a unique amino-terminal site that is specifically phosphorylated during cytokinesis
39. Cdc42hs facilitates cytoskeletal reorganization and neurite outgrowth by localizing the 58-kD insulin receptor substrate to filamentous actin
40. RhoE regulates actin cytoskeleton organization and cell migration
41. Microtubules and signal transduction
42. Characterization of RAC3, a novel member of the Rho family
43. Rho GTPases and the actin cytoskeleton
44. Serum-activated assembly and membrane translocation of an endogenous Rac1: Effector complex
45. Induced expression of Rnd3 is associated with transformation of polarized epithelial cells by the Raf-MEK-extracellular signal-regulated kinase pathway
46. Spatial sensing in fibroblasts mediated by 3′ phosphoinositides
47. Intermediate filaments and their associates: Multi-talented structural elements specifying cytoarchitecture and cytodynamics
48. Involvement of phosphatidylinositide 3′-kinase and Rac in platelet-derived growth factor-induced actin reorganization and chemotaxis
49. Coordination of microtubules and the actin cytoskeleton by the Rho effector mDia1
50. Biomechanical regulation of matrix metalloproteinase-9 in cultured chondrocytes
51. Adhesion-linked kinases in cancer; emphasis on src, focal adhesion kinase and P13-kinase
52. Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells
53. The sensory-motor role of growth cone filopodia
54. Small GTPase RhoG is a key regulator for neurite outgrowth in PC12 cells
55. Microtubule targeting of substrate contacts promotes their relaxation and dissociation
56. Enforced polarisation and locomotion of fibroblasts lacking microtubules
57. Role of Rac1 and oxygen radicals in collagenase-1 expression induced by cell shape change
58. Cell polarity: New PARtners for Cdc42 and Rac
59. A role for p21-activated kinase in endothelial cell migration
60. Rac recruits high-affinity integrin αvβ3 to lamellipodia in endothelial cell migration
61. Activation of Rac1 by a Crk SH3-binding protein, DOCK180
62. Visualizing muscle cell migration in situ
63. Phosphorylation of glial fibrillary acidic protein at the same sites by cleavage furrow kinase and Rho-associated kinase
64. Localized Rac activation dynamics visualized in living cells
65. Cell migration: A physically integrated molecular process
66. Potentiation of cell migration by adhesion-dependent cooperative signals from the GTPase Rac and Raf kinase
67. Bacterial protein toxins targeting rho GTPases
68. Wiskott-Aldrich syndrome protein regulates podosomes in primary human macrophages
69. Microtubule-dependent formation of podosomal adhesion structures in primary human macrophages
70. Microtubule depolymerization induces stress fibers, focal adhesions, and DNA synthesis via the GTP-binding protein Rho
71. The role of rho family GTPases in development: Lessons from Drosophila melanogaster
72. Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase
73. Differential expression of distinct members of Rho family GTP-binding proteins during neuronal development: Identification of Rac1B, a new neural-specific member of the family
74. Specific localization of serine 19 phosphorylated myosin II during cell locomotion and mitosis of cultured cells
75. Domain-specific phosphorylation of vimentin and glial fibrillary acidic protein by PKN
76. Involvement of the Arp2/3 complex in phagocytosis mediated by FcγR or CR3
77. Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium
78. Cdc42Hs and rac1 GTPases induce the collapse of the vimentin intermediate filament network
79. Unconventional myosins in cell movement, membrane traffic, and signal transduction
80. Differential localization of Rho GTPases in live cells: Regulation by hypervariable regions and RhoGDI binding
81. IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling
82. Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway
83. Actin-based cell motility and cell locomotion
84. Vav family proteins couple to diverse cell surface receptors
85. Proteolysis and cell migration: Creating a path?
86. Distinct cellular effects and interactions of the Rho-family GTPase TC10
87. Rho-kinase in human neutrophils: A role in signalling for myosin light chain phosphorylation and cell migration
88. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
89. Rho GTPases control polarity, protrusion, and adhesion during cell movement
90. Myoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a Rac signaling pathway utilized for multiple developmental processes
91. RhoA function in lamellae formation and migration is regulated by the alpha6beta4 integrin and cAMP metabolism
92. Stimulation of phosphatidylinositol-4-phosphate 5-kinase by Rho-kinase
93. Physical and biochemical regulation of integrin release during rear detachment of migrating cells
94. Microinjection of recombinant p21rho induces rapid changes in cell morphology
95. Induction of cortical oscillations in spreading cells by depolymerization of microtubules
96. Molecular mechanisms controlling actin filament dynamics in nonmuscle cells
97. Activation of Rac and Cdc42 by integrins mediates cell spreading
98. CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans
99. Regulation of inositol lipid kinases by Rho and Rac
100. Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases
101. Leukocytes navigate by compass: Roles of P13Kγ and its lipid products
102. Rho GTPases. Integrating integrin signaling
103. Stress fibres take shape
104. Rho proteins: Linking signalling with membrane trafficking
105. The Dictyostelium discoideum family of Rho-related proteins
106. Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense
107. Interplay between Rac and Rho in the control of substrate contact dynamics
108. Activation of cdc42, rac, PAK, and rho-kinase in response to hepatocyte growth factor differentially regulates epithelial cell colony spreading and dissociation
109. Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility
110. Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase
111. Rac downregulates Rho activity: Reciprocal balance between both GTPases determines cellular morphology and migratory behavior
112. Rho GTPases: Signaling, migration, and invasion
113. Signaling networks linking integrins and rho family GTPases
114. EPS8 and E3B1 transduce signals from Ras to Rac
115. Membrane association and targeting of prenylated Ras-like GTPases
116. Purification of recombinant Rho/Rac/G25K from Escherichia coli
117. p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts
118. Polarization of chemoattractant receptor signaling during neutrophil chemotaxis
119. RhoA-binding kinase alpha translocation is facilitated by the collapse of the vimentin intermediate filament network
120. Rab5 induces Rac-independent lamellipodia formation and cell migration
121. LIM-kinase1
122. Rac1 is required for the formation of three germ layers during gastrulation
123. Cofilin phosphorylation and actin cytoskeletal dynamics regulated by rho- and Cdc42-activated LIM-kinase 2
124. The small GTP-binding protein TC10 promotes nerve elongation in neuronal cells, and its expression is induced during nerve regeneration in rats
125. Cdc42-interacting protein 4 mediates binding of the Wiskott-Aldrich syndrome protein to microtubules
126. Type I alpha phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly
127. Diaphanous-related formins bridge Rho GTPase and Src tyrosine kinase signaling
128. Distinct roles of ROCK (Rho-kinase) and MLCK in spatial regulation of MLC phosphorylation for assembly of stress fibers and focal adhesions in 3T3 fibroblasts
129. PDGF induces reorganization of vimentin filaments
130. Rho GTPases and signaling networks
131. Characterization of p190RhoGEF: A RhoA-specific guanine nucleotide exchange factor that interacts with microtubules
132. Rac regulates phosphorylation of the myosin-II heavy chain, actinomyosin disassembly and cell spreading
133. Characterization of TCL, a new GTPase of the Rho family related to TC10 and Cdc42
134. Positive feedback interactions between microtubule and actin dynamics during cell motility
135. Microtubule growth activates Rac1 to promote lamellipodial protrusion in fibroblasts
136. Tenascin-C suppresses Rho activation
137. Rac is required for constitutive macropinocytosis by dendritic cells but does not control its downregulation
138. Regulation of matrix metalloproteinase expression in tumor invasion
139. The Rho/Rho-kinase and the phosphatidylinositol 3-kinase pathways are essential for spontaneous locomotion of Walker 256 carcinosarcoma cells
140. A novel C3-like ADP-ribosyltransferase from Staphylococcus aureus modifying RhoE and Rnd3
141. Genetic structure and evolution of RAC-GTPases in Arabidopsis thaliana
142. The gamma-subunit of the coatomer complex binds Cdc42 to mediate transformation
143. Phosphorylation of ADF/cofilin abolishes EGF-induced actin nucleation at the leading edge and subsequent lamellipod extension
144. Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly