Roles of hepatocyte growth factor activator (HGFA) and its inhibitor HAI-1 in the regeneration of injured gastrointestinal mucosa

Journal of Gastroenterology

Volumn 37, Issue SUPPL. 14, 2002, Pages 15-21

  Itoh, Hiroshi ^a   Kataoka, Hiroaki ^a  

^a UNIVERSITY OF MIYAZAKI   (Japan)

Author keywords

Gastrointestinal tissue; Hepatocyte growth factor (HGF); HGF activator (HGFA); HGFA inhibitor (HAI); Mucosal regeneration

Indexed keywords

ACETIC ACID; BINDING PROTEIN; CELL SURFACE PROTEIN; HEPATOCYTE GROWTH FACTOR ACTIVATOR; HEPATOCYTE GROWTH FACTOR ACTIVATOR INHIBITOR; INTERLEUKIN 1; PROTEIN PRECURSOR; SCATTER FACTOR; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR; THROMBIN; UNCLASSIFIED DRUG;

CELL CULTURE; CELL MIGRATION; CELL PROLIFERATION; COMPLEX FORMATION; ENZYME ACTIVITY; EPITHELIUM CELL; GASTROINTESTINAL MUCOSA; HUMAN; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SECRETION; PROTEIN SYNTHESIS; REVIEW; SIGNAL TRANSDUCTION; STROMA CELL; TISSUE REGENERATION; UPREGULATION;

EID: 0036855774     PISSN: 09441174     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf03326408     Document Type: Review

References (51)

1. Gordon JI. Intestinal epithelial differentiation: new insights from chimeric and transgenic mice. J Cell Biol 1989;108:1187-94.
2. Beck PL, Wallace JL. Cytokines in inflammatory bowel disease. Mediators Inflamm 1997;6:95-103.
3. Efstathiou JA, Pignatelli M. Modulation of epithelial cell adhesion in gastrointestinal homeostasis. Am J Pathol 1998;153:341-7.
4. Wright NA. Aspects of the biology of regeneration and repair in the human gastrointestinal tract. Phil Trans R Soc Lond B 1998;353:925-33.
5. Matsumoto K, Nakamura T. Emerging multipotent aspects of hepatocyte growth factor. J Biochem 1996;119:591-600.
6. Boros P, Miller CM. Hepatocyte growth factor: a multifunctional cytokine. Lancet 1995;345:293-5.
7. Gohda E, Tsubouchi H, Nakayama H, Hirono S, Sakiyama O, Takahashi K, et al. Purification and partial characterization of hepatocyte growth factor from plasma of a patient with fulminant hepatic failure. J Clin Invest 1988;81:414-9.
8. Nakayama T, Nama K, Ichihara A, Kaise N, Nishino T. Purification and subunit structure of hepatocyte growth factor from rat platelets. FEBS Lett 1987;224:311-6.
9. Stoker M, Gherardi E, Perryman M, Gray J. Scatter factor is a fibroblast-derived modulator of epithelial cell mobility. Nature 1987;327:239-42.
10. Weidner KM, Arakaki N, Hartmann G, Vandekerckhove J, Weingart S, Reider H, et al. Evidence for the identity of human scatter factor and human hepatocyte growth factor. Proc Natl Acad Sci USA 1991;88:7001-5.
11. Naldini L, Weidner KM, Vigna E, Gaudino G, Bardelli A, Ponzetto C, et al. Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor. EMBO J 1991; 10:2867-78.
12. Kinoshita Y, Nakata H, Sazzad H, Asahara M, Kawanami C, Matsushima Y, et al. Gene expression of keratinocyte and hepatocyte growth factor during the healing of rat gastric mucosal lesions. Gastroenterology 1995;109:1068-77.
13. Schmassmann A, Stettler C, Poulsom R, Tarasova N, Hirschi C, Flogerzi B, et al. Roles of hepatocyte growth factor and its receptor met during gastric ulcer healing in rats. Gastroenterology 1997;113:1858-72.
14. Dignass AU, Lynch-Devaney K, Podolsky DK. Hepatocyte growth factor/scatter factor modulates intestinal epithelial cell proliferation and migration. Biochem Biophys Res Commun 1994;202:701-9.
15. Watanabe S, Hirose M, Wang XE, Maehiro K, Kobayashi O, Nagahara A, et al. Hepatocyte growth factor accelerates the wound repair of cultured gastric mucosal cells. Biochem Biophys Res Commun 1994;199:1453-60.
16. Naldini L, Tamagnone L, Vigna E, Sachs M, Hartmann G, Birchmeier W, et al. Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor. EMBO J 1992;11:4825-33.
17. Naka D, Ishii T, Yoshiyama Y, Miyazawa K, Hara H, Hishida T, et al. Activation of hepatocyte growth factor by proteolytic conversion of a single chain form to a heterodimer. J Biol Chem 1992;267:20114-9.
18. Birchmeier C, Gherardi E. Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase. Trends Cell Biol 1998;10:404-10.
19. Mars WM, Zarnegar R, Michalopoulos GK. Activation of hepatocyte growth factor by the plasminogen activators uPA and tPA. Am J Pathol 1993;143:949-58.
20. Naldini L, Vigna E, Bardelli A, Follenzi A, Galimi F, Comoglio PM, et al. Biological activation of pro-HGF (hepatocyte growth factor) by urokinase is controlled by a stoichiometric reaction. J Biol Chem 1995;270:603-11.
21. Shimomura T, Ochiai M, Kondo J, Morimoto Y. A novel protease obtained from FBS-containing culture supernatant, that processes single-chain form hepatocyte growth factor to two-chain form in serum-free culture. Cytotechnology 1992;8:219-29.
22. Miyazawa K, Shimomura T, Kitamura A, Kondo J, Morimoto Y, Kitamura N. Molecular cloning and sequence analysis of the cDNA for a human serine protease responsible for activation of hepatocyte growth factor. J Biol Chem 1993;268:10024-8.
23. Shimomura T, Miyazawa K, Komiyama Y, Hiraoka H, Naka D, Morimoto Y, et al. Activation of hepatocyte growth factor by two homologous proteases, blood-coagulation factor XIIa and hepatocyte growth factor activator. Eur J Biochem 1995;229:257-61.
24. Mizuno K, Takehara T, Nakamura T. Proteolytic activation of a single-chain precursor of hepatocyte growth factor by extracellular serine protease. Biochem Biophys Res Commun 1992;189: 1631-8.
25. Lee SL, Dickson RB, Lin CY. Activation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, and epithelial membrane serine protease. J Biol Chem 2000;275: 36720-5.
26. Kataoka H, Hamasuna R, Itoh H, Kitamura N, Koono M. Activation of hepatocyte growth factor/scatter factor in colorectal carcinoma. Cancer Res 2000;60:6148-59.
27. Kinoshita Y, Kishi K, Asahara M, Matsushima Y, Wang HY. Production and activation of hepatocyte growth factor during the healing of rat gastric ulcers. Digestion 1996;58:225-31.
28. Itoh H, Hamasuna R, Kataoka H, Yamauchi M, Miyazawa K, Kitamura N, et al. Mouse hepatocyte growth factor activator gene: its expression not only in the liver but also in the gastrointestinal tract. Biochim Biophys Acta 2000;1491:295-302.
29. Matsubara Y, Ichinose M, Yahagi N, Tsukada S, Oka M, Miki K, et al. Hepatocyte growth factor activator: a possible regulator of morphogenesis during fetal development of the rat gastrointestinal tract. Biochem Biophys Res Commun 1998;253:477-84.
30. Miyazawa K, Wang Y, Minoshima S, Shimizu N, Kitamura N. Structural organization and chromosomal localization of the human hepatocyte growth factor activator gene: phylogenetic and functional relationship with blood coagulation factor XII, urokinase, and tissue-type plasminogen activator. Eur J Biochem 1998;258:355-61.
31. Shimomura T, Kondo J, Ochiai M, Naka D, Miyazawa K, Morimoto K, et al. Activation of the zymogen of hepatocyte growth factor activator by thrombin. J Biol Chem 1993;268:22927-32.
32. Miyazawa K, Shimomura T, Naka D, Kitamura N. Proteolytic activation of hepatocyte growth factor in response to tissue injury. J Biol Chem 1994;269:8966-70.
33. Miyazawa K, Shimomura T, Kitamura N. Activation of hepatocyte growth factor in the injured tissues is mediated by hepatocyte growth factor activator. J Biol Chem 1996;271:3615-18.
34. Shimomura T, Denda K, Kitamura A, Kawaguchi T, Kito M, Kondo J, et al. Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor. J Biol Chem 1997; 272:6370-6.
35. Kawaguchi T, Qin L, Shimomura T, Kondo J, Matsumoto K, Denda K, et al. Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor. J Biol Chem 1997;272:27558-64.
36. Marlor CW, Delaria KA, Davis G, Muller DK, Greve JM, Tamburini PP. Identification and cloning of human placental bikunin, a novel serine protease inhibitor containing two Kunitz domains. J Biol Chem 1997;272:12202-8.
37. Delaria KA, Muller DK, Marlor CW, Brown JE, Das RC, Roczniak SO, et al. Characterization of placental bikunin, a novel human serine proteinase inhibitor. J Biol Chem 1997;272:12209-14.
38. Kataoka H, Suganuma T, Shimomura T, Itoh H, Kitamura N, Nabeshima K. Distribution of hepatocyte growth factor activator inhibitor type 1 (HAI-1) in human tissues: cellular surface localization of HAI-1 in simple columnar epithelium and its modulated expression in injured and regenerative tissues. J Histochem Cytochem 1999;47:673-82.
39. Itoh H, Yamauchi M, Kataoka H, Hamasuna R, Kitamura N, Koono M. Genomic structure and chromosomal localization of the human hepatocyte growth factor activator inhibitor type 1 and 2 genes. Eur J Biochem 2000;267:3351-9.
40. Itoh H, Kataoka H, Hamasuna R, Kitamura N, Koono M. Hepatocyte growth factor activator inhibitor type 2 lacking the first Kunitz-type serine proteinase inhibitor domain is a predominant product in mouse but not in human. Biochem Biophys Res Commun 1999;255:740-8.
41. Itoh H, Kataoka H, Yamauchi M, Naganuma S, Akiyama Y, Nuki Y, et al. Identification of hepatocyte growth factor activator inhibitor type 2 (HAI-2)-related small peptide (H2RSP): its nuclear localization and generation of chimeric mRNA transcribed from both HAI-2 and H2RSP genes. Biochem Biophys Res Commun 2001;288:390-9.
42. Qin L, Denda K, Shimomura T, Kawaguchi T, Kitamura N. Functional characterization of Kunitz domains in hepatocyte growth factor activator inhibitor type 2. FEBS Lett 1998;436:111-4.
43. Kataoka H, Itoh H, Nuki Y, Hamasuna R, Naganuma S, Kitamura N, et al. Mouse hepatocyte growth factor (HGF) activator inhibitor type 2 lacking the first Kunitz domain potently inhibits the HGF activator. Biochem Biophys Res Commun 2002;290: 1096-100.
44. Lin CY, Anders J, Johnson M, Dickson RB. Purification and characterization of a complex containing matriptase and a Kunitz-type serine protease inhibitor from human milk. J Biol Chem 1999;274:18237-42.
45. Shimomura T, Denda K, Kawaguchi T, Matsumoto K, Miyazawa K, Kitamura N. Multiple sites of proteolytic cleavage to release soluble forms of hepatocyte growth factor activator inhibitor type 1 from a transmembrane form. J Biochem 1999;126: 821-8.
46. Kataoka H, Shimomura T, Kawaguchi T, Hamasuna R, Itoh H, Kitamura N, et al. Hepatocyte growth factor activator inhibitor type 1 is a specific cell surface binding protein of hepatocyte growth factor activator (HGFA) and regulates HGFA activity in pericellular microenvironments. J Biol Chem 2000;275:40453-62.
47. Itoh H, Kataoka H, Tomita M, Hamasuna R, Nawa Y, Kitamura N, et al. Up-regulation of hepatocyte growth factor activator inhibitor type-1 but not type-2 along with regeneration of intestinal mucosa. Am J Phys 2000;278:G635-43.
48. Itoh H, Kataoka H, Meng JY, Hamasuna R, Kitamura N, Koono M. Mouse hepatocyte growth factor activator inhibitor type 1 (HAI-1) and type 2 (HAI-2)/placental bikunin genes and their promoters. Biochim Biophys Acta 2001:1519:92-5.
49. Schmidt C, Bladt F, Goedecke S, Brinkmann V, Zschiesche W, Sharpe M, et al. Scatter factor/hepatocyte growth factor is essential for liver development. Nature 1995;373:699-702.
50. Uehara Y, Minowa O, Mori C, Shiota K, Kuno J, Noda T, et al. Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor. Nature 1995;373:702-5.
51. Denda K, Shimomura T, Kawaguchi T, Miyazawa K, Kitamura N. Functional characterization of Kunitz domains in hepatocyte growth factor activator inhibitor type 1. J Biol Chem 2002;277: 14053-9.