A hammerhead ribozyme suppresses expression of hepatocyte growth factor/scatter factor receptor c-MET and reduces migration and invasiveness of breast cancer cells

Clinical Cancer Research

Volumn 7, Issue 8, 2001, Pages 2555-2562

  Jiang, Wen G ^a   Grimshaw, David ^a   Lane, Jane ^a   Martin, Tracey A ^a   Abounder, Roger ^b   Laterra, John ^b   Mansel, Robert E ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RIBOZYME; SCATTER FACTOR; SCATTER FACTOR RECEPTOR;

ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CANCER GROWTH; CANCER INVASION; CELL MIGRATION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GENE TARGETING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOLECULAR CLONING; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION;

BASE SEQUENCE; BREAST NEOPLASMS; CELL MOVEMENT; DNA, ANTISENSE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MOLECULAR SEQUENCE DATA; NEOPLASM INVASIVENESS; PLASMIDS; PROTO-ONCOGENE PROTEINS C-MET; RNA, CATALYTIC; RNA, MESSENGER; RNA, SMALL NUCLEAR; TIME FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0034881625     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Molecular cloning and expression of human hepatocyte growth factor
2. Hepatocyte and scatter factor
3. Regulation of spreading and growth of human colon cancer cells by hepatocyte growth factor
4. FAK) and promotes migration and invasion by oral squamous cell carcinoma cells
5. Hepatocyte growth factor/scatter factor, its molecular and cellular and clinical implications in cancer
6. Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial motility and growth
7. Scatter factor induces blood vessel formation in vivo
8. Scatter factor/hepatocyte growth factor gene transfer enhances glioma growth and angiogenesis in vivo
9. Molecular cloning of a new transforming gene from a chemically transformed human cell line
10. Identification of the hepatocyte growth factor as the c-met protooncogene product
11. Expression of the c-met/HGF receptor in human breast carcinoma: Correlation with tumor progression
12. Scatter factor protein levels in human breast cancers-clinicopathological and biological correlations
13. Co-expression of hepatocyte growth factor and receptor (met) in human breast carcinoma
14. Expression of scatter factor and c-met receptor I benign and malignant breast tissue
15. Immunoreactive hepatocyte growth factor is a strong and independent predictor of recurrence and survival in human breast cancer
16. Inhibitory effects of tumor invasion inhibiting factor 2 and its conjugate on disseminating tumor cells
17. Regulation of the expression of E-cadherin on human cancer cells by γ linolenic acid
18. Regulation of desmosomal cell adhesion in human tumour cells by polyunsaturated fatty acids
19. Inhibition of motility and invasion of human colon cancer cells by interleukin-12
20. Interleukin-4 inhibits hepatocyte growth factor-induced invasion and migration of colon carcinomas
21. HGF/NK4 is a specific antagonist for pleiotrophic actions of hepatocyte growth factor
22. Cooperative interaction between α and β chains of hepatocyte growth factor on c-Met receptor confers ligand-induced receptor tyrosine phosphorylation and multiple biological responses
23. Inhibition of HGF/SF and fibroblasts induced motility and invasion of colorectal cancer cells by NK4, a new HGF antagonist
24. Reversion of human glioblastoma malignancy by U1 small nuclear RNA/ribozyme targeting of scatter factor/hepatocyte growth factor and c-met expression
25. Inhibition of fibrillin expression using U1 snRNA as a vehicle for the presentation of antisense targeting sequence
26. A rapid in vitro assay for quantitating the invasive potential of tumor cells
27. Inhibition of invasion and motility of human colon cancer cells by γ linolenic acid
28. NK4, a HGF/SF variant, inhibits in vitro invasiveness of breast cancer cells
29. Antagonistic effects of NK4, an novel HGF variant, on the in vitro angiogenesis of human vascular endothelial cells
30. ErbB-4 ribozyme abolish neuregulin-induced mitogenesis
31. Hammerhead ribozyme mediated cleavage of the human insulin like growth factor II ribonucleic acid in vitro and in prostate cancer cells
32. Can hammerhead ribozymes be efficient tools to inactivate gene function?
33. Specificity of hammerhead ribozyme cleavage
34. Adenovirus mediated ribozyme targeting of HER-2/neu inhibits in vivo growth of breast cancer cells
35. Induction of apoptosis in oral cancer cells by an anti-bcl-2 ribozyme delivered by an adenovirus vector
36. Serum concentrations of hepatocyte growth factor in breast cancer patients
37. Hepatocyte growth factor/scatter factor, a cytokine playing multiple and converse role