Y-27632, an inhibitor of Rho-associated protein kinase, suppresses tumor cell invasion via regulation of focal adhesion and focal adhesion kinase

Japanese Journal of Cancer Research

Volumn 91, Issue 8, 2000, Pages 811-816

  Imamura, Fumio ^a   Mukai, Mutsuko ^a   Ayaki, Masako ^a   Akedo, Hitoshi ^b  

^a OSAKA MEDICAL CENTER FOR CANCER AND CARDIOVASCULAR DISEASES   (Japan)

^b HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

Focal adhesion; Focal adhesion kinase; Invasion; ROCK; Y 27632

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ACTIN; BACTERIAL ENZYME; FIBRONECTIN; FOCAL ADHESION KINASE; GUANOSINE TRIPHOSPHATASE; LYSOPHOSPHATIDIC ACID; PAXILLINE; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; RHO KINASE; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ASCITES HEPATOMA; CANCER INHIBITION; CANCER INVASION; CELL MIGRATION; CELL MOTILITY; CELL SHAPE; CELL STIMULATION; CELL STRUCTURE; CELL TRANSFORMATION; CLOSTRIDIUM BOTULINUM; CONTROLLED STUDY; ENZYME REGULATION; HEPATOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PSEUDOPODIUM; RAT; SPINDLE CELL; TUMOR CELL;

ACTINS; AMIDES; ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL ADHESION; CELL MOVEMENT; CYTOSKELETAL PROTEINS; DRUG INTERACTIONS; ENZYME INHIBITORS; FOCAL ADHESION KINASE 1; FOCAL ADHESION PROTEIN-TYROSINE KINASES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER NEOPLASMS; LYSOPHOSPHOLIPIDS; NEOPLASM INVASIVENESS; PAXILLIN; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PYRIDINES; RATS; TUMOR CELLS, CULTURED; TYROSINE;

EID: 0033864069     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2000.tb01018.x     Document Type: Article

References (25)

1. Integrin function: Molecular hierarchies of cytoskeletal and signaling molecules
2. Signaling through focal adhesion kinase
3. Paxillin
4. The small GTP-binding protein rho regulates the assembly of focal adhesions and stress fibers in response to growth factors
5. Rho, Rac, Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
6. Rho effectors and reorganization of actin cytoskeleton
7. PAK to the future
8. Interaction of rat ascites hepatoma cells with cultured mesothelial cell monolayer: A model for cancer invasion
9. Induction of in vitro tumor cell invasion by lysophosphatidic acid or phospholipase D
10. Cooperation of FN with lysophosphatidic acid induces motility and transcellular migration of rat ascites hepatoma cells
11. Involvement of small GTPases Rho and Rac in the invasion of rat ascites hepatoma cells
12. Participation of rhop21 in serum-dependent invasion by rat ascites hepatoma cells
13. An essential part for Rho-associated kinase in the transcellular invasion of tumor cells
14. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
15. Cell motility mediated by rho and rho-associated protein kinase plays a critical role in intrahepatic metastasis of human hepatocellular carcinoma
16. Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization
17. Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase
18. Signaling from Rho to the actin cytoskeleton through protein kinase ROCK and LIM-kinase
19. Small GTP-binding protein Rho stimulates the actomyosin system, leading to invasion of tumor cells
20. Rho-mediated protein tyrosine phosphorylation in lysophosphatidic-acid-induced tumor-cell invasion
21. Microspike-mediated particle transport towards the cell body during early spreading of 3T3 cells
22. Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells
23. P160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions
24. P160ROCK mediates RhoA activation of Na-H exchange
25. Na-H exchange acts downstream of RhoA to regulate integrin-induced cell adhesion and spreading