Regulation of the activity of matriptase on epithelial cell surfaces by a blood-derived factor

European Journal of Biochemistry

Volumn 268, Issue 5, 2001, Pages 1439-1447

  Benaud, Christelle ^a   Dickson, Robert B ^a   Lin, Chen Yong ^a  

^a GEORGETOWN UNIVERSITY   (United States)

Author keywords

Activation; Ectodomain shedding; HAI 1; Matriptase; Serine protease

Indexed keywords

APROTININ; ENZYME PRECURSOR; MATRIPTASE; MONOCLONAL ANTIBODY; SERINE PROTEINASE; UNCLASSIFIED DRUG;

ARTICLE; BREAST MILK; ENZYME ACTIVITY; ENZYME REGULATION; EPITHELIUM CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; BIOLOGICAL FACTORS; BLOOD; BREAST; CELL MEMBRANE; ENZYME ACTIVATION; EPITHELIAL CELLS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; MEMBRANE GLYCOPROTEINS; MILK, HUMAN; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN CONFORMATION; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; TRYPSIN; TUMOR CELLS, CULTURED;

AVES; MAMMALIA; REPTILIA;

EID: 0035081038     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2001.02016.x     Document Type: Article

References (15)

1. Molecular cloning of cDNA for matriptase, a matrix-degrading serine protease with trypsin-like activity
2. Identification and characterization of a novel matrix-degrading protease from hormone-dependent human breast cancer cells
3. Characterization of a novel, membrane-bound, 80-kDa matrix-degrading protease from human breast cancer cells
4. Purification and characterization of a complex containing matrip-tase and a Kunitz-type serine protease inhibitor from human milk
5. Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor
6. Matriptase and its cognate inhibitor HAI-1 are expressed by normal and malignant epithelial cells in vitro and in vivo
7. Reverse biochemistry: Use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue
8. Cloning and chromosomal mapping of a gene isolated from thymic stromal cells encoding a new mouse type II membrane serine protease, epithin, containing four LDL receptor modules and two CUB domains
9. Cellular localization of membrane-type serine protease 1 and identification of protease activated receptor-2 and single-chain urokinase-type plasiminigen activator as substrates
10. Activation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, an epithelial membrane serine protease
11. Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo[a]pyrene
12. Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes
13. X-ray diffraction studies of enzymes
14. Structure and functions of the interaction domains of C1r and C1s: Keystones of the architecture of the C1 complex
15. Structural and functional studies on C1r and C1s: New insights into the mechanisms involved in C1 activity and assembly