Critical determinants of cancer metastasis: Rationale for therapy

Cancer Chemotherapy and Pharmacology, Supplement

Volumn 43, Issue , 1999, Pages

  Fidler, Isaiah J ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

Angiogenesis; Drug resistance; Homeostasis; Metastasis

Indexed keywords

DOXORUBICIN;

CANCER CHEMOTHERAPY; CANCER GROWTH; CANCER INVASION; CONFERENCE PAPER; DRUG TARGETING; GENE EXPRESSION REGULATION; HUMAN; METASTASIS POTENTIAL; MICROSATELLITE INSTABILITY; MULTIDRUG RESISTANCE; NEOVASCULARIZATION (PATHOLOGY); ONCOGENE; PRIORITY JOURNAL; TREATMENT PLANNING; TUMOR VASCULARIZATION;

EID: 0033052436     PISSN: 09439404     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800051091     Document Type: Conference Paper

References (94)

1. Auerbach W, Auerbach R (1994) Angiogenesis inhibition: a review. Pharmacol Ther 63: 265
2. Aukerman SL, Price JE, Fidler IJ (1986) Different deficiencies in the prevention of tumorigenic-low-metastatic murine K-1735 melanoma cells from producing metastases. J Natl Cancer Inst 77: 915
3. Bouck N, Stellmach V, Hsu SC (1996) How tumors become angiogenic. Adv Cancer Res 69: 135
4. Bradley G, Juranka PE, Ling V (1988) Mechanism of multidrug resistance. Biochim Biophys Acta 948: 87
5. Bradley G, Sharma R, Rajalakshmi S, Ling V (1992) P-glycoprotein expression during tumor progression in the rat liver. Cancer Res 52: 5154
6. Brocker EG, Rechenbeld C, Hamm H, Ruiter DJ, Sorg C (1992) Macrophages in melanocytic naevi. Arch Dermatol Res 284: 127
7. Brown LF, Berse B, Jackman RW, Tognazzi K, Manseau EJ, Senger DR, Dvorak HF (1993) Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in adenocarcinomas of the gastrointestinal tract. Cancer Res 53: 4727
8. Chabner BA, Foji A (1989) Multidrug resistance: P-glycoprotein and its allies-the elusive foes. J Natl Cancer Inst 81: 910
9. Dameron KM, Volpert OV, Tainsky MA, Bouk N (1994) Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1. Science 265: 1502
10. Donelli MG, Russo R, Garattini S (1975) Selective chemotherapy in relation to the site of tumor transplantation. Int J Cancer 32: 78
11. Dong Z, Radinsky R, Fan D, Tsan R, Bucana CD, Wilmanns C, Fidler IJ (1994) Organ-specific modulation of steady-state mdr gene expression and drug resistance in murine colon cancer cells. J Natl Cancer Inst 86: 913
12. Dvorak HF (1986) Tumors: wounds that do not heal. N Engl J Med 315: 1650
13. Ewing J (1928) Neoplastic diseases, 6th edn. Philadelphia, WB Saunders
14. Ezekowitz RAB, Mulliken JB, Folkman J (1992) Interferon alfa-2a therapy for life-threatening hemangiomas of infancy. N Engl J Med 326: 1456
15. Fabra A, Nakajima M, Bucana CD, Fidler IJ (1992) Modulation of the invasive phenotype of human colon carcinoma cells by organ-specific fibroblasts of nude mice. Differentiation 52: 101
16. 125I-5-iodo-2′-deoxyuridine. J Natl Cancer Inst 45: 773
17. Fidler IJ (1973) Selection of successive tumor lines for metastasis. Nature (New Biol) 242: 148
18. Fidler IJ (1990) Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes Memorial Award Lecture. Cancer Res 50: 6130
19. Fidler IJ (1991) Orthotopic implantation of human colon carcinomas into nude mice provides a valuable model for the biology and therapy of cancer metastasis. Cancer Metastasis Rev 10: 229
20. Fidler IJ (1995) Modulation of the organ microenvironment for the treatment of cancer metastasis (editorial). J Natl Cancer Inst 84: 1588
21. Fidler IJ, Nicolson G (1976) Organ selectivity for implantation survival and growth of B16 melanoma variant tumor lines. J Natl Cancer Inst 57: 1199
22. Fidler IJ, Kripke ML (1977) Metastasis results from pre-existing variant cells within a malignant tumor. Science 197: 893
23. Fidler IJ, Poste G (1985) The cellular heterogeneity of malignant neoplasms: implications for adjuvant chemotherapy. Semin Oncol 12: 207
24. Fidler IJ, Talmadge JE (1986) Evidence that intravenously derived murine pulmonary melanoma metastases can originate from the expansion of a single tumor cell. Cancer Res 46: 5167
25. Fidler IJ, Ellis LM (1994) The implications of angiogenesis for the biology and therapy of cancer metastasis. Cell 79: 185
26. Fidler IJ, Gersten DM, Kripke ML (1979) Influence of immune status on the metastasis of three murine fibrosarcomas of different immunogenicities. Cancer Res 39: 3816
27. Folkman J (1986) How is blood vessel growth regulated in normal and neoplastic tissue? G.H.A. Clowes Memorial Award Lecture. Cancer Res 46: 467
28. Folkman J (1995) Clinical applications of research on angiogenesis. N Engl J Med 333: 1753
29. Folkman J, Klagsbrun M (1987) Angiogenic factors. Science 235: 444
30. Fujimaki T, Price JE, Fan D, Bucana CD, Itoh K, Kirino T, Fidler IJ (1996) Selective growth of human melanoma cells in the brain parenchyma of nude mice. Melanoma Res 6: 363
31. Germann UA, Pastan I, Gottesman MM (1993) P-glycoproteins: mediators of multidrug resistance. Semin Cell Biol 4: 63
32. Giavazzi R, Jessup JM, Campbell DE, Walker SM, Fidler IJ (1986) Experimental nude mouse model of human colorectal cancer liver metastasis. J Natl Cancer Inst 77: 1303
33. Gohji K, Fidler IJ, Fabra A, Bucana CD, von Eschenbach AC, Nakajima M (1994) Regulation of gelatinase production in metastatic renal cell carcinoma by organ-specific fibroblasts. Jpn J Cancer Res 85: 152
34. Gohji K, Fidler IJ, Tsan R, Radinsky R, von Eschenbach AC, Tsuruo T, Nakajima M (1994) Human recombinant interferons-beta and -gamma decrease gelatinase production and invasion by human KG-2 renal carcinoma cells. Int J Cancer 58: 380
35. Gutman M, Singh RK, Yoon S, Xie K, Bucana CD, Fidler IJ (1994) Leukocyte-induced angiogenesis and subcutaneous growth of B16 melanoma. Cancer Biother 9: 163
36. Gutman M, Singh, RK, Xie K, Bucana CD, Fidler IJ (1995) Regulation of IL-8 expression in human melanoma cells by the organ environment. Cancer Res 55: 2470
37. Hanahan D, Folkman J (1996) Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86: 353
38. Hart IR (1982) "Seed and soil" revisited: mechanisms of site-specific metastasis. Cancer Metastasis Rev 1: 5
39. Hart IR, Fidler IJ (1981) Role of organ selectivity in the determination of metastatic patterns of B16 melanoma. Cancer Res 41: 1281
40. Herlyn M (1990) Human melanoma: development and progression. Cancer Metastasis Rev 9: 101
41. Hu F, Wang RY, Hsu TC (1987) Clonal origin of metastasis in B16 murine melanoma: a cytogenetic study. J Natl Cancer Inst 78: 155
42. Jain RK (1994) Barriers to drug delivery in solid tumors. Scientific Amer 271: 58
43. Kartner N, Riordan JR, Ling V (1983) Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines. Science 221: 1285
44. Kinsey DL (1960) An experimental study of preferential metastasis. Cancer 13: 874
45. Kitadai Y, Ellis LM, Takahashi Y, Bucana CD, Anzai H, Tahara T, Fidler IJ (1995) Multiparametric in situ mRNA hybridization analysis to detect metastasis-related genes in surgical specimens of human colon carcinoma. Clin Cancer Res 1: 1095
46. Kitadai Y, Ellis LM, Tucker SL, Greene GF, Bucana CD, Cleary KR, Takahashi Y, Tahara E, Fidler IJ (1996) Multiparametric in situ mRNA hybridization analysis to predict disease recurrence in patients with colon carcinoma. Am J Pathol 149: 1541
47. Koura AN, Liu W, Kitadai Y, Radinsky R, Ellis LM (1996) Regulation of vascular endothelial growth factor expression in human colon carcinoma cells by cell density. Cancer Res 56: 3891
48. Leek RD, Harris AL, Lewis CE (1994) Cytokine networks in solid human tumors: regulation of angiogenesis. J Leukoc Biol 56: 423
49. Levy AP, Levy NS, Wegner S, Goldberg MA (1996) Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia. J Biol Chem 270: 13333
50. Liotta LA, Steeg PS, Stetler-Stevenson WG (1991) Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell 64: 327
51. Meininger CJ, Zetter BR (1992) Mast cells and angiogenesis. Semin Cancer Biol 3: 73
52. Mizoguchi T, Yamada K, Furukawa T, Hidaka T, Hisatsugu H, Shimazu T, Tsuruo T, Sumizawa T, Akiyama S (1990) Expression of the mdr1 gene in human gastric and colorectal carcinomas. J Natl Cancer Inst 82: 1679
53. Morikawa K, Walker SM, Jessup JM, Fidler IJ (1988) In vivo selection of highly metastatic cells from surgical specimens of different human colon carcinomas implanted into nude mice. Cancer Res 48: 1943
54. Morrow CS, Cowan KH (1988) Mechanisms and clinical significance of multidrug resistance. Oncology 2: 55-63
55. Nakajima M, Morikawa K, Fabra A, Bucana CD, Fidler IJ (1990) Influence of organ environment on extracellular matrix degradative activity and metastasis of human colon carcinoma cells. J Natl Cancer Inst 82: 1890
56. Noh R, Karp GI, Devereaux DF (1991) The effect of doxorubicin and mitoxantrone on wound healing. Cancer Chemother Pharmacol 29: 141
57. Ootsuyama A, Tanaka K, Tanooka H (1987) Evidence by cellular mosaicism for monoclonal metastasis of spontaneous mouse mammary tumors. J Natl Cancer Inst 78: 1223
58. Paget S (1889) The distribution of secondary growths in cancer of the breast. Lancet i: 571
59. Polverini P, Cotran R, Gimbrone N, Unanue E (1977) Activated macrophages induce vascular proliferation. Nature 269: 804
60. Poste G, Fidler IJ (1979) The pathogenesis of cancer metastasis. Nature 283: 139
61. Pratesi G, Manzotti C, Tortoreto M, Audisio RA, Zunino F (1991) Differential efficacy of flavone acetic acid against liver versus lung metastases in a human tumour xenograft. Br J Cancer 663: 71
62. Price JE, Natio S, Fidler IJ (1988) Growth in an organ microenvironment as a selective process in metastasis. Clin Exp Metastasis 6: 91
63. Radinsky R, Aukerman SL, Fidler IJ (1998) The heterogeneous nature of metastatic neoplasms: relevance to biotherapy. In: Oldham RK (ed) Principles of cancer biotherapy, 3rd edn. Kluwer Academic Publishers, Boston, p. 16
64. Rak J, Filmus J, Finkenzeller G, Grugel S, Marme D, Kerbel RS (1995) Oncogenes as inducers of tumor angiogenesis. Cancer Metastasis Rev 14: 263
65. Schackert G, Fidler IJ (1988) Development of in vivo models for studies of brain metastasis. Int J Cancer 41: 589
66. Schackert G, Fidler IJ (1988) Site-specific metastasis of mouse melanomas and a fibrosarcoma in the brain or the meninges of syngeneic animals. Cancer Res 48: 3478
67. Schackert G, Price JE, Bucana CD, Fidler IJ (1989) Unique patterns of brain metastasis produced by different human carcinomas in athymic nude mice. Int J Cancer 44: 892
68. Schackert G, Price JE, Zhang RD, Bucana CD, Itoh K, Fidler IJ (1990) Regional growth of different human melanoma as metastases in the brain of nude mice. Am J Pathol 136: 95
69. Sidky YA, Auerbach R (1976) Lymphocyte-induced angiogenesis in tumor-bearing mice. Science 192: 1237
70. Shweiki D, Itin A, Stoffer D, Keshet E (1992) Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359: 843
71. Singh RK, Bucana CD, Gutman M, Fan D, Wilson MR, Fidler IJ (1994) Organ site-dependent expression of basic fibroblast growth factor in human renal cell carcinoma cells. Am J Pathol 145: 365
72. Singh RK, Gutman M, Radinsky R, Bucana CD, Fidler IJ (1994) Expression of interleukin 8 correlates with the metastatic potential of human melanoma cells in nude mice. Cancer Res 54: 3242
73. Singh RK, Gutman M, Bucana CD, Sanchez R, Llansa N, Fidler IJ (1995) Interferons alpha and beta downregulate the expression of basic fibroblast growth factor in human carcinomas. Proc Natl Acad Sci USA 92: 4562
74. Singh RK, Llansa N, Bucana CD, Sanchez R, Koura A, Fidler IJ (1996) Cell density-dependent regulation of basic fibroblast growth factor expression in human renal cell carcinoma cells. Cell Growth Differen 7: 397
75. Slack NH, Bross JDJ (1975) The influence of the site of metastasis on tumor growth and response to chemotherapy. Br J Cancer 32: 78
76. Smith KA, Begg AC, Denekamp J (1985) Differences in chemosensitivity between subcutaneous and pulmonary tumors. Eur J Cancer Clin Oncol 21: 249
77. Staroselsky A, Fan D, O'Brian CA, Bucana CD, Gupta KP, Fidler IJ (1990) Site-dependent differences in response of the UV-2237 murine fibrosarcoma to systemic therapy with adriamycin. Cancer Res 40: 7775
78. Sugarbaker EV (1979) Cancer metastasis: a product of tumor-host interactions. Curr Probl Cancer 3: 1-59
79. Sunderkotter C, Steinbrink K, Goebeler M, Bhardwaj R, Sorg C (1994) Macrophages and angiogenesis. J Leukoc Biol 55: 410
80. Takahashi Y, Bucana CD, Liu W, Yoneda J, Kitadai Y, Cleary KR, Ellis LM (1996) Platelet-derived endothelial cell growth factor in human colon cancer angiogenesis: role of infiltrating cells. J Natl Cancer Inst 88: 1146
81. Takahashi Y, Mai M, Wilson MR, Kitadai Y, Bucana CD, Ellis LM (1996) Site-dependent expression of vascular endothelial growth factor, angiogenesis and proliferation in human gastric carcinoma. Int J Oncol 8: 701
82. Talmadge JE, Fidler IJ (1978) Cancer metastasis is selective or random depending on the parent tumor population. Nature 27: 593
83. Talmadge JE, Wolman SR, Fidler IJ (1982) Evidence for the clonal origin of spontaneous metastasis. Science 217: 361
84. Talmadge JE, Benedict K, Madsen J, Fidler IJ (1984) The development of biological diversity and susceptibility to chemotherapy in cancer metastases. Cancer Res 44: 3801
85. Tarin D, Price JE, Kettlewell MGW, Souter RG, Vass ACR (1984) Mechanisms of human tumor metastasis studied in patients with peritoneovenous shunts. Cancer Res 44: 3584
86. Tarin D, Price JE, Kettlewell MGW, Souter RG, Vass ACR, Crossley B (1984) Clinicopathological observations on metastasis in man studied in patients treated with peritoneovenous shunts. BMJ 288: 749
87. Tsuruo T (1988) Mechanisms of multidrug resistance and implications for therapy. Gann 79: 285
88. Weinstein RS, Kuszak IR, Kluskens LF, Cons JS (1990) P-glycoprotein in pathology: the multidrug resistance gene family in humans. Hum Pathol 21: 34
89. Weiss L (1985) Principles of metastasis. Academic Press, Orlando
90. Willis RA (1972) The spread of tumors in the human body. Butterworth, London
91. Wilmanns C, Fan D, O'Brian CA, Bucana CD, Fidler IJ (1992) Orthotopic and ectopic organ environments differentially influence the sensitivity of murine colon carcinoma cells to doxorubicin and 5-fluorouracil. Int J Cancer 52: 98
92. Wilmanns C, Fan D, O'Brian CA, Radinsky R, Bucana CD, Tsan R, Fidler IJ (1993) Modulation of doxorubicin sensitivity and level of P-glycoprotein expression in human colon carcinoma cells by ectopic and orthotopic environments in nude mice. Int J Oncol 3: 412
93. Yoon SS, Zhang RD, Bucana CD, Fidler IJ (1995) Epigenetic regulation of multidrug resistance and metastasis-related genes in human lung adenocarcinoma cells growing in ectopic and orthotopic organs of nude mice. Int J Oncol 7: 1261
94. Zhang R, Price JE, Fujimaki T, Bucana CD, Fidler IJ (1992) Differential permeability of the blood-brain barrier in experimental brain metastases produced by human neoplasms implanted into nude mice. Am J Pathol 141: 1115