Hepatocyte growth factor modulates motility and invasiveness of ovarian carcinomas via ras mediated pathway

Molecular and Cellular Endocrinology

Volumn 202, Issue 1-2, 2003, Pages 81-88

  Ueoka, Yousuke ^a   Kato, Kiyoko ^a   Wake, Norio ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Hepatocyte growth factor; Invasion; MAP kinase; Motility; Ovarian carcinoma; Ras

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; RAS PROTEIN; SCATTER FACTOR; SCATTER FACTOR RECEPTOR;

ADENOVIRUS; AUTOPHOSPHORYLATION; CANCER CELL; CANCER CELL CULTURE; CANCER GROWTH; CANCER INVASION; CELL MOTILITY; CELL PROLIFERATION; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVATION; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; MITOGENESIS; MORPHOGENESIS; OVARY CARCINOMA; PERITONEUM; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; VIRUS INFECTION;

EID: 0038288765     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(03)00067-4     Document Type: Conference Paper

References (19)

1. Boccacino C., Ando M., Tamagnone L., Bardelli A., Michieli P., Battistini C., Comoglio P.M. Induction of epitherial tubules by growth factor HGF depends on the STAT pathway. Nature. 391:1998;285-288.
2. Corps A.N., Sowter H.M., Smith S.K. Hepatocyte growth factor stimulates motility, chemotaxis and mitogenesis in ovarian carcinoma cells expressing high levels of c-Met. Int. J. Cancer. 73:1997;151-155.
3. DiRenzo M.F., Olivero M., Katsaros D., Crepaldi T., Gaglis P., Zola P., Sismondi P., Comoglio P.M. Overexpression of the Met/HGF receptor in ovarian cancer. Int. J. Cancer. 58:1994;658-662.
4. Hartmann G., Weidner K.M., Schwartz H., Birchmeier W. The motility signal of scatter factor/hepatocyte growth factor mediated through the receptor tyrosine kinase Met requires intracellular action of Ras. J. Biol. Chem. 269:1994;21936-21939.
5. Jeffer M., Rong S., Anver M., VandeWoude G.F. Autocrine hepatocyte growth favor/scatter factor-met signaling induces transformation and invasive/metastatic phenotype in C127 cells. Oncogene. 13:1996;853-861.
6. Jeffer M., Rong S., VandeWoude G.F. Enhanced tumorigenicity and invasion-metastasis by hepatocyte growth favor/scatter factor-met signaling in human cells concomitant with induction of the urokinase proteolysis network. Mol. Cell Biol. 16:1996;1115-1125.
7. Kobayashi H., Moniwa N., Gotoh J., Sugimura M., Terao T. Role of activated protein C in facilitating basement membrane invasion by tumor cells. Cancer Res. 54:1994;261-267.
8. Lamszus K., Schmidt N., Jin L., Laterra J., Zagzag D., Way D., White M., Weinand M., Goldberg I.D., Westphal M., Rosen E.M. Scatter factor promotes motility of human glioma and neuromicrovascular endotherial cells. Int. J. Cancer. 75:1998;19-28.
9. Moghul A., Lin L., Beedle A., Kanbour-Shakir A., DeFrances M.C., Liu Y., Zarnegar R. Modulation of c-MET proto-oncogene (HGF receptor) mRNA abundance by cytokines and hormones: evidence for rapid decay of 8 kb c-MET transcript. Oncogene. 9:1994;2045-2052.
10. Montesano R., Matsumoto K., Nakamura T., Orci L. Identification of a fibroblast-derived epitherial morphoge as hepatocyte growth factor. Cell. 67:1991;901-908.
11. Nakamura T., Matsumoto K., Kiritoshi A., Tano Y., Nakamura T. Induction of hepatocyte growth factor in fibroblasts by tumor-derived factors affects invasive growth of tumor cells: in vitro analysis of tumor-stromal interactions. Cancer Res. 57:1997;3305-3313.
12. Pelicci G., Giordano S., Zhen Z., Salcini A.E., Lanfrancone L., Bardelli A., Panayotou G., Waterfield M.D., Ponzetto C., Pelicci P.G., Comoglio P.M. The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein. Oncogene. 10:1995;1631-1638.
13. Ponzetto C., Bardelli A., Zhen Z., Maina F., Zonca P.D., Giordano S., Graziani A., Panayotou G., Comoglio P.M. A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family. Cell. 77:1994;261-271.
14. Potempa S., Ridley A.J. Activation of both MAP kinase and phosphatidylinositide 3-kinase by ras is required for hepatocyte growth factor/scatter factor-induced adherens junction disassembly. Mol. Cell Biol. 9:1998;2185-2200.
15. Ridley A.J., Comoglio P.M., Hall A. Regulation of scatter factor/hepatocyte growth factor responses by ras, rac, and rho in MDCK cells. Mol. Cell Biol. 15:1995;1110-1122.
16. Stoker M., Gherardi E., Perryman M., Gray J. Scatter factor is a fibroblast-derived modulator of epitherial cell motility. Nature. 327:1987;239-242.
17. Teneriello M.G., Ebina M., Linnoila R.I., Henry M., Nash J.D., Park R.C., Bierrer M.J. p53 and Ki-ras gene mutations in epitherial ovarian neoplasms. Cancer Res. 53:1993;3103-3108.
18. Ueno H., Yamamoto H., Ito S., Li J.J., Takeshita A. Adenovirus-mediated transfer of a dominant-negative H-ras suppresses neointimal formation in balloon-injured arteries in vivo. Arterioscler. Thromb. Vasc. Biol. 17:1997;898-904.
19. Webb C.P., Aelst L.V., Wilger M.H., Vande Woude G.F. Signaling pathways in ras-mediated tumorigenicity and metastasis. Proc. Natl. Acad. Sci. USA. 95:1998;8773-8778.