Distinct mechanisms by mutant presenilin 1 and 2 leading to increased intracellular levels of amyloid β-protein 42 in Chinese hamster ovary cells

Biochemistry

Volumn 42, Issue 4, 2003, Pages 1042-1052

  Qi, Yue ^a   Morishima Kawashima, Maho ^a   Sato, Toru ^a   Mitsumori, Rie ^a   Ihara, Yasuo ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PRECURSOR PROTEINS;

BIOLOGICAL MEMBRANES; GENES;

PROTEINS;

ALPHA SECRETASE; AMYLOID BETA PROTEIN; MUTANT PROTEIN; PRESENILIN 1; PRESENILIN 2;

ANIMAL CELL; ARTICLE; CELL LEVEL; CHO CELL; GENE MUTATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; WILD TYPE;

AMINO ACID SUBSTITUTION; AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARAGINE; ASPARTIC ACID; ASPARTIC ENDOPEPTIDASES; CARBAMATES; CELL LINE; CELL-FREE SYSTEM; CHO CELLS; CRICETINAE; CULTURE MEDIA; DIPEPTIDES; ENDOPEPTIDASES; HUMANS; INTRACELLULAR FLUID; ISOLEUCINE; MEMBRANE PROTEINS; METHIONINE; MUTAGENESIS, SITE-DIRECTED; PEPTIDE FRAGMENTS; PRESENILIN-1; PRESENILIN-2; SERINE PROTEINASE INHIBITORS; THREONINE; TRANSFECTION; UP-REGULATION; VALINE;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

EID: 0037417750     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0267590     Document Type: Article

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