NF-κB as an Integrator of Diverse Signaling Pathways: The Heart of Myocardial Signaling?

Cardiovascular Toxicology

Volumn 3, Issue 3, 2003, Pages 229-253

  Jones, W Keith ^a   Brown, Maria ^a   Ren, Xiaoping ^a   He, Suiwen ^a   McGuinness, Michael ^a  

^a UNIVERSITY OF CINCINNATI   (United States)

Author keywords

Cardiomyopathy; Ischemia; NF kappaB; Reperfusion

Indexed keywords

CYTOKINE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; TRANSCRIPTION FACTOR; CALCINEURIN; ESTROGEN; HEAT SHOCK PROTEIN;

ANGINA PECTORIS; APOPTOSIS; ATHEROSCLEROSIS; BURN; CARDIOVASCULAR DISEASE; CELL DIFFERENTIATION; CELL DIVISION; CELL GROWTH; CELL SURVIVAL; CELLULAR IMMUNITY; CONGESTIVE HEART FAILURE; ENZYME PHOSPHORYLATION; GENE EXPRESSION; GENE TARGETING; GRAFT REJECTION; HEART DILATATION; HEART MUSCLE; HEART MUSCLE ISCHEMIA; HEART VENTRICLE HYPERTROPHY; HEAT SHOCK; HYPOXIA; MOUSE; MYOCARDITIS; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROMOTER REGION; REPERFUSION INJURY; REVIEW; SIGNAL TRANSDUCTION; STRESS; ANIMAL; BIOSYNTHESIS; CARDIOMEGALY; CARDIOMYOPATHY; GENETICS; HEART; HUMAN; PATHOLOGY; PHYSIOLOGY; TRANSACTIVATION;

MURINAE;

ANIMALS; CALCINEURIN; CARDIOMEGALY; CARDIOMYOPATHIES; CYTOKINES; ESTROGENS; HEART; HEAT-SHOCK PROTEINS; HUMANS; I-KAPPA B PROTEINS; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; NF-KAPPA B; SIGNAL TRANSDUCTION; TRANS-ACTIVATION (GENETICS);

EID: 0142085794     PISSN: 15307905     EISSN: None     Source Type: Journal    
DOI: 10.1385/CT:3:3:229     Document Type: Review

References (248)

1. Sen, R. and Baltimore, D. (1986). Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 46:705-716.
2. Baldwin, A.S. Jr. (1996). The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu. Rev. Immunol. 14:649-683.
3. Parry, G. and Mackman, N. (1994). A set of inducible genes expressed by activated human monocytic and endothelial cells contain κB-like sites that specifically bind c-Rel-p65 heterodimers. J. Biol. Chem. 269:20823-20825.
4. Knuefermann, P., Chen, P., Misra, A., Shi, S.P., Abdellatif, M., and Sivasubramanian, N. (2002). Myotrophin/V-1, a protein up-regulated in the failing human heart and in postnatal cerebellum, converts NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. J. Biol. Chem. 277:23888-23897.
5. Dawn, B., Xuan, Y.T., Marian, M., et al. (2001). Cardiac-specific Abrogation of NF-kappaB activation in mice by transdominant expression of a mutant Ikappa-Balpha. J. Mol. Cell. Cardiol. 33:161-173.
6. Haudek, S.B., Bryant, D.D., and Giroir, B.P. (2001). Differential regulation of myocardial NF kappa B following acute or chronic TNF-alpha exposure. J. Mol. Cell. Cardiol. 33:1263-1271.
7. Haudek, S.B., Spencer, E., Bryant, D.D., et al. (2001). Overexpression of cardiac I-kappaBalpha prevents endotoxin-induced myocardial dysfunction. Am. J. Physiol. Heart Circ. Physiol. 280:H962-H968.
8. Kubota, T., Miyagishima, M., Frye, C., et al. (2001). Overexpression of tumor necrosis alpha activates both anti- and pro- apoptotic pathways in the myocardium. JMCC 33:1331-1344.
9. Baldwin, A.S. Jr. (2001). The transcription factor NF-κB and human disease. JCI 107:3-6.
10. Regula, K.M., Ens, K., and Kirshenbaum, L.A. (2002). IKK beta is required for Bcl-2-mediated NF-kappa B activation in ventricular myocytes. J. Biol. Chem. 277:38676-38682.
11. Zingarelli, B., Hake, P.W., Yang, Z., O'Connor, M., Denenberg, A., and Wong, H.R. (2002). Absence of inducible nitric oxide synthase modulates early reperfusion-induced NF-kappaB and AP-1 activation and enhances myocardial damage. FASEB J. 16:327-342.
12. Abu-Amer, Y., Ross, F.P., McHugh, K.P., et al. (1998). Tumor necrosis factor-α activation of nuclear transcription factor-κB in marrow macrophages is mediated by c-Src tyrosine phosphorylation of IκBα. JBC 273:29417-29423.
13. Diaz-Guerra, M.J., Castrillo, A., Martin-Sanz, P., and Bosca, L. (1999). Negative regulation by protein tyrosine phosphatase of IFN-gamma-dependent expression of inducible nitric oxide synthase. J. Immunol. 162:6776-6783.
14. Livolsi, A., Busuttil, V., Imbert, V., Abraham, R.T., and Peyron, J.F. (2001). Tyrosine phosphorylation-dependent activation of NF-kappa B. Requirement for p56 LCK and ZAP-70 protein tyrosine kinases. Eur. J. Biochem. 268:1508-1515.
15. Birbach, A., Gold, P., Binder, B.R., Hofer, E., de Martin, R., and Schmidt, J.A. (2002). Signaling molecules of the NF-κB pathway shuttle constitutively between cytoplasm and nucleus. JBC 277:10842-10851.
16. Carlotti, F., Dower, S.K., and Qwarnstrom, E.E. (2000). Dynamic shuttling of nuclear factor kappa B between the nucleus and cytoplasm as a consequence of inhibitor dissociation. J. Biol. Chem. 275:41028-41034.
17. Arenzana-Seisdedos, F., Thompson, J., Rodriguez, M.S., et al. (1995). Inducible nuclear expression of newly synthesized I kappa B alpha negatively regulates DNA-binding and transcriptional activities of NF-kappa B. Mol. Cell. Biol. 15:2689-2696.
18. Wen, W., Meinkoth, J.L., Tsien, R.Y., and Taylor, S.S. (1995). Identification of a signal for rapid export of proteins from the nucleus. Cell 82:463-473.
19. Suyang, H., Phillips, R., Douglas, I., and Ghosh, S. (1996). Role of unphosphorylated, newly synthesized I kappa B beta in persistent activation of NF-kappa B. Mol. Cell. Biol. 16:5444-5449.
20. Baeuerle, P. and Henkel, T. (1994). Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12:141-179.
21. Siebenlist, U., Franzoso, G., and Brown, K. (1994). Structure, regulation and function of NF-κB. Annu. Rev. Cell Biol. 10:405-455.
22. Hoffmann, A., Levchenko, A., Scott, M.L., and Baltimore, D. (2002). The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. Science 298:1241-1245.
23. Chandrasekar, B. and Freemen, G.L. (1997). Induction of nuclear factor-kappaB and activation factor 1 in post-ischemic myocardium. FEBS Lett. 401:30-34.
24. Ladner, K.J., Caligiuri, M.A., and Guttridge, D.C. (2003). Tumor necrosis factor-regulated biphasic activation of NF-kappa B is required for cytokine-induced loss of skeletal muscle gene products. JBC 278:2294-2303.
25. Lille, S.T., Lefler, S.R., Mowlavi, A., et al. (2001). Inhibition of the initial wave of NF-kappaB activity in rat muscle reduces ischemia/reperfusion injury. Muscle Nerve 24:534-541.
26. Li, C., Kao, R.L., Ha, T., Kelley, J., Browder, I.W., and Williams, D.L. (2001). Early activation of IKκBeta during in vivo myocardial ischemia. Am. J. Physiol. Heart Circ. Physiol. 280:H1264-H1271.
27. Condorelli, G., Morisco, C., Latronico, M.V., et al. (2002). TNF-alpha signal transduction in rat neonatal cardiac myocytes: definition of pathways generating from the TNF-alpha receptor. FASEB J. 16:1732-1737.
28. Craig, R., Wagner, M., McCardle, T., Craig, A.G., and Glembotski, CC. (2001). The cytoprotective effects of the glycoprotein 130 receptor-coupled cytokine, cardiotrophin-1, require activation of NF-kappa B. J. Biol. Chem. 276:37621-37629.
29. Maulik, N., Sato, M., Price, B.D., and Das, D.K. (1998). An essential role of NFkappaB in tyrosine kinase signaling of p38 MAP kinase regulation of myocardial adaptation to ischemia. FEBS Lett. 429:365-369.
30. Zechner, D., Craig, R., Hanford, D.S., McDonough, P.M., Sabbadini, R.A., and Glembotski, C.C. (1998). MKK6 activates myocardial cell NF-kappaB and inhibits apoptosis in a p38 mitogen-activated protein kinase-dependent manner. J. Biol. Chem. 273:8232-8239.
31. Force, T., Haq, S., Kilter, H., and Michael, A. (2002). Apoptosis signal-regulating kinase/nuclear factor-kappaB: a novel signaling pathway regulates cardiomyocyte hypertrophy. Circulation 105:402-404.
32. Hirotani, S., Otsu, K., Nishida, K., et al. (2002). Involvement of nuclear factor-kappaB and apoptosis signal-regulating kinase 1 in G-protein-coupled receptor agonist-induced cardiomyocyte hypertrophy. Circulation 105:509-515.
33. Lee, F.S., Hagler, J., Chen, Z.J., and Maniatis, T. (1997). Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway. Cell 88:213-222.
34. Lee, F.S., Peters, R.T., Dang, L.C., and Maniatis, T. (1998). MEKK1 activates both I-kappaB kinase alpha and I-kappaB kinase beta. PNAS 95:9319-9324.
35. Vanden Berghe, W., Plaisance, S., Boone, E., et al. (1998). p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-kappaB p65 transactivation mediated by tumor necrosis factor. J. Biol. Chem. 273:3285-3290.
36. Wesselborg, S., Bauer, M.K., Vogt, M., Schmitz, M.L., and Schulze-Osthoff, K. (1997). Activation of transcription factor NF-kappaB and p38 mitogen-activated protein kinase is mediated by distinct and separate stress effector pathways. J. Biol. Chem. 272:12422-12429.
37. Yang, J., Fan, G.H., Wadzinski, B.E., Sakurai, H., and Richmond, A. (2001). Protein phosphatase 2A interacts with and directly dephosphorylates RelA. J. Biol. Chem. 276:47828-47833.
38. Zhao, X. and Eghbali-Webb, M. (2002). Gender-related differences in basal and hypoxia-induced activation of signal transduction pathways controlling cell cycle progression and apoptosis, in cardiac fibroblasts. Endocrine 18:137-145.
39. Huynh, Q.K., Boddupalli, H., Rouw, S.A., et al. (2000). Characterization of the recombinant IKK1/IKK2 heterodimer. Mechanisms regulating kinase activity. J. Biol. Chem. 275:25883-25891.
40. Peters, R.T., Liao, S.M., and Maniatis, T. (2000). IKK-epsilon is part of a novel PMA-inducible Ikappa-B kinase complex. Mol. Cell. 5:513-522.
41. Shimada, T., Kawai, T., Takeda, K., et al. (1999). IKK-I, a novel lipopolysaccharide inducible kinase that is related to IkappaB kinases. Int. Immunol. 11:1357-1362.
42. Valen, G., Yan, Z., and Hansson, G.K. (2001). Nuclear factor kappaB and the heart. JACC 38:307-314.
43. Janssen-Heininger, Y.M., Pointer, M.E., and Baeuerle, P.A. (2000). Recent advances towards understanding redox mechanisms in the activation of nuclear factor κB. Free Rad. Biol. Med. 28:1317-1327.
44. Wang, D. and Baldwin, A.S. Jr. (1998). Activation of nuclear factor-kappaB-dependent transcription by tumor necrosis factor-alpha is mediated through phosphorylation of RelA/p65 on serine 529. J. Biol. Chem. 273:29411-29416.
45. Sakurai, H., Chiba, H., Miyoshi, H., Sugita, T., and Toruimi, W. (1999). IκB kinases phosphorylate NF-κB p65 subunit on serine 536 in the transactivation domain. JBC 274:30353-30356.
46. Sizemore, N., Lerner, N., Dombrowski, N., Sakurai, H., and Stark, G.R. (2002). Distinct roles of the Ikappa B kinase alpha and beta subunits in liberating nuclear factor kappa B (NF-kappa B) from Ikappa B and in phosphorylating the p65 subunit of NF-kappa B. J. Biol. Chem. 277:3863-3869.
47. Sizemore, N., Leung, S., and Stark, G.R. (1999). Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit. Mol. Cell. Biol. 19:4798-4805.
48. Anrather, J., Csizmadia, V., Soares, M.P., and Winkler, H. (1999). Regulation of NF-kappaB RelA phosphorylation and transcriptional activity by p21(ras) and protein kinase Czeta in primaryendothelial cells. J. Biol. Chem. 274:13594-13603.
49. Leitges, M., Sanz, L., Martin, P., et al. (2001). Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway. Mol. Cell. 8:771-780.
50. Zhong, H., Voll, R.E., and Ghosh, S. (1998). Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with thecoactivator CBP/p300. Mol. Cell. 1:661-671.
51. Karin, M. and Ben-Neriah, Y. (2000). Phosphorylation meets ubiquitination: the control of NF-κB activity. Ann. Rev. Immun. 18:621-623.
52. Vermeulin, L., De Wilde, G., Notebaert, S., Berghe, W.V., and Haegeman, G. (2002). Regulation of the transcriptional activity of the nuclear factor-κB p65 subunit. Biochem. Pharmacol. 64:963-970.
53. Meyer, C.F., Wang, X., Chang, C., Templeton, D., and Tan, T.H. (1996). Interaction between c-Rel and the mitogen-activated protein kinase kinase kinase I signaling cascade in mediating kappaB enhancer activation. J. Biol. Chem. 271:8971-8976.
54. Sun, S.C., Maggirwar, S.B., and Harhaj, E. (1995). Activation of NF-kappa B by phosphatase inhibitors involves the phosphorylation of I kappa B alpha at phosphatase 2A-sensitive sites. J. Biol. Chem. 270:18347-18351.
55. Chen, L.F., Mu, Y., and Greene, W.C. (2002). Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB. EMBO J. 21:6539-6548.
56. Furia, B., Deng, L., Wu, K., et al. (2002). Enhancement of nuclear factor-kappa B acetylation by coactivator p300 and HIV-1 Tat proteins. J. Biol. Chem. 277:4973-4980.
57. Kiernan, R., Bres, V., Ng, R.W., et al. (2003). Post-activation turn-off of NF-kappa B-dependent transcription is regulated by acetylation of p65. J. Biol. Chem. 278:2758-2766.
58. Cogswell, J.P., Godlevski, M.M., Wisely, G.B., et al. (1994). NF-kappa B regulates IL-1 beta transcription through a consensus NF-kappa B binding site and a nonconsensus CRE-like site. J. Immunol. 153:712-723.
59. McKay, L.I. and Cidlowski, J.A. (2000). CBP (CREB binding protein) integrates NF-kappaB (nuclear factor-kappaB) and glucocorticoid receptor physical interactions and antagonism. Mol. Endocrinol. 14:1222-1234.
60. Ohmori, Y. and Hamilton, T.A. (1995). The interferon-stimulated response element and a kappa B site mediate synergistic induction of murine IP-10 gene transcription by IFN-gamma and TNF-alpha. J. Immunol. 154:5235-5244.
61. Hassa, P.O. and Hottiger, M.O. (1999). A role of poly (ADP-ribose) polymerase in NF-kappaB transcriptional activation. Biol. Chem. 380:953-959.
62. Oliver, F.J., Menissier-de Murcia, J., Nacci, C., et al. (1999). Resistance to endotoxic shock as a consequence of defective NF-κB activation in poly (ADP-ribose) polymerase-1 deficient mice. EMBO J. 18:4446-4454.
63. Shall, S. and de Murcia, G. (2000). Poly(ADP-ribose-polymerase-1: what have we learned from the deficient mouse model? Mutat. Res. 460:1-15.
64. Lopez-Rodriguez, C., Aramburu, J., Jin, L., Rakeman, A.S., Michino, M., and Rao, A. (2001). Bridging the NFAT and NF-kappaB families: NFAT5 dimerization regulates cytokine gene transcription in response to osmotic stress. Immunity 15:47-58.
65. Casolaro, V., Georas, S.N., Song, Z., et al. (1995). Inhibition of NF-AT-dependent transcription by NF-kappa B: implications for differential gene expression in T helper cell subsets. Proc. Natl. Acad. Sci. USA 92:11623-11627.
66. Tsuboi, A., Muramatsu, M., Tsutsumi, A., Arai, K., and Arai, N. (1994). Calcineurin activates transcription from the GM-CSF promoter in synergy with either protein kinase C or NF-kappa B/AP-1 in T cells. Biochem. Biophys. Res. Commun. 199:1064-1072.
67. Sica, A., Dorman, L., Viggiano, V., et al. (1997). Interaction of NF-kappaB and NFAT with the interferon-gamma promoter. J. Biol. Chem. 272:30412-30420.
68. Bueno, O.F., De Windt, L.J., Tymitz, K.M., et al. (2000). The MEK1-ERK1/ 2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice. EMBO J. 19:6341-6350.
69. Bueno, O.F., van Rooij, E., Molkentin, J.D., Doevendans, P.A., and De Windt, L.J. (2002a). Calcineurin and hypertrophic heart disease: novel insights and remaining questions. Cardiovasc. Res. 53:806-821.
70. Molkentin, J.D., Lu, J.R., Antos, C.L., et al. (1998). A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell 93:215-228.
71. Molkentin, J.D. (2000). Calcineurin and beyond: cardiac hypertrophic signaling. Circ. Res. 87:731-738.
72. Frantz, B., Nordby, E.C., Bren, G., et al. (1994). Calcineurin acts in synergy with PMA to inactivate I kappa B/MAD3, an inhibitor of NF-kappa B. EMBO J. 13:861-870.
73. Shumway, S.D., Berchtold, C.M., Gould, M.N., and Miyamoto, S. (2002). Evidence for unique calmodulin-dependent nuclear factor-kappaB regulation in WEHI-231 B cells. Mol. Pharmacol. 61:177-185.
74. Steffan, N.M., Bren, G.D., Frantz, B., Tocci, M.J., O'Neill, E.A., and Paya, C.V. (1995). Regulation of IκB alpha phosphorylation by PKC- and Ca(2+)-dependent signal transduction pathways. J. Immunol. 155:4685-4691. PMID:7594468.
75. Pons, S. and Torres-Aleman, I. (2000). Insulin-like growth factor-I stimulates dephosphorylation of ikappa B through the serine phosphatase calcineurin (protein phosphatase 2B). J. Biol. Chem. 275:38620-38625.
76. Trushin, S.A., Pennington, K.N., Algeciras-Schimnich, A., and Paya, C.V. (1999). Protein kinase C and calcineurin synergize to activate IkappaB kinase and NF-kappaB in T lymphocytes. J. Biol. Chem. 274:22923-22931.
77. Biswas, G., Anandatheerthavarada, H.K., Zaidi, M., and Avadhani, N.G. (2003). Mitochondria to nucleus stress signaling: a distinctive mechanism of NF-κB/Rel activation through calcineurin-mediated inactivation of IκBα. J. Cell. Biol. 161:507-519.
78. Catz, S.D. and Johnson, J.L. (2001). Transcriptional regulation of bcl-2 by nuclear factor kappa B and its significance in prostate cancer. Oncogene 20:7342-7351.
79. Chilov, D., Kukk, E., Taira, S., et al. (1997). Genomic organization of human and mouse genes for vascular endothelial growth factor C. J. Biol. Chem. 272:25176-25183.
80. Collart, M.A., Baeuerle, P., and Vassalli, P. (1990). Regulation of tumor necrosis factor alpha transcription in macrophages: involvement of four kappa B-like motifs and of constitutive and inducible forms of NF-kappa B. Mol. Cell. Biol. 10:1498-1506.
81. Hiscott, J., Marois, J., Garoufalis, J., et al. (1993). Characterization of a functional NF-kappa B site in the human interleukin 1 beta promoter: evidence for a positive autoregulatory loop. Mol. Cell. Biol. 13:6231-6240.
82. Kinugawa, K., Shimizu, T., Yao, A., Kohmoto, O., Serizawa, T., and Takahashi, T. (1997). Transcriptional regulation of inducible nitric oxide synthase in cultured neonatal rat cardiac myocytes. Circ. Res. 81:911-921.
83. Kishimoto, I., Rossi, K., and Garbers, D.L. (2001). A genetic model provides evidence that the receptor for atrial natriuretic peptide (guanylyl cyclase-A) inhibits cardiac ventricular myocyte. Proc. Natl. Acad. Sci. USA 98:2703-2706.
84. Pan, J. and McEver, R.P. (1995). Regulation of the human P-selectin promoter by Bcl-3 and specific homodimeric members of the NF-kappa B/Rel family. J. Biol. Chem. 270:23077-23083.
85. Shakhov, A.N., Collart, M.A., Vassalli, P., Nedospasov, S.A., and Jongeneel, C.V. (1990). Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophages. J. Exp. Med. 171:35-47.
86. Yamamoto, K., Arakawa, T., Ueda, N., and Yamamoto, S. (1995). Transcriptional roles of nuclear factor kappa B and nuclear factor-interleukin-6 in the tumor necrosis factor alpha-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells. J. Biol. Chem. 270:31315-31320.
87. Yin, L., Hubbard, A.K., and Giardina, C. (2002). NF-kappa B regulates transcription of the mouse telomerase catalytic subunit. J. Biol. Chem. 275:36671-36675.
88. Han, R., Ray, P., Baughman, K., and Feldman, A. (1991). Detection of interleukin and interleukin receptor mRNA in human heart by polymerase chain reaction. Biochem. Biophys. Res. Commun. 181:520-523.
89. Matsumori, A., Yamada, T., Suzuki, H., Matoba, Y., and Sasayama, S. (1994). Increased circulating cytokines in patients with myocarditis and cardiomyopathy. Br. Heart J. 72:561-566.
90. Satoh, M., Tamura, G., Segawa, I., Tashiro, A., Hiramori, K., and Satodate, R. (1996). Expression of cytokine genes and presence of enteroviral genomic RNA in endomyocardial biopsy tissues of myocarditis and cardiomyopathy. Virchows Arch. 427:503-509.
91. Testa, M., Yeh, M., Lee, P., et al. (1996). Circulating levels of cytokines and their endogenous modulators in patients with mild to severe congestive heart failure due to coronary artery disease or hypertension. J. Am. Coll. Cardiol. 28:964-971.
92. Long, C.S. (2001). The role of interleukin-1 in the failing heart. Heart Fail. Rev. 6:81-94.
93. Frangogiannis, N.G., Smith, C.W., and Entman, M.L. (2002). The inflammatory response in myocardial infarction. Cardiovasc. Res. 53:31-47.
94. Kaminski, K.A., Bonda, T.A., Korecki, J., and Musial, W.J. (2002). Oxidative stress and neutrophil activation - the two keystones of ischemia/reperfusion injury. Int. J. Cardiol. 86:41-59.
95. Kanda, T., Inoue, M., Kotajima, N., et al. (2000). Circulating interleukin-6 and interleukin-6 receptors in patients with acute and recent myocardial infarction. Cardiology 93:191-196.
96. Neumann, F.J., Ott, I., Gawaz, M., et al. (1995). Cardiac release of cytokines and inflammatory responses in acute myocardial infarction. Circulation 92:748-755.
97. Shibata, M., Endo, S., Inada, K., et al. (1997). Elevated plasma levels of interleukin-1 receptor antagonist and interleukin-10 in patients with acute myocardial infarction. J. Interferon Cytokine Res. 17:145-150.
98. Mann, D.L. (1999). Cytokines as mediators of disease progression in the failing heart, in Congestive Heart Failure (J.D. Hosenpud and B.H. Greenberg, eds), Lippincott Williams & Wilkins, Philadelphia, pp. 213-232.
99. Wollert, K.C. and Drexler, H. (2001). The role of interleukin-6 in the failing heart. Heart Failure Reviews 6:95-103.
100. Cain, B.S., Meldrum, D.R., Dinarello, C.A., et al. (1999). Tumor necrosis factor-alpha and interleukin-1-beta synergistically depress human myocardial function. Crit. Care Med. 27:1309-1318.
101. Panas, D., Khadow, F.H., Szabo, C., and Schultz, R. (1998). Proinflammatory cytokines depress cardiac efficiency by nitric oxide dependent mechanism. Am. J. Physiol. 275: H1016-H1023.
102. Chandrasekar, B., Smith, J.B., and Freeman, G.L. (2001). Ischemia-reperfusion of rat myocardium activates nuclear factor-KappaB and induces neutrophil infiltration via lipopolysaccharide-induced CXC chemokine. Circulation 103:2296-2302.
103. Das, U.N. (2000). Free radicals, cytokines and nitric oxide in cardiac failure and myocardial infarction. Mol. Cell. Biochem. 215:145-152.
104. Ono, K., Matsumori, A., Furukawa, Y., et al. (1999). Prevention of myocardial reperfusion injury in rats by an antibody against monocyte chemotactic and activating factor/monocyte chemoattractant protein-1. Lab. Invest. 79:195-203.
105. Bauriedel, G., Hutter, R., Welsch, U., Bach, R., Sievert, H., and Luderitz, B. (1999). Role of smooth muscle cell death in advanced coronary primary lesions: implications for plaque instability. Cardiovasc. Res. 41:480-488.
106. Breuss, J.M., Cejna, M., Bergmeister, H., et al. (2002). Activation of nuclear factor-kappa B significantly contributes to lumen loss in a rabbit iliac artery balloon angioplasty model. Circulation 105:633-638.
107. Cooper, M., Lindholm, P., Peiper, G., et al. (1998). Myocardial nuclear factor-κB activity and nitric oxide production in rejecting cardiac allografts. Transplantation 66:838-844.
108. Ritchie, M.E. (1998). Nuclear factor-κB is selectively and markedly activated in humans with unstable angina pectoris. Circulation 98:1707-1713.
109. Valen, G., Hansson, G.K., Dumitrescu, A., and Vaage, J. (2000). Unstable angina activates myocardial heat shock protein 72, endothelial nitric oxide synthase, and transcription factors NFkappaB and AP-1. Cardiovasc. Res. 47:49-56.
110. Kubota, T., McTiernan, C.F., Frye, C.S., et al. (1997). Dilated cardiomyopathy in transgenic mice with cardiac-specific overexpression of tumor necrosis factor-alpha. Circ. Res. 81:627-635.
111. Morgan, E.N., Boyle, E.M. Jr., Yun, W., et al. (1999). An essential role for NF-kappaB in the cardioadaptive response to ischemia. Ann. Thorac. Surg. 68:377-382.
112. Xuan, Y.T., Tang, X.L., Banerjee, S., et al. (1999). Nuclear factor-kappaB plays an essential role in the late phase of ischemic preconditioning in conscious rabbits. Circ. Res. 84:1095-1109.
113. Zhao, T.C. and Kukreja, R.C. (2002). Related Articles, Links Abstract Late preconditioning elicited by activation of adenosine A(3) receptor in heart: role of NF-kappa B, iNOS and mitochondrial K(ATP) channel. J. Mol. Cell. Cardiol. 34:263-277.
114. Canty, T.G. Jr., Boyle, E.M. Jr., Farr, A., Morgan, E.N., Verrier, E.D., and Pohlman, T.H. (1999). Oxidative stress induces NF-kappaB nuclear translocation without degradation of IkappaBalpha. Circulation 100(19 Suppl II):361-364.
115. Maulik, N., Sasaki, H., Addya, S., and Das, D.K. (2000). Regulation of cardiomyocyte apoptosis by redox-sensitive transcription factors. FEBS Lett. 485:7-12.
116. Sasaki, H., Galang, N., and Maulik, N. (1999). Redox regulation of NF-kappaB and AP-1 in ischemic reperfused heart. Antioxid. Redox Signal 1:317-324.
117. Wong, S.C., Fukuchi, M., Melnyk, P., Rodger, I., and Giaid, A. (1998). Induction of cyclooxygenase-2 and activation of NF-κB in myocardium of patients with congestive heart failure. Circulation 98:100-103.
118. Gupta, S. and Sen, S. (2002). Myotrophin-kappaB DNA interaction in the initiation process of cardiac hypertrophy. Biochim. Biophys. Acta 1589:247-260.
119. Higuchi, Y., Otsu, K., Nishida, K., et al. (2002). Involvement of reactive oxygen species-mediated NF-kappa B activation in TNF-alpha-induced cardiomyocyte hypertrophy. J. Mol. Cell. Cardiol. 34:233-240.
120. Purcell, N.H., Tang, G., Yu, C., Mercurio, F., DiDonato, J.A., and Lin, A. (2001). Activation of NF-κB is required for hypertrophic growth of primary rat neonatal ventricular cardiomyocytes. PNAS 98:6668-6673.
121. Bryant, D., Becker, L., Richardson, J., et al. (1998). Cardiac failure in transgenic mice with myocardial expression of tumor necrosis factor-alpha. Circulation 97:1375-1381.
122. Sivasubramanian, N., Coker, M.L., Kurrelmeyer, K.M., et al. (2001). Left ventricular remodeling in transgenic mice with cardiac restricted overexpression of tumor necrosis factor. Circulation 104:826-831.
123. Baumgarten, G., Knuefermann, P., Kalra, D., et al. (2002). Load-dependent and -independent regulation of proinflammatory cytokine and cytokine receptor gene expression in the adultmammalian heart. Circulation 105:2192-2197.
124. De Keulenaer, G.W., Wang, Y., Feng, Y., et al. (2002). Identification of IEX-1 as a biomechanically controlled nuclear factor-kappaB target gene that inhibits cardiomyocyte hypertrophy. Circ. Res. 90:690-696.
125. Liang, F. and Gardner, D.G. (1999). Mechanical strain activates BNP gene transcription through a p38/NF-kappaB-dependent mechanism. J. Clin. Invest. 104:1603-1612.
126. Saganek, L.J., Ignasiak, D.P., Batley, B.L., Potoczak, R.E., Dodd, G., and Gallagher, K.P. (1997). Heat stress increases cardiac HSP72i but fails to reduce myocardial infarct size in rabbits 24 hours later. Basic Res. Cardiol. 92:331-338.
127. Carlson, D.L., White, D.J., Maass, D.L., Nguyen, R.C., Giroir, B., and Horton, J.W. (2003). Ikappa B overexpression in cardiomyocytes prevents NF-kappa B translocation and provides cardioprotection in trauma. Am. J. Physiol. Heart Circ. Physiol. 284:H804-H814.
128. Maass, D.L., Hybki, D.P., White, J., and Horton, J.W. (2002). The time course of cardiac NF-kappaB activation and TNF-alpha secretion by cardiac myocytes after burn injury: contribution toburn-related cardiac contractile dysfunction. Shock 17:293-299.
129. Bergmann, M.W., Loser, P., Dietz, R., and von Harsdorf, R. (2001). Effect of NF-kappa B Inhibition on TNF-alpha-induced apoptosis and downstream pathways in cardiomyocytes. J. Mol. Cell. Cardiol. 33:1223-1232.
130. Cowling, R.T., Gurantz, D., Peng, J., Dillmann, W.H., and Greenberg, B.H. (2002). Transcription factor NF-kappa B is necessary for up-regulation of type 1 angiotensin II receptor mRNA in rat cardiac fibroblasts treatedwith tumor necrosis factor-alpha or interleukin-1 beta. J. Biol. Chem. 277:5719-5724.
131. Wang, S., Kotamraju, S., Konorev, E., Kalivendi, S., Joseph, J., and Kalyanaraman, B. (2002). Activation of nuclear factor-kappaB during doxorubicin-induced apoptosis in endothelial cells and myocytes is pro-apoptotic: the role of hydrogen peroxide. Biochem. J. 367:729-740.
132. Wei, Z., Costa, K., Al-Mehdi, A.B., Dodia, C., Muzykantov, V., and Fisher, A.B. (1999). Simulated ischemia in flow-adapted endothelial cells leads to generation of reactive oxygen species and cell signaling. Circ. Res. 85:682-689.
133. Bourcier, T., Sukhova, G., and Libby, P. (1997). The nuclear factor-κB signaling pathway participates in dysregulation of vascular smooth muscle cells in vitro and in human atherosclerosis. JBC 272:15817-15824.
134. Brand, K., Page, S., Rogler, G., et al. (1996). Activated nuclear factor-κB in present in the atherosclerotic lesion. JCI 97:1715-1722.
135. Bellas, R.E., Lee, J.S., and Sonenshein, G.E. (1995). Expression of a constitutive NF-kappa B-like activity is essential for proliferation of cultured bovine vascular smooth muscle cells. J. Clin. Invest. 96:2521-2527.
136. Autieri, M.V., Yue, T.L., Ferstein, G.Z., and Ohlstein, E. (1995). Antisense oligonucleotides to the p65 subunit of NF-κB inhibit human vascular smooth muscle cell adherence and proliferation and prevent neointima formation in rat carotid arteries. Biochem. Biophys. Res. Commun. 213:827-836.
137. Berliner, J.A., Navab, M., Fogelman, A.M., et al. (1995). Atherosclerosis: basic mechanisms. Oxidation, inflammation, and genetics. Circulation 91:2488-2496.
138. Erl, W., Hansson, G.K., de Martin, R., Draude, G., Weber, K.S., and Weber, C. (1999). Nuclear factor-kappa B regulates induction of apoptosis and inhibitor of apoptosis protein-1 expression in vascular smooth muscle cells. Circ. Res. 84:668-677.
139. Hayashi, K., Takahata, H., Kitagawa, N., Kitange, G., Kaminogo, M., and Shibata, S. (2001). N-acetylcysteine inhibited nuclear factor-kappaB expression and the intimal hyperplasia in rat carotid arterial injury. Neurol. Res. 23:731-738.
140. Ortego, M., Bustos, C., Hernandez-Presa, M.A., et al. (1999). Atorvastatin reduces NF-kappaB activation and chemokine expression in vascular smooth muscle cells and mononuclear cells. Atherosclerosis 147:253-261.
141. Matsui, H., Ihara, Y., Fujio, Y., et al. (1999). Induction of interleukin (IL)-6 by hypoxia is mediated by nuclear factor (NF)-kappa B and NF-IL6 in cardiac myocytes. Cardiovasc. Res. 42:104-112.
142. Peng, M., Huang, L., Xie, Z.J., Huang, W.H., and Askari, A. (1995). Oxidant-induced activations of nuclear factor-kappa B and activator protein-1 in cardiac myocytes. Cell. Mol. Biol. Res. 41:189-197.
143. Fisher, A.B., Al-Mehdi, A.B., and Manevich, Y. (2002). Shear stress and endothelial cell activation. Crit. Care Med. 30(5 Suppl):S192-S197.
144. McGuinness, M., Brown, M., Wright, T., et al. (2003). Transdominant blockade of NF-κB in cardiac pathophysiology. Submitted.
145. Gupta, S., Purcell, N.H., Lin, A., and Sen, S. (2002). Activation of nuclear factor-κB is necessary for myotrophin-induced cardiac hypertrophy. J Cell Biol. 159:1019-1028.
146. Anderson, K.M., Berrebi-Bertrand, I., Kirkpatrick, R.B., et al. (1999). cDNA sequence and characterization of the gene that encodes human myotrophin/ V-1 protein, a mediator of cardiac hypertrophy. J. Mol. Cell. Cardiol. 31:705-719.
147. Sivasubramanian, N., Adhikary, G., Sil, P.C., and Sen, S. (1996). Cardiac myotrophin exhibits rel/NF-kappa B interacting activity in vitro. J. Biol. Chem. 271:2812-2816.
148. Sil, P., Misono, K., and Sen, S. (1993). Myotrophin in human cardiomyopathic heart. Circ. Res. 73:98-108.
149. Sen, S., Kundu, G., Mekhail, N., Castel, J., Misono, K., and Healy, B. (1990). Myotrophin: purification of a novel peptide from spontaneously hypertensive rat heart that influences myocardial growth. J. Biol. Chem. 265:16635-16643.
150. Grabellus, F., Lavkau, B., Sokoll, A., et al. (2002). Reversible activation of nuclear factor-kappa B in human end-stage heart failure after left ventricular mechanical support. Cardiovasc. Res. 53:124-130.
151. Saito, T. and Giaid, A. (1999). Cyclooxygenase-2 and nuclear factor-kappaB in myocardium of end stage human heart failure. Congest. Heart Fail. 5:222-227.
152. Wang, W., Tam, W.F., Hughes, C.C., Rath, S., and Sen, R. (1997). c-Rel is a target of pentoxifylline-mediated inhibition of T lymphocyte activation. Immunity 6:165-174.
153. Sliwa, K., Skudicky, D., Candy, G., Wisenbaugh, T., and Sareli, P. (1998). Randomized investigation of effects of pentoxlflline on left ventricular performance in idiopathic dilated cardiomyopathy. Lancet 351:1091-1093.
154. Jimenez, J.L., Punzon, C., Navarro, J., Munoz-Fernandez, M.A., and Fresno, M. (2001). Phosphodiesterase 4 inhibitors prevent cytokine secretion by T lymphocytes by inhibiting nuclear factor-kappaB and nuclear factor of activated T cells activation. J. Pharmacol. Exp. Ther. 299:753-759.
155. 2, but not that activated by ceramide, lipopolysaccharides, or phorbol ester. J. Immunol. 168:2644-2651.
156. Kondratyev, A.D., Chung, K.N., and Jung, M.O. (1996). Identification and characterization of a radiation-inducible glycosylated human early-response gene. Cancer Res. 56:1498-1502.
157. Ohki, R., Yamamoto, K., Mano, H., Lee, R.T., Ikeda, U., and Shimada, K. (2002). Identification of mechanically induced genes in human monocytic cells by DNA microarrays. J. Hypertens. 20:685-691.
158. Garcia, J., Ye, Y., Arranz, V., Letourneux, C., Pezeron, G., and Porteu, F. (2002). IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation. EMBO J. 21:5151-5163.
159. Izumi, T., Saito, Y., Kishimoto, I., et al. (2001). Blockade of the natriuretic peptide receptor guanylyl cyclase-A inhibits NF-kappaB activation and alleviates myocardial ischemia/reperfusion injury. J. Clin. Invest. 108:203-213.
160. Kiemer, A.K., Weber, N.C., and Vollmar, A.M. (2002). Induction of
161. Kadokami, T., Frye, C., Lemster, B., Wagner, C., Feldman, A., and McTiernan, C. (2001). Anti-tumor necrosis factor-alpha antibody limits heart failure in a transgenic model. Circulation 104:1094-1097.
162. Kubota, T., Bounoutas, G.S., Miyagishima, M., et al. (2000). Soluble tumor necrosis factor receptor abrogates myocardial inflammation but not hypertrophy in cytokine-induced cardiomyopathy. Circulation 101:2518-2525.
163. Li, Y.Y., Feng, Y.Q., Kadokami, T., et al. (2000). Myocardial extracellular matrix remodeling in transgenic mice overexpressing tumor necrosis factor alpha can be modulated by tumor necrosis factor alpha therapy. Proc. Natl. Acad. Sci. USA 97:12746-12751.
164. Li, Y.Y., Kadokami, T., Wang, P., McTiernan, C.F., and Feldman, A.M. (2002). MMP inhibition modulates TNF-alpha transgenic mouse phenotype early in the development of heart failure. Am. J. Physiol. Heart Circ. Physiol. 282:H983-H989.
165. Funakoshi, H., Kubota, T., Machita, Y., et al. (2002). Disruption of inducible nitric oxide synthase improves beta-adrenergic inotropic responsiveness but not the survival of mice with cytokine-induced cardiomyopathy. Circ. Res. 90:959-965.
166. Funakosh, I.H., Kubota, T., Machita, Y., et al. (2002a). Involvement of inducible nitric oxide synthase in cardiac dysfunction with tumor necrosis factor-α. Am. J. Physiol. Heart. 282:H2159-H2166.
167. Kaye, D.M., Wiviott, S.D., and Kelly, R.A. (1999). Activation of nitric oxide synthase (NOS3) by mechanical activity alters mechanical contractile activity in a Ca+2-independent manner in cardiac myocytes: role of troponin I phosphorylation. Biochem. Biophys. Res. Commun. 256:398-403.
168. Tavernier, B., Li, J.M., El-Omar, M.M., et al. (2001). Cardiac contractile impairment associated with increased phosphorylation of troponin I in endotoxemic rats. FASEB J. 15:294-296.
169. Hirota, H., Chen, J., Betz, U.A., et al. (1999). Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress. Cell 97:189-198.
170. Kunisada, K., Tone, E., Fujio, Y., Matsui, H., Yamauchi-Takihara, K., and Kishimoto, T. (1998). Activation of gp130 transduces hypertrophic signals via STAT3 in cardiac myocytes. Circulation 98:346-352.
171. Matsui, H., Fujio, Y., Kunisada, K., Hirota, H., and Yamauchi-Takihara, K. (1996). Leukemia inhibitory factor induces a hypertrophic response mediated by gp130 in murine cardiac myocytes. Res. Commun. Mol. Pathol. Pharmacol. 93:149-162.
172. Brasier, A.R., Jamaluddin, M., Han, Y., Patterson, C., and Runge, M.S. (2000). Angiotensin II induces gene transcription through cell-type-dependent effects on the nuclear factor-kappaB (NF-kappaB) transcription factor. Mol. Cell. Biochem. 212:155-169.
173. Rouet-Benzineb, P., Gontero, B., Dreyfus, P., and Lafuma, C. (2000). Angiotensin II induces nuclear factor-kappa B activation in cultured neonatal rat cardiomyocytes through protein kinase C signaling pathway. J. Mol. Cell. Cardiol. 32:1767-1778.
174. Bueno, O.F. and Molkentin, J.D. (2002). Involvement of extracellular signal-regulated kinases 1/2 in cardiac hypertrophy and cell death. Circ. Res. 91:776-781.
175. Abbate, A., Biondi-Zoccai, G.G., and Baldi, A. (2002). Pathophysiologic role of myocardial apoptosis in post-infarction left ventricular remodeling. J. Cell Physiol. 193:145-153.
176. Kumar, D., Lou, H., and Singal, P.K. (2002). Oxidative stress and apoptosis in heart dysfunction. Herz 27:662-668.
177. Tomei, L.D. and Umansky, S.R. (2001). Apoptosis and the heart: a brief review. Ann. NY Acad. Sci. 946:160-168.
178. Wernig, F. and Xu, Q. (2002). Mechanical stress-induced apoptosis in the cardiovascular system. Prog. Biophys. Mol. Biol. 78:105-137.
179. Bernecker, O.Y., Huq, F., Heist, E.K., Podesser, B.K., and Haijar, R.J. (2003). Apoptosis in heart failure and the senescent heart. Cardiovasc. Toxicol. 3:183-190.
180. McGowan, B.S., Ciccimaro, E.F., Chan, T.O., and Feldman, A.M. (2003). The balance between pro-apoptotic and antiapoptotic pathways in the failing myocardium. Cardiovasc. Toxicol. 3:191-206.
181. Clerk, A., Cole, S.M., Cullingford, T.E., Harrison, J.G., Jormakka, M., and Valks, D.M. (2003). Regulation of cardiac myocyte cell death. Pharm. Ther. 97:223-261.
182. Leri, A., Claudio, P.P., Li, Q., et al. (1998). Stretch-mediated release of angiotensin II induces myocyte apoptosis by activating p53 that enhances the local renin-angiotensin system and decreases the Bcl-2-to-Bax protein ratio in the cell. J. Clin. Invest. 101:1326-1342.
183. Yussman, M.G., Toyokawa, T., Odley, A., et al. (2002). Mitochondrial death protein Nix is induced in cardiac hypertrophy and triggers apoptotic cardiomyopathy. Nat. Med. 8:725-730.
184. Nadal-Ginard, B., Kajstura, J., Leri, A., and Anversa, P. (2003). Myocyte death, growth, and regeneration in cardiac hypertrophy and failure. Circ. Res. 92:139-150.
185. Canicio, J., Ruiz-Lozano, P., Carrasco, M., et al. (2001). Nuclear factor kappa B-inducing kinase and Ikappa B kinase-alpha signal skeletal muscle cell differentiation. J. Biol. Chem. 276:20228-20233.
186. Conejo, R., Valverde, A.M., Benito, M., and Lorenzo, M. (2001). Insulin produces myogenesis in C2C12 myoblasts by induction of NF-kappaB and downregulation of AP-1 activities. J. Cell Physiol. 186:82-94.
187. Li, Y.P. and Reid, M.B. (2000). NF-kappaB mediates the protein loss induced by TNF-alpha in differentiated skeletal muscle myotubes. Am. J. Physiol. Regul. Integr. Comp. Physiol. 279:R1165-R1170.
188. Thaloor, D., Miller, K.J., Gephart, J., Mitchell, P.O., and Pavlath, G.K. (1999). Systemic administration of the NF-kappaB inhibitor curcumin stimulates muscle regeneration after traumatic injury. Am. J. Physiol. 277:C320-C329.
189. Guttridge, D.C., Mayo, M.W., Madrid, L.V., Wang, C.Y., and Baldwin, A.S. Jr. (2000). NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia. Science 289:2363-2366.
190. Shintani, T., Sawa, Y., Takahashi, T., et al. (2002). Intra-operative transfection of vein grafts with the NFkappaB decoy in a canine aortocoronary bypass model: a strategy to attenuate intimal hyperplasia. Ann. Thorac. Surg. 74:1132-1137; discussion 1137-1138.
191. Misra, A., Chen, Z., Sivasubramanian, N., et al. (2001). Both cardiac myocyte apoptosis and infarct size are increased in mice with defective NF-κB signaling. Circulation 104(Suppl.):II-11.
192. Bolli, R., Shinmura, K., Tang, X.L., et al. (2002). Discovery of a new function of cyclooxygenase (COX)-2: COX-2 is a cardioprotective protein that alleviates ischemia/reperfusion injury and mediates the late phase of preconditioning. Cardiovasc. Res. 55:506-519.
193. Li, C., Browder, W., and Kao, R.L. (1999). Early activation of transcription factor NF-kappaB during ischemia in perfused rat heart. Am. J. Physiol. 276:H543-H552.
194. Balligand, J.L., Ungureanu-Longrois, D., Simmons, W.W., et al. (1994). Cytokine-inducible nitric oxide synthase (iNOS) expression in cardiac myocytes. Characterization and regulation of iNOS expression and detection of iNOS activity in single cardiac myocytes in vitro. J. Biol. Chem. 269:L27580-27588.
195. Zhang, D., Jiang, S.L., Rzewnicki, D., Samols, D., and Kushner, I. (1995). The effect of interleukin-1 on C-reactive protein expression in Hep3B cells is exerted at the transcriptional level. Biochem. J. 310:143-148.
196. Maulik, N., Goswami, S., Galang, N., and Das, D.K. (1999). Differential regulation of Bcl-2, AP-1 and NF-kappaB on cardiomyocyte apoptosis during myocardial ischemic stress adaptation. FEBS Lett. 443:331-336.
197. Mustapha, S., Kirshner, A., De Moissac, D., and Kirshenbaum, L.A. (2000). A direct requirement of nuclear factor-kappa B for suppression of apoptosis in ventricular myocytes. Am. J. Physiol. Heart Circ. Physiol. 279: H939-H945.
198. Irem, S.O., Eyer, C.L., Smith, J.R., and Anderson, A.C. (1991). Protective effects of selected sulfhydryl containing compounds against global ischemia in isolated perfused rat hearts. Proc. West Pharmacol. Soc. 34:161-165.
199. Biagini, G., Sala, D., and Zini, I. (1995). Diethyldithiocarbamate, a superoxide dismutase inhibitor, counteracts the maturation of ischemic-like lesions caused by endothelin-1 intrastriatal injection. Neurosci. Lett. 190:212-216.
200. Sawa, Y., Morishita, R., Suzuki, K., et al. (1997). A novel strategy for myocardial protection using in vivo transfection of cis element 'decoy' against NFkappaB binding site: evidence for a role of NFkappaB in ischemia-reperfusion injury. Circulation 96(9 Suppl II):280-284.
201. Morishita, R., Sugimoto, T., Aoki, M., et al. (1997). In vivo transfection of cis element "decoy" against nuclear factor-kappaB binding site prevents myocardial infarction. Nat. Med. 3:894-899.
202. Saito, T., Rodger, I.W., Shennib, H., Hu, F., Tayara, L., and Giaid, A. (2003). Cyclooxygenase-2 (COX-2) in acute myocardial infarction: cellular expression and use of selective COX-2 inhibitor. Can. J. Physiol. Pharmacol. 81:114-119.
203. Hocherl, K., Dreher, F., Kurtz, A., and Bucher, M. (2002). Cyclooxygenase-2 inhibition attenuates lipopolysaccharide-induced cardiovascular failure. Hypertension 40:947-953.
204. Kurrelmeyer, K.M., Michael, L.H., Baumgarten, G., et al. (2000). Endogenous tumor necrosis factor protects the adult cardiac myocyte against ischemic-induced apoptosis in a murine model of acute myocardial infarction. PNAS 99:5456-5461.
205. Maekawa, N., Wada, H., Kanda, T., et al. (2002). Improved myocardial ischemia/reperfusion injury in mice lacking tumor necrosis factor-alpha. J. Am. Coll. Cardiol. 39:1229-1235.
206. Kajstura, J., Cheng, W., Reiss, K., et al. (1996). Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats. Lab. Invest. 74:86-107.
207. Gustafsson, A.B., Sayen, M.R., Williams, S.D., Crow, M.T., and Gottlieb, R.A. (2002). TAT protein transduction into isolated perfused hearts: TAT-apoptosis repressor with caspase recruitment domain is cardioprotective. Circulation 106:735-739.
208. Halestrap, A.P. (1999). The mitochondrial permeability transition: its molecular mechanism and role in reperfusion injury. Biochem. Soc. Symp. 66:181-203.
209. Pacher, P., Csordas, G., and Hajnoczky, G. (2001). Mitochondrial Ca(2+) signaling and cardiac apoptosis. Biol. Signals Recept. 10:200-223.
210. Meldrum, D.R., Cleveland, J.C. Jr., Sheridan, B.C., et al. (1997). Alpha-adrenergic activation of myocardial NF kappa B during hemorrhage. J. Surg. Res. 69:268-276.
211. Hiasa, G., Hamada, M., Ikeda, S., and Hiwada, K. (2001). Ischemic preconditioning and lipopolysaccharide attenuate nuclear factor-kappaB activation and gene expression of inflammatorycytokines in the ischemia-reperfused rat heart. Jpn. Circ. J. 65:984-990.
212. Kim, H. and Koh, G. (2000). Lipopolysaccharide activates matrix metalloproteinase-2 in endothelial cells through an NF-kappaB-dependent pathway. Biochem. Biophys. Res. Commun. 269:401-405.
213. Lakshminarayanan, V., Lewallen, M., Frangogiannis, N.G., et al. (2001). Reactive oxygen intermediates induce monocyte chemotactic protein-1 in vascular endothelium after brief ischemia. Am. J. Pathol. 159:1301-1311.
214. Sasaki, H., Fukuda, S., Otani, H., et al. (2002). Hypoxic preconditioning triggers myocardial angiogenesis: a novel approach to enhance contractile functional reserve in rat with myocardial infarction. J. Mol. Cell. Cardiol. 34:335-348.
215. Maulik, N. and Das, D.K. (2002). Potentiation of angiogenic response by ischemic and hypoxic preconditioning of the heart. J. Cell. Mol. Med. 6:13-24.
216. Delogu, G., Signore, M., Mechelli, A., and Famularo, G. (2002). Heat shock proteins and their role in heart injury. Curr. Opin. Crit. Care 8:411-416.
217. Dillmann, W.H. (1999). Small heat shock proteins and protection against injury. Ann. NY Acad. Sci. 874:66-68.
218. Dillmann, W.H. (1999). Heat shock proteins and protection against ischemic injury. Infect. Dis. Obstet. Gynecol. 7:55-57.
219. Latchman, D.S. (2001). Heat shock proteins and cardiac protection. Cardiovasc. Res. 51:637-646.
220. Knowlton, A.A. and Gupta, S. (2003). HSP60, Bax and cardiac apoptosis. Cardiovasc. Toxicol. 3:263-268.
221. Dobbin, C.A., Smith, N.C., and Johnson, A.M. (2002). Heat shock protein 70 is a potential virulence factor in murine toxoplasma infection via immunomodulation of host NF-κB and nitric oxide. J. Immunol. 169:958-965.
222. Heimbach, J.K., Reznikov, L.L., Calkins, C.M., et al. (2001). TNF receptor I is required for induction of macrophage heat shock protein 70. Am. J. Physiol. Cell Physiol. 281:C241-C247.
223. Kim, Y.M., de Vera, M.E., Watkins, S.C., and Billiar, T.R. (1997). Nitric oxide protects cultured rat hepatocytes from tumor necrosis factor-alpha-induced apoptosis by inducing heat shock protein 70 expression. J. Biol. Chem. 272:1402-1411.
224. Meng, X. and Harken, A.H. (2002). The interaction between Hsp70 and TNF-alpha expression: a novel mechanism for protection of the myocardium against post-injury depression. Shock 17:345-353.
225. Malhotra, V. and Wong, H.R. (2002). Interactions between the heat shock response and the nuclear factor-kappaB signaling pathway. Crit. Care Med. 30(1Suppl):S89-S95.
226. Guzhova, I.V., Darieva, Z.A., Melo, A.R., and Margulis, B.A. (1997). Major stress protein Hsp 70 interacts with NF-κB regulatory complex in human T-lymphoma cells. Cell Stress Chaperones 2:132-139.
227. Nayeem, M.A., Elliott, G.T., Shah, M.R., Hastillo-Hess, S.L., and Kukreja, R.C. (1997a). Monophosphoryl lipid A protects adult rat cardiac myocytes with the induction of the 72 kD heat shock protein: a cellular model of pharmacologic preconditioning. JMCC 29:2305-2310.
228. Nayeem, M.A., Hess, M.L., Qian, Y.Z., Loesser, K.E., and Kukreja, R.C. (1997b). Delayed preconditioning of cultured rat cardiac myocytes: role of 70- and 90- kDa heats shock proteins. Am. J. Physiol. 273:H861-H868.
229. Chong, K.Y., Lai, C.C., Lille, S., Chang, C., and Su, C.Y. (1998). Stable overexpression of the constitutive form of heat shock protein 70 confers oxidative protection. JMCCC 30:599-608.
230. Miller, M.J. (2001). Preconditioning for cardioprotection against ischemia reperfusion injury: the roles of nitric oxide, reactive oxygen species, heat shock proteins, reactive hyperemia and antioxidants - a mini review. Can. J. Cardiol. 17:1075-1082.
231. Qian, Y.Z., Bernardo, N.I., Nayeem, M.A., Chelliah, J., and Kukreja, R.C. (1999). Induction of the 72 kDa heat shock protein does not produce the second window of ischemic preconditioning in rat heart. Am. J. Physiol. 276: H224-H234.
232. Lee, S.H., Kim, M., Yoon, B.W., et al. (2001). Targeted Hsp70.1 disruption increases infarction volume after focal cerebral ischemia in mice. Stroke 32:2905-2912.
233. Gottdiener, J.S., Arnold, A.M., Aurigemma, G.P., et al. (2000). Predictors of congestive heart failure in the elderly: the Cardiovascular Health Study. J. Am. Coll. Cardiol. 35:1628-1637.
234. Hayward, C.S., Kelly, R.P., and Collins, P. (2000). The roles of gender, the menopause and hormone replacement on cardiovascular function. Cardiovasc. Res. 46:28-49.
235. Stampfer, M.J. and Coditz, G.A. (1991). Estrogen replacement therapy and coronary heart disease: a quantitative assessment of the epidemiologic evidence. Prev. Med. 20:47-63.
236. Mendelsohn, M.E. (2000). Mechanisms of estrogen action in the cardiovascular system. J. Steroid Biochem. Mol. Biol. 74:337-343.
237. Johnson, B.D., Zheng, W., Korach, K.S., Scheuer, T., Catterall, W.A., and Rubanyi, G.M. (1997). Increased expression of the cardiac L-type calcium channel in estrogen receptor-deficient mice. J. Gen. Physiol. 110:135-140.
238. Chen, Y.F., Naftilan, A.J., and Oparil, S. (1992). Androgen-dependent angiotensinogen and renin messenger RNA expression in hypertensive rats. Hypertension 19:456-463.
239. Pelzer, T., Neumann, M., deJager, T., Jazbutyte, V., and Neyses, L. (2001). Estrogen effects in the myocardium: inhibition on NF-κB DNA binding by estrogen receptor-α and -β. Biochem. Biophys. Res. Commun. 286:1153-1157.
240. Pelzer, T., Schumann, M., Neumann, M., et al. (2000). 17beta-estradiol prevents programmed cell death in cardiac myocytes. Biochem. Biophys. Res. Commun. 268:192-200.
241. van Eickels, M., Grohe, C., Cleutjens, J.P., Janssen, B.J., Wellens, H.J., Doevendans, P.A. (2001). 17beta-estradiol attenuates the development of pressure-overload hypertrophy. Circulation 104:1419-1423.
242. Zhai, P., Eurell, T.E., Cooke, P.S., Lubahn, D.B., and Gross, D.R. (2000). Myocardial ischemia-reperfusion injury in estrogen receptor-alpha knockout and wild-type mice. Am. J. Physiol. Heart Circ. Physiol. 278:H1640-H1647.
243. Camper-Kirby, D., Welch, S., Walker, A., et al. (2001). Myocardial Akt activation and gender: Increased nuclear activity in females versus males. Circ. Res. 88:1020-1027.
244. Fujio, Y., Nguyen, T., Wencker, D., Kitsis, R.N., and Walsh, K. (2000). Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury inmouse heart. Circulation 101:660-667.
245. Matsui, T., Li, L., del Monte, F., et al. (1999). Adenoviral gene transfer of activated phosphatidylinositol 3′-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro. Circulation 100:2373-2379.
246. Matsui, T., Tao, J., del Monte, F., et al. (2001). Akt activation preserves cardiac funciton and prevents injury after transient cardiac ischemia in vivo. Circulation 104:330-335.
247. Dash, R., Schmidt, A.G., Pathak, A., et al. (2003). Differential regulation of p38 mitogen-activated protein kinase mediates gender-dependent catecholamine-induced hypertrophy. Cardiovasc. Res. 57:704-714.
248. Sasaki, H., Ray, P.S., Zhu, L., Otani, H., Asahara, T., and Maulik, N. (2001). Hypoxia/reoxygenation promotes myocardial angiogenesis via an NF kappa B-dependent mechanism in a rat model of chronic myocardial infarction. J. Mol. Cell. Cardiol. 33:283-294.