Heat shock protein 70 is a potential virulence factor in murine Toxoplasma infection via immunomodulation of host NF-κB and nitric oxide

Journal of Immunology

Volumn 169, Issue 2, 2002, Pages 958-965

  Dobbin, Caroline A ^a   Smith, Nicholas C ^a   Johnson, Alan M ^a  

^a UNIVERSITY OF TECHNOLOGY SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

HEAT SHOCK PROTEIN 70; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; QUERCETIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; HOST RESISTANCE; IMMUNOCYTOCHEMISTRY; IMMUNOMODULATION; MACROPHAGE; MOUSE; NONHUMAN; PARASITE VIRULENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRAIN DIFFERENCE; TOXOPLASMA GONDII; TOXOPLASMOSIS;

EID: 0037100504     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.2.958     Document Type: Article

References (35)

1. Cytokines, nitric oxide, heat shock proteins and virulence in Toxoplasma
2. Acute cerebral toxoplasmosis is induced by in vivo neutralization of TNF-α and correlates with the down-regulated expression of inducible nitric oxide synthase and other markers of macrophage activation
3. The role of dendritic cells in the initiation of host resistance to Toxoplasma gondii
4. Tumour necrosis factor-α triggers antitoxoplasmal activity of IFN-γ primed macrophages
5. Toxoplasma gondii induces a T-independent IFN-T response in natural killer cells that requires both adherent accessory cells and tumor necrosis factor-α
6. IFN-γ induced L-arginine dependent toxoplasmastatic activity in murine peritoneal macrophages is mediated by endogenous TNF-α
7. Activators and target genes of Rel/NF-κB transcription factors
8. NF-κB is a central regulator of the intestinal epithelial cell innate immune response induced by infection with enteroinvasive bacteria
9. IκB: A specific inhibitor of NF-κB transcription factor
10. NF-κB and Rel proteins: Evolutionarily conserved proteins of immune responses
11. Role of transcription factor NF-κB/Rel in induction of nitric oxide synthase
12. The NF-κB family member RelB is required for innate and adaptive immunity to Toxoplasma gondii
13. Toxoplasma gondii tachyzoites inhibit proinflammatory cytokine induction in infected macrophages by preventing nuclear translocation of the transcription factor NF-κB
14. Heat shock proteins of Toxoplasma gondii
15. Gene sequence and transcription differences in 70 kDa heat shock protein correlate with murine virulence of Toxoplasma gondii
16. Nitric oxide protects cultured rat hepatocytes from turnout necrosis factor α-induced apoptosis by inducing heat shock protein 70 expression
17. HSP70 overexpression confers resistance against NO
18. Heat shock protein 70 suppresses astroglial-inducible nitric oxide synthase expression by decreasing NFκB activation
19. The constitutive HSP70 is required for optimal expression of myelin basic protein during differentiation of oligodendrocytes
20. Effects of quercefin and suphenon on responses of cancer cells to heat shock damage
21. 72 kDa HSP is a mediator of resistance to UVB light
22. Immunogenicity of Toxoplasma gondii heat shock protein 70
23. The production of a 70 kDa heat shock protein by Toxoplasma gondii RH strain in immunocompromised mice
24. 15N] nitrate in biological fluids
25. Experimental approaches to understanding virulence in toxoplasmosis
26. The development and biology of bradyzoites of Toxoplasma gondii
27. Plasmodium falciparum gene encoding a protein similar to the 78 kDa rat glucose-related stress protein
28. Human immune response directed against Plasmodium falciparum heat shock-related proteins
29. A malaria heat shock-like determinant expressed on the infected hepatocyte surface is the target of antibody-dependent cell-mediated mechanisms by noparenchymal liver cells
30. A 75 kDa merozoite surface protein of Plasmodium falciparum which is related to the 70 kDa heat shock protein
31. Ultrastructural localisation of HSP72 examined with a new polyclonal antibody raised against the truncated variable domain of the HSP
32. Flavonoid impairment of neutrophil response
33. Proteasome inhibitors induce heat shock response and increase IL-6 expression in human intestinal epithelial cells
34. Effects of Ginkgo biloba extract (EGb 761) and quercetin on lipopolysaccharide-induced release of nitric oxide
35. Effects of the wine polyphenolics quercetin and resveratrol on pro-inflammatory cytokine expression in RAW 264.7 macrophages