Soluble tumor necrosis factor receptor abrogates myocardial inflammation but not hypertrophy in cytokine-induced cardiomyopathy

Circulation

Volumn 101, Issue 21, 2000, Pages 2518-2525

  Kubota, Toru ^a   Bounoutas, George S ^a   Miyagishima, Masayuki ^a   Kadokami, Toshiaki ^a   Sanders, Virginia J ^a   Bruton, Christina ^a   Robbins, Paul D ^a   McTiernan, Charles F ^a   Feldman, Arthur M ^a,b  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b S 572 Scaife Hall ^*  (United States)

Author keywords

Genes; Hormones; Viruses

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); CYTOKINE; HYBRID PROTEIN; IMMUNOGLOBULIN G; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; MYOSIN HEAVY CHAIN; PHOSPHOLAMBAN; TUMOR NECROSIS FACTOR RECEPTOR;

ADENOVIRUS; ADOLESCENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ECHOCARDIOGRAPHY; GENE EXPRESSION; HEART DILATATION; HEART VENTRICLE SIZE; HYPERTROPHIC CARDIOMYOPATHY; IMMUNOTHERAPY; MOUSE; MYOCARDITIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; TRANSGENIC MOUSE; VIRUS RECOMBINANT;

EID: 0034738142     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.101.21.2518     Document Type: Article

References (25)

1. Zhang M, Tracey KJ. Tumor necrosis factor. In: Thomson AW, ed. The Cytokine Handbook. 3rd ed. San Diego, Calif: Academic Press; 1998: 517-548.
2. Meldrum DR, Cleveland JC Jr, Cain BS, et al. Increased myocardial tumor necrosis factor-alpha in a crystalloid-perfused model of cardiac ischemia-reperfusion injury. Ann Thorac Surg. 1998;65:439-443.
3. Torre-Amione G, Kapadia S, Lee J, et al. Tumor necrosis factor-alpha and tumor necrosis factor receptors in the failing human heart. Circulation. 1996;93:704-711.
4. Kubota T, McTiernan CF, Frye CS, et al. Cardiac-specific overexpression of tumor necrosis factor-alpha causes lethal myocarditis in transgenic mice. J Card Fail. 1997;3:117-124.
5. Kubota T, McTiernan CF, Frye CS, et al. Dilated cardiomyopathy in transgenic mice with cardiac-specific overexpression of tumor necrosis factor-α. Circ Res. 1997;81:627-635.
6. Smith SC, Allen PM. Neutralization of endogenous tumor necrosis factor ameliorates the severity of myostn-induced myocarditis. Circ Res. 1992;70:856-863.
7. Yamada T, Matsumori A, Sasayama S. Therapeutic effect of anti-tumor necrosis factor-α antibody on the murine model of viral myocarditis induced by encephalomyocarditis virus. Circulation. 1994;89:846-851.
8. Kapadia S, Torre-Amione G, Yokoyama T, et al. Soluble TNF binding proteins modulate the negative inotropic properties of TNF-alpha in vitro. Am J Physiol. 1995;268:H517-H525.
9. Kolls J, Peppel K, Silva M, et al. Prolonged and effective blockade of tumor necrosis factor activity through adenovirus-mediated gene transfer. Proc Natl Acad Sci U S A. 1994;91:215-219.
10. Kubota T, Mahler CM, McTiernan CF, et al. End-systolic pressure-dimension relationship of in situ mouse left ventricle. J Mol Cell Cardiol. 1998;30:357-363.
11. Robhins J, Gulick J, Sanchez A. et al. Mouse embryonic stem cells express the cardiac myosin heavy chain genes during development in vitro. J Biol Chem. 1990;265:11905-11909.
12. McTiernan CF, Lemster BH, Frye C, et al. Interleukin-1β inhibits phospholamban gene expression in cultured cardiomyocytes. Circ Res. 1997; 81:493-503.
13. Gulick T, Chung MK, Pieper SJ, et al. Interleukin 1 and tumor necrosis factor inhibit cardiac myocyte beta-adrenergic responsiveness. Proc Natl Acad Sci U S A. 1989;86:6753-6757.
14. Rollins BJ, Yoshimura T, Leonard EJ, et al. Cytokine-activated human endothelial cells synthesize and secrete a monocyte chemoattractant, MCP-1/JE. Am J Pathol. 1990;136:1229-1233.
15. Kolattukudy PE, Quach T, Bergese S, et al. Myocarditis induced by targeted expression of the MCP-1 gene in murine cardiac muscle. Am J Pathol. 1998;152:101-111.
16. Kolls JK, Lei D, Nelson S, et al. Adenovirus-mediated blockade of tumor necrosis factor in mice protects against endotoxic shock yet impairs pulmonary host defense. J Infect Dis. 1995;171:570-575.
17. Mohler KM, Torrance DS, Smith CA, et al. Soluble tumor necrosis factor (TNF) receptors are effective therapeutic agents in lethal endotoxemia and function simultaneously as both TNF carriers and TNF antagonists. J Immunol. 1993;151:1548-1561.
18. Nadal-Ginard B, Mahdavi V. Molecular basis of cardiac performance: plasticity of the myocardium generated through protein isoform switches. J Clin Invest. 1989;84:1693-1700.
19. Gupta M, Zak R. Reversibility of load-induced changes in myosin heavy chain gene expression. Am J Physiol. 1992;262:R346-R349.
20. 2(+)-ATPase gene expression in the human ventricle during end-stage heart failure. J Clin Invest. 1990;85:305-309.
21. Feldman AM, Ray PE, Silan CM, et al. Selective gene expression in failing human heart: quantification of steady-state levels of messenger RNA in endomyocardial biopsies using the polymerase chain reaction. Circulation. 1991;83:1866-1872.
22. Rockman HA, Ono S, Ross RS, et al. Molecular and physiological alterations in murine ventricular dysfunction. Proc Natl Acad Sci U S A. 1994;91:2694-2698.
23. Deswal A, Bozkurt B, Seta Y, et al. Safety and efficacy of a soluble P75 tumor necrosis factor receptor (Enbrel, etanercept) in patients with advanced heart failure. Circulation. 1999;99:3224-3226.
24. Bozkurt B, Kribbs SB, Clubb FJ Jr, et al. Pathophysiologically relevant concentrations of tumor necrosis factor-α promote progressive left ventricular dysfunction and remodeling in rats. Circulation. 1998;97: 1382-1391.
25. Lima EC, Garcia I, Vicentelli MH, et al. Evidence for a protective role of tumor necrosis factor in the acute phase of Trypanosoma cruzi infection in mice. Infect Immun. 1997;65:457-465.