Monophosphoryl lipid A protects adult rat cardiac myocytes with induction of the 72-kD heat shock protein: A cellular model of pharmacologic preconditioning

Journal of Molecular and Cellular Cardiology

Volumn 29, Issue 8, 1997, Pages 2305-2310

  Nayeem, Mohammed A ^a   Elliott, Gary T ^b   Shah, Maulik R ^a   Hastillo Hess, Samantha L ^a   Kukreja, Rakesh C ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GLAXOSMITHKLINE   (United States)

Author keywords

Cultured cardiomyocytes; Endotoxin; Heat shock proteins; Monophosphoryl lipid A; Preconditioning; Simulated ischemia; Stress proteins

Indexed keywords

DEOXYGLUCOSE; HEAT SHOCK PROTEIN; LACTATE DEHYDROGENASE; LACTIC ACID; PHOSPHORYL LIPID A; POTASSIUM CHLORIDE; SODIUM DITHIONITE;

ANIMAL CELL; ARTICLE; CONDITIONING; CONTROLLED STUDY; HEART CELL CULTURE; HEART MUSCLE CELL; HEART PROTECTION; IMMUNOBLOTTING; ISCHEMIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; RAT;

ANIMALIA;

EID: 0031214688     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmcc.1997.0452     Document Type: Article

References (32)

1. BAXTER GF, GOODWIN RW, WRIGHT MJ, KERAC M, HEADS RJ, YELLON DM, 1996. Myocardial protection after monophosphoryl lipid A: studies of delayed anti-ischemic properties in rabbit heart. Br J Pharmacol 117: 1685-1692.
2. BROWN JM, GROSSO MA, TERADA LS, WHITMAN GJR, BANERJEE A, WHITE CW, HARKEN AH, REPINE JE, 1989. Endotoxin pretreatment increases endogenous myocardial catalase activity and decreases ischemia-reperfusion injury of isolated rat hearts. Proc Natl Acad Sci USA 86: 2516-2520.
3. CURRIE RW, Ross BM, DAVID TA, 1990. Induction of the heat shock response in rats modulate heart rate, creatine kinase and protein synthesis after subsequent hyperthermic treatment. Cardiovasc Res 14: 87-93.
4. ELLIOTT GT, COMERFORD ML, SMITH JR, ZHAO L, 1996. Myocardial ischemia-reperfusion using monophosphoryl lipid A is abrogated by the ATP-sensitive potassium channel blocker, glibenclamide. Cardiovasc Res 32: 1071-1080.
5. ESUMI K, NISHIDA K, SHAW D, SMITH TW, MARSH JD, 1991. NADH measurement in adult rat myocytes during simulated ischemia. Am J Physiol 29: H1743-H1752.
6. HOAG J, QIAN Y-Z, NAYEEM MA, D'ANGELO M, KUKREJA RC, 1997. ATP-sensitive potassium channel mediates delayed ischemic protection by heat stress in rabbit hearts. Submitted.
7. HORWITZ L, LEFF J, 1995. Catalase and hydrogen peroxide cytotoxicity in cultured cardiac myocytes. J Mol Cell Cardiology 27: 909-915.
8. IWAKI K, CHI SH, DILLMANN WH, MESTRIL R, 1993. Induction of HSP 70 in cultured rat neonatal cardiomyocytes by hypoxia and metabolic stress. Circulation 87: 2023-2032.
9. ATP channel. J Cardiovasc Pharmacol (In Press).
10. KNOWLES RG, MERRETT M, SALTER M, MONCADA S, 1990. Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat. Biochem J 270: 833-836.
11. KONTOS MC, SHIPLEY JS, KUKREJA RC, 1996. Heat stress improves functional recovery and induces synthesis of 27- and 70-kDa heat shock proteins without preserving sarcoplasmic reticulum function in the ischemic rat heart. J Mol Cell Cardiol 28: 1885-1895.
12. KUKREJA RC, KONTOS MC, LOESSER KE, BATRA SK, QIAN YZ, GBUR CJ JR, NASEEM SA, JESSE RL, HESS ML, 1994. Oxidant stress increases heat shock protein 70 mRNA in isolated perfused rat heart. Am J Physiol 267: H2213-H2219.
13. KUKREJA RC, QIAN Y, KONTOS MC, HESS ML, 1995. Quercetin blocks ischemic tolerance and synthesis of HSP 70 in rat heart (Abstract). J Cell Biochem 19B: 219.
14. LUSS H, WATKINS SC, FREESWICK PD, IMRO AK, NUSSLER AK, BULLIAR TR, SIMMONS RL, DEL NIDO PJ, MCGOWAN FX JR, 1995. Characterization of inducible nitric oxide synthase expression in endotoxemic rat cardiac myocytes in vivo and following cytokine exposure in vitro. J Mol Cell Cardiol 27: 2015-2029.
15. MADONNA GS, PETERSON JE, RIBI EE, VOGEL SN, 1986. Early-phase endotoxin tolerance: induction by a detoxified lipid A derivative, monophosphoryl lipid A. Infect Immun 52: 6-11.
16. MALYSHEV I, MANUKHINA EB, MIKOYAN VD, KUBRINA LN, VANIN AF, 1995. Nitric oxide is involved in heat-induced HSP70 accumulation. FEBS Lett 370: 159-162.
17. MARBER MS, MESTRIL R, CHI S, SAYEN R, YELLOM DM, DILLMANN WH, 1995. Overexpression of the rat inducible 70-kD heat stress protein in a transgenic mouse increases the resistance of the heart to ischemic injury. J Clin Invest 95: 1446-1456.
18. ATP channels mediate late preconditioning against infarction produced by monophosphoryl lipid A. Am J Physiol 271: H-2723-H2729.
19. MESTRIL R, CHI S, SAYEN MR, O'REILLY K, DILLMANN WH, 1994. Expression of inducible stress protein 70 in rat heart myogenic cells confers protection against simulated ischemia-induced injury. J Clin Invest 93: 759-767.
20. NAYEEM MA, HESS ML, KUKREJA RC, 1996. Metabolic and thermal preconditioning protects cultured adult cardiac myocytes: role of heat shock proteins (Abstract). Faseb J 10: A313.
21. NAYEEM MA, HESS ML, QIAN Y, LOESSER KE, KUKREJA RC, 1997. Delayed preconditioning of cultured adult rat cardiac myocytes. Role of 70 and 90 kD heat stress proteins in protection against lethal cellular injury. Am J Physiol (In Press).
22. PLUMIER JL, ROSS BM, CURRIE RW, ANGELIDIS CE, KAZLARIS H, KOLLIAS G, PAGOULATOS GN, 1995. Transgenic mice expressing the human heat shock protein 70 have improved post-ischemic myocardial recovery. J Clin Invest 95: 1854-1860.
23. RIBI E, 1984. Beneficial modification of the endotoxin molecule. J Biol Resp Modif 3: 1-9.
24. SHINDO T, IKEDA U, OHKAWA F, KAWAHARA Y, YOKOYAMA M, SHIMADA K, 1995. Nitric oxide synthesis in cardiac myocytes and fibroblasts by inflammatory cytokines. Cardiovasc Res 29: 813-819.
25. SHIPLEY JB, QIAN Y, LEVASSEUR JE, KUKREJA RC, 1995. Expression of the stress proteins HSP-27 and HSP-72 in rat hearts does not correlate with ischemic tolerance after heat shock. Circulation (Abstract). 92: 1-654.
26. SIEGFRIED MR, MA XL, LEEER AM, 1992. Splanchnic vascular endothelial dysfunction in rat endotoxemia: role of superoxide radicals. Eur J Pharmacol 212: 171-176.
27. SONG W, FURMAN BL, PARRATT JR, 1994. Attenuation by dexamethasone of endotoxin protection against ischaemia-induced ventricular arrhythmias. Br J Pharmacol 113: 1083-1084.
28. TAKAYAMA K, QURESHI N, RAETZ CRH, RIBI E, PETERSON J, CANTRELL JL, PEARSON FC, WIGGINS J, JOHNSON AG, 1984. Influence of fine structure of lipid A on limulus amebocyte lysate clotting and toxic activities. Infect Immun 45: 350-355.
29. YAO Z, AUCHAMPACH JA, PIEPER GM, GROSS GJ, 1993. Cardioprotective effects of monophosphoryl lipid A, a novel endotoxin analigue, in the dog. Cardiovasc Res 27: 832-838.
30. YOSHIDA K, MAAIEH MM, SHIPLEY JB, DOLORESCO M, BERNARDO NL, QIAN Y, ELLIOTT GT, KUKREJA RC, 1996. Monophosphoryl lipid A induces pharmacologic 'preconditioning' in rabbit hearts without concomittant expression of 70-kDa heat shock protein. Mol Cell Biochem 156: 1-8.
31. ZHAO L, KIRSCH CC, HAGEN SR, ELLIOTT GT, 1996. Preservation of global cardiac function in the rabbit following protracted ischemia/reperfusion using monophosphoryl lipid A (MLA). J Mol Cell Cardiol 28: 197-208.
32. ZHOU XB, ZHAI XL, ASHRAF M, 1996. Direct evidence that initial oxidative stress triggered by preconditioning contributes to second window of protection by endogenous antioxidant enzyme in myocytes. Circulation 93: 1177-1184.