Bridging the NFAT and NF-κB families: NFAT5 dimerization regulates cytokine gene transcription in response to osmotic stress

Immunity

Volumn 15, Issue 1, 2001, Pages 47-58

  López Rodríguez, Cristina ^a   Aramburu, José ^b   Jin, Lei ^c   Rakeman, Andrew S ^d   Michino, Mayako ^a   Rao, Anjana ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITAT POMPEU FABRA   (Spain)

^c HARVARD UNIVERSITY   (United States)

^d Weill Cornell Graduate School of Biomedical Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LYMPHOTOXIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NFAT5; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DIMERIZATION; DNA BINDING; FIBROBLAST; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HOST RESISTANCE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; NONHUMAN; OSMOTIC STRESS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; REGULATORY MECHANISM;

EID: 0034907525     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(01)00165-0     Document Type: Article

References (56)

1. The genome sequence of Drosophila melanogaster
2. Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo
3. Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A
4. Crystal structure of the lambda repressor C-terminal domain provides a model for cooperative operator binding
5. Tumor necrosis factor-α, interleukin-1β, and interleukin-1 receptor antagonist in dialysate and serum from patients on continuous ambulatory peritoneal dialysis
6. Regulation of gene expression by hypertonicity
7. Chronic T-lymphocyte activation in chronic renal failure: A study of hemodialysis, CAPD and pre-dialysis patients
8. Role of CBP/P300 in nuclear receptor signalling
9. Signal integration by transcription-factor assamblies: Interactions of NFAT1 and AP-1 on the IL-2 promoter
10. Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA
11. Crystal structure of p50/p65 heterodimer of transcription factor NF-kB bound to DNA
12. The Rel family of eukaryotic transcription factors
13. Balance between IL-1β, TNF-α, and their specific inhibitors in chronic renal failure and maintenance dialysis. Relationships with activation markers of T cells, B cells, and monocytes
14. Structure of NF-kB p50 homodimer bound to a kB site
15. NF-kB and Rel proteins: Evolutionarily conserved mediators of immune responses
16. Identification of a novel Cyclosporin-sensitive element in the human tumor necrosis factor α gene promoter
17. Chronic arthropathy in long-term hemodialysis
18. The role of cellular hydratation in the regulation of cell function
19. Delta-opioid receptors expressed by Jurkat T cells enhance IL-2 secretion by increasing AP-1 complexes and activity of the NFAT/AP-1-binding promoter element
20. Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins
21. Signaling mechanisms in the antimicrobial host defense of Drosophila
22. A metabolic complication of severe burns
23. Hypertonic saline enhances cellular immune function
24. Hypertonic saline resuscitation: A tool to modulate immune function in trauma patients?
25. Manipulating immune responses with immunosuppressive agents that target NFAT
26. The T cell activation factor NF-ATc positively regulates HIV-1 replication and gene expression in T cells
27. Identification and characterization of multiple osmotic response sequences in the human aldose reductase gene
28. Acute peritoneal dialysis prescription
29. Functional analysis of the lymphotoxin-β promoter. Sequence requirements for PMA activation
30. Cell volume regulated transporters of compatible osmolytes
31. The TNF and TNF receptor superfamilies: Integrating mammalian biology
32. NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun
33. NFAT5: The Nfat family of transcription factors expands in a new direction
34. Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA
35. Reciprocal modulatory interaction between human immunodeficiency virus type 1 Tat and transcription factor NFAT1
36. IKK-1 and IKK-2: Cytokine-activated IkB kinases essential for NF-kB activation
37. Fluid and electrolyte therapy for children
38. Tonicity-responsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicity
39. Structure of the NF-kB p50 homodimer bound to DNA
40. Interleukin-8 in chronic renal failure and dialysis patients
41. Monitoring the duration of antigen-receptor occupancy by calcineurin/glycogen-synthase-kinase-3 control of NF-AT nuclear shuttling
42. Inflammation, a prototype for organogenesis of the lymphopoietic/hematopoietic system
43. Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity
44. Virus infection leads to localized hyperacetylation of histones H3 and H4 at the IFN-β promoter
45. Plasma levels of IL-1β, TNFα, and their specific inhibitors in undialyzed chronic renal failure, CAPD and hemodialysis patients
46. Transcription factors of the NFAT family: Regulation and function
47. Characterization of elements determining the dimerization properties of RelB and p50
48. T cell life and death signalling via TNF-receptor family members
49. Characterization of the dimer interface of transcription factor NF-kB p50 homodimer
50. Osmotic regulation of cytokine synthesis in vitro
51. Hyperosmotic stress as a stimulant for proinflammatory cytokine production
52. The role of T-lymphocytes and cytokines in rheumatoid arthritis
53. Involvement of interleukin-8 in dialysis-related arthritis
54. The NFAT-related portein NFATL1 (TonEBP-NFAT5) is induced upon T cell activation in a calcineurin-dependent manner
55. Activation of transcription factor NF-kB and p38 mitogen-activated protein kinase is mediated by distinct and separate stress effector pathways
56. Solution structure of the core NFATC1/DNA complex