Proinflammatory cytokines depress cardiac efficiency by a nitric oxide-dependent mechanism

American Journal of Physiology

Volumn 275, Issue 3 PART 2, 1998, Pages

  Panas, Donna ^a   Khadour, Fadi H ^b   Szabö, Csaba ^a   Schulz, Richard ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Dexamethasone; Inducible nitric oxide synthase; Isolated heart; Mercaptoethylguanidine; Peroxynitrite

Indexed keywords

EID: 0031684359     PISSN: 00029513     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. 2+, and NO in myocardial depression (Abstract). J. Mol. Cell. Cardiol. 27: A185,1995.
2. Balligand, J.-L., L. Kobzik, X. Han, D. M. Kaye, L. Belhassen, D. S. O'Hara, R. A. Kelly, T. W. Smith, and T. Michel. Nitric oxide-dependent parasympathetic signaling'is due to activation of constitutive endothelial (type III) nitric oxide synthase in cardiac myocytes. J. Biol. Chem. 270:14582-14586, 1995.
3. Balligand, J.-L., D. Ungureanu-Longrois, W. W. Simmons, D. Pimentai, T. A. Malinski, M. Kapturczak, Z. Taha, C. J. Lowenstein, A. J. Davidoff, R. A. Kelly, T. W. Smith, and T. Michel. Cytokine-inducible nitric oxide synthase (iNOS) expression in cardiac myocytes. J. Biol. Chem. 269:27580-27588,1994.
4. Bateson, A. N., O. M. Jakiwczyk, and R. Schulz. Rapid increase in inducible nitric oxide synthase gene expression in the heart during endotoxemia. Eur. J. Pharmacol. 303: 141-144, 1996.
5. Brady, A. J. B., P.A. Poole-Wilson, S. E. Harding, and J. B. Warren. Nitric oxide production within cardiac myocytes reduces their contractility in endotoxemia. Am. J. Physiol. 263 (Heart Circ. Physiol. 32): H1963-H1966,1992.
6. Brady, A. J. B., J. B. Warren, P. A. Poole-Wilson, T. J. Williams, and S. E. Harding. Nitric oxide attenuates cardiac myocyte contraction. Am. J. Physiol. 265 (Heart Circ. Physiol. 34): H176-H182,1993.
7. Castro, L., R. Rodriguez, and R. Radi. Aconitase is readily inactivated by peroxynitrite, but not by its precursor, nitric oxide. J. Biol. Chem. 47:29409-29415,1994.
8. Cunnion, R. E., and J. E. Parrillo. Myocardial dysfunction in sepsis. Crit. Care Clin. 5: 99-118,1989.
9. De Beider, A. J., M. W. Radomski, H. J. F. Why, P. J. Richardson, C. A. Bucknall, E. Salas, J. F. Martin, and S. Moncada. Nitric oxide synthase activities in human myocardium. Lancet 341:84-85,1993.
10. Dupont, G. P., T. P. Huecksteadt, B. C. Marshall, U. S. Ryan, J. R. Michael, and J. R. Hoidal. Regulation of xanthine dehydrogenase and xanthine oxidase activity and gene expression in cultured rat pulmonary endothelial cells. J. Clin. Invest. 89:197-202,1992.
11. Evans, H. G., M. J. Lewis, and A. M. Shah. Interleukin-l modulates myocardial contraction via dexamethasone sensitive production of ni trie oxide. Cardiovasc. Res. 27:1486-1490,1993.
12. Finkel, M. S., C. V. Oddis, T. D. Jacob, S. C. Watkins, B. G. Hattler, and R. L. Simmons. Negative inotropic effects of cytokines on the heart mediated by nitric oxide. Science 257: 387-389,1992.
13. Geng, Y.-J., G. K. Hansson, and E. Hohne. Interferon-/ and tumor necrosis factor synergize to induce nitric oxide production and inhibit mitochondrial respiration in vascular smooth muscle cells. Circ. Res. 71:1268-1276,1992.
14. Gross, W. L., M. I. Bak, J. S. Ingwall, M. A. Arstall, T. W. Smith, J.-L. Balligand, and R. A. Kelly. Nitric oxide inhibits creatine kinase and regulates rat heart contractile reserve. Proc. Natl. Acad. Sei. USA 93:5604-5609,1996.
15. Han, X., Y. Shimoni, and W. R. Giles. An obligatory role for nitric oxide in autonomie control of mammalian heart rate. J. Physiol. (Land.) 476:309-314,1994.
16. Hare, J. M., J. F. Keaney, Jr., J.-L. Balligand, J. Loscalzo, T. W. Smith, and W. S. Colluci. Role of nitric oxide in parasympathetic modulation of adrenergic myocardial contractility in normal dogs. J. Clin. Invest. 95:360-366,1995.
17. Haywood, G. A., P. S. Tsao, H. E. von der Leyen, M. J. Mann, P. J. Keeling, P. T. Trindade, N. P. Lewis, C. D. Byrne, P. R. Rickenbacher, N. H. Bishopric, J. P. Cooke, W. J. McKenna, andM. B. Fowler. Expression of inducible nitric oxide synthase in human heart failure. Circulation 93:1087-1094,1996.
18. Keim, M., and J. Schrader. Control of coronary vascular tone by nitric oxide. Cz'rc. Res. 66:1561-1575,1990.
19. King, C. E., M. J. Melinhyshyn, J. D. Mewburn, S. E. Curtis, M. J. Winn, S. M. Cain, and C. K. Chapler. Canine hindlimb blood flow and U2 uptake after inhibition of EDRF/NO synthesis. J.Appl. Physiol. 76:1166-1171,1994.
20. Kleinert, H., C. Euchenhofer, I. Ihrig-Biedert, and U. Förstermann. Glucocorticoids inhibit the induction of nitric oxide synthase II by down-regulating cytokine-induced activity of transcription factor nuclear factor-KB. Mol. Pharmacol. 49: 15-21,1996.
21. Klemm, P., T. D. Warner, T. Hohlfeld, R. Corder, and J. R. Vane. Endothelin 1 mediates ex vivo coronary vasoconstriction caused by exogenous and endogenous cytokines. Proc. Natl. Acad. Sei. USA 92:2691-2695,1995.
22. Knowles, R. G., M. Merrett, M. Salter, and S. Moncada. Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat. Biochem. J. 270:833-836,1990.
23. Kumar, A., V. Thota, L. Dee, J. Olson, E. Uretz, and J. E. Parrillo. Tumour necrosis factor alpha and interleukin-1 beta are responsible for in vitro myocardial cell depression induced by septic shock serum. J. Exp. Med. 183:949-958,1996.
24. Kunz, D., G. Walker, W. Eberhardt, and J. Pfeilschifter. Molecular mechanisms of dexamethasone inhibition of nitric oxide synthase expression in interleukin 1-stimulated mesangial cells: evidence for the involvement of transcriptional and posttran-scriptional regulation. Proc. Natl. Acad. Sei. USA 93: 255-259, 1996.
25. Palmer, R. M., A. G. Ferrige, and S. Moncada. Nitric oxide release accounts for the biological activity of endotheliumderived relaxing factor. Nature 327:524-526,1987.
26. Paulus, W. J., P. J. Vantrimpont, and A. M. Shah. Acute effects of nitric oxide on left ventricular relaxation and diastolic distensibility in humans. Circulation 89:2070-2078,1994.
27. Pinsky, D. J., B. Cai, X. Yang, C. Rodriguez, R. R. Aciacca, and P. J. Cannon. The lethal effects of cytokine-induced nitric oxide on cardiac myocytes are blocked by nitric oxide synthase antagonism or transforming growth factor. J. Clin. Invest. 95: 677-685,1995.
28. Radi, R., J. S. Beckman, K. M. Bush, and B. A. Freeman. Peroxynitrite oxidation of sulfhydryls: the cytotoxic potential of Superoxide and nitric oxide. J. Biol. Chem. 266: 4244-4250, 1991.
29. Radi, R., M. Rodriguez, L. Castro, and R. Teller!. Inhibition of mitochondrial electron transport by peroxynitrite. Arch. Biochem. Biophys. 308: 89-95,1994.
30. Radomski, M. W., R. M. Palmer, and S. Moncada. Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells. Proc. Natl. Acad. Sei. USA 87:10043-10047,1990.
31. Radomski, M. W., R. M. J. Palmer, and S. Moncada. The anti-aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide. Br. J. Pharmacol. 92: 639-646,1987.
32. Schulz, R., K. L. Dodge, G. Lopaschuk, and A. S. Clanachan. Peroxynitrite impairs cardiac contractile function by decreasing cardiac efficiency. Am. J. Physiol. 272 (Heart Circ. Physiol. 41): H1212-H1219,1997.
33. 2+-independent nitric oxide synthase in the myocardium. Br. J. Pharmacol. 105: 575-580,1992.
34. Schulz, R., D. L. Panas, R. Catena, S. Moncada, P. M. Olley, and G. D. Lopaschuk. The role of nitric oxide in cardiac depression induced by interleukin-l and tumour necrosis factor-a. Br. J. Pharmacol. 114:27-34,1995.
35. Schulz, R., J. A. Smith, M. J. Lewis, and S. Moncada. Nitric oxide synthase in cultured endocardial cells of the pig. Br. J. Pharmacol. 104:21-24,1991.
36. Simmons, W. W., D. Ungureanu-Longrois, G. K. Smith, and R. A. Kelly. Glucocorticoids regulate inducible nitric oxide synthase by inhibiting tetrahydrobiopterin synthesis and Larginine transport. J. Biol. Chem. 271:23928-23937,1996.
37. Singh, K., J.-L. Ballingand, T. A., Fisher, T. W. Smith, and . R. A. Kelly. Glucocorficoids increase osteopontin expression in cardiac myocytes and microvascular endothelial cells. J. Biol. Chem. 270:28471-28478,1995.
38. Sobotka, P. A., J. McMannis, R. I. Fisher, D. G. Stein, and J. X. Thomas. Effects of interleukin 2 on cardiac function in the isolated rat heart. J. Clin. Invest. 86:845-850,1990.
39. Southan, G. J., B. Zingarelli, M. O'Connor, A. L. Salzman, and C. Szabo. Spontaneous rearrangement of aminoalkylisothioureas into mercaptoalkylguanidines, a novel class of nitric oxide synthase inhibitors with selectivity towards the inducible isoform. Br. J. Pharmacol. 117: 619-632,1996.
40. Szabö, C. Alterations in the production of nitric oxide in various forms of circulatory shock. New Horizons 3:3-32,1995.
41. Szabö, C., G. Ferrer-Sueta, B. Zingarelli, G. J. Southan, A. L. Salzman, and R. Radi. Mercaptoethylguanidine and guanidine inhibitors of nitric-oxide synthase react with peroxynitrite and protect against peroxynitrite-induced oxidative damage. J. Biol. Chem. 272: 9030-9036,1997.
42. Szabö, C., A. L. Salzman, and H. Ischiropoulos. Peroxynitritemediated oxidation of dihydrorhodamine 123 occurs in early stages of endotoxic and hemorrhagic shock and ischemiareperfusion injury. FEES Lett. 372:229-232,1995.
43. Szabö, C., B. Zingaelli, M. O'Connor, and A, L. Salzman. DNAstrand breakage, activation of poly-ADP ribosyl synthetasc, and cellular energy depletion are involved in the cytotoxicity in macrophages and smooth muscle cells exposed to peroxynitrite. Proc. Natl. Acad. Sei. USA 93:1753-1758,1996.
44. Szefler, S. J., C. E. Norton, B. Ball, J. M. Gross, Y. Aida, and M. J. Pabst. IFN-gamma and LPS overcome glucocorticoid inhibition of priming for Superoxide release in human monocytes. Evidence that secretion of IL-1 and tumor necrosis factor-alpha is not essential for monocyte priming. J. Immunol. 142: 39853992,1989.
45. Taegtmeyer, H., R. Hems, and H. A. Krebs. Utilization of energy providing substrates in the isolated working rat heart. Biochem. J. 186: 701-711,1980.
46. Tanaka, K., C. J. S. Hassall, and G. Burnstock. Distribution of intracardiac neurones and nerve terminals that contain a marker for nitric oxide, NADPH-diaphorase, in the guinea-pig heart. Cell Tissue Res. 273:293-300,1993.
47. Ungureanu-Longrois, D., J.-L. Balligand, W. W. Simmons, W. W. Okada, L. Kobzik, C. J. Lowenstein, S. L. Kunkel, T. Michel, R. A. Kelly, and T. W. Smith. Induction of nitric oxide synthase activity by cytokines in ventricular myocytes is necessary but not sufficient to decrease contractile responsiveness to beta-adrenergic agonists. Circ. Res. 77:494-502,1995.
48. Wildhirt, S. M., R. R. Dudek, H. Suzuki, V. Pinto, K. S. Narayan, and R. J. Bing. Immunohistochemistry in the identification of nitric oxide synthase isoenzymes in myocardial infarction. Cardiovasc. Res. 29: 526-531,1995.
49. Wu, C.-C., J. D. Croxtall, M. Perretti, C. C. Bryant, C. Thiermermann, R. J. Flower, and J. R. Vane. Lipocortin 1 mediates the inhibition by dexamethasone of the induction by endotoxin of nitric oxide synthase in the rat. Proc. Natl. Acad. Sei. USA 92:3473-3477,1995.
50. Xie, Y.-W., and M. S. Wolin. Role of nitric oxide and its interaction with Superoxide in the suppression of cardiac muscle mitochondrial respiration. Circulation 94: 2580-2586,1996.
51. Yang, X., N. Chowdhury, B. Cai, J. Brett, C. Marboe, R. R. Sciacca, R. E. Michler, and P. J. Cannon. Induction of myocardial nitric oxide synthase by cardiac allograft rejection. J. Clin. Invest. 94: 714-721,1994.
52. Yasmin, W., K. D. Strynadka, and R. Schulz. Generation of peroxynitrite contributes to ischemia-reperfusion injury in isolated rat hearts. Cardiovasc. Res. 33:422-432,1997.
53. Yoshizumi, M., M. A. Perella, J. C. Burnett, Jr., and M.-E. Lee. Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life. Circ. Res. 73: 205-209,1993.