Reversible activation of nuclear factor-κB in human end-stage heart failure after left ventricular mechanical support

Cardiovascular Research

Volumn 53, Issue 1, 2002, Pages 124-130

  Grabellus, Florian ^a   Levkau, Bodo ^b   Sokoll, Andrea ^b   Welp, Hendryk ^b   Schmid, Christof ^b   Deng, Mario C ^c   Takeda, Atsushi ^d   Breithardt, Günter ^b   Baba, Hideo A ^a  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c Och Spine at New York Presbyterian Hospitals   (United States)

^d Jikei University Katsushika Medical Center   (Japan)

Author keywords

Heart failure; Hypertrophy; Myocytes; Remodeling; Signal transduction

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

ADULT; ARTICLE; CELL COUNT; CELL SIZE; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONGENITAL HEART DISEASE; CONTROLLED STUDY; DEVICE; DNA BINDING; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; GEL; HEART DILATATION; HEART FAILURE; HEART MUSCLE; HEART VENTRICLE REMODELING; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; IMPLANTATION; ISCHEMIC HEART DISEASE; MALE; MYOCARDITIS; PRIORITY JOURNAL;

ADULT; AUTORADIOGRAPHY; CARDIOMYOPATHY, DILATED; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FEMALE; HEART FAILURE, CONGESTIVE; HEART-ASSIST DEVICES; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL ISCHEMIA; MYOCARDITIS; MYOCARDIUM; NF-KAPPA B; TETRALOGY OF FALLOT;

EID: 0036135073     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(01)00433-3     Document Type: Article

References (20)

1. Implantable left ventricular assist devices
2. Improved left ventricular function after chronic left ventricular unloading
3. Weaning from mechanical cardiac support in patients with idiopathic dilated cardiomyopathy
4. Regression of cellular hypertrophy after left ventricular assist device support
5. Altered myocardial phenotype after mechanical support in human beings with advanced cardiomyopathy
6. Reversal of myocardial interleukin-6-mRNA expression following long-term left ventricular assist device support for myocarditis-associated low output syndrome
7. Decreased expression of tumor necrosis factor-alpha in failing human myocardium after mechanical circulatory support: A potential mechanism for cardiac recovery
8. Apoptosis in the failing human heart
9. Myocardial gene expression of regulators of myocyte apoptosis and myocyte calcium homeostasis during hemodynamic unloading by ventricular assist devices in patients with end-stage heart failure
10. Activate NF-kappa B or die?
11. Induction of cyclooxygenase-2 and activation of nuclear factor-kappaB in myocardium of patients with congestive heart failure
12. Apoptosis overrides survival signals through a caspase-mediated dominant-negative NF-kappa B loop
13. Nuclear factor-kappaB: A pivotal transcription factor in chronic inflammatory diseases
14. Reversal of metallothionein expression is different throughout the human myocardium after prolonged left-ventricular mechanical support
15. Reduction of hypoxia inducible heme oxygenase-1 in the myocardium after left ventricular mechanical support
16. Unloaded heart in vivo replicates fetal gene expression of cardiac hypertrophy
17. Identification of binding sites for transcription factors NF-kappa B and AP-2 in the promoter region of the human heme oxygenase 1 gene
18. Pressure-flow relations in coronary circulation
19. Hypoxic activation of nuclear factor-kappa B is mediated by a Ras and Raf signaling pathway and does not involve MAP kinase (ERK1 or ERK2)
20. Increased JNK, AP-1 and NF-κB DNA binding activities in isoproterenol-induced cardiac remodeling