A direct requirement of nuclear factor-κB for suppression of apoptosis in ventricular myocytes

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 279, Issue 3 48-3, 2000, Pages

  Mustapha, Shareef ^a   Kirshner, Alla ^a   De Moissac, Danielle ^a   Kirshenbaum, Lorrie A ^a,b  

^a UNIVERSITY OF MANITOBA   (Canada)

^b ST BONIFACE GENERAL HOSPITAL RESEARCH CENTRE   (Canada)

Author keywords

Adenovirus; Cytokines; Heart failure; Inflammation

Indexed keywords

CYTOKINE; CYTOPLASMIC INHIBITOR PROTEIN KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR PROTEIN; PROTEIN SUBUNIT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADENOVIRUS; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; HEART MUSCLE CELL; HEART VENTRICLE; IMMUNOMODULATION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 0033831027     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.2000.279.3.h939     Document Type: Article

References (53)

1. Xenotransplantation: Endothelial cell activation and beyond
2. Bcl-2 and Bcl-XL serve an anti-inflammatory function in endothelial cells through inhibition of NF-κB
3. IκB: A specific inhibitor of the NF-κB transcription factor
4. The IκB proteins: Multifunctional regulators of Rel/NF-κB transcription factors
5. An essential role for NF-κB in preventing TNF-α-induced cell death
6. Human T-cell leukemia virus type I Tax associates with and is negatively regulated by the NF-κ B2 p100 gene product: Implications for viral latency
7. Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-κB control
8. A20 blocks endothelial cell activation through a NF-κB-dependent mechanism
9. Bcl-2 activates the transcription factor NFκB through the degradation of the cytoplasmic inhibitor IκBα
10. Linkage of the BH4 domain of Bcl-2 and the nuclear factor κB signaling pathway for suppression of apoptosis
11. Analysis of TNFα-induced DNA strand breaks at the single cell level
12. Selective changes in cardiac gene expression during compensated hypertrophy and the transition to cardiac decompensation in rats with chronic aortic banding
13. Xenotransplantation: Progress toward clinical development
14. Mechanistic aspects of NF-κB regulation: The emerging role of phosphorylation and proteolysis
15. Apoptosis in ischemic and reperfused rat myocardium
16. Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione
17. Reperfusion injury induces apoptosis in rabbit cardiomyocytes
18. The effects of αvirus infection on neurons
19. Modulation of cytokine-induced cardiac myocyte apoptosis by nitric oxide, Bak, and Bcl-x
20. Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats
21. Tumor necrosis factor-α gene and protein expression in adult feline myocardium after endotoxin administration
22. The bcl-2 gene product prevents programmed cell death of ventricular myocytes
23. Highly efficient gene transfer into adult ventricular myocytes by recombinant adenovirus
24. Adenovirus E1A represses cardiac gene transcription and reactivates DNA synthesis in ventricular myocytes, via alternative pocket protein- and p300-binding domains
25. Transcriptional activation of the tumor necrosis factor α-inducible zinc finger protein, A20, is mediated by κB elements
26. Tumor necrosis factor α-induced apoptosis in cardiac myocytes. Involvement of the sphingolipid signaling cascade in cardiac cell death
27. Dilated cardiomyopathy in transgenic mice with cardiac-specific overexpression of tumor necrosis factor-α
28. Cytokines in acute myocardial infarction: Selective increase in circulating tumor necrosis factor, its soluble receptor, interleukin-1 receptor antagonist
29. The cytopathic effect of HIV is associated with apoptosis
30. Tumor necrosis factor-induced apoptosis during the poisoning of mice with hepatotoxins
31. Elevated circulating levels of tumor necrosis factor in severe chronic heart failure
32. The effect of tumor necrosis factor-α on cardiac structure and function: A tale of two cytokines
33. Basic mechanisms in congestive heart failure. Recognizing the role of proinflammatory cytokines
34. RIP2 is a novel NF-κB-activating and cell death-inducing kinase
35. Human myocardial tissue TNFα expression following acute global ischemia in vivo
36. Apoptosis in Burkitt lymphoma cells is driven by c-myc
37. Apoptosis in myocytes in end-stage heart failure
38. Apoptosis in the failing human heart
39. Sphingosine mediates the immediate negative inotropic effects of tumor necrosis factor-α in the adult mammalian cardiac myocyte
40. Induction of endothelial cell apoptosis by TNF α: Modulation by inhibitors of protein synthesis
41. End-stage cardiac failure in humans is coupled with the induction of proliferating cell nuclear antigen and nuclear mitotic division in ventricular myocytes
42. Bcl-2 family proteins: Regulators of apoptosis and chemoresistance in hematologic malignancies
43. The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-κB activation
44. Anatomy of TRAF2. Distinct domains for nuclear factor-κB activation and association with tumor necrosis factor signaling proteins
45. Extensive apoptosis occurring in the thymus during accelerated rejection of cardiac allografts in presensitized rats
46. Embryonic lethality, liver degeneration, impaired NF-κB activation in IKK-β-deficient mice
47. Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: A report from the studies of left ventricular dysfunction (SOLVD)
48. Tumor necrosis factor-α and tumor necrosis factor receptors in the failing human heart
49. Suppression of TNF-α-induced apoptosis by NF-κB
50. TNF- and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-κB
51. NF-κB antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
52. Inhibition of NF-κB/Rel induces apoptosis of murine B cells
53. IEX-1L an apoptosis inhibitor involved in NF-κB-mediated cell survival