Randomised investigation of effects of pentoxifylline on left-ventricular performance in idiopathic dilated cardiomyopathy

Lancet

Volumn 351, Issue 9109, 1998, Pages 1091-1093

  Sliwa, Karen ^a   Skudicky, Daniel ^a   Candy, Geoffrey ^a   Wisenbaugh, Thomas ^a   Sareli, Pinhas ^a  

^a UNIVERSITY OF THE WITWATERSRAND   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

PENTOXIFYLLINE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL EXAMINATION; CLINICAL TRIAL; CONGESTIVE CARDIOMYOPATHY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ECHOCARDIOGRAPHY; FEMALE; HEART EJECTION FRACTION; HEART LEFT VENTRICLE FUNCTION; HUMAN; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCINTISCANNING;

EID: 0032507428     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(97)09338-0     Document Type: Article

References (24)

1. 1 Hegewisch S, Weh HJ, Hossfeld DK. TNF-induced cardiomyopathy. Lancet 1990; 335: 294-95.
2. 2 Habib FM, Springall DR, Davies GJ, Oakley CM, Yacoub MH, Polak JM. Tumour necrosis factor and inducible nitric oxide synthase in dilated cardiomyopathy. Lancet 1996; 347: 1151-55.
3. 3 Torre-Amione G, Kapadia S, Benedict C, Oral H, Young JB, Mann DL. Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: a report from the studies of left ventricular dysfunction (SOLVD). J Am Coll Cardiol 1996; 27: 1201-06.
4. 4 Testa M, Yeh M, Lee P, et al. Circulating levels of cytokines and the endogenous modulators in patients with mild to severe congestive heart failure due to coronary artery disease or hypertension. J Am Coll Cardiol 1996; 28: 964-71.
5. 5 Levine B, Kalman J, Mayer L, Fillit HM, Packer M. Elevated circulating levels of tumor necrosis factor in severe chronic heart failure. N Engl J Med 1990; 323: 236-41.
6. 6 Suffredini AF, Fromm RE, Parker MM, et al. The cardiovascular response of normal humans to the administration of endotoxin. N Engl J Med 1989; 321: 280-87.
7. 7 Finkel MS, Oddis CV, Jacob TD, Watkins SC, Hattler BG, Simmons RL. Negative inotropic effects of cytokines on the heart mediated by nitric oxide. Science 1992; 257: 387-89.
8. 8 Balligand JL, Ungureanu-Longrois D, Simmons WW, et al. Cytokine-inducible nitric oxide synthase (iNOS) expression in cardiac myocytes: characterization and regulation of iNOS expression and detection of iNOS activity in single cardiac myocytes in vitro. J Biol Chem 1994; 269: 27580-88.
9. 9 Waage A, Sorensen M, Stordal B. Differential effect of pentoxifylline on tumour necrosis factor and interleukin-6 production. Lancet 1990; 335: 543.
10. 10 Zabel P, Schonharting MM, Wolter DT, Schade UF. Oxpentifylline in endotoxaemia. Lancet 1989; ii: 1474-77.
11. 11 Kremsner PG, Grundmann H, Neifer S, et al. Pentoxifylline prevents murine cerebral malaria. J Infect Dis 1991; 164: 605-08.
12. 12 Antin JH, Ferrara JLM. Cytokine dysregulation and acute graft-versus-host disease. Blood 1992; 80: 2964-86.
13. 13 Maksymowich WP, Avina-Zubieta A, Luong MH, Russell AS. An open study of pentoxifylline in the treatment of severe refractory rheumatoid arthritis. J Rheumatol 1995; 22: 625-29.
14. 14 MacDonald MJ, Shahidi NT, Allen DB, Lustig RH, Mitchell TL, Cornwell ST. Pentoxifylline in the treatment of children with new-onset type I diabetes mellitus. JAMA 1994; 271: 27-28.
15. 15 Calderon MJ, Landa N, Aguirre A, Diaz-Perez JL. Successful treatment of cutaneous PAN with pentoxifylline. Br J Dermatol 1993; 128: 706-08.
16. 16 Reiber JHC. Quantitative analysis of left ventricular function from equilibrium gated blood scintigrams: an overview of computer methods. Eur J Nucl Med 1985; 10: 97-110.
17. 17 Sahn DJ, DeMaria A, Kisslo J, Weyman A, the Committee on M-mode Standardization of the American Society of Echocardiography. Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. Circulation 1978; 58: 1072-83.
18. 18 Borrow KM, Newburger JW. Noninvasive estimation of central aortic pressure using the oscillometric method for analyzing systemic artery pulsatile blood flow: comparative study of indirect systolic, diastolic and mean brachial artery pressure with simultaneous direct ascending aortic pressure measurements. Am Heart J 1982; 103: 879-86.
19. 19 Quinones MA, Mokotoff DM, Nouri S, Winters WL, Miller RR. Noninvasive quantification of left ventricular wall stress. Validation of method and application of assessment of chronic pressure overload. Am J Cardiol 1980; 45: 782-90.
20. 20 Pinsky DJ, Cai B, Yang X, Rodriguez C, Sciacca RR, Cannon PJ. The lethal effects of cytokine-induced nitric oxide on cardiac myocytes are blocked by nitric oxide synthase antagonism or transforming growth factor beta. J Clin Invest 1995; 95: 677-85.
21. 21 Kapadia S, Torre-Amione G, Yokoyama T, Mann DL. Soluble TNF binding proteins modulate the negative inotropic properties of TNF-α in vitro. Am J Physiol 1995; 268: H517-25.
22. 22 Kelly RA, Smith TW. Cytokines and cardiac contractile function. Circulation 1997; 95: 778-81.
23. 23 Ward A, Clissold SP. Pentoxifylline: a review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy. Drugs 1987; 34: 50-97.
24. 24 Packer M, Carver JR, Rodeheffer RJ, et al. Effect of oral milrinone on mortality in severe chronic heart failure. N Engl J Med 1991; 325: 1468-75.