NMDA-receptor trafficking and targeting: Implications for synaptic transmission and plasticity

Trends in Neurosciences

Volumn 25, Issue 11, 2002, Pages 571-577

  Carroll, Reed C ^a   Zukin, R Suzanne ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN KINASE C; RECEPTOR SUBUNIT;

CENTRAL NERVOUS SYSTEM; ENDOCYTOSIS; EXOCYTOSIS; INTERNALIZATION; MEMBRANE TRANSPORT; MOLECULAR MECHANICS; NERVE CELL NETWORK; NERVE CELL PLASTICITY; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TARGETING; PROTEIN TRANSPORT; REGULATORY MECHANISM; REVIEW; SYNAPSE; SYNAPTIC MEMBRANE; SYNAPTIC TRANSMISSION; TISSUE DISTRIBUTION;

ANIMALS; HUMANS; NEURONAL PLASTICITY; PROTEIN TRANSPORT; RECEPTORS, N-METHYL-D-ASPARTATE; SYNAPTIC TRANSMISSION;

EID: 0036828497     PISSN: 01662236     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-2236(02)02272-5     Document Type: Review

References (85)

1. Constantine-Paton M. NMDA receptor as a mediator of activity-dependent synaptogenesis in the developing brain. Cold Spring Harb. Symp. Quant. Biol. 55:1990;431-443.
2. Malenka R.C., Nicoll R.A. Long-term potentiation - a decade of progress? Science. 285:1999;1870-1874.
3. Mori H., Mishina M. Structure and function of the NMDA receptor channel. Neuropharmacology. 34:1995;1219-1237.
4. Swope S.L., et al. Regulation of ligand-gated ion channels by protein phosphorylation. Adv. Second Messenger Phosphoprotein Res. 33:1999;49-78.
5. Cull-Candy S., et al. NMDA receptor subunits: diversity, development and disease. Curr. Opin. Neurobiol. 11:2001;327-335.
6. Malinow R., et al. LTP mechanisms: from silence to four-lane traffic. Curr. Opin. Neurobiol. 10:2000;352-357.
7. Carroll R.C., et al. Role of AMPA receptor endocytosis in synaptic plasticity. Nat. Rev. Neurosci. 2:2001;315-324.
8. Wang Y.T., Linden D.J. Expression of cerebellar long-term depression requires postsynaptic clathrin-mediated endocytosis. Neuron. 25:2000;635-647.
9. Kauer J.A., et al. A persistent postsynaptic modification mediates long-term potentiation in the hippocampus. Neuron. 1:1988;911-917.
10. Muller D., Lynch G. Long-term potentiation differentially affects two components of synaptic responses in hippocampus. Proc. Natl. Acad. Sci. U. S. A. 85:1988;9346-9350.
11. Perkel D.J., Nicoll R.A. Evidence for all-or-none regulation of neurotransmitter release: implications for long-term potentiation. J. Physiol. 471:1993;481-500.
12. Bashir Z.I., et al. Long-term potentiation of NMDA receptor-mediated synaptic transmission in the hippocampus. Nature. 349:1991;156-158.
13. Clark K.A., Collingridge G.L. Synaptic potentiation of dual-component excitatory postsynaptic currents in the rat hippocampus. J. Physiol. 482:1995;39-52.
14. Kullmann D.M., et al. LTP of AMPA and NMDA receptor-mediated signals: evidence for presynaptic expression and extrasynaptic glutamate spill-over. Neuron. 17:1996;461-474.
15. Selig D.K., et al. Independent mechanisms for long-term depression of AMPA and NMDA responses. Neuron. 15:1995;417-426.
16. Scannevin R.H., Huganir R.L. Postsynaptic organization and regulation of excitatory synapses. Nat. Rev. Neurosci. 1:2000;133-141.
17. Monyer H., et al. Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron. 12:1994;529-540.
18. McIlhinney R.A., et al. Assembly intracellular targeting and cell surface expression of the human N-methyl-D-aspartate receptor subunits NR1a and NR2A in transfected cells. Neuropharmacology. 37:1998;1355-1367.
19. Ozawa S., et al. Glutamate receptors in the mammalian central nervous system. Prog. Neurobiol. 54:1998;581-618.
20. O'Brien R.J., et al. Activity-dependent modulation of synaptic AMPA receptor accumulation. Neuron. 21:1998;1067-1078.
21. Friedman H.V., et al. Assembly of new individual excitatory synapses: time course and temporal order of synaptic molecule recruitment. Neuron. 27:2000;57-69.
22. Quinlan E.M., et al. Rapid, experience-dependent expression of synaptic NMDA receptors in visual cortex in vivo. Nat. Neurosci. 2:1999;352-357.
23. Rao A., Craig A.M. Activity regulates the synaptic localization of the NMDA receptor in hippocampal neurons. Neuron. 19:1997;801-812.
24. Liao D., et al. Regulation of morphological postsynaptic silent synapses in developing hippocampal neurons. Nat. Neurosci. 2:1999;37-43.
25. Watt A.J., et al. Activity coregulates quantal AMPA and NMDA currents at neocortical synapses. Neuron. 26:2000;659-670.
26. Mori H., et al. Role of the carboxy-terminal region of the GluR epsilon2 subunit in synaptic localization of the NMDA receptor channel. Neuron. 21:1998;571-580.
27. Steigerwald F., et al. C-Terminal truncation of NR2A subunits impairs synaptic but not extrasynaptic localization of NMDA receptors. J. Neurosci. 20:2000;4573-4581.
28. Okabe S., et al. Alternative splicing of the C-terminal domain regulates cell surface expression of the NMDA receptor nr1 subunit. J. Neurosci. 19:1999;7781-7792.
29. Scott D.B., et al. An NMDA receptor ER retention signal regulated by phosphorylation and alternative splicing. J. Neurosci. 21:2001;3063-3072.
30. Standley S., et al. PDZ domain suppression of an ER retention signal in NMDA receptor NR1 splice variants. Neuron. 28:2000;887-898.
31. Zerangue N., et al. A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane K(ATP) channels. Neuron. 22:1999;537-548.
32. Margeta-Mitrovic M., et al. A trafficking checkpoint controls GABA(B) receptor heterodimerization. Neuron. 27:2000;97-106.
33. Ellgaard L., et al. Setting the standards: quality control in the secretory pathway. Science. 286:1999;1882-1888.
34. 2+ channel α1 subunit contains an endoplasmic reticulum retention signal antagonized by the beta subunit. Neuron. 25:2000;177-190.
35. McIlhinney R.A., et al. Cell surface expression of the human N-methyl-D-aspartate receptor subunit 1a requires the co-expression of the NR2A subunit in transfected cells. Neuroscience. 70:1996;989-997.
36. 2+ block of NMDA-receptor channels as a mechanism of modulation. Nature. 356:1992;521-523.
37. Gerber G., et al. Multiple effects of phorbol esters in the rat spinal dorsal horn. J. Neurosci. 9:1989;3606-3617.
38. Roche K.W., et al. Molecular determinants of NMDA receptor internalization. Nat. Neurosci. 4:2001;794-802.
39. Xiong Z.G., et al. Regulation of N-methyl-D-aspartate receptor function by constitutively active protein kinase C. Mol. Pharmacol. 54:1998;1055-1063.
40. Zheng X., et al. Protein kinase C potentiation of N-methyl-D-aspartate receptor activity is not mediated by phosphorylation of N-methyl-D-aspartate receptor subunits. Proc. Natl. Acad. Sci. U. S. A. 96:1999;15262-15267.
41. Hall R.A., Soderling T.R. Differential surface expression and phosphorylation of the N-methyl-D-aspartate receptor subunits NR1 and NR2 in cultured hippocampal neurons. J. Biol. Chem. 272:1997;4135-4140.
42. Leonard A.S., Hell J.W. Cyclic AMP-dependent protein kinase and protein kinase C phosphorylate N-methyl-D-aspartate receptors at different sites. J. Biol. Chem. 272:1997;12107-12115.
43. Tingley W.G., et al. Characterization of protein kinase A and protein kinase C phosphorylation of the N-methyl-D-aspartate receptor NR1 subunit using phosphorylation site-specific antibodies. J. Biol. Chem. 272:1997;5157-5166.
44. Ehlers M.D., et al. Regulated subcellular distribution of the NR1 subunit of the NMDA receptor. Science. 269:1995;1734-1737.
45. Strong J.A., et al. Stimulation of protein kinase C recruits covert calcium channels in Aplysia bag cell neurons. Nature. 325:1987;714-717.
46. Connolly C.N., et al. Cell surface stability of γ-aminobutyric acid type A receptors. Dependence on protein kinase C activity and subunit composition. J. Biol. Chem. 274:1999;36565-36572.
47. Filippova N., et al. Evidence for phosphorylation-dependent internalization of recombinant human rho1 GABAC receptors. J. Physiol. 518:1999;385-399.
48. Zheng X., et al. Mutation of structural determinants lining the N-methyl-D-aspartate receptor channel differentially affects phencyclidine block and spermine potentiation and block. Neuroscience. 93:1999;125-134.
49. Hirschberg K., et al. Kinetic analysis of secretory protein traffic and characterization of Golgi to plasma membrane transport intermediates in living cells. J. Cell Biol. 143:1998;1485-1503.
50. Lan J.Y., et al. Protein kinase C modulates NMDA receptor trafficking and gating. Nat. Neurosci. 4:2001;382-390.
51. Lin, Y. (2001) PSD-95 increases surface expression and channel opening rate of NMDA receptors and reduces PKC potentiation of NMDA-elicited currents. Soc. for Neurosci. Abstr. 277.3
52. Yamada Y., et al. Modulation of the channel activity of the epsilon2/zeta1-subtype N-methyl D-aspartate receptor by PSD-95. J. Biol. Chem. 274:1999;6647-6652.
53. Bonifacino J.S., Dell-Angelica E.C. Molecular bases for the recognition of tyrosine-based sorting signals. J. Cell Biol. 145:1999;923-926.
54. Pearse B.M., Robinson M.S. Clathrin, adaptors, and sorting. Annu. Rev. Cell Biol. 6:1990;151-171.
55. Ehlers M.D. Reinsertion or degradation of AMPA receptors determined by activity-dependent endocytic sorting. Neuron. 28:2000;511-525.
56. Lin J.W., et al. Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization. Nat. Neurosci. 3:2000;1282-1290.
57. Luscher C., et al. Role of AMPA receptor cycling in synaptic transmission and plasticity. Neuron. 24:1999;649-658.
58. Vissel B., et al. A use-dependent tyrosine dephosphorylation of NMDA receptors is independent of ion flux. Nat. Neurosci. 4:2001;587-596.
59. Allison D.W., et al. Role of actin in anchoring postsynaptic receptors in cultured hippocampal neurons: differential attachment of NMDA versus AMPA receptors. J. Neurosci. 18:1998;2423-2436.
60. Kennedy M.B. Signal-processing machines at the postsynaptic density. Science. 290:2000;750-754.
61. Young S.H., Poo M.M. Rapid lateral diffusion of extrajunctional acetylcholine receptors in the developing muscle membrane of Xenopus tadpole. J. Neurosci. 3:1983;225-231.
62. Weiss R.E., et al. Mobility of voltage-dependent ion channels and lectin receptors in the sarcolemma of frog skeletal muscle. J. Gen. Physiol. 87:1986;955-983.
63. Akaaboune M., et al. Rapid and reversible effects of activity on acetylcholine receptor density at the neuromuscular junction in vivo. Science. 286:1999;503-507.
64. Meier J., et al. Fast and reversible trapping of surface glycine receptors by gephyrin. Nat. Neurosci. 4:2001;253-260.
65. Borgdorff A.J., Choquet D. Regulation of AMPA receptor lateral movements. Nature. 417:2002;649-653.
66. Tovar K.R., Westbrook G.L. Mobile NMDA receptors at hippocampal synapses. Neuron. 34:2002;255-264.
67. Barria A., Malinow R. Subunit-specific NMDA receptor trafficking to synapses. Neuron. 35:2002;345-354.
68. Tovar K.R., Westbrook G.L. The incorporation of NMDA receptors with a distinct subunit composition at nascent hippocampal synapses in vitro. J. Neurosci. 19:1999;4180-4188.
69. Lu W., et al. Activation of synaptic NMDA receptors induces membrane insertion of new AMPA receptors and LTP in cultured hippocampal neurons. Neuron. 29:2001;243-254.
70. Hardingham G.E., et al. Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways. Nat. Neurosci. 5:2002;405-414.
71. Sattler R., et al. Distinct roles of synaptic and extrasynaptic NMDA receptors in excitotoxicity. J. Neurosci. 20:2000;22-33.
72. Fong D.K., et al. Rapid synaptic remodeling by protein kinase C: reciprocal translocation of NMDA receptors and calcium/calmodulin-dependent kinase II. J. Neurosci. 22:2002;2153-2164.
73. Watanabe M., et al. Developmental changes in distribution of NMDA receptor channel subunit mRNAs. Neuroreport. 3:1992;1138-1140.
74. Williams K., et al. Developmental switch in the expression of NMDA receptors occurs in vivo and in vitro. Neuron. 10:1993;267-278.
75. Carmignoto G., Vicini S. Activity-dependent decrease in NMDA receptor responses during development of the visual cortex. Science. 258:1992;1007-1011.
76. Timney B., et al. Behavioral evidence for prolonged sensitivity to effects of monocular deprivation in dark-reared cats. J. Neurophysiol. 43:1980;1041-1054.
77. Nase G., et al. Genetic and epigenetic regulation of NMDA receptor expression in the rat visual cortex. Eur. J. Neurosci. 11:1999;4320-4326.
78. Quinlan E.M., et al. Bidirectional, experience-dependent regulation of N-methyl-D-aspartate receptor subunit composition in the rat visual cortex during postnatal development. Proc. Natl. Acad. Sci. U. S. A. 96:1999;12876-12880.
79. Fagiolini M., et al. Functional postnatal development of the rat primary visual cortex and the role of visual experience: dark rearing and monocular deprivation. Vision Res. 34:1994;709-720.
80. Petralia R.S., et al. Selective acquisition of AMPA receptors over postnatal development suggests a molecular basis for silent synapses. Nat. Neurosci. 2:1999;31-36.
81. Grosshans D.R., et al. LTP leads to rapid surface expression of NMDA but not AMPA receptors in adult rat CA1. Nat. Neurosci. 5:2002;27-33.
82. Snyder E.M., et al. Internalization of ionotropic glutamate receptors in response to mGluR activation. Nat. Neurosci. 4:2001;1079-1085.
83. Bolshakov V.Y., Siegelbaum S.A. Postsynaptic induction and presynaptic expression of hippocampal long-term depression. Science. 264:1994;1148-1152.
84. Montgomery J.M., Madison D.V. State-dependent heterogeneity in synaptic depression between pyramidal cell pairs. Neuron. 33:2002;765-777.
85. Heynen A.J., et al. Bidirectional, activity-dependent regulation of glutamate receptors in the adult hippocampus in vivo. Neuron. 28:2000;527-536.