Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments

Journal of Cell Biology

Volumn 155, Issue 5, 2001, Pages 739-745

  Jenkins, Scott M ^a,b   Bennett, Vann ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DUKE UNIVERSITY   (United States)

Author keywords

IV spectrin; Axon hillock; Neurofascin; NrCAM; Sodium channel Nav1.6

Indexed keywords

ANKYRIN; ION CHANNEL; L1 CELL ADHESION MOLECULE; NERVE CELL ADHESION MOLECULE; NEUROFASCIN; SODIUM CHANNEL; SPECTRIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CEREBELLUM; IMMUNOCYTOCHEMISTRY; KNOCKOUT MOUSE; MOUSE; NERVE CELL; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PURKINJE CELL;

ANIMALS; ANKYRINS; CELL ADHESION MOLECULES; CEREBELLUM; CYTOSKELETON; ION CHANNEL GATING; LEUKOCYTE L1 ANTIGEN COMPLEX; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; MICROSCOPY, FLUORESCENCE; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS; NEURAL CELL ADHESION MOLECULES; PURKINJE CELLS; RATS; SODIUM CHANNELS; SPECTRIN;

ANIMALIA;

EID: 0035956420     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200109026     Document Type: Article

References (25)

1. Spectrin and ankyrin-based pathways: Metazoan inventions for integrating cells into tissues
2. βIV spectrin, a new spectrin localized at axon initial segments and nodes of Ranvier in the central and peripheral nervous system
3. Compacr myelin dictares the differential targeting of two sodium channel isoforms in the same axon
4. v1.6 is localized at nodes of Ranvier, dendrites, and synapses
5. Molecular composition of the node of Ranvier: Identification of ankyrin-binding cell adhesion molecules neurofascin (mucin⊥/third FNIII domain-) and NrCAM at nodal axon segments
6. Ankyrin-binding proteins related to nervous system cell adhesion molecules: Candidates to provide transmembrane and intercellular connections in adult brain
7. Cerebellar structure and function in the murine mutant jolting
8. Structural and functional evolution of the L1 family: Are four adhesion molecules better than one?
9. FIGQY-phosphorylation defines discrete populations of L1 cell adhesion molecules at sites of cell-cell contact and in migrating neurons
10. v1.6 at developing CNS nodes of Ranvier
11. Induction of sodium channel clustering by oligodendrocytes
12. A missense mutation in the sodium channel Scn8a is responsible for cerebellar ataxia in the mutant mouse jolting
13. A new ankyrin gene with neural-specific isoforms localized at the axonal initial segment and node of ranvier
14. Morphogenesis of the node of Ranvier: Co-clusters of ankyrin and ankyrin-binding integral proteins define early developmental intermediates
15. Sodium channel β subunits mediate homophilic cell adhesion and recruit ankyrin to points of cell-cell contact
16. - anion exchanger
17. Caenorhabditis elegans β-G spectrin is dispensible for establishment of epithelial polarity, but essential for muscular and neuronal function
18. Mutant β-spectrin 4 causes auditory, and motor neuropathies in quivering mice
19. Altered subthreshold sodium currents and disrupted firing patterns in Purkinje neurons of Scn8a mutant mice
20. Dependence of nodal sodium channel clustering on paranodal axoglial contact in the developing CNS
21. Sodium channel β1 and β3 subunits associate with neurofascin through their extracellular immunoglobulin-like domain
22. A diffusion barrier maintains distribution of membrane proteins in polarized neurons
23. G-specific domains
24. Structural requirements for association of neurofascin with ankyrin
25. Ankyrin G is required for clustering of voltage-gated Na channels at axon initial segments and for normal action potential firing