Cdc-42 controls early cell polarity and spindle orientation in C. elegans

Current Biology

Volumn 11, Issue 7, 2001, Pages 482-488

  Gotta, Monica ^a   Abraham, Mary C ^a   Ahringer, Julie ^a  

^a WELLCOME CRC INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BLASTOMERE; CELL POLARITY; GENETIC CONSERVATION; GENETIC REGULATION; GUANINE NUCLEOTIDE BINDING PROTEIN; MOLECULAR EVOLUTION; PROTEIN CDC42; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; SPINDLE ORIENTATION;

INVERTEBRATA; MAMMALIA; RICKETTSIA SP. PAR;

EID: 0035799292     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00142-7     Document Type: Article

References (28)

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7. Post-translational processing of RhoA. Carboxyl methylation of the carboxyl-terminal prenylcysteine increases the half-life of Rhoa
8. Asymmetrically distributed PAR-3 protein contributes to cell polarity and spindle alignment in early C. elegans embryos
9. par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3
10. PAR-6 is a conserved PDZ domain-containing protein that colocalizes with PAR-3 in Caenorhabditis elegans embryos
11. Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorhabditis elegans
12. A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCζ signaling and cell transformation
13. The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42
14. A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and αPKC signalling and cell polarity
15. par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed
16. PAR-2 is asymmetrically distributed and promotes association of P granules and PAR-1 with the cortex in C. elegans embryos
17. Immunofluorescence visualization of germ-line-specific cytoplasmic granules in embryos, larvae, and adults of Caenorhabditis elegans
18. Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion
19. Fission yeast pak1 + encodes a protein kinase that interacts with Cdc42p and is involved in the control of cell polarity and mating
20. Mutational analysis of CDC42Sc, a Saccharomyces cerevisiae gene that encodes a putative GTP-binding protein involved in the control of cell polarity
21. Mutations in the par genes of Caenorhabditis elegans affect cytoplasmic reorganization during the first cell cycle
22. par-2, a gene required for blastomere asymmetry in Caenorhabditis elegans, encodes zinc-finger and ATP-binding motifs
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24. The Caenorhabditis elegans p21-activated kinase (CePAK) colocalizes with CeRac1 and CDC42Ce at hypodermal cell boundaries during embryo elongation
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26. Interaction trap/two hybrid system to identify two hybrid proteins
27. Identification of genes required for cytoplasmic localization in early C. elegans embryos
28. CDC-42 regulates PAR protein localization and function to control cellular and embryonic polarity in C. elegans