βIV spectrin, a new spectrin localized at axon initial segments and nodes of ranvier in the central and peripheral nervous system

Journal of Cell Biology

Volumn 151, Issue 5, 2000, Pages 985-1001

  Berghs, Stanny ^a   Aggujaro, Diego ^a   Dirkx Jr , Ronald ^a   Maksimova, Elena ^a   Stabach, Paul ^a   Hermel, Jean Michel ^a   Zhang, Jian Ping ^a   Philbrick, William ^a   Slepnev, Vladimir ^a   Ort, Tatiana ^a   Solimena, Michele ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Chromosome 19; Diabetes; Neuropathies; Secretion; Signal transduction

Indexed keywords

SPECTRIN; SPECTRIN BETA SUBUNIT; UNCLASSIFIED DRUG; ANKYRIN; AUTOANTIGEN; BETAIV SPECTRIN; IA 2 PROTEIN; IA-2 PROTEIN; MEMBRANE PROTEIN; MESSENGER RNA; NERVE PROTEIN; PHOSPHOPROTEIN; PLASMA PROTEIN; PLATELET PROTEIN P47; PROTEIN TYROSINE PHOSPHATASE; SODIUM CHANNEL;

ANIMAL CELL; ARTICLE; CELL FRACTIONATION; HUMAN; HUMAN CELL; IN SITU HYBRIDIZATION; NERVE FIBER; NONHUMAN; NUCLEOTIDE SEQUENCE; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; RANVIER NODE; RAT; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANIMAL; BRAIN LEVEL; CELL STRAIN COS1; CHEMISTRY; CHROMOSOME; CYTOLOGY; CYTOPLASM; CYTOSKELETON; DIABETIC NEUROPATHY; GENE EXPRESSION; GENETICS; HIPPOCAMPUS; MALE; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; MOUSE; PANCREAS ISLET; PATHOPHYSIOLOGY; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; SCIATIC NERVE; SPRAGUE DAWLEY RAT;

ANIMALIA;

AMINO ACID SEQUENCE; ANIMALS; ANKYRINS; AUTOANTIGENS; AXONS; BLOOD PROTEINS; BRAIN CHEMISTRY; CHROMOSOMES; CLONING, MOLECULAR; COS CELLS; CYTOPLASM; CYTOSKELETON; DIABETIC NEUROPATHIES; GENE EXPRESSION; HIPPOCAMPUS; HUMANS; ISLETS OF LANGERHANS; MALE; MEMBRANE PROTEINS; MICE; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; PHOSPHOPROTEINS; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE-PHOSPHATASE; RANVIER'S NODES; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SCIATIC NERVE; SIGNAL TRANSDUCTION; SODIUM CHANNELS; SPECTRIN;

EID: 0034722147     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.151.5.985     Document Type: Article

References (84)

1. Basic local alignment search tool
2. Structural comparisons of calponin homology domains: Implications for actin binding
3. A spectrin membrane skeleton of the Golgi complex
4. Golgi spectrin: Identification of an erythroid β-spectrin homolog associated with the Golgi complex
5. The spectrin-based membrane skeleton and micron-scale organization of the plasma membrane
6. Nonerythrocyte spectrins: Actin-membrane attachment proteins occurring in many cell types
7. Amphiphysin II (SH3P9: BIN1), a member of the amphiphysin/Rvs family, is concentrated in the cortical cytomatrix of axon initial segments and nodes of Ranvier in brain and around T tubules in skeletal muscle
8. Visualization of the protein associations in the erythrocyte membrane skeleton
9. Colocalization of synaptophysin with transferrin receptors: Implications for synaptic vesicle biogenesis
10. Structure, function, and molecular genetics of erythroid membrane skeletal protein 4.1 in normal and abnormal red blood cells
11. Molecular composition of the node of Ranvier: Identification of ankyrin-binding cell adhesion molecules neurofascin (mucin+/third FNIII domain-) and NrCAM at nodal axon segments
12. Identification of two regions of β(G) spectrin that bind to distinct sites in brain membranes
13. Synapsin I (protein I), a nerve terminal-specific phosphoprotein. I. Its general distribution in synapses of the central and peripheral nervous system demonstrated by immuno-fluorescence in frozen and plastic sections
14. The role of ankyrin and spectrin in membrane transport and domain formation
15. The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate ras-specific and rho-specific guanine nucleotide exchange factor domains
16. Drosophila develop-ment requires spectrin network formation
17. Na, K-ATPase transport from endoplasmic reticulum to Golgi requires the Golgi spectrin-ankyrin G119 in Madin Darby canine kidney cells
18. 2-terminal region of the 65-kDa isoform of glutamic acid decarboxylase
19. A beta-spectrin isoform from Drosophila (beta H) is similar in size to vertebrate dystrophin
20. Stromal cells are critical targets in the regulation of mammary ductal morphogenesis by parathyroid hormone-related protein
21. Localization of the tetrodotoxin-resistant sodium channel NaN in nociceptors
22. Spectrin redistributes to the cytosol and is phosphorylated during mitosis in cultured cells
23. Actin and neurofilament binding domain of brain spectrin beta subunit
24. Hematologically important mutations: Spectrin and ankyrin variants in hereditary spherocytosis
25. F-actin-binding and cross-linking properties of porcine brain fodrin, a spectrin-related molecule
26. ADP ribosylation factor regulates spectrin binding to the Golgi complex
27. Brain spectrin: Of mice and men
28. Identification of a spectrin-like protein in none rythroid cell
29. Identification of a novel C-terminal variant of (andbgr;)II spectrin: Two isoforms of (andbgr;) II spectrin have distinct intra-cellular locations and activities
30. Post-translational modifications of ICA512, a receptor tyrosine phosphatase-like protein of secretory granules
31. 2-terminal repeats associate with mouse macrophage lysosomes
32. Characterization of human brain cDNA encoding the general isoform of beta-spectrin
33. Structure of the binding site for inositol phosphates in a PH domain
34. Mapping the fodrin binding domain in CD45, a leukocyte membrane-associated tyrosine phosphatase
35. The identification and sequence of the actin-binding domain of human red blood cell beta-spectrin
36. A partial structural repeat forms the heterodimer self-association site of all beta-spectrins
37. Ankyrin binds to the 15th repetitive unit of erythroid and nonerythroid β-spectrin
38. An isoform of ankyrin is localized at nodes of Ranvier in myelinated axons of central and peripheral nerves
39. Ankyrin G: A new ankyrin gene with neural-specific isoforms localized at the axon initial segment and nodes of Ranvier
40. Morphogenesis of the node of Ranvier: Co-clusters of ankyrin and ankyrin-binding integral proteins define early developmental intermediates
41. Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma
42. Stabilization of the receptor protein tyrosine phosphatase-like protein ICA512 in GH4C1 cells upon treatment with estradiol insulin, and epidermal growth factor
43. Tyrosine phosphatase activity of lymphoma CD45 (GP180) is regulated by a direct interaction with the cytoskeleton
44. 2- and COOH-terminal membrane association domains (MAD1 and MAD2)
45. Identification of a second transmembrane protein tyrosine phosphatase, IA-2beta, as an autoantigen in insulin dependent diabetes mellitus: Precursur of the 37-kDa tryptic fragment
46. Predicting coiled coils from pro-tein sequences
47. The complete amino acid sequence for brain beta spectrin (beta fodrin): Relationship to globin sequences
48. Substitution of two variant residues in the protein tyrosine phosphatase-like PTP35/IA-2 sequence reconstitutes catalytic activity
49. The 270 kDa splice variant of erythrocyte β-spectrin (βIΣ2) segregates in vivo and in vitro to specific domains of cerebellar neurons
50. The erythrocyte cytoskeleton in hereditary elliptocytosis and spherocytosis
51. Selective solubilization of a protein component of the red cell membrane
52. Plasma membrane structure at the axon hillock, initial segment and cell body of frog dorsal root ganglion cells
53. Characterization of a new beta-spectrin gene which is predominantly expressed in brain
54. The receptor tyrosine phosphatase like-protein ICA512 binds the PDZ domains of β2-syntrophin and nNOS in pancreatic β-cells
55. Evolution of the spectrin repeat
56. Ank3 (epithelial ankyrin), a widely distributed new member of the ankyrin gene family and the major ankyrin in kidney, is expressed in alternatively spliced forms, including forms that lack the repeat domain
57. Islet cell autoantigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases
58. Cloning and expression of IDDM-specific human autoantigens
59. Brain spectrin (240/235) and brain spectrin (240/235E): Two distinct spectrin subtypes with different locations within mammalian neural cells
60. Density of sodium channels in mammalian myelinated nerve fibers and nature of the axonal membrane under the myelin sheath
61. Cloning and stable maintenance of 300-kilobase-pair fragments of human DNA in Escherichia coli using an F-factor-based vector
62. Spectrin (βSpIIΣ1) is an essential component of synaptic transmission
63. Synapsin I-mediated interaction of brain spectrin with synaptic vesicles
64. Vesicular autoantigens of type 1 diabetes
65. 2-terminal region
66. ICA512, an autoantigen of type I diabetes, is an intrinsic membrane protein of neurosecretory granules
67. A widely expressed betaIII spectrin associated with Golgi and cytoplasmic vesicles
68. Erythrocyte spectrin is comprised of many homologous triple helical segments
69. Identification and characterization of βV spectrin, a mammalian ortholog of Drosophila betaH spectrin
70. A physical map of chromosome 20 established using fluorescent in situ hybridization (FISH) and digital image analysis
71. Co-localization of the myelin-associated glycoprotein and the microfilament components, F-actin and spectrin, in Schwann cells of myelinated nerve fibres
72. Spectrin: On the path from structure to function
73. Mammalian Ras interacts directly with the serine/threonine kinase Raf
74. Molecular cloning of phogrin, a proteintyrosine phosphatase homologue localized to insulin secretory granule membranes
75. A diffusion barrier maintains distribution of membrane proteins in polarized neurons
76. Erythroid and nonerythroid spectrins
77. Full-length sequence of the cDNA for human erythroid β-spectrin
78. β Spectrin in human skeletal muscle. Tissue specific differential processing of 3' β spectrin pre-mRNA generates a β spectrin isoform with a unique carboxyl terminus
79. Crystal structure of the repetitive segments of spectrin
80. Pleckstrin homology domains interact with filamentous actin
81. Spectrin sub-types in mammalian brain: An immunoelectron microscopic study
82. Localization of spectrin in the mammalian brain
83. Ankyrin G is required for clustering of voltage-gated Na channels at axon initial segments and for normal action potential firing