Junctional adhesion molecule (JAM) binds to PAR-3: A possible mechanism for the recruitment of PAR-3 to tight junctions

Journal of Cell Biology

Volumn 154, Issue 3, 2001, Pages 491-497

  Itoh, Masahiko ^a   Sasaki, Hiroyuki ^b   Furuse, Mikio ^a   Ozaki, Harunobu ^a   Kita, Toru ^a   Tsukita, Shoichiro ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KAN Research Institute Inc ^*  (Japan)

Author keywords

Claudin; JAM; PAR 3; Tight junction; ZO 1

Indexed keywords

CELL ADHESION MOLECULE; CLAUDIN; JUNCTIONAL ADHESION MOLECULE; POLYCLONAL ANTIBODY; PROTEIN ZO1; PROTEINASE ACTIVATED RECEPTOR 3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL ADHESION; ELECTRON MICROSCOPY; EPITHELIUM CELL; FIBROBLAST; IMMUNOFLUORESCENCE MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; STRUCTURE ANALYSIS; TIGHT JUNCTION;

ANIMALS; CELL ADHESION; CELL ADHESION MOLECULES; CELL POLARITY; CELLS, CULTURED; EPITHELIAL CELLS; FIBROBLASTS; FREEZE FRACTURING; MEMBRANE PROTEINS; MICE; MUTAGENESIS; PHOSPHOPROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, THROMBIN; SIGNAL TRANSDUCTION; TIGHT JUNCTIONS; TRANSFECTION;

ANIMALIA; RICKETTSIA SP. PAR;

EID: 0035817623     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200103047     Document Type: Article

References (31)

1. Tight junctions and the molecular basis for regulation of paracellular permeability
2. Assembly of the tight junction: The role of diacylglycerol
3. Homophilic interaction of junctional adhesion molecule
4. Interaction of junctional adhesion molecule with the tight junction components ZO-1, cingulin, and occludin
5. Freeze-fracture replica electron microscopy combined with SDS digestion for cytochemical labeling of integral membrane proteins. Application to the immunogold labeling of intercellular junctional complexes
6. Occludin: A novel inregral membrane protein localizing at tight junctions
7. Claudin-1 and -2: Novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin
8. A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblasts
9. Identification of a 160-kDa polypeptide that binds to the tight junction protein ZO-1
10. Molecular genetics of asymmetric cleavage in the early Caenorhabditis elegans embryo
11. ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin
12. The 220-kD protein colocalizing with cadherins in non-epithelial cells is identical to ZO-1, a tight junction-associated protein in epithelial cells: cDNA cloning and immunoelectron microscopy
13. Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins
14. An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3
15. Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppresser protein
16. The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42
17. PARsing embryonic polarity
18. Identification of genes required for cytoplasmic localization in early C. elegans embryos
19. A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Racl and aPKC signalling and cell polarity
20. Human junction adhesion molecule regulates tight junction resealing in epithelia
21. Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigrarion
22. Cutting edge: Combined treatment of TNF-α and IFN-γ causes redistribution of junctional adhesion molecule in human endothelial cells
23. Vascular endothelial junction-associated molecule, a novel member of the immunoglobulin superfamily, is localized to intercellular boundaries of endothelial cells
24. A human homolog of the C. elegans polarity determinant par-6 links rac and cdc42 to PKCzeta signaling and cell transformation
25. Structure and function of intercellular junctions
26. Identification of ZO-1: A high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia
27. Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures
28. Structural and signaling molecules come together at tight junctions
29. Multifunctonal strands in tight junctions
30. Identification and characterization of human junctional adhesion molecule (JAM)
31. The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppresser protein of septate junctions