PDZ proteins and polarity: Functions from the fly

Trends in Genetics

Volumn 17, Issue 9, 2001, Pages 511-519

  Bilder, David ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISHEVELLED PROTEIN; INSECT PROTEIN; MEMBRANE PROTEIN; MUTANT PROTEIN; PDZ PROTEIN; PROTEIN ARC; PROTEIN BAZ; PROTEIN CNK; PROTEIN CNO; PROTEIN DLG; PROTEIN DLT; PROTEIN DMPAR 6; PROTEIN DRHOGEF2; PROTEIN INAD; PROTEIN SCRIB; PROTEIN SIF; PROTEIN ZO1; UNCLASSIFIED DRUG;

CELL POLARITY; CELL STRUCTURE; CELL TRANSFORMATION; DROSOPHILA; EMBRYO CELL; EPITHELIUM CELL; GENE ACTIVITY; GENE FUNCTION; GENETIC ANALYSIS; GENETIC CONSERVATION; MORPHOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN TARGETING; REVIEW; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELL MEMBRANE; CELL POLARITY; CYTOGENETIC ANALYSIS; DROSOPHILA; HUMANS; IMMUNOHISTOCHEMISTRY; INSECT PROTEINS; MUTATION; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035451134     PISSN: 01689525     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-9525(01)02407-6     Document Type: Review

References (68)

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2. LET-23 receptor localization by the cell junction protein LIN-7 during C. elegans vulval induction
3. Initial sequencing and analysis of the human genome
4. The sequence of the human genome
5. Shroom, a PDZ domain-containing actin-binding protein, is required for neural tube morphogenesis in mice
6. Absence of the tight junctional protein AF-6 disrupts epithelial cell-cell junctions and cell polarity during mouse development
7. Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein
8. Contrasting localizations of MALS/LIN-7 PDZ proteins in brain and molecular compensation in knockout mice
9. The genome sequence of Drosophila melanogaster
10. Drosophila coracle, a member of the protein 4.1 superfamily, has essential structural functions in the septate junctions and developmental functions in embryonic and adult epithelial cells
11. The Canoe protein is necesssary in adherens junctions for development of the ommatidial architecture of the Drospohila compound eye
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13. Epithelial differentiation in Drosophila
14. Discs Lost, a novel multi-PDZ domain protein, establishes and maintains epithelial polarity
15. Armadillo, bazooka, and stardust are critical for early stages in formation of the zonula adherens and maintenance of the polarized blastoderm epithelium in Drosophila
16. The Drosophila genes crumbs and stardust are involved in the biogenesis of adherens junctions
17. Crumbs, a component of the apical membrane, is required for zonula adherens formation in primary epithelia of Drosophila
18. Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors
19. Localization of apical epithelial determinants by the basolateral PDZ protein Scribble
20. Molecular cloning of the lethal(1)discs large-1 oncogene of Drosophila
21. Inhibition of patterned cell shape change and cell invasion by Discs large during Drosophila oogenesis
22. The Drosophila tumor suppressor gene dlg is required for normal synaptic bouton structure
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24. Synaptic clustering of the cell adhesion molecule fasciclin II by Discs-large and its role in the regulation of presynaptic structure
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27. The tumour-suppressor genes lgl and dlg regulate basal protein targeting in Drosophila neuroblasts
28. Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblast
29. Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts
30. Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblasts
31. DmPar-6 directs epithelial polarity and assymetric cell division of neuroblasts in Drosophila
32. A conserved motif in Crumbs is required for E-cadherin localisation and zonula adherens formation in Drosophila
33. Apical, lateral, and basal polarization cues contribute to the development of the follicular epithelium during Drosophila oogenesis
34. Organizing a functional junctional complex requires specific domains of the Drosophila MAGUK Discs large
35. Synaptic targeting and localization of Discs-large is a stepwise process controlled by different domains of the protein
36. Dual palmitoylation of PSD-95 mediates its vesiculotubular sorting, postsynaptic targeting, and ion channel clustering
37. Regulation of Dlg localization at synapses by CaMKII-dependent phosphorylation
38. Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways
39. Drosophila atypical protein kinase C associates with Bazooka and controls polarity of epithelia and neuroblasts
40. A multivalent PDZ-domain protein assembles signalling complexes a G-protein-coupled cascade
41. Independent anchoring and assembly mechanisms of InaD signaling complexes in Drosophila photoreceptors
42. Recognition of unique carboxyl-terminal motifs by distinct PDZ domains
43. New perspectives on mechanisms involved in generating epithelial cell polarity
44. A role for a PDZ protein in the early secretory pathway for the targeting of proTGF-alpha to the cell surface
45. Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport
46. Ligand-gated ion channel interactions with cytoskeletal and signaling proteins
47. PDZ-mediated interactions retain the epithelial GABA transporter on the basolateral surface of polarized epithelial cells
48. Trp and the PDZ protein, InaD, form the core complex required for retention of the signalplex in Drosophila photoreceptor cells
49. Neoplasms in mutant and cultured wild-tupe tissues of Drosophila
50. Structure of the l(2)gl gene of Drosophila and delimitation of its tumor suppressor domain
51. The Drosophila lethal(2)giant larvae tumor suppressor protein is a component of the cytoskeleton
52. The tumor suppressor gene, lethal(2)giant larvae (1(2)g1), is required for cell shape change of epithelial cells during Drosophila development
53. Requirement of Drosophila l(2)gl function for survival of the germline cells and organization of the follicle cells in a columnar epithelium during oogenesis
54. Sro7p, a Saccharomyces cerevisiae counterpart of the tumor suppressor l(2)gl protein, is related to myosins in function
55. Yeast homologues of tomosyn and lethal giant larvae function in exocytosis and are associated with the plasma membrane SNARE, Sec9
56. Tight junction, a platform for trafficking and signaling protein complexes
57. Polarized insertion of new membrane from a cytoplasmic reservoir during cleavage of the Drosophila embryo
58. Trp trapped in fly signaling web
59. Growth, metastasis, and invasiveness of Drosophila tumors caused by mutations in specific tumor suppressor genes
60. Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein
61. Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein
62. Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein
63. Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase
64. A human homologue of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCz signaling and cell transformation
65. LET-413 is a basolateral protein required for the assembly of adherens junctions in Caenorhabditis elegans
66. Zonula Adherens Formation in Caenorhabditis elegans requires dlg-1, the homologue of the Drosophila gene discs large
67. The Drosophila tamou gene, a component of the activating pathway of extramacrochaetae expression, encodes a protein homologous to mammalian cell-cell junction-associated protein ZO-1
68. Functional expression of rat synapse-associated proteins SAP97 and SAP102 in Drosophila dlg-1 mutants: Effects on tumor suppression and synaptic bouton structure