Somatic EPSP amplitude is independent of synapse location in hippocampal pyramidal neurons

Nature Neuroscience

Volumn 3, Issue 9, 2000, Pages 895-903

  Magee, Jeffrey C ^a   Cook, Erik P ^b  

^a LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; COMPUTER MODEL; DENDRITE; EXCITATORY POSTSYNAPTIC POTENTIAL; HIPPOCAMPUS; NERVE CONDUCTION; NONHUMAN; PRIORITY JOURNAL; RAT; SYNAPSE;

ANIMALS; CELL SIZE; DENDRITES; ELECTROPHYSIOLOGY; EXCITATORY POSTSYNAPTIC POTENTIALS; HIPPOCAMPUS; KINETICS; MODELS, NEUROLOGICAL; PYRAMIDAL CELLS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, AMPA; SYNAPSES; TIME FACTORS;

EID: 0033850511     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/78800     Document Type: Article

References (41)

1. Bannister, N. J. & Larkman, A. U. Dendritic morphology of CA1 pyramidal neurones from the rat hippocampus: II. Spine distributions. J. Comp. Neurol. 360, 161-171 (1995).
2. Rall, W. Theory of physiological properties of dendrites. Ann. NY Acad. Sci. 96, 1071-1079 (1962).
3. Jack, J. J. & Redman, S. J. The propagation of transient potentials in some linear cable structures. J. Physiol. (Lond.) 215, 283-320 (1971).
4. Mainen, Z. F., Carnevale, N. T., Zador, A. M., Claiborne, B. J. & Brown, T. H. Electrotonic architecture of hippocampal CA1 pyramidal neurons based on three-demensional reconstruction. J. Neurophysiol. 76, 1904-1923 (1996).
5. Jaffe, D. B. & Carnevale, N. T. Passive normalization of synaptic integration influenced by dendritic architecture. J. Neurophysiol. 82, 3268-3285 (1999).
6. Magee, J. C., Hoffman, D., Colbert, C. & Johnston, D. Electrical and calcium signaling in dendrites of hippocampal pyramidal neurons. Annu. Rev. Physiol. 60, 327-346 (1998).
7. + channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons. Nature 387, 869-875 (1997).
8. Magee, J. C. Dendritic hyperpolarization-activated currents modify the integrative properties of hippocampal CA1 pyramidal neurons. J. Neurosci. 18, 7613-7624 (1998).
9. h normalizes temporal summation in hippocampal CA1 neurons. Nat. Neurosci. 2, 508-514 (1999).
10. 2+ channels in apical dendrites of rat CA1 pyramidal neurons. J. Neurophysiol. 77, 1639-1643 (1997).
11. + channels amplify EPSPs in hippocampal CA1 pyramidal cells. J. Neurophysiol. 76, 2181-2191 (1996).
12. Rall, W. Distinguishing theoretical synaptic potentials computed for different soma-dendritic distributions of synaptic input. J. Neurophysiol. 30, 1138-1168 (1967).
13. Rinzel, J. & Rall, W. Transient response in a dendritic neuron model for current injected at one branch. Biophys. J. 14, 759-790 (1974).
14. Pettit, D. L. & Augustine, G. J. Distribution of functional glutamate and GABA receptors on hippocampal pyramidal cells and interneurons J. Neurophysiol. 84, 28-38 (2000).
15. Inasek, R. & Redman, S. J. The amplitude, time course and charge of unitary excitatory post-synaptic potentials evoked in spinal motoneurone dendrites. J. Physiol. (Lond.) 234, 665-688 (1973).
16. Andersen, P., Silfvenius, H., Sundberg, S. H. & Sveen, O. A comparison of distal and proximal dendrite synapses on CA1 pyramids in guinea pig hippocampal slices in vitro. J. Physiol. (Lond.) 307, 273-299 (1980).
17. Jack, J. J., Redman, S. J. & Wong, K. The components of synaptic potentials evoked in cat spinal motoneurones by impulses in single group Ia afferents. J. Physiol. (Lond.) 321, 65-96 (1981).
18. Stricker, C., Field, A. C. & Redman S. J. Statistical analysis of amplitude fluctuations in EPSCs evoked in rat CA1 pyramidal neurones in vitro. J. Physiol. (Lond.) 490, 419-441 (1996).
19. Larkman, A., Stratford, K. & Jack, J. Quantal analysis of excitatory synaptic action and depression in hippocampal slices. Nature 350, 344-347 (1991).
20. Kullmann, D. M. & Nicoll, R. A. Long-term potentiation is associated with increases in quantal content and quantal amplitude. Nature 357, 240-243 (1992).
21. Liao, D., Jones, A. & Malinow, R. Direct measurement of quantal changes underlying long-term potentiation in CA1 hippocampus. Neuron 9, 1089-1094 (1992).
22. Bolshakov, V. Y., Golan, H., Kandel, E. R. & Siegelbaum, S. A. Recruitment of new sites of synaptic transmission during the cAMP-dependent late phase of LTP at CA3-CA1 synapses in the hippocampus. Neuron 19, 635-646 (1997).
23. Larkman, A. U., Jack, J. J. & Stratford, K. J. Quantal analysis of excitatory synapses in rat hippocampal CA1 in vitro during low-frequency depression. J. Physiol. (Lond.) 505, 457-472 (1997).
24. Bekkers, J. M. & Clements, J. D. Quantal amplitude and quantal variance of strontium-induced asynchronous EPSCs in rat dentate granule neurons. J. Physiol. (Lond.) 516, 227-248 (1999).
25. Korn, H., Bausela, F., Charpier, S. & Faber, D. S. Synaptic noise and multiquantal release at dendritic synapses. J. Neurophysiol. 70, 1249-1253 (1993).
26. Lim, R., Alvarez, F. J. & Walmsley, B. Quantal size is correlated with receptor cluster area at glycinergic synapses in the rat brainstem. J. Physiol. (Lond.) 516, 505-520 (1999).
27. Liu, G., Choi, S. & Tsien, R. W. Variability of neurotransmitter concentration and nonsaturation of postsynaptic AMPA receptors at synapses in hippocampal cultures and slices. Neuron 22, 395-402 (1999).
28. Prange, O. & Murphy, T. H. Analysis of multiquantal transmitter release from single cultured cortical neuron terminals. J. Neurophysiol. 81, 1810-1818 (1999).
29. Bykhovskaia, M., Hackett, J. T. & Worden, M. K. Asynchrony of quantal events in evoked multiquantal responses indicates presynaptic quantal interaction. J. Neurophysiol. 81, 2234-2242 (1999).
30. Sorra, K. E. & Harris, K. M. Occurrence and three dimensional structure of multiple synapses between individual radiatum axons and their target pyramidal cells in hippocampal area CA1. J. Neurosci. 13, 3736-3747 (1993).
31. Nusser, Z. et al. Cell type and pathway dependence of synaptic AMPA receptor number and variability in the hippocampus. Neuron 21, 545-559 (1998).
32. Takumi, Y., Ramírez-Léon, V., Laake, P., Rinvik, E. & Ottersen, O. P. Different modes of expression of AMPA and NMDA receptors in hippocampal synapse. Nat. Neurosci. 2, 618-624 (1999).
33. Nusser, Z. Cull-Candy, S. & Farrant, M. Differences in synaptic GABA(A) receptor number underlie variation in GABA mini amplitude. Neuron 19, 697-709 (1997).
34. Cook, E. P. & Johnston, D. Active dendrites reduce location-dependent variability of synaptic input trains. J. Neurophysiol. 78, 2116-2128 (1997).
35. Johnston, D., Hoffman, D. A., Colbert, C. M. & Magee, J. C. Regulation of back-propagating action potentials in hippocampal neurons. Curr. Opin. Neurobiol. 9, 288-292 (1999).
36. Mel, B. Synaptic integration in a excitable dendritic tree. J. Neurophysiol. 70, 1086-1101 (1993).
37. Archie, K. A. & Mel, B. W. A model for intradendritic computation of binocular disparity. Nat. Neurosci. 3, 54-63 (2000).
38. Golding, N. L. & Spruston, N. Dendritic sodium spikes are variable triggers of axonal action potentials in hippocampal CA1 pyramidal neurons. Neuron 21, 1189-1200 (1998).
39. Bekkers, J. M. & Stevens, C. F. Cable properties of cultured hippocampal neurons determined from sucrose-evoked miniature EPSCs. J. Neurophysiol. 75, 1250-1255 (1995).
40. Magee, J. C. & Carruth, M. Dendritic voltage-gated ion channels regulate the firing mode of CA1 pyramidal neurons. J. Neurophysiol. 82, 1895-1901 (1999).
41. Johnston, D. & Wu, S. M. in Foundations of Cellular Neurophysiology 294-301 (MIT Press, Cambridge, Massachusetts, 1995).