The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1

Journal of Cell Science

Volumn 113, Issue 18, 2000, Pages 3267-3275

  Johansson, A S ^a   Driessens, M ^a   Aspenstrom, P ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Cell polarity; Epithelial cell; Par gene; Rho GTPase; Tight junction

Indexed keywords

BINDING PROTEIN; FUNGAL PROTEIN; GENE PRODUCT; GUANOSINE TRIPHOSPHATASE; MEMBRANE PROTEIN; NUCLEAR PROTEIN; PAR 3 PROTEIN; PAR 6 PROTEIN; PROTEIN CDC42; RAC PROTEIN; RHO FACTOR; SCATTER FACTOR; UNCLASSIFIED DRUG; ZO 1 PROTEIN;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CAENORHABDITIS ELEGANS; CELL CONTACT; CELL DIVISION; CELL NUCLEUS; CELL POLARITY; CELL STRAIN COS1; COMPLEX FORMATION; CONTROLLED STUDY; DOG; EMBRYO DEVELOPMENT; EPITHELIUM CELL; HYBRIDIZATION; IMMUNOPRECIPITATION; IN VITRO STUDY; KIDNEY CELL; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN LOCALIZATION; SEQUENCE HOMOLOGY; TIGHT JUNCTION; YEAST;

ANIMAL; CAENORHABDITIS ELEGANS; CDC42 GTP-BINDING PROTEIN; CELL LINE; CELL LINE, TRANSFORMED; COS CELLS; DOGS; EPITHELIAL CELLS; GUANOSINE TRIPHOSPHATE; HELMINTH PROTEINS; HUMAN; MAMMALS; MICE; PRECIPITIN TESTS; PROTEIN BINDING; PROTEINS; RAC1 GTP-BINDING PROTEIN; SUBCELLULAR FRACTIONS; SUPPORT, NON-U.S. GOV'T; TRANSFECTION;

EID: 0033790539     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. CDC42 and CDC43, two additional genes involved in budding and the establishment of cell polarity in the yeast Saccharomyces cerevisiae
2. A role for Cdc42 in macrophage chemotaxis
3. Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich Syndrome
4. A Cdc42 target protein with homology to the non-kinase domain of FER has a potential role in regulating the actin cytoskeleton
5. The Rho GTPases have multiple effects on the actin cytoskeleton
6. Effectors for the Rho GTPases
7. Tight junctions
8. A role for Rho-like GTPases in the polarisation of mouse eight-cell blastomeres
9. Regulation of gene expression by HTLV-1 Tax protein
10. Cingulin contains globular and coiled-coil domains and interacts with ZO-1, ZO-2, ZO-3, and myosin
11. Origins of cell polarity
12. PDZ domains: Fundamental building blocks in the organisation of protein complexes at the plasma membrane
13. Cell adhesion and Rho small GTPases
14. Cdc42 and Rac1 regulate the interaction of IQGAP1 with β-catenin
15. Rho GTPase signaling regulates tight junction assembly and protects tight junctions during ATP depletion
16. The junction-associated protein, zonula occludens-1, localizes to the nucleus before the maturation and during the remodeling of cell-cell contacs. (1996)
17. Molecular genetics of asymmetric cleavage in the early Caenorhabditis elegans embryo
18. Rho GTPases and the actin cytoskeleton
19. PAR-6 is a conserved PDZ domain-containing protein that colocalizes with PAR-3 in Caenorhabditis elegans embryos
20. Rho and Rab small G proteins coordinately reorganize stress fibers and focal adhesions in MDCK cells
21. An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3
22. Molecular cloning of CDC42, a Saccharomyces cerevisiae gene involved in the development of cell polarity
23. Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity
24. Effects of regulated expression of mutant RhoA and Rac1 small GTPases on the development of epithelial (MDCK) cell polarity
25. Structural and functional regulation of tight junctions by RhoA and Rac1 small GTPases
26. Symplekin, a novel type of tight junction plaque protein
27. Signaling to Rho GTPases
28. Involvement of Cdc42 small G protein in cell-cell adhesion, migration and morphology of MDCK cells
29. Cdc42 controls secretory and endocytic transport to the basolateral plasma membrane of MDCK cells
30. The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif
31. Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65(PAK) and the JNK/SAPK MAP kinase cascade
32. Rho GTPases control polarity, protrusion, and adhesion during cell movement
33. Rho protein regulates tight junctions and perijunctional actin organization in polarized epithelia
34. Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac and Rho in MDCK cells
35. The C-terminus of HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins
36. Purification of recombinant Rho/Rac/Cdc42 from Escherichia coli
37. Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42
38. Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorhabditis elegans
39. Regulation of cell-cell adhesion by Rac and Rho small G proteins in MDCK cells
40. Structural and signalling molecules come together at tight junctions
41. Rho GTPases and signaling networks
42. Par-6, a gene involved in the establishment of assymetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3