Sulphonylurea action revisited: The post-cloning era

Diabetologia

Volumn 46, Issue 7, 2003, Pages 875-891

  Gribble, F M ^a   Reimann, F ^a  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

KATP channel; Kir6.2; Sulphonylurea; Sulphonylurea receptor; Type 2 diabetes

Indexed keywords

ADENOSINE TRIPHOSPHATE; CHLORPROPAMIDE; CROMAKALIM; DIAZOXIDE; GLIBENCLAMIDE; GLICLAZIDE; GLIMEPIRIDE; INSULIN; INWARDLY RECTIFYING POTASSIUM CHANNEL; MEGLITINIDE; MITIGLINIDE; NATEGLINIDE; NICORANDIL; PINACIDIL; RECEPTOR SUBTYPE; REPAGLINIDE; SULFONYLUREA; SULFONYLUREA RECEPTOR; TOLBUTAMIDE;

CLONING; CROSS REACTION; DRUG BINDING SITE; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; HEART; HUMAN; INSULIN RELEASE; KNOCKOUT MOUSE; MEDICAL DECISION MAKING; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SIDE EFFECT; SKELETAL MUSCLE; VASCULAR SMOOTH MUSCLE;

ANIMALS; DIABETES MELLITUS, TYPE 2; HUMANS; HYPOGLYCEMIC AGENTS; MEMBRANE PROTEINS; POTASSIUM CHANNELS; RESEARCH; SULFONYLUREA COMPOUNDS;

EID: 0042071600     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-003-1143-3     Document Type: Review

References (163)

1. Aguilar-Bryan L, Nichols CG, Wechsler SW et al. (1995) Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion. Science 268:423-426
2. ATP - an inward rectifier subunit plus the sulfonylurea receptor. Science 270:1166-1170
3. Sakura H, Ammala C, Smith PA, Gribble FM, Ashcroft FM (1995) Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel subunit expressed in pancreatic beta cells, brain, heart and skeletal muscle. FEBS Lett 377:338-344
4. + channels in health and disease. Diabetologia 42:903-919
5. Aguilar-Bryan L, Bryan J (1999) Molecular biology of adenosine triphosphate-sensitive potassium channels. Endocr Rev 20:101-135
6. + channels. Prog Biophys Mol Biol 81:133-176
7. + channels in cardiac muscle. Nature 305:147-148
8. Nichols CG, Lederer WJ (1991) Adenosine triphosphate-sensitive potassium channels in the cardiovascular system. Am J Physiol 261:H1675-H1686
9. Quayle JM, Nelson MT, Standen NB (1997) ATP-sensitive and inwardly-rectifying potassium channels in smooth muscle. Physiol Rev 77:1165-1232
10. Davis NW, Standen NB, Stanfield PR (1991) ATP-dependent potassium channels of muscle cells: their properties, regulation, and possible functions. J Bioenerg Biomembr 23:509-535
11. + channels. Science 247:852-854
12. ATP channels in dopaminergic midbrain neurons. EMBO J 18:833-846
13. Spanswick D, Smith MA, Groppi VE, Logan SD, Ashford ML (1997) Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nature 390:521-525
14. Rorsman P (1997) The pancreatic beta cell as a fuel sensor: an electrophysiologist's viewpoint. Diabetologia 40:487-495
15. Ashcroft FM, Rorsman P (1989) Electrophysiology of the pancreatic beta cell. Prog Biophys Mol Biol 54:87-143
16. Ashcroft SJ, Weerasinghe LC, Randle PJ (1973) Interrelationship of islet metabolism, adenosine triphosphate content and insulin release. Biochem J 132:223-231
17. Mertz RJ, Worley JF, Spencer B, Johnson JH, Dukes ID (1996) Activation of stimulus-secretion coupling in pancreatic beta cells by specific products of glucose metabolism. Evidence for privileged signaling by glycolysis. J Biol Chem 271:4838-4845
18. Eto K, Tsubamoto Y, Terauchi Y et al. (1999) Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion. Science 283:981-985
19. Smith PA, Sakura H, Coles B, Gummerson N, Proks P, Ashcroft FM (1997) Electrogenic arginine transport mediates stimulus-secretion coupling in mouse pancreatic beta cells. J Physiol 499:625-635
20. Reimann F, Gribble FM (2002) Glucose-sensing in glucagon-like peptide-1-secreting cells. Diabetes 51:2757-2763
21. Gribble FM, Williams L, Simpson AK, Reimann F (2003) A novel glucose-sensing mechanism contributing to Glucagon-Like Peptide-1 secretion from the GLUTag cell line. Diabetes 52:1147-1154
22. Inagaki N, Tsuura Y, Namba N et al. (1995) Cloning and functional characterization of a novel ATP-sensitive potassium channel ubiquitously expressed in rat tissues, including pancreatic islets, pituitary, skeletal muscle, and heart. J Biol Chem 270:5691-5694
23. ATP channel complex. J Gen Physiol 110:655-664
24. ATP channel subunits. Neuron 18:827-838
25. + channel. J Physiol 499:715-720
26. ATP channels. Mol Cell Neurosci 18:671-690
27. + channel. J Physiol 512:395-406
28. ATP channels. Neuron 22:537-548
29. + channels in the absence of the sulphonylurea receptor. Nature 387:179-183
30. ATP channel inhibition by ATP. EMBO J 17:3290-3296
31. ATP channels composed of Kir6.1 and SUR1 subunits. J Physiol 515:439-452
32. Liu M, Seino S, Kirchgessner AL (1999) Identification and characterization of glucoresponsive neurons in the enteric nervous system. J Neurosci 19:10305-10317
33. ATP channels. Endocrinology 144:1331-1340
34. + channels. Neuron 16:1011-1017
35. + channel. J Biol Chem 271:24321-24324
36. Chutkow WA, Makielski JC, Nelson DJ, Burant CF, Fan Z (1999) Alternative splicing of sur2 Exon 17 regulates nucleotide sensitivity of the ATP-sensitive potassium channel. J Biol Chem 274:13656-13665
37. ATP channels. Diabetes 45:1439-1445
38. Gros L, Trapp S, Dabrowski M, Ashcroft FM, Bataille D, Blache P (2002) Characterization of two novel forms of the rat sulphonylurea receptor SUR1A2 and SUR1BDelta31. Br J Pharmacol 137:98-106
39. Hambrock A, Preisig-Muller R, Russ U et al. (2002) Four novel splice variants of sulfonylurea receptor 1. Am J Physiol Cell Physiol 283: C587-C598
40. ATP channel conferred by a novel splice variant of SUR1. J Physiol 521:337-350
41. Tusnady GE, Bakos E, Varadi A, Sarkadi B (1997) Membrane topology distinguishes a subfamily of the ATP-binding cassette (ABC) transporters. FEBS Lett 402:1-3
42. Conti LR, Radeke CM, Shyng SL, Vandenberg CA (2001) Transmembrane topology of the sulfonylurea receptor SUR1. J Biol Chem 276:41270-41278
43. ATP channel openers. Trends Pharmacol Sci 21:439-445
44. ATP channels. Diabetes 47:1412-1418
45. ATP channels to gliclazide. Diabetologia 42:845-848
46. Song DK, Ashcroft FM (2001) Glimepiride block of cloned β-cell, cardiac and smooth muscle K-ATP channels. Brit J Pharmacol 133:193-199
47. Dabrowski M, Wahl P, Holmes WE, Ashcroft FM (2001) Effect of repaglinide on cloned beta cell, cardiac and smooth muscle types of ATP-sensitive potassium channel. Diabetologia 44:747-756
48. Reimann F, Proks P, Ashcroft FM (2001) Effects of mitiglinide (S 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2/SUR2B types of ATP-sensitive potassium channel. Br J Pharmacol 132:1542-1548
49. Hansen AM, Christensen IT, Hansen JB, Carr RD, Ashcroft FM, Wahl P (2002) Differential interactions of nateglinide and repaglinide on the human beta cell sulphonylurea receptor 1. Diabetes 51:2789-95
50. ATP channels. J Pharmacol Exp Ther 304:1025-1032
51. Reimann F, Ashcroft FM, Gribble FM (2001) Structural basis for the interference between nicorandil and sulfonylurea action. Diabetes 50:2253-2259
52. Uhde I, Toman A, Gross I, Schwanstecher C, Schwanstecher M (1999) Identification of the potassium channel opener site on sulfonylurea receptors. J Biol Chem 274:28079-28082
53. ATP channel by interaction with its SUR1 subunit. Proc Natl Acad Sci USA 95:7185-7190
54. Gribble FM, Tucker SJ, Ashcroft FM (1997) The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide. EMBO J 16:1145-1152
55. ATP channel activity by diazoxide and MgADP. Distinct functions of the two nucleotide binding folds of the sulfonylurea receptor. J Gen Physiol 110:643-654
56. Nichols CG, Shyng SL, Nestorowicz A et al. (1996) Adenosine diphosphate as an intracellular regulator of insulin secretion. Science 272:1785-1787
57. + channel openers. J Biol Chem 275:717-720
58. Senior AE, al-Shawi MK, Urbatsch IL (1995) The catalytic cycle of P-glycoprotein. FEBS Lett 377:285-289
59. Higgins CF (1992) ABC transporters: from microorganisms to man. Annu Rev Cell Biol 8:67-113
60. 2+-independent ATP binding of the sulfonylurea receptor SUR1. J Biol Chem 272:22983-22986
61. Ueda K, Komine J, Matsuo M, Seino S, Amachi T (1999) Cooperative binding of ATP and MgADP in the sulfonyl-urea receptor is modulated by glibenclamide. Proc Natl Acad Sci USA 96:1268-1272
62. + conductance. Neuron 31:233-245
63. Matsuo M, Dabrowski M, Ueda K, Ashcroft FM (2002) Mutations in the linker domain of NBD2 of SUR inhibit transduction but not nucleotide binding. EMBO J 21:4250-4258
64. Carrasco AJ, Dzeja PP, Alekseev AE et al. (2001) Adenylate kinase phosphotransfer communicates cellular energetic signals to ATP-sensitive potassium channels. Proc Natl Acad Sci USA 98:7623-7628
65. + channel in vivo. FASEB J 16:102-104
66. Matsuo M, Kioka N, Amachi T, Ueda K (1999) ATP binding properties of the nucleotide-binding folds of SUR1. J Biol Chem 274:37479-37482
67. ATP channel complex. FASEB J 14:1943-1952
68. Matsuo M, Tanabe K, Kioka N, Amachi T, Ueda K (2000) Different binding properties and affinities for ATP and ADP among sulfonylurea receptor subtypes, SUR1, SUR2A, and SUR2B. J Biol Chem 275:28757-28763
69. Thomas PM, Cote GJ, Wohllk N et al. (1995) Mutations in the sulfonylurea receptor gene in familial persistent hyperinsulinemic hypoglycemia of infancy. Science 268:426-429
70. ATP channels in pancreatic β-cells causes persistent hyperinsulinemic hypoglycemia of infancy. Nature Med 2:1344-1347
71. ATP channels and insulin secretion disorders. Am J Physiol 283:E207-E216
72. Glaser B, Thornton P, Otonkoski T, Junien C (2000) Genetics of neonatal hyperinsulinism. Arch Dis Child Fetal Neonatal Ed 82:F79-F86
73. Lonlay P de, Fournet JC, Touati G et al. (2002) Heterogeneity of persistent hyperinsulinaemic hypoglycaemia. A series of 175 cases. Eur J Pediatr 161:37-48
74. ATP channels caused by a sulfonylurea receptor 1 mutation associated with persistent hyperinsulinemic hypoglycemia of infancy. Proc Natl Acad Sci 98:2882-2887
75. Tanizawa Y, Matsuda K, Matsuo M et al. (2000) Genetic analysis of Japanese patients with persistent hyperinsulinemic hypoglycemia of infancy: nucleotide-binding fold-2 mutation impairs cooperative binding of adenine nucleotides to sulfonylurea receptor 1. Diabetes 49:114-120
76. Shyng SL, Ferrigni T, Shepard JB et al. (1998) Functional analyses of novel mutations in the sulfonylurea receptor 1 associated with persistent hyperinsulinemic hypoglycemia of infancy. Diabetes 47:1145-1151
77. ATP-channel mutations associated with congenital hyperinsulinism in the Finnish population Diabetologia 46:241-249
78. Huopio H, Reimann F, Ashfield R et al. (2000) Dominantly inherited hyperinsulinism caused by a mutation in the sulfonylurea receptor type 1. J Clin Invest 106:897-906
79. Huopio H, Otonkoski T, Vauhkonen I, Reimann F, Ashcroft FM, Laakso M (2003) A new subtype of autosomal dominant diabetes attributable to a mutation in the gene for sulfonylurea receptor 1. Lancet 361:301-307
80. + channel gene (KIR6.2/BIR): a meta-analysis suggests a role in the polygenic basis of Type II diabetes mellitus in Caucasians. Diabetologia 41:1511-1515
81. ATP Channel Subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) Confirm That the KCNJ11 E23K Variant Is Associated With Type 2 Diabetes. Diabetes 52:568-572
82. Love-Gregory L, Wasson J, Lin J, Skolnick G, Suarez B, Permutt MA (2003) An E23K single nucleotide polymorphism in the islet ATP-sensitive potassium channel gene (Kir6.2) contributes as much to the risk of Type II diabetes in Caucasians as the PPAR Pro12Ala variant. Diabetologia 46:136-137
83. Schwanstecher C, Neugebauer B, Schulz M, Schwanstecher M (2002) The common single nucleotide polymorphism E23K in Kir6.2 sensitizes pancreatic beta cell ATP-sensitive potassium channels toward activation through nucleoside diphosphates. Diabetes 51 (Suppl 3):S363-S367
84. + channels. Diabetes 51:875-879
85. + channel in the beta cell. Diabetes 51:3135-3138
86. Nielsen EM, Hansen L, Carstensen B et al. (2003) The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of Type 2 diabetes. Diabetes 52:573-577
87. Gribble FM, Tucker SJ, Ashcroft FM (1997) The interaction of nucleotides with the tolbutamide block of K-ATP currents: a reinterpretation. J Physiol 504:35-45
88. ATP channel. Biochem Biophys Res Commun 257:766-770
89. Proks P, Reimann F, Green N, Gribble FM, Ashcroft FM (2002) Sulphonylurea stimulation of insulin secretion. Diabetes 51 [Suppl 3]:S368-S376
90. + channel in insulin-secreting cells. J Biol Chem 262:15840-15844
91. ATP channel. Diabetes 48:1341-1347
92. Hambrock A, Löffler-Walz C, Russ U, Lange U, Quast U (2001) Characterization of a mutant sulfonylurea receptor SUR2B with high affinity for sulfonylureas and openers: differences in the coupling to Kir6.x subtypes. Mol Pharmacol 60:190-199
93. Muller G, Hartz D, Punter J, Okonomopulos R, Kramer W (1994) Differential interaction of glimepiride and glibenclamide with the beta cell sulfonylurea receptor. I. Binding characteristics. Biochim Biophys Acta 1191:267-277
94. ATP channel activity and membrane-binding studies with nateglinide: a comparison with sulfonylureas and repaglinide. J Pharmacol Exp Ther 293:444-452
95. UK Prospective Diabetes Study Group (1995) United Kingdom Prospective Diabetes Study (UKPDS). 13: Relative efficacy of randomly allocated diet, sulphonylurea, insulin, or metformin in patients with newly diagnosed non-insulin dependent diabetes followed for three years. BMJ 310:83-88
96. Clarke BF, Campbell IW (1975) Long-term comparative trial of glibenclamide and chlorpropamide in diet-failed, maturity-onset diabetics. Lancet 1:246-248
97. Jennings AM, Wilson RM, Ward JD (1989) Symptomatic hypoglycemia in NIDDM patients treated with oral hypoglycemic agents. Diabetes Care 12:203-208
98. Drouin P (2000) Diamicron MR once daily is effective and well tolerated in type 2 diabetes: a double-blind, randomized, multinational study. J Diabetes Complications 14:185-191
99. + channels and insulin secretion: comparison with the sulfonylureas and nateglinide. Eur J Pharmacol 431:119-125
100. ATP channels. FEBS Lett 482:59-64
101. ATP channel. FEBS Lett 499:154-160
102. + channel Kir6.1 increases the affinity of the vascular sulfonylurea receptor SUR2B for glibenclamide. Mol Pharmacol 56:955-961
103. Dorschner H, Brekardin E, Uhde I, Schwanstecher C, Schwanstecher M (1999) Stoichiometry of sulfonylurea-induced ATP-sensitive potassium channel closure. Mol Pharmacol 55:1060-1066
104. Reimann F, Tucker SJ, Proks P, Ashcroft FM (1999) Involvement of the N-terminus of Kir6.2 in coupling to the sulphonylurea receptor. J Physiol 518:325-336
105. ATP channels. Functional coupling of Kir6.2 and SUR1 subunits. J Gen Physiol 114:203-213
106. ATP channels by an N-terminal Kir6.2 peptide. Defining intersubunit gating interactions. J Biol Chem 277:43997-44004
107. + channels from pancreatic B-cells. FEBS Lett 239:241-244
108. + channel in mouse pancreatic B cells by their combined actions at inhibitory and stimulatory receptors. Mol Pharmacol 41:480-486
109. ATP channels by Mg-nucleotides. J Physiol 547:159-168
110. + loss during hypoxia, ischemia, and metabolic inhibition in mammalian ventricle. Circ Res 69:623-637
111. + channels during metabolic stress in cardiac muscle. J Pharmacol Exp Ther 266:456-467
112. Niki I, Nicks JL, Ashcroft SJ (1990). The beta cell glibenclamide receptor is an ADP-binding protein. Biochem J 268:713-718
113. Schwanstecher M, Loser S, Brandt C, Scheffer K, Rosenberger F, Panten U (1992) Adenine nucleotide-induced inhibition of binding of sulphonylureas to their receptor in pancreatic islets. Br J Pharmacol 105:531-534
114. ATP channel modulator binding to the recombinant sulphonylurea receptor, SUR2B. Br J Pharmacol 125:577-583
115. ATP channel modulators with sulfonylurea receptor SUR2B: implication for tetramer formation and allosteric coupling of subunits. Mol Pharmacol 61:407-614
116. Hambrock A, Loffler-Walz C, Quast U (2002) Glibenclamide binding to sulphonylurea receptor subtypes: dependence on adenine nucleotides. Br J Pharmacol 136:995-1004
117. ATP channel in unstable angina. Is this a clinical manifestation of myocardial preconditioning? Results of a randomized study with nicorandil. CESAR 2 investigation. Clinical European studies in angina and revascularization. Eur Heart J 20:51-57
118. D'hahan N, Moreau C, Prost AL et al. (1999) Pharmacological plasticity of cardiac ATP-sensitive potassium channels toward diazoxide revealed by ADP. Proc Natl Acad Sci USA 96:12162-12167
119. ATP channel openers. EMBO J 19:6644-6651
120. + channel openers in rat aorta. J Biol Chem 267:11689-11692
121. + channel-opening drugs. Am J Physiol 269:C525-C545
122. ATP channels containing SUR2A or SUR2B subunits to nucleotides and pinacidil. Mol Pharmacol 58:1318-1325
123. + channels. Circ Res 87:873-880
124. Cogolludo AL, Perez-Vizcaino F, Fajardo S, Ibarra M, Tamargo J (1999) Effects of nicorandil as compared to mixtures of sodium nitroprusside and levcromakalim in isolated rat aorta. Br J Pharmacol 126:1025-1033
125. Bijlstra PJ, Lutterman JA, Russel FGM, Thien T, Smits P (1996) Interaction of sulphonylurea derivatives with vascular ATP-sensitive potassium channels in humans. Diabetologia 39:1083-1090
126. ATP channels in mouse isolated pancreatic β-cells but not rat heart or arterial smooth muscle cells. Diabetologia 44:1019-1025
127. Hata N, Takano M, Kunimi T, Kishida H, Takano T (2001) Lack of antagonism between nicorandil and sulfonylurea in stable angina pectoris. Int J Clin Pharmacol Res 21:59-63
128. ATP channel subunit essential for cell protection against ischemia. EMBO J 21:3936-3948
129. + channel. A molecular probe for the mechanism of ATP-sensitive inhibition. J Gen Physiol 114:251-269.
130. ATP channels. Science 282:1138-1141
131. + channel openers, and ATP. Mol Pharmacol 59:1086-1093
132. + channel in the mitochondrial inner membrane. Nature 352:244-247
133. Garlid KD (1996) Cation transport in mitochondria - the potassium cycle. Biochim Biophys Acta 1275:123-126
134. Grover GJ, Garlid KD (2000) ATP-sensitive potassium channels: a review of their cardioprotective pharmacology. J Mol Cell Cardiol 32:677-695
135. Ozanne SE, Guest PC, Hutton JC, Hales CN (1995) Intracellular localization and molecular heterogeneity of the sulphonylurea receptor in insulin-secreting cells. Diabetologia 38:277-282
136. ATP channels of the endocrine pancreas. Diabetes 52:767-776
137. Ozaki N, Shibasaki T, Kashima Y et al. (2000) cAMP-GEFII is a direct target of cAMP in regulated exocytosis. Nat Cell Biol 2:805-811
138. Kashima Y, Miki T, Shibasaki T et al. (2001) Critical role of cAMP-GEFII-Rim2 complex in incretin-potentiated insulin secretion. J Biol Chem 276:46046-46053
139. 2+ release in INS-1 pancreatic beta cells. J Physiol 536:375-385
140. 2+ channels accounts for first-phase insulin secretion in mouse beta cells. Diabetes 51 Suppl 1:S74-S82
141. UK Prospective Diabetes Study Group (1998) Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 352:837-853
142. ATP channel-deficient mice. Proc Natl Acad Sci USA 95:10402-10406.
143. + channels in cell survival and differentiation in the endocrine pancreas. Diabetes 50 (Suppl 1):S48-S51
144. ATP channel-independent regulation of insulin secretion. J Biol Chem 275:9270-9277
145. Nakazaki M, Crane A, Hu M et al. (2002) cAMP-activated protein kinase-independent potentiation of insulin secretion by cAMP is impaired in SUR1 null islets. Diabetes 51:3440-3449
146. Shiota C, Larsson O, Shelton KD et al. (2002) Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose. J Biol Chem 277:37176-37183
147. ATP channels enhances insulin-stimulated glucose uptake in skeletal muscle. Proc Natl Acad Sci USA 98:11760-11764
148. Miki T, Minami K, Zhang L et al. (2002) ATP-sensitive potassium channels participate in glucose uptake in skeletal muscle and adipose tissue. Am J Physiol 283:E1178-E1184
149. + channels in the hypothalamus are essential for the maintenance of glucose homeostasis. Nat Neurosci 4:507-512
150. + channels and myocardial preconditioning. Circ Res 84:973-979
151. Suzuki M, Li RA, Miki T et al. (2001) Functional roles of cardiac and vascular ATP-sensitive potassium channels clarified by Kir6.2-knockout mice. Circ Res 88:570-577
152. ATP channels in cardioprotection against ischemia/reperfusion injury in mice. J Clin Invest 109:509-516
153. Li RA, Leppo M, Miki T, Seino S, Marban E (2000) Molecular basis of electrocardiographic ST-segment elevation. Circ Res 87:837-839
154. Miki T, Suzuki M, Shibasaki T et al. (2002) Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1. Nat Med 8:466-472
155. ATP channels. J Clin Invest 110:203-208
156. Zingman LV, Hodgson DM, Bast PH et al. (2002) Kir6.2 is required for adaptation to stress. Proc Natl Acad Sci USA 99:13278-13283
157. + channel blocker. Circulation 90:700-705
158. Kondo T, Kubota I, Tachibana H, Yamaki M, Tomoike H (1996) Glibenclamide attenuates peaked T wave in early phase of myocardial ischemia. Cardiovasc Res 31:683-687
159. Wilde AA (1996) ATP-sensitive potassium channels, transmural ischemia and the ECG implications for the non-insulin dependent diabetic patient? Cardiovasc Res 31:688-690
160. K.ATP blockers glibenclamide and HMR1883 on cardiac electrophysiology during ischemia and reperfusion. Eur J Pharmacol 398:273-284
161. ATP channel deficiency affects resting tension, not contractile force, during fatigue in skeletal muscle. Am J Physiol 279:C1351-C1358
162. Yamada K, Ji JJ, Yuan H et al. (2001) Protective role of ATP-sensitive potassium channels in hypoxia-induced generalized seizure. Science 292:1543-1546
163. Chang G, Roth CB (2001) Structure of MsbA from E. coli: a homolog of the multidrug resistance ATP binding cassette (ABC) transporters. Science 293:1793-1800