The effects of mitiglinide (KAD-1229), a new anti-diabetic drug, on ATP-sensitive K+ channels and insulin secretion: Comparison with the sulfonylureas and nateglinide

European Journal of Pharmacology

Volumn 431, Issue 1, 2001, Pages 119-125

  Sunaga, Yasuhiro ^a   Gonoi, Tohru ^a   Shibasaki, Tadao ^a   Ichikawa, Kiyoshi ^b   Kusama, Hiroshi ^b   Yano, Hideki ^a   Seino, Susumu ^a  

^a CHIBA UNIVERSITY   (Japan)

^b KISSEI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Insulin secretion; KATP channel; Mitiglinide; Nateglinide; Sulfonylurea receptor (SUR)

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIDIABETIC AGENT; GLIBENCLAMIDE; GLUCOSE; MEGLITINIDE; MITIGLINIDE; NATEGLINIDE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; REPAGLINIDE; SULFONYLUREA DERIVATIVE; TOLBUTAMIDE; TRITIUM;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING; DRUG BINDING SITE; DRUG EFFECT; DRUG SELECTIVITY; DRUG SPECIFICITY; INSULIN RELEASE; INSULIN RESPONSE; NONHUMAN; PANCREAS ISLET BETA CELL; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CELL LINE; COS CELLS; CYCLOHEXANES; GLYBURIDE; HYPOGLYCEMIC AGENTS; INDOLES; INSULIN; PATCH-CLAMP TECHNIQUES; PHENYLALANINE; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; RECEPTORS, DRUG; SULFONYLUREA COMPOUNDS; TOLBUTAMIDE; TRANSFECTION;

EID: 0035834523     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)01412-1     Document Type: Article

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