Effects of nicorandil as compared to mixtures of sodium nitroprusside and levcromakalim in isolated rat aorta

British Journal of Pharmacology

Volumn 126, Issue 4, 1999, Pages 1025-1033

  Cogolludo, Angel L ^a   Pérez Vizcaíno, Francisco ^b   Fajardo, Susana ^c   Ibarra, Manuel ^a   Taniargo, Juan ^b  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b UNIVERSITY OF ALCALÁ   (Spain)

^c SCHOOL OF MEDICINE   (Spain)

Author keywords

Drug mixtures; Levcromakalim; Nicorandil; Nitroprusside; Rat aorta

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; CYCLIC GMP; GLIBENCLAMIDE; LEMAKALIM; NICORANDIL; NITROPRUSSIDE SODIUM; NORADRENALIN; POTASSIUM CHLORIDE;

ANIMAL TISSUE; AORTA; ARTERY DILATATION; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VASCULAR ENDOTHELIUM;

EID: 0032965049     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702375     Document Type: Article

References (15)

1. + channel opening and guanylate cyclase stimulation to its vasorelaxant efTects on various endothelin-1-contracted arterial preparations. Comparison to aprikalim (RP 52891) and nitroglycerin. J. Phannacol. Exp. Ther., 259, 526-534.
2. CAUVIN, C, LOUTZENHISER. R. & VAN BREEMEN, C. (1983). Mechanism of calcium antagonist-induced vasodilation. Anna. Rev. Pharmacol. Toxicol., 23, 373-396.
3. EDWARDS, G. & WESTON, A.M. (1993). The pharmacology of ATP-sensitive potassium channels. Anmi. Rev. Pharmacol. Toxicol., 33,597-637.
4. FUJIWARA, T. & ANGUS, J.A. (1996). Analysis of relaxation and repolarization mechanisms of nicorandil in rat mesenteric artery. Br. J. Pliarmacol.. 119, 1549-1556.
5. FURUKAWA, K., 1TOH, T., KAJIWARA, M., KITAMURA, K., SUZUKI, H, ITO, Y. &. KURIYAMA, H. (1981). Vasodilating actions of 2-nicotinamidoethyl nitrate on porcine and guinea-pig coronary arteries. J. Pliarmacol. Exp. Tlier.. 218, 248-259.
6. GREENBERG, S.S., CANTOR, E., HO, E. & WALEGA, M (1991). Comparison of nicorandil-induced relaxation, elevations of cyclic guanosine monophosphate and stimulation of guanylate cyclase with organic nitrate esters. J. Pliarmacol. Exp. Thcr., 258, 1061-1071.
7. GRYGLEWSKI, R.J., ZEMBOWICK, A.. SALVEMINI, D., TAYLOR, G.W. & VANE, J.R. (1992). Modulation of the pharmacological actions of nitrovasodilators by methylene blue and pyocyanin. Br. J. Pliarmacol., 106, 838-845.
8. HAMILTON, T.C. & WESTON, A.H. (1989). Cromakalim, nicorandil and pinacidil: novel drugs which open potassium channels in smooth muscle. Gen. Pliarmacol., 20, 1-9.
9. + + entry in rabbit aorta. J. Pliarmacol. Exp. Tlier.. 233, 100-110.
10. KSOLL, E., PARSONS, A.A., MACKERT, J.R.L., SCHILLING, L. & WAUL, M. (1991). Analysis of cromakalim-, pinacidil-, and nicorandil-induced relaxation of the 5-hydroxytryptamine precontracted rat isolated basilar artery. Naunyn-SchmieJeberg's Arch. Pliarmacol., 3-43, 377-383.
11. + channel opening to nicorandil-induced vasorelaxation depends on the conduit vessel and on the nature of the spasmogen. J. Phannacol. Exp. Ther., 268, 1411-1418.
12. + channel-dependent and cyclic GMP-dependent components in a single vascular preparation. J. Cardiovasc. Plmrmacol., 17,903-912.
13. PEREZ-VIZCAINO, F., CASIS, O., RODRIGUEZ, R., GOMEZ, G.A., GARCIA-RAFANELL, 3. & TAMARGO, }. (1993). Effects of the novel potassium channel opener UR-8225 in rat vascular smooth muscle. Br. J. Phannacol., 110, 1165-1171.
14. + channel opening and stimulation of cyclic GMP in the vasorelaxant effects of nicorandil in isolated piglet pulmonary and mesenteric arteries: relative efficacy and interactions between both pathways. Br. J. Phannacol., 123, 847-854.
15. SCHRAMMEL, A., BEHRENDS, S., SCHMIDT, K., KOESLING, D. & MAYER, B. (1996). Characterization of lH-[l,2,4]oxadiazolo[4,3a]quinoxalin-l-one as a heme-site inhibitor of nitric oxidesensitive guanylyl cyclase. Afol. Phannacol., 50, 1-5.