Differential response of K(ATP) channels containing SUR2A or SUR2B subunits to nucleotides and pinacidil

Molecular Pharmacology

Volumn 58, Issue 6, 2000, Pages 1318-1325

  Reimann, Frank ^a   Gribble, Fiona M ^a   Ashcroft, Frances M ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 CYANO 1 (1,1 DIMETHYLPROPYL) 3 (3 PYRIDYL)GUANIDINE; MAGNESIUM DERIVATIVE; MAGNESIUM ION; NUCLEOSIDE TRIPHOSPHATE; NUCLEOTIDE; PINACIDIL; POTASSIUM CHANNEL; POTASSIUM CHANNEL AFFECTING AGENT; RECEPTOR SUBUNIT; SULFONYLUREA RECEPTOR;

ANIMAL CELL; BINDING AFFINITY; BINDING SITE; CHANNEL GATING; CONCENTRATION RESPONSE; FEMALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; PRIORITY JOURNAL; SHORT SURVEY; XENOPUS LAEVIS;

EID: 0033664249     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.58.6.1318     Document Type: Short Survey

References (38)

1. Cloning of the beta cell high-affinity sulfonylurea receptor: A regulator of insulin secretion
2. + channels in health and disease
3. Identification of the high-affinity tolbutamide site on the SUR1 subunit of the K(ATP) channel
4. Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance
5. + channel openers
6. Two regions of sulfonylurea receptor specify the spontaneous bursting and ATP inhibition of K(ATP) channel isoforms
7. The two nucleotide-binding domains of cystic fibrosis transmembrane conductance regulator (CFTR) have distinct functions in controlling channel activity
8. Association and stoichiometry of K(ATP) channel subunits
9. ATP-dependent potassium channels of muscle cells: Their properties, regulation, and possible functions
10. + channel openers
11. Pharmacological plasticity of cardiac ATP-sensitive potassium channels toward diazoxide revealed by ADP
12. The pharmacology of ATP-sensitive potassium channels
13. + currents expressed in Xenopus oocytes
14. Nucleotide modulation of pinacidil stimulation of the cloned K(ATP) channel, Kir6.2/SUR2A
15. The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide
16. MgATP activates the beta cell K(ATP) channel by interaction with its SUR1 subunit
17. + channel modulator binding to sulphonylurea receptors SUR2A and SUR2B: Opposite effects of MgADP
18. + channels
19. + channel
20. + channels by ATP and nucleotide diphosphate in rabbit portal vein
21. The first nucleotide binding fold of the cystic fibrosis transmembrane conductance regulator can function as an active ATPase
22. + channels in isolated membrane patches
23. ATP binding properties of the nucleotide-binding folds of SUR1
24. Different binding properties and affinities for ATP and ADP among sulfonylurea receptor subtypesm, SUR1, SUR2A, and SUR2B
25. Adenosine triphosphate-sensitive potassium channels in the cardiovascular system
26. + channel expressed in a mammalian cell line, HEK293T cells
27. ATP-sensitive and inwardly-rectifying potassium channels in smooth muscle
28. Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel subunit expressed in pancreatic beta-cells, brain, heart and skeletal muscle
29. Potassium channel openers require ATP to bind to and act through sulfonylurea receptors
30. ATP hydrolysis cycles and mechanism in P-glycoprotein and CFTR
31. + channels by pinacidil and nicerandil
32. Regulation of K(ATP) channel activity by diazoxide and MgADP. Distinct functions of the two nucleotide binding folds of the sulfonylurea receptor
33. Activation and inhibition of K-ATP currents by guanine nucleotides is mediated by different channel subunits
34. Molecular determinants of K(ATP) channel inhibition by ATP
35. + channels in the absence of the sulphonylurea receptor
36. 2+-independent ATP binding of the sulfonylurea receptor SUR1
37. Cooperative binding of ATP and MgADP in the sulfonylurea receptor is modulated by glibenclamide
38. Identification of the potassium channel opener site on sulfonylurea receptors