Characterization of two novel forms of the rat sulphonylurea receptor SUR1A2 and SUR1BΔ31

British Journal of Pharmacology

Volumn 137, Issue 1, 2002, Pages 98-106

  Gros, Laurent ^a   Trapp, Stefan ^a   Dabrowski, Michael ^a   Ashcroft, Frances M ^a   Bataille, Dominique ^a   Blache, Philippe ^a  

^a HÔPITAL ARNAUD DE VILLENEUVE   (France)

Author keywords

Glibenclamide; Sulphonylurea binding sites; Sulphonylurea receptor variants; SUR Kir trafficking

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMINO ACID; GLIBENCLAMIDE; POTASSIUM CHANNEL; SULFONYLUREA 1A2 RECEPTOR; SULFONYLUREA 1BDELTA31 RECEPTOR; SULFONYLUREA RECEPTOR; UNCLASSIFIED DRUG;

ALLELE; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL MEMBRANE; CELL STRAIN; CONTROLLED STUDY; EXON; HUMAN; HUMAN CELL; MOLECULAR BIOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; RAT; WILD TYPE; XENOPUS;

ADENOSINE TRIPHOSPHATE; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CELL LINE; GLYBURIDE; HUMANS; IMMUNOBLOTTING; INSULIN; OOCYTES; ORGAN SPECIFICITY; PATCH-CLAMP TECHNIQUES; POLYMERASE CHAIN REACTION; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN ISOFORMS; RADIOLIGAND ASSAY; RATS; RECEPTORS, DRUG; XENOPUS;

EID: 0036729489     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704836     Document Type: Article

References (37)

1. Co-expression of sulfonylurea receptors and KATP channels in hamster insulinoma tumor (HIT) cells. Evidence for direct association of the receptor with the channel
2. Cloning of the β-cell high-affinity sulfonylurea receptor: A regulator of insulin secretion
3. ATP-sensitive K+ channels and insulin secretion: Their role in health and disease
4. The sulfonylurea receptor
5. The beta-cell sulfonylurea receptor
6. Identification of the high affinity tolbutamide site on the SUR1 subunit of the KATP channel
7. A novel KATP current in cultured neonatal rat atrial appendage cardiomyocytes
8. ATP channels caused by a sulfonylurea receptor 1 mutation associated with persistent hyperinsulinemic hypoglycaemia of infancy
9. Association and stoichiometry of K(ATP) channel subunits
10. Transmembrane topology of the sulfonylurea receptor SUR1
11. A transmembrane domain of the sulfonylurea receptor mediates activation of ATP-sensitive K(+) channels by K(+) channel openers
12. Familial persistent hyperinsulinemic hypoglycaemia of infancy and mutations in the sulfonylurea receptor
13. Identification of high and low (GTP-sensitive) affinity [3H]-glibenclamide binding sites in cardiac ventricular membranes
14. Continuous, clonal, insulin- and somatostatin-secreting cell lines established from a transplantable rat islet cell tumor
15. = currents expressed in Xenopus oocytes
16. The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide
17. MgATP activates the beta cell KATP channel by interaction with its SUR1 subunit
18. Characterisation of low-affinity binding sites for glibenclamide on the Kir6.2 subunit of the beta-cell KATP channel
19. Characterization of the mouse sulfonylurea receptor 1 promoter and its regulation
20. Reconstitution of IKATP: An inward rectifier subunit plus the sulfonylurea receptor
21. Subunit stoichiometry of the pancreatic beta-cell ATP-sensitive K+ channel
22. Different binding properties and affinities for ATP and ADP among sulfonylurea receptor subtypes, SUR1, SUR2A, and SUR2B
23. ATP channel
24. A point mutation inactivating the sulfonylurea receptor causes the severe form of persistent hyperinsulinemic hypoglycaemia of infancy in Finland
25. Reconstitution and partial purification of the glibenclamide-sensitive, ATP-dependent potassium channel from rat liver and beef heart mitochondria
26. Inwardly rectifying potassium channels
27. Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel subunit expressed in pancreatic β-cells, brain, heart and skeletal muscle
28. ATP channel conferred by a novel splice variant of SUR1
29. Photoaffinity labelling of the cerebral sulfonylurea receptor using a novel radioiodinated azidoglibenclamide analogue
30. Potassium channel openers require ATP to bind to and act through sulfonylurea receptors
31. SUR1 knockout mice. A model for K(ATP) channel-independent regulation of insulin secretion
32. Effects of sulphonylureas and diazoxide on insulin secretion and nucleotide-sensitive channels in an insulin-secreting cell line
33. + conductance in pancreatic zymogen granules: Block by glyburide and activation by diazoxide
34. Molecular determinants of KATP channel inhibition by ATP
35. Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor
36. Membrane topology distinguishes a subfamily of the ATP-binding cassette (ABC) transporters
37. A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane K(ATP) channels