Characterization of a mutant sulfonylurea receptor SUR2B with high affinity for sulfonylureas and openers: Differences in the coupling to Kir6.x Subtypes

Molecular Pharmacology

Volumn 60, Issue 1, 2001, Pages 190-199

  Hambrock, Annette ^a   Löffler Walz, Cornelia ^a   Russ, Ulrich ^a   Lange, Ulf ^a   Quast, Ulrich ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 CYANO 1 (1,1 DIMETHYLPROPYL) 3 (3 PYRIDYL)GUANIDINE; 4 [[2 (1 PIPERIDYL)BENZHYDRYL]CARBAMOYLMETHYL]BENZOIC ACID; ADENOSINE TRIPHOSPHATE MAGNESIUM; GLIBENCLAMIDE; LEMAKALIM; MEGLITINIDE; POTASSIUM CHANNEL; RECEPTOR SUBTYPE; SERINE; SULFONYLUREA DERIVATIVE; SULFONYLUREA RECEPTOR; TYROSINE;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; KIDNEY CELL; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR AFFINITY; SITE DIRECTED MUTAGENESIS;

EID: 0034948401     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.60.1.190     Document Type: Article

References (39)

1. Molecular biology of adenosine triphosphate-sensitive potassium channels
2. Cloning of the β cell high-affinity sulfonylurea receptor: A regulator of insulin secretion
3. + channels
4. Properties and functions of ATP-sensitive K-channels
5. The sulfonylurea receptor
6. ATP channel
7. + channel openers
8. + channel openers in rat aorta
9. Assessing the distribution of parameters in models of ligand-receptor interaction: To log or not to log
10. ATP channel subunits
11. Stoichiometry of sulfonylurea-induced ATP-sensitive potassium channel closure
12. The pharmacology of ATP-sensitive potassium channels
13. Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins
14. The molecular assembly of ATP-sensitive potassium channels. Determinants on the pore forming subunit
15. + channel modulator binding to sulfonylurea receptors SUR2A and SUR2B: Opposite effects of MgADP
16. ATP channel modulator binding to the recombinant sulphonylurea receptor, SUR2B
17. Ligand competition curves as a diagnostic tool for delineating the nature of site-site interactions: Theory
18. KATP: An inward rectifier subunit plus the sulfonylurea receptor
19. + channels
20. + channel
21. + channel openers and ATP
22. 3H-glibenclamide binding in rat aortic rings
23. ATP channels
24. ATP channels
25. 3H]flunitrazepam with the benzodiazepine receptor: Evidence for a ligand-induced conformation change
26. Co-oparative and allosteric enzymes: 20 Years on
27. + channel Kir6.1 increases the affinity of the vascular sulfonylurea receptor SUR2B for glibenclamide
28. Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel subunit expressed in pancreatic β-cells, brain, heart and skeletal muscle
29. Effect of MgATP on pinacidil-induced displacement of glibenclamide from the sulphonylurea receptor in a pancreatic β-cell line and rat cerebral cortex
30. Potassium channel openers require ATP to bind to and act through sulfonylurea receptors
31. + channel with an ABC transporter
32. ATP Channels
33. ATP channel complex
34. A single residue in SURs is essential for sulphonylurea binding
35. + channels in the absence of the sulphonylurea receptor
36. Cooperative binding of ATP and MgADP in the sulfonylurea receptor is modulated by glibenclamide
37. Identification of the potassium charmer opener site on sulfonylurea receptors
38. + channel
39. ATP channels