메뉴 건너뛰기




Volumn 2, Issue 9, 2003, Pages 539-547

Treatment of Alzheimer's disease: Current status and new perspectives

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; ANTIINFLAMMATORY AGENT; BETA SECRETASE INHIBITOR; CELECOXIB; CHOLINESTERASE INHIBITOR; DONEPEZIL; ENZYME INHIBITOR; GALANTAMINE; GAMMA SECRETASE INHIBITOR; HYDROXYCHLOROQUINE; HYPOCHOLESTEROLEMIC AGENT; IBUPROFEN; INDOMETACIN; MEMANTINE; METAL CHELATE; NAPROXEN; NCX 2216; NIMESULIDE; NOOTROPIC AGENT; PREDNISONE; RIVASTIGMINE; ROFECOXIB; SULINDAC; TACRINE; UNCLASSIFIED DRUG;

EID: 0042020173     PISSN: 14744422     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1474-4422(03)00502-7     Document Type: Review
Times cited : (695)

References (119)
  • 1
    • 0019972810 scopus 로고
    • The cholinergic hypothesis of geriatric memory dysfunction
    • Bartus R.T., Dean R.L., Beer B., et al. The cholinergic hypothesis of geriatric memory dysfunction. Science. 217:1982;408-414.
    • (1982) Science , vol.217 , pp. 408-414
    • Bartus, R.T.1    Dean, R.L.2    Beer, B.3
  • 2
    • 0022645755 scopus 로고
    • The cholinergic hypothesis ten years on
    • Perry E.K. The cholinergic hypothesis ten years on. Br Med Bull. 42:1986;63-69.
    • (1986) Br Med Bull , vol.42 , pp. 63-69
    • Perry, E.K.1
  • 3
    • 0026536517 scopus 로고
    • Treatment strategies for Alzheimer's disease
    • Bowen D.M., Francis P.T., Pangalos M.N., et al. Treatment strategies for Alzheimer's disease. Lancet. 339:1992;132-133.
    • (1992) Lancet , vol.339 , pp. 132-133
    • Bowen, D.M.1    Francis, P.T.2    Pangalos, M.N.3
  • 4
    • 0022457840 scopus 로고
    • Nicotinic acetylcholine binding sites in Alzheimer's disease
    • Whitehouse P.J., Martino A.M., Antuono P.G., et al. Nicotinic acetylcholine binding sites in Alzheimer's disease. Brain Res. 371:1986;146-151.
    • (1986) Brain Res , vol.371 , pp. 146-151
    • Whitehouse, P.J.1    Martino, A.M.2    Antuono, P.G.3
  • 5
    • 0030751425 scopus 로고    scopus 로고
    • Nicotinic acetylcholine involvement in Alzheimer's and Parkinson's disease: Implications for therapeutics
    • Newhouse P.A., Potter A., Levin E.D. Nicotinic acetylcholine involvement in Alzheimer's and Parkinson's disease: implications for therapeutics. Drugs Aging. 11:1997;206-228.
    • (1997) Drugs Aging , vol.11 , pp. 206-228
    • Newhouse, P.A.1    Potter, A.2    Levin, E.D.3
  • 6
    • 0031875257 scopus 로고    scopus 로고
    • Cholinergic strategies for Alzheimer's disease
    • Winkler J., Thal L.J., Gage F.H., et al. Cholinergic strategies for Alzheimer's disease. J Mol Med. 76:1998;555-567.
    • (1998) J Mol Med , vol.76 , pp. 555-567
    • Winkler, J.1    Thal, L.J.2    Gage, F.H.3
  • 7
    • 0033591017 scopus 로고    scopus 로고
    • Cholinergic markers in elderly patients with early signs of Alzheimer's disease
    • Davis K.L., Mohs R.C., Marin D., et al. Cholinergic markers in elderly patients with early signs of Alzheimer's disease. JAMA. 281:1999;1401-1406.
    • (1999) JAMA , vol.281 , pp. 1401-1406
    • Davis, K.L.1    Mohs, R.C.2    Marin, D.3
  • 8
    • 0036156958 scopus 로고    scopus 로고
    • Upregulation of choline acetyltransferase in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment
    • Dekosky S.T., Ikonomovic M.D., Styren S.D., et al. Upregulation of choline acetyltransferase in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment. Ann Neurol. 51:2002;144-155.
    • (2002) Ann Neurol , vol.51 , pp. 144-155
    • Dekosky, S.T.1    Ikonomovic, M.D.2    Styren, S.D.3
  • 9
    • 0033809884 scopus 로고    scopus 로고
    • Loss of nucleus basalis neurons containing trkA immunoreactivity in individuals with mild cognitive impairment and early Alzheimer's disease
    • Mufson E.J., Ma S.Y., Cochran E.J., et al. Loss of nucleus basalis neurons containing trkA immunoreactivity in individuals with mild cognitive impairment and early Alzheimer's disease. J Comp Neurol. 427:2000;19-30.
    • (2000) J Comp Neurol , vol.427 , pp. 19-30
    • Mufson, E.J.1    Ma, S.Y.2    Cochran, E.J.3
  • 10
    • 0035826771 scopus 로고    scopus 로고
    • Practice parameter: Management of dementia (an evidence-based review)
    • Doody R.S., Stevens J.C., Beck C., et al. Practice parameter: management of dementia (an evidence-based review). Neurology. 56:2001;1154-1166.
    • (2001) Neurology , vol.56 , pp. 1154-1166
    • Doody, R.S.1    Stevens, J.C.2    Beck, C.3
  • 11
    • 0031883716 scopus 로고    scopus 로고
    • A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease
    • Rogers S.L., Farlow M.R., Doody R.S., et al. A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease. Neurology. 50:1998;136-145.
    • (1998) Neurology , vol.50 , pp. 136-145
    • Rogers, S.L.1    Farlow, M.R.2    Doody, R.S.3
  • 12
    • 0031902795 scopus 로고    scopus 로고
    • A randomized trial evaluating the efficacy and safety of ENA 713 (rivastigmine tartrate), a new acetylcholinesterase inhibitor, in patients with mild to moderately severe Alzheimer's disease
    • Corey-Bloom J., Anand R., Veach J., et al. A randomized trial evaluating the efficacy and safety of ENA 713 (rivastigmine tartrate), a new acetylcholinesterase inhibitor, in patients with mild to moderately severe Alzheimer's disease. Int J Geriatr Psychopharmacol. 1:1998;55-65.
    • (1998) Int J Geriatr Psychopharmacol , vol.1 , pp. 55-65
    • Corey-Bloom, J.1    Anand, R.2    Veach, J.3
  • 13
    • 0034720864 scopus 로고    scopus 로고
    • A 5-month, randomized, placebo-controlled trial of galantamine in AD
    • Tariot P.N., Solomon P.R., Morris J.C., et al. A 5-month, randomized, placebo-controlled trial of galantamine in AD. Neurology. 54:2000;2269-2276.
    • (2000) Neurology , vol.54 , pp. 2269-2276
    • Tariot, P.N.1    Solomon, P.R.2    Morris, J.C.3
  • 14
    • 0033980910 scopus 로고    scopus 로고
    • Cholinesterase inhibitors: A new class of psychotropic agents
    • Cummings J.L. Cholinesterase inhibitors: a new class of psychotropic agents. Am J Psychiatry. 157:2000;4-15.
    • (2000) Am J Psychiatry , vol.157 , pp. 4-15
    • Cummings, J.L.1
  • 15
    • 0033668050 scopus 로고    scopus 로고
    • Galantamine: A review of its use in Alzheimer's Disease
    • Scott L., Goa K. Galantamine: a review of its use in Alzheimer's Disease. Drugs. 60:2000;1095-1122.
    • (2000) Drugs , vol.60 , pp. 1095-1122
    • Scott, L.1    Goa, K.2
  • 16
    • 0018129338 scopus 로고
    • Changes in brain cholinesterases in senile dementia of Alzheimer's type
    • Perry E.K., Perry R.H., Blessed G., et al. Changes in brain cholinesterases in senile dementia of Alzheimer's type. Neuropathol Appl Neurobiol. 4:1978;273-277.
    • (1978) Neuropathol Appl Neurobiol , vol.4 , pp. 273-277
    • Perry, E.K.1    Perry, R.H.2    Blessed, G.3
  • 17
    • 0026794041 scopus 로고
    • Changes in acetylcholinesterases and butyrylcholinesterases in Alzheimer's disease resemble embryonic development: A study of molecular forms
    • Arendt T., Bruckner M.K., Lange M., et al. Changes in acetylcholinesterases and butyrylcholinesterases in Alzheimer's disease resemble embryonic development: a study of molecular forms. Neurochem Int. 21:1992;381-396.
    • (1992) Neurochem Int , vol.21 , pp. 381-396
    • Arendt, T.1    Bruckner, M.K.2    Lange, M.3
  • 18
    • 0034119973 scopus 로고    scopus 로고
    • Postnatal developmental delay and supersensitivity to organophosphate in gene-targeted mice lacking acetylcholinesterase
    • Xie W., Stribley J.A., Chatonnet A., et al. Postnatal developmental delay and supersensitivity to organophosphate in gene-targeted mice lacking acetylcholinesterase. J Pharmacol Exp Ther. 293:2000;896-902.
    • (2000) J Pharmacol Exp Ther , vol.293 , pp. 896-902
    • Xie, W.1    Stribley, J.A.2    Chatonnet, A.3
  • 19
    • 0032439162 scopus 로고    scopus 로고
    • Cholinesterase inhibitors in the treatment of Alzheimer's disease: A comparison of tolerability and pharmacology
    • Nordberg A., Svensson A.L. Cholinesterase inhibitors in the treatment of Alzheimer's disease: a comparison of tolerability and pharmacology. Drug Saf. 19:1998;465-480.
    • (1998) Drug Saf , vol.19 , pp. 465-480
    • Nordberg, A.1    Svensson, A.L.2
  • 20
    • 0036349129 scopus 로고    scopus 로고
    • Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitors
    • Jann M.W., Shirley K.L., Small G.W. Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitors. Clin Pharmacokinet. 41:2002;719-739.
    • (2002) Clin Pharmacokinet , vol.41 , pp. 719-739
    • Jann, M.W.1    Shirley, K.L.2    Small, G.W.3
  • 21
    • 0034565684 scopus 로고    scopus 로고
    • Donepezil for mild and moderate Alzheimer's disease (Cochrane Review)
    • Oxford: Update Software. Issue 3
    • Birks J., Melzer D., Beppu H. Donepezil for mild and moderate Alzheimer's disease (Cochrane Review). The Cochrane Library. 2002;Update Software, Oxford. Issue 3.
    • (2002) The Cochrane Library
    • Birks, J.1    Melzer, D.2    Beppu, H.3
  • 22
    • 84944447830 scopus 로고    scopus 로고
    • Rivastigmine for Alzheimer's disease (Cochrane Review)
    • Oxford: Update Software. Issue 3
    • Birks J., Grimley Evans J., Iakovidou V., et al. Rivastigmine for Alzheimer's disease (Cochrane Review). The Cochrane Library. 2002;Update Software, Oxford. Issue 3.
    • (2002) The Cochrane Library
    • Birks, J.1    Grimley Evans, J.2    Iakovidou, V.3
  • 23
    • 0035225736 scopus 로고    scopus 로고
    • Galantamine for Alzheimer's disease (Cochrane Review)
    • Oxford: Update Software. Issue 3
    • Olin J., Schneider L. Galantamine for Alzheimer's disease (Cochrane Review). The Cochrane Library. 2002;Update Software, Oxford. Issue 3.
    • (2002) The Cochrane Library
    • Olin, J.1    Schneider, L.2
  • 24
    • 0035859879 scopus 로고    scopus 로고
    • A 1-year, randomized, placebo-controlled study of donepezil in patients with mild to moderate AD
    • Winblad B., Engedal K., Soininen H., et al. A 1-year, randomized, placebo-controlled study of donepezil in patients with mild to moderate AD. Neurology. 57:2001;489-495.
    • (2001) Neurology , vol.57 , pp. 489-495
    • Winblad, B.1    Engedal, K.2    Soininen, H.3
  • 25
    • 0035964226 scopus 로고    scopus 로고
    • A 24-week, randomized, double-blind study of donepezil in moderate to severe Alzheimer's disease
    • Feldman H., Gauthier S., Hecker J., et al. A 24-week, randomized, double-blind study of donepezil in moderate to severe Alzheimer's disease. Neurology. 57:2001;613-620.
    • (2001) Neurology , vol.57 , pp. 613-620
    • Feldman, H.1    Gauthier, S.2    Hecker, J.3
  • 26
    • 0036336383 scopus 로고    scopus 로고
    • A multinational, randomised, 12-week, comparative study of donepezil and rivastigmine in patients with mild to moderate Alzheimer's disease
    • Wilkinson D.G., Passmore A.P., Bullock R., et al. A multinational, randomised, 12-week, comparative study of donepezil and rivastigmine in patients with mild to moderate Alzheimer's disease. Int J Clin Pract. 56:2002;441-446.
    • (2002) Int J Clin Pract , vol.56 , pp. 441-446
    • Wilkinson, D.G.1    Passmore, A.P.2    Bullock, R.3
  • 27
    • 85031079672 scopus 로고    scopus 로고
    • First head-to-head study comparing the tolerability and efficacy of donepezil and galantamine in Alzheimer's disease
    • April 3-6 2002, Geneva, Switzerland
    • Jones RW, Passmore P, Wetterberg P, et al. First head-to-head study comparing the tolerability and efficacy of donepezil and galantamine in Alzheimer's disease. Presented as poster at the 7th International Geneva/Springfield Symposium on Advances in Alzheimer Therapy, April 3-6 2002, Geneva, Switzerland.
    • 7th International Geneva/Springfield Symposium on Advances in Alzheimer Therapy
    • Jones, R.W.1    Passmore, P.2    Wetterberg, P.3
  • 28
    • 0042139091 scopus 로고    scopus 로고
    • Galantamine demonstrates superior efficacy on attention and MMSE compared with donepezil in patients with Alzheimer's disease actively treated for 52 weeks: An initial analysis
    • McKeith I., Truyen L., Lilienfeld S., Mahableshwarkar A. Galantamine demonstrates superior efficacy on attention and MMSE compared with donepezil in patients with Alzheimer's disease actively treated for 52 weeks: an initial analysis. Neurology. 60:(suppl 5):2003;A141.
    • (2003) Neurology , vol.60 , Issue.SUPPL. 5 , pp. 141
    • McKeith, I.1    Truyen, L.2    Lilienfeld, S.3    Mahableshwarkar, A.4
  • 29
    • 0035991594 scopus 로고    scopus 로고
    • Efficacy and safety of rivastigmine in patients with Alzheimer's disease who failed to benefit from treatment with donepezil
    • Auriacombe S., Pere J.J., Loria-Kanza Y., et al. Efficacy and safety of rivastigmine in patients with Alzheimer's disease who failed to benefit from treatment with donepezil. Curr Med Res Opin. 18:2002;129-138.
    • (2002) Curr Med Res Opin , vol.18 , pp. 129-138
    • Auriacombe, S.1    Pere, J.J.2    Loria-Kanza, Y.3
  • 30
    • 0036063226 scopus 로고    scopus 로고
    • Switching cholinesterase inhibitors in patients with Alzheimer's disease
    • Emre E. Switching cholinesterase inhibitors in patients with Alzheimer's disease. Int J Clin Pract. 127:2002;64-72.
    • (2002) Int J Clin Pract , vol.127 , pp. 64-72
    • Emre, E.1
  • 31
    • 0035007833 scopus 로고    scopus 로고
    • Switching previous therapies for Alzheimer's disease to galantamine
    • Ferris S.H. Switching previous therapies for Alzheimer's disease to galantamine. Clin Ther. 23:(suppl A):2001;A3-A7.
    • (2001) Clin Ther , vol.23 , Issue.SUPPL. A
    • Ferris, S.H.1
  • 33
    • 0027476024 scopus 로고
    • A synaptic model of memory: Long term potentiation in the hippocampus
    • Bliss T.V., Collinridge G.L. A synaptic model of memory: long term potentiation in the hippocampus. Nature. 361:1993;31-39.
    • (1993) Nature , vol.361 , pp. 31-39
    • Bliss, T.V.1    Collinridge, G.L.2
  • 34
    • 0028535113 scopus 로고
    • Anatomy and physiology of glutamate in the CNS
    • Greenamyre J.T., Porter R.H. Anatomy and physiology of glutamate in the CNS. Neurology. 44:(suppl 8):1994;S7-S13.
    • (1994) Neurology , vol.44 , Issue.SUPPL. 8
    • Greenamyre, J.T.1    Porter, R.H.2
  • 35
    • 0024363934 scopus 로고
    • Excitatory amino acids and Alzheimer's disease
    • Greenamyre J.T., Young A.B. Excitatory amino acids and Alzheimer's disease. Neurobiol Aging. 10:1989;593-602.
    • (1989) Neurobiol Aging , vol.10 , pp. 593-602
    • Greenamyre, J.T.1    Young, A.B.2
  • 36
    • 0032983786 scopus 로고    scopus 로고
    • Memantine in severe dementia: Results of the M-Best Study (Benefit and efficacy in severely demented patients during treatment with memantine)
    • Winblad B., Poritis N. Memantine in severe dementia: results of the M-Best Study (Benefit and efficacy in severely demented patients during treatment with memantine). Int J Geriatr Psychiat. 14:1999;135-146.
    • (1999) Int J Geriatr Psychiat , vol.14 , pp. 135-146
    • Winblad, B.1    Poritis, N.2
  • 37
    • 0037417238 scopus 로고    scopus 로고
    • Memantine in moderate-to-severe Alzheimer's disease
    • Reinsberg B., Doody R., Stoffer A., et al. Memantine in moderate-to-severe Alzheimer's disease. N Engl J Med. 348:2003;1333-1341.
    • (2003) N Engl J Med , vol.348 , pp. 1333-1341
    • Reinsberg, B.1    Doody, R.2    Stoffer, A.3
  • 38
    • 0038529085 scopus 로고    scopus 로고
    • Memantine/donepezil dual therapy is superior to placebo/donepezil therapy for treatment of moderate to severe AD
    • Farlow M.R., Tariot P.N., Grossberg G.T., et al. Memantine/donepezil dual therapy is superior to placebo/donepezil therapy for treatment of moderate to severe AD. Neurology. 60:(suppl 1):2003;A412.
    • (2003) Neurology , vol.60 , Issue.SUPPL. 1 , pp. 412
    • Farlow, M.R.1    Tariot, P.N.2    Grossberg, G.T.3
  • 39
    • 84928760036 scopus 로고    scopus 로고
    • Memantine for Dementia (Cochrane Review)
    • Oxford: Update Software. Issue 1
    • Areosa Sastre A., Sherriff F. Memantine for Dementia (Cochrane Review). The Cochrane Library. 2003;Update Software, Oxford. Issue 1.
    • (2003) The Cochrane Library
    • Areosa Sastre, A.1    Sherriff, F.2
  • 40
    • 0035949487 scopus 로고    scopus 로고
    • Presenilin, Notch, and the genesis and treatment of Alzheimer's disease
    • Selkoe D.J. Presenilin, Notch, and the genesis and treatment of Alzheimer's disease. Proc Natl Acad Sci. 98:2001;11039-11041.
    • (2001) Proc Natl Acad Sci , vol.98 , pp. 11039-11041
    • Selkoe, D.J.1
  • 41
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy J., Selkoe D.J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science. 297:2002;353-356.
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 42
    • 0029147583 scopus 로고
    • Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors
    • Lee R.K., Wurtman R.J., Cox A.J., et al. Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors. Proc Natl Acad Sci. 17:1995;8083-8087.
    • (1995) Proc Natl Acad Sci , vol.17 , pp. 8083-8087
    • Lee, R.K.1    Wurtman, R.J.2    Cox, A.J.3
  • 43
    • 0035943345 scopus 로고    scopus 로고
    • A portrait of Alzheimer secretases-new features and familiar faces
    • Esler W.P., Wolfe M.S. A portrait of Alzheimer secretases-new features and familiar faces. Science. 293:2001;1449-1454.
    • (2001) Science , vol.293 , pp. 1449-1454
    • Esler, W.P.1    Wolfe, M.S.2
  • 44
    • 0036548070 scopus 로고    scopus 로고
    • Gamma-Secretase, Notch, Abeta and Alzheimer's disease: Where do the presenilins fit in?
    • Sisodia S.S., St George-Hyslop P.H. Gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in? Nat Rev Neurosci. 3:2002;281-290.
    • (2002) Nat Rev Neurosci , vol.3 , pp. 281-290
    • Sisodia, S.S.1    St George-Hyslop, P.H.2
  • 45
    • 0042630561 scopus 로고    scopus 로고
    • Secretases as targets for the treatment of Alzheimer's disease: The prospects
    • Dewachter I., Van Leuven F. Secretases as targets for the treatment of Alzheimer's disease: the prospects. Lancet Neurology. 1:2002;409-416.
    • (2002) Lancet Neurology , vol.1 , pp. 409-416
    • Dewachter, I.1    Van Leuven, F.2
  • 46
    • 0034966874 scopus 로고    scopus 로고
    • Presenilins as therapeutic targets for the treatment of Alzheimer's disease
    • Golde T.E., Younkin S.G. Presenilins as therapeutic targets for the treatment of Alzheimer's disease. Trends Mol Med. 6:2001;264-269.
    • (2001) Trends Mol Med , vol.6 , pp. 264-269
    • Golde, T.E.1    Younkin, S.G.2
  • 47
    • 0035112647 scopus 로고    scopus 로고
    • BACE1 is the major β secretase for generation of Aβ peptides by neurons
    • Cai H., Wang Y., McCarthy D., et al. BACE1 is the major β secretase for generation of Aβ peptides by neurons. Nat Neurosci. 4:2001;233-234.
    • (2001) Nat Neurosci , vol.4 , pp. 233-234
    • Cai, H.1    Wang, Y.2    McCarthy, D.3
  • 48
    • 0035116273 scopus 로고    scopus 로고
    • Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation
    • Luo Y., Bolon B., Kahn S., et al. Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation. Nat Neurosci. 4:2001;231-232.
    • (2001) Nat Neurosci , vol.4 , pp. 231-232
    • Luo, Y.1    Bolon, B.2    Kahn, S.3
  • 49
    • 0035005101 scopus 로고    scopus 로고
    • New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage
    • Petit A., Bihel F., Alves da Costa C., et al. New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage. Nat Cell Biol. 3:2001;507-511.
    • (2001) Nat Cell Biol , vol.3 , pp. 507-511
    • Petit, A.1    Bihel, F.2    Alves da Costa, C.3
  • 50
    • 0034618715 scopus 로고    scopus 로고
    • Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing
    • Yu G., Nishimura M., Arawaka S., et al. Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature. 407:2000;48-54.
    • (2000) Nature , vol.407 , pp. 48-54
    • Yu, G.1    Nishimura, M.2    Arawaka, S.3
  • 51
    • 0035163347 scopus 로고    scopus 로고
    • Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain
    • Dovey H.F., John V., Anderson J.P., et al. Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain. J Neurochem. 76:2001;173-181.
    • (2001) J Neurochem , vol.76 , pp. 173-181
    • Dovey, H.F.1    John, V.2    Anderson, J.P.3
  • 52
    • 0033536163 scopus 로고    scopus 로고
    • Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse
    • Schenk D., Barbour R., Dunn W., et al. Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature. 400:1999;173-177.
    • (1999) Nature , vol.400 , pp. 173-177
    • Schenk, D.1    Barbour, R.2    Dunn, W.3
  • 53
    • 0028985574 scopus 로고
    • Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
    • Games D., Adams D., Alessandrini R., et al. Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein. Nature. 373:1995;523-527.
    • (1995) Nature , vol.373 , pp. 523-527
    • Games, D.1    Adams, D.2    Alessandrini, R.3
  • 54
    • 0033801852 scopus 로고    scopus 로고
    • Nasal administration of amyloid- peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease
    • Weiner H.L., Lemere C.A., Maron R., et al. Nasal administration of amyloid- peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease. Ann Neurol. 48:2000;567-579.
    • (2000) Ann Neurol , vol.48 , pp. 567-579
    • Weiner, H.L.1    Lemere, C.A.2    Maron, R.3
  • 55
    • 0033835996 scopus 로고    scopus 로고
    • Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer's disease
    • Bard F., Cannon C., Barbour R., et al. Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer's disease. Nat Med. 6:2000;916-919.
    • (2000) Nat Med , vol.6 , pp. 916-919
    • Bard, F.1    Cannon, C.2    Barbour, R.3
  • 56
    • 0035902619 scopus 로고    scopus 로고
    • Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease
    • DeMattos R.B., Bales K.R., Cummins D.J., et al. Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease. Proc Natl Acad Sci. 98:2001;8850-8855.
    • (2001) Proc Natl Acad Sci , vol.98 , pp. 8850-8855
    • DeMattos, R.B.1    Bales, K.R.2    Cummins, D.J.3
  • 57
    • 0034700471 scopus 로고    scopus 로고
    • A β-peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
    • Janus C., Pearson J., McLaurin J., et al. A β-peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature. 408:2000;979-982.
    • (2000) Nature , vol.408 , pp. 979-982
    • Janus, C.1    Pearson, J.2    McLaurin, J.3
  • 58
    • 84984755327 scopus 로고    scopus 로고
    • A β-peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
    • Morgan D., Diamond D.M., Gottschall P.E., et al. A β-peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature. 408:2000;982-985.
    • (2000) Nature , vol.408 , pp. 982-985
    • Morgan, D.1    Diamond, D.M.2    Gottschall, P.E.3
  • 59
    • 0036240395 scopus 로고    scopus 로고
    • Immunization reverses memory deficits without reducing brain A beta burden in Alzheimer's disease model
    • Dodart J.C., Bales K.R., Gannon K.S., et al. Immunization reverses memory deficits without reducing brain A beta burden in Alzheimer's disease model. Nat Neurosci. 5:2002;452-457.
    • (2002) Nat Neurosci , vol.5 , pp. 452-457
    • Dodart, J.C.1    Bales, K.R.2    Gannon, K.S.3
  • 60
    • 0034744296 scopus 로고    scopus 로고
    • TGF-beta 1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice
    • Wyss-Coray T., Lin C., Yan F., et al. TGF-beta 1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice. Nat Med. 7:2001;612-618.
    • (2001) Nat Med , vol.7 , pp. 612-618
    • Wyss-Coray, T.1    Lin, C.2    Yan, F.3
  • 61
    • 0037107177 scopus 로고    scopus 로고
    • Non-Fc-mediated mechanisms are involved in clearance of Amyloid-b in vivo by immunotherapy
    • Backsai B., Kajdasz S., McKellen M., et al. Non-Fc-mediated mechanisms are involved in clearance of Amyloid-b in vivo by immunotherapy. J Neurosci. 22:2002;7873-7878.
    • (2002) J Neurosci , vol.22 , pp. 7873-7878
    • Backsai, B.1    Kajdasz, S.2    McKellen, M.3
  • 62
    • 0030058382 scopus 로고    scopus 로고
    • Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide
    • Solomon B., Koppel R., Hanan E., et al. Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide. Proc Natl Acad Sci. 93:1996;452-455.
    • (1996) Proc Natl Acad Sci , vol.93 , pp. 452-455
    • Solomon, B.1    Koppel, R.2    Hanan, E.3
  • 63
    • 0032590054 scopus 로고    scopus 로고
    • Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease
    • McLean C.A., Cherny R.A., Fraser F.W., et al. Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease. Ann Neurol. 46:1999;860-866.
    • (1999) Ann Neurol , vol.46 , pp. 860-866
    • McLean, C.A.1    Cherny, R.A.2    Fraser, F.W.3
  • 64
    • 0035807829 scopus 로고    scopus 로고
    • Specific spatial learning deficits become severe with age in beta amyloid precursor protein transgenic mice that harbor diffuse beta amyloid deposits but do not form plaques
    • Koistinaho M., Ort M., Cimadevilla J.M., et al. Specific spatial learning deficits become severe with age in beta amyloid precursor protein transgenic mice that harbor diffuse beta amyloid deposits but do not form plaques. Proc Natl Acad Sci. 25:2001;14675-14680.
    • (2001) Proc Natl Acad Sci , vol.25 , pp. 14675-14680
    • Koistinaho, M.1    Ort, M.2    Cimadevilla, J.M.3
  • 65
    • 0036780877 scopus 로고    scopus 로고
    • Amyloid-beta immunotherapy for Alzheimer's disease: The end of the beginning
    • Schenk D. Amyloid-beta immunotherapy for Alzheimer's disease: the end of the beginning. Nature. 3:2002;824-828.
    • (2002) Nature , vol.3 , pp. 824-828
    • Schenk, D.1
  • 66
    • 0037393454 scopus 로고    scopus 로고
    • Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: A case report
    • Nicoll J.A.R., Wilkinson D., Holmes C., Steart P., Markham H., Weller R. Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report. Nat Med. 9:2003;448-452.
    • (2003) Nat Med , vol.9 , pp. 448-452
    • Nicoll, J.A.R.1    Wilkinson, D.2    Holmes, C.3    Steart, P.4    Markham, H.5    Weller, R.6
  • 67
    • 0036853548 scopus 로고    scopus 로고
    • Generation of antibodies specific for β-amyloid by vaccination of patients with Alzheimer disease
    • Hock C., Konietzko U., Papassotiropoulos A., et al. Generation of antibodies specific for β-amyloid by vaccination of patients with Alzheimer disease. Nat Med. 11:2002;1270-1275.
    • (2002) Nat Med , vol.11 , pp. 1270-1275
    • Hock, C.1    Konietzko, U.2    Papassotiropoulos, A.3
  • 69
    • 0037133324 scopus 로고    scopus 로고
    • A liposome-based therapeutic vaccine against beta amyloid plaques on the pancreas of transgenic NORBA mice
    • Nicolau C., Greferath R., Balaban T.S. A liposome-based therapeutic vaccine against beta amyloid plaques on the pancreas of transgenic NORBA mice. Proc Natl Acad Sci. 99:2002;2332-2337.
    • (2002) Proc Natl Acad Sci , vol.99 , pp. 2332-2337
    • Nicolau, C.1    Greferath, R.2    Balaban, T.S.3
  • 70
    • 0034884382 scopus 로고    scopus 로고
    • Immunization with a nontoxic/nonfibrillar amyloid-β homologous peptide reduces Alzheimer's disease associated pathology in transgenic mice
    • Sigurdsson E.M., Scholtzova H., Mehta P.D., et al. Immunization with a nontoxic/nonfibrillar amyloid-β homologous peptide reduces Alzheimer's disease associated pathology in transgenic mice. Am J Pathol. 159:2001;439-447.
    • (2001) Am J Pathol , vol.159 , pp. 439-447
    • Sigurdsson, E.M.1    Scholtzova, H.2    Mehta, P.D.3
  • 71
    • 0035702068 scopus 로고    scopus 로고
    • Towards Alzheimer's beta-amyloid vaccination
    • Frenkel D., Solomon B. Towards Alzheimer's beta-amyloid vaccination. Biologicals. 29:2001;243-247.
    • (2001) Biologicals , vol.29 , pp. 243-247
    • Frenkel, D.1    Solomon, B.2
  • 73
    • 0035827318 scopus 로고    scopus 로고
    • Protein misfolding and disease; Protein refolding and therapy
    • Soto C. Protein misfolding and disease; protein refolding and therapy. FEBS Lett. 498:2001;204-207.
    • (2001) FEBS Lett , vol.498 , pp. 204-207
    • Soto, C.1
  • 74
    • 0036615884 scopus 로고    scopus 로고
    • Reduction of amyloid load and cerebral damage in a transgenic mouse model of Alzheimer's disease by treatment with a beta-sheet breaker peptide
    • Permanne B., Adessi C., Saborio G.P., et al. Reduction of amyloid load and cerebral damage in a transgenic mouse model of Alzheimer's disease by treatment with a beta-sheet breaker peptide. FASEB J. 16:2002;860-862.
    • (2002) FASEB J , vol.16 , pp. 860-862
    • Permanne, B.1    Adessi, C.2    Saborio, G.P.3
  • 75
    • 0037118028 scopus 로고    scopus 로고
    • Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis
    • Pepys M.B., Herbert J., Hutchinson W.L., et al. Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis. Nature. 417:2002;254-259.
    • (2002) Nature , vol.417 , pp. 254-259
    • Pepys, M.B.1    Herbert, J.2    Hutchinson, W.L.3
  • 76
    • 0029010736 scopus 로고
    • Serum amyloid P component prevents proteolysis of the amyloid fibrils of Alzheimer's disease and systemic amyloidosis
    • Tennent G.A., Lovat L.B., Pepys M.B. Serum amyloid P component prevents proteolysis of the amyloid fibrils of Alzheimer's disease and systemic amyloidosis. Proc Natl Acad Sci USA. 92:1995;4299-4303.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 4299-4303
    • Tennent, G.A.1    Lovat, L.B.2    Pepys, M.B.3
  • 77
    • 0032557425 scopus 로고    scopus 로고
    • Dramatic aggregation of Alzheimer Abeta by Cu(II) is induced by conditions representing physiological acidosis
    • Atwood C.S., Moir R.D., Huang X., et al. Dramatic aggregation of Alzheimer Abeta by Cu(II) is induced by conditions representing physiological acidosis. J Biol Chem. 273:1998;12817-12826.
    • (1998) J Biol Chem , vol.273 , pp. 12817-12826
    • Atwood, C.S.1    Moir, R.D.2    Huang, X.3
  • 78
    • 0033844944 scopus 로고    scopus 로고
    • Characterization of copper interactions with Alzheimer amyloid beta peptides: Identification of an attomolar-affinity copper binding site on amyloid beta 1-42
    • Atwood C.S., Scarpa R.C., Huang X., et al. Characterization of copper interactions with Alzheimer amyloid beta peptides: identification of an attomolar-affinity copper binding site on amyloid beta 1-42. J Neurochem. 75:2000;1219-1233.
    • (2000) J Neurochem , vol.75 , pp. 1219-1233
    • Atwood, C.S.1    Scarpa, R.C.2    Huang, X.3
  • 79
    • 0035827681 scopus 로고    scopus 로고
    • Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits
    • Curtain C.C., Ali F., Volitakis I., et al. Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits. J Biol Chem. 276:2001;20466-20473.
    • (2001) J Biol Chem , vol.276 , pp. 20466-20473
    • Curtain, C.C.1    Ali, F.2    Volitakis, I.3
  • 80
    • 0032507975 scopus 로고    scopus 로고
    • Copper, iron and zinc in Alzheimer's disease senile plaques
    • Lovell M.A., Robertson J.D., Teesdale W.J., et al. Copper, iron and zinc in Alzheimer's disease senile plaques. J Neurol Sci. 158:1998;47-52.
    • (1998) J Neurol Sci , vol.158 , pp. 47-52
    • Lovell, M.A.1    Robertson, J.D.2    Teesdale, W.J.3
  • 81
    • 0033551782 scopus 로고    scopus 로고
    • Aqueous dissolution of Alzheimer's disease: Beta amyloid deposits by biometal depletion
    • Cherny R.A., Legg J.T., McLean C.A., et al. Aqueous dissolution of Alzheimer's disease: beta amyloid deposits by biometal depletion. J Biol Chem. 274:1999;23223-23228.
    • (1999) J Biol Chem , vol.274 , pp. 23223-23228
    • Cherny, R.A.1    Legg, J.T.2    McLean, C.A.3
  • 82
    • 0034964390 scopus 로고    scopus 로고
    • Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice
    • Cherny R.A., Atwood C.S., Xilinas M.E., et al. Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron. 30:2001;665-676.
    • (2001) Neuron , vol.30 , pp. 665-676
    • Cherny, R.A.1    Atwood, C.S.2    Xilinas, M.E.3
  • 83
    • 0033974529 scopus 로고    scopus 로고
    • Changes in uptake of vitamin B(12) and trace metals in brains of mice treated with clioquinol
    • Yassin M.S., Ekblom J., Xilinas M., et al. Changes in uptake of vitamin B(12) and trace metals in brains of mice treated with clioquinol. J Neurol Sci. 173:2000;40-44.
    • (2000) J Neurol Sci , vol.173 , pp. 40-44
    • Yassin, M.S.1    Ekblom, J.2    Xilinas, M.3
  • 84
    • 0034612175 scopus 로고    scopus 로고
    • Inflammation and Alzheimer's disease
    • Akiyama H., Barger S., Barnum S., et al. Inflammation and Alzheimer's disease. Neurobiol Aging. 21:2000;383-421.
    • (2000) Neurobiol Aging , vol.21 , pp. 383-421
    • Akiyama, H.1    Barger, S.2    Barnum, S.3
  • 85
    • 0029811901 scopus 로고    scopus 로고
    • Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: A review of 17 epidemiologic studies
    • McGeer P.L., Schulzer M., McGeer E.G. Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies. Neurology. 47:1996;425-432.
    • (1996) Neurology , vol.47 , pp. 425-432
    • McGeer, P.L.1    Schulzer, M.2    McGeer, E.G.3
  • 86
    • 0030897133 scopus 로고    scopus 로고
    • Risk of Alzheimer's disease and duration of NSAID use
    • Stewart W.F., Kawas C., Corrada M., et al. Risk of Alzheimer's disease and duration of NSAID use. Neurology. 48:1997;626-632.
    • (1997) Neurology , vol.48 , pp. 626-632
    • Stewart, W.F.1    Kawas, C.2    Corrada, M.3
  • 87
    • 0035936004 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs and the risk of Alzheimer's disease
    • In t'Veld B.A., Ruitenberg A., Hofman A., et al. Nonsteroidal anti-inflammatory drugs and the risk of Alzheimer's disease. N Engl J Med. 345:2001;1515-1521.
    • (2001) N Engl J Med , vol.345 , pp. 1515-1521
    • In t'Veld, B.A.1    Ruitenberg, A.2    Hofman, A.3
  • 88
    • 0041628645 scopus 로고    scopus 로고
    • Cyclo-oxygenase inhibitors and Alzheimer's: Are we well ADAPTed?
    • Pasinetti G., Pompl P. Cyclo-oxygenase inhibitors and Alzheimer's: are we well ADAPTed? Lancet Neurology. 1:2002;403-404.
    • (2002) Lancet Neurology , vol.1 , pp. 403-404
    • Pasinetti, G.1    Pompl, P.2
  • 89
    • 0035690720 scopus 로고    scopus 로고
    • Glial activation in Alzheimer's disease: The role of Abeta and its associated proteins
    • Meda L., Baron P.L., Scarlato G. Glial activation in Alzheimer's disease: the role of Abeta and its associated proteins. Neurobiol Aging. 22:2001;885-893.
    • (2001) Neurobiol Aging , vol.22 , pp. 885-893
    • Meda, L.1    Baron, P.L.2    Scarlato, G.3
  • 90
    • 0035100231 scopus 로고    scopus 로고
    • Neuronal cyclooxygenase-2 expression in the hippocampal formation of the clinical progression of Alzheimer's disease
    • Ho L., Purohit D., Haroutunian V., et al. Neuronal cyclooxygenase-2 expression in the hippocampal formation of the clinical progression of Alzheimer's disease. Arch Neurol. 58:2001;487-492.
    • (2001) Arch Neurol , vol.58 , pp. 487-492
    • Ho, L.1    Purohit, D.2    Haroutunian, V.3
  • 91
    • 0036424134 scopus 로고    scopus 로고
    • COX-2 promotes amyloid plaque deposition in a mouse model of Alzheimer's disease neuropathology
    • Xiang Z., Ho L., Yemul S., et al. COX-2 promotes amyloid plaque deposition in a mouse model of Alzheimer's disease neuropathology. Gene Expression. 10:2002;271-278.
    • (2002) Gene Expression , vol.10 , pp. 271-278
    • Xiang, Z.1    Ho, L.2    Yemul, S.3
  • 92
    • 0034254924 scopus 로고    scopus 로고
    • Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease
    • Lim G.P., Yang F., Chu T., et al. Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease. J Neurosci. 20:2000;5709-5714.
    • (2000) J Neurosci , vol.20 , pp. 5709-5714
    • Lim, G.P.1    Yang, F.2    Chu, T.3
  • 93
    • 0035829592 scopus 로고    scopus 로고
    • A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity
    • Weggen S., Eriksen J.L., Das P., et al. A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity. Nature. 414:2001;212-216.
    • (2001) Nature , vol.414 , pp. 212-216
    • Weggen, S.1    Eriksen, J.L.2    Das, P.3
  • 94
    • 0037088914 scopus 로고    scopus 로고
    • Microglial activation and beta-amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice
    • Jantzen P.T., Connor K.E., DiCarlo G., et al. Microglial activation and beta-amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice. J Neurosci. 22:2002;2246-2254.
    • (2002) J Neurosci , vol.22 , pp. 2246-2254
    • Jantzen, P.T.1    Connor, K.E.2    DiCarlo, G.3
  • 95
    • 0027268393 scopus 로고
    • Clinical trial of indomethacin in Alzheimer's disease
    • Rogers J., Kirby L.C., Hempelman S.R., et al. Clinical trial of indomethacin in Alzheimer's disease. Neurology. 43:1993;1609-1611.
    • (1993) Neurology , vol.43 , pp. 1609-1611
    • Rogers, J.1    Kirby, L.C.2    Hempelman, S.R.3
  • 96
    • 0041638098 scopus 로고    scopus 로고
    • Indomethacin for treatment of AD Patients (Cochrane review)
    • Oxford: Update Software. issue 2
    • Tabet N., Feldman H. Indomethacin for treatment of AD Patients (Cochrane review). The Cochrane Library. 2003;Update Software, Oxford. issue 2.
    • (2003) The Cochrane Library
    • Tabet, N.1    Feldman, H.2
  • 97
    • 0037046179 scopus 로고    scopus 로고
    • Randomized pilot study of nimesulide treatment in Alzheimer's disease
    • Aisen P.S., Schmeidler J., Pasinetti G.M., et al. Randomized pilot study of nimesulide treatment in Alzheimer's disease. Neurology. 58:2002;1050-1054.
    • (2002) Neurology , vol.58 , pp. 1050-1054
    • Aisen, P.S.1    Schmeidler, J.2    Pasinetti, G.M.3
  • 98
    • 0001643004 scopus 로고    scopus 로고
    • Results of a multicenter trial of rofecoxib and naproxen in Alzheimer's disease
    • Aisen P.S., Schafer K., Grundman M., et al. Results of a multicenter trial of rofecoxib and naproxen in Alzheimer's disease. Neurobiol Aging. 23:(suppl 1):2002;S429.
    • (2002) Neurobiol Aging , vol.23 , Issue.SUPPL. 1 , pp. 429
    • Aisen, P.S.1    Schafer, K.2    Grundman, M.3
  • 100
    • 0001849987 scopus 로고    scopus 로고
    • A clinical trial of Rofecoxib, a selective COX-2 inhibitor, for the treatment of Alzheimer's disease
    • Block G., Norman B., Liu G., et al. A clinical trial of Rofecoxib, a selective COX-2 inhibitor, for the treatment of Alzheimer's disease. Neurobiol Aging. 23:2002;S73-S74.
    • (2002) Neurobiol Aging , vol.23
    • Block, G.1    Norman, B.2    Liu, G.3
  • 101
    • 0034620538 scopus 로고    scopus 로고
    • A randomized controlled trial of prednisone in Alzheimer's disease
    • Aisen P., Davis K.L., Berg J.D., et al. A randomized controlled trial of prednisone in Alzheimer's disease. Neurology. 54:2000;588-593.
    • (2000) Neurology , vol.54 , pp. 588-593
    • Aisen, P.1    Davis, K.L.2    Berg, J.D.3
  • 102
    • 0035845325 scopus 로고    scopus 로고
    • Effect of hydroxychloroquine on progression of dementia in early Alzheimer's disease: An 18-month randomized, double-blind, placebo-controlled study
    • Van Gool W.A., Weinstein H.C., Scheltens P.K., et al. Effect of hydroxychloroquine on progression of dementia in early Alzheimer's disease: an 18-month randomized, double-blind, placebo-controlled study. Lancet. 358:2001;455-460.
    • (2001) Lancet , vol.358 , pp. 455-460
    • Van Gool, W.A.1    Weinstein, H.C.2    Scheltens, P.K.3
  • 103
    • 0141453824 scopus 로고    scopus 로고
    • The potential of anti-inflammatory drugs for the treatment of Alzheimer's disease
    • Aisen P. The potential of anti-inflammatory drugs for the treatment of Alzheimer's disease. Lancet Neurol. 1:2002;279-284.
    • (2002) Lancet Neurol , vol.1 , pp. 279-284
    • Aisen, P.1
  • 104
    • 0033851022 scopus 로고    scopus 로고
    • Genetic epidemiology of Alzheimer's disease
    • Dartigues J.F., Letenneur L. Genetic epidemiology of Alzheimer's disease. Curr Opin Neurol. 13:2000;385-389.
    • (2000) Curr Opin Neurol , vol.13 , pp. 385-389
    • Dartigues, J.F.1    Letenneur, L.2
  • 105
    • 0021824223 scopus 로고
    • Role of the apolipoprotein E polymorphism in determining normal plasma lipid and lipoprotein variation
    • Sing C.F., Davignon J. Role of the apolipoprotein E polymorphism in determining normal plasma lipid and lipoprotein variation. Am J Hum Genet. 37:1985;268-285.
    • (1985) Am J Hum Genet , vol.37 , pp. 268-285
    • Sing, C.F.1    Davignon, J.2
  • 106
    • 0029072551 scopus 로고
    • Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease: A case-control study
    • Jarvik G.P., Wijsman E.M., Kukull W.A., et al. Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease: a case-control study. Neurology. 45:1995;1092-1096.
    • (1995) Neurology , vol.45 , pp. 1092-1096
    • Jarvik, G.P.1    Wijsman, E.M.2    Kukull, W.A.3
  • 107
    • 0031278270 scopus 로고    scopus 로고
    • Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition
    • Bales K., Verina T., Dodel R.C., et al. Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition. Nat Genet. 17:1997;263-264.
    • (1997) Nat Genet , vol.17 , pp. 263-264
    • Bales, K.1    Verina, T.2    Dodel, R.C.3
  • 108
    • 4243215848 scopus 로고    scopus 로고
    • Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease
    • Holtzman D.M. Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA. 97:2000;2892-2897.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 2892-2897
    • Holtzman, D.M.1
  • 109
    • 0028177562 scopus 로고
    • Induction of Alzheimer-like beta-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol
    • Sparks D.L., Scheff S.W., Hunsaker J.C., et al. Induction of Alzheimer-like beta-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol. Exp Neurol. 126:1994;88-94.
    • (1994) Exp Neurol , vol.126 , pp. 88-94
    • Sparks, D.L.1    Scheff, S.W.2    Hunsaker, J.C.3
  • 110
    • 0033833354 scopus 로고    scopus 로고
    • Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model
    • Refolo L.M., Malester B., LaFrancois J., et al. Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model. Neurobiol Dis. 7:2000;321-331.
    • (2000) Neurobiol Dis , vol.7 , pp. 321-331
    • Refolo, L.M.1    Malester, B.2    LaFrancois, J.3
  • 111
    • 0032568552 scopus 로고    scopus 로고
    • Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons
    • Simons M., Keller P., De Strooper B., et al. Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons. Proc Natl Acad Sci USA. 95:1998;6460-6464.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 6460-6464
    • Simons, M.1    Keller, P.2    De Strooper, B.3
  • 112
    • 0035826909 scopus 로고    scopus 로고
    • Low cholesterol stimulates the non-amyloidogenic pathway by its effect on the α-secretase ADAM 10
    • Kojro E. Low cholesterol stimulates the non-amyloidogenic pathway by its effect on the α-secretase ADAM 10. Proc Natl Acad Sci USA. 98:2001;5815-5820.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 5815-5820
    • Kojro, E.1
  • 113
    • 0001504829 scopus 로고    scopus 로고
    • Simvastatin strongly reduces levels of Alzheimers disease β-amyloid peptides Aβ 42 and Aβ 40 in vitro and in vivo
    • Fassbender K. Simvastatin strongly reduces levels of Alzheimers disease β-amyloid peptides Aβ 42 and Aβ 40 in vitro and in vivo. Proc Natl Acad Sci USA. 98:2001;5856-5861.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 5856-5861
    • Fassbender, K.1
  • 114
    • 0035160066 scopus 로고    scopus 로고
    • A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease
    • Refolo L.M., Pappolla M.A., LaFrancois J., et al. A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease. Neurobiol Dis. 8:2001;890-899.
    • (2001) Neurobiol Dis , vol.8 , pp. 890-899
    • Refolo, L.M.1    Pappolla, M.A.2    LaFrancois, J.3
  • 115
    • 0034795651 scopus 로고    scopus 로고
    • Acyl-coenzyme A: Cholesterol acyltransferase (ACAT) modulates the generation of the amyloid β peptide
    • Puglielli L., Konopka G., Pack-Chung E., et al. Acyl-coenzyme A: cholesterol acyltransferase (ACAT) modulates the generation of the amyloid β peptide. Nat Cell Biol. 3:2001;905-912.
    • (2001) Nat Cell Biol , vol.3 , pp. 905-912
    • Puglielli, L.1    Konopka, G.2    Pack-Chung, E.3
  • 116
    • 0035888328 scopus 로고    scopus 로고
    • Cholesterol modulation as an emerging strategy for the treatment of Alzheimer's disease
    • Golde T.E., Eckman C.B. Cholesterol modulation as an emerging strategy for the treatment of Alzheimer's disease. Drug Discov Today. 20:2001;1049-1055.
    • (2001) Drug Discov Today , vol.20 , pp. 1049-1055
    • Golde, T.E.1    Eckman, C.B.2
  • 117
    • 0034638746 scopus 로고    scopus 로고
    • Statins and the risk of dementia
    • Jick H. Statins and the risk of dementia. Lancet. 356:2000;1627-1631.
    • (2000) Lancet , vol.356 , pp. 1627-1631
    • Jick, H.1
  • 118
    • 0033772113 scopus 로고    scopus 로고
    • Decreased prevalence of Alzheimer's disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors
    • Wolozin B. Decreased prevalence of Alzheimer's disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. Arch Neurol. 57:2000;1439-1443.
    • (2000) Arch Neurol , vol.57 , pp. 1439-1443
    • Wolozin, B.1
  • 119
    • 0037164314 scopus 로고    scopus 로고
    • Pravastatin in elderly individuals at risk of vascular disease (PROSPER): A randomised controlled trial
    • Shepherd J., Blauw G., Murphy M., et al. Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial. Lancet. 360:2002;1623-1630.
    • (2002) Lancet , vol.360 , pp. 1623-1630
    • Shepherd, J.1    Blauw, G.2    Murphy, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.