Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment

Annals of Neurology

Volumn 51, Issue 2, 2002, Pages 145-155

  Dekosky, Steven T ^a,d   Ikonomovic, Milos D ^a   Styren, Scot D ^a   Beckett, Laurel ^b   Wisniewski, Stephen ^c   Bennett, David A ^a   Cochran, Elizabeth J ^a   Kordower, Jeffrey H ^b   Mufson, Elliott J ^c  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^c RUSH UNIVERSITY MEDICAL CENTER   (United States)

^d UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINE ACETYLTRANSFERASE;

AGED; ALZHEIMER DISEASE; ARTICLE; CHOLINERGIC SYSTEM; CINGULATE GYRUS; COGNITIVE DEFECT; DEMENTIA; DISEASE SEVERITY; ENZYME ACTIVITY; ENZYME LOCALIZATION; ENZYME REGULATION; FEMALE; FRONTAL CORTEX; HIPPOCAMPUS; HUMAN; MAJOR CLINICAL STUDY; MALE; PARIETAL LOBE; PRIORITY JOURNAL; TEMPORAL CORTEX; TISSUE DISTRIBUTION;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; CHOLINE O-ACETYLTRANSFERASE; CHOLINERGIC FIBERS; COGNITION DISORDERS; FEMALE; FRONTAL LOBE; HIPPOCAMPUS; HUMANS; MALE; NEUROPSYCHOLOGICAL TESTS; PARIETAL LOBE; TEMPORAL LOBE;

EID: 0036156958     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.10069     Document Type: Article

References (73)

1. Cholinergic systems and related neuropathological predilection patterns in Alzheimer's disease
2. On neurodegenerative diseases, models, and treatment strategies: Lessons learned and lessons forgotten a generation following the cholinergic hypothesis
3. Central cholinergic pathways in the rat: An overview based on an alternative nomenclature (Ch1-Ch6)
4. Cholinergic innervation of cortex by the basal forebrain: Cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (substantia innominata), and hypothalamus in the rhesus monkey
5. Selective loss of central cholinergic neurons in Alzheimer's disease
6. Necropsy evidence of central cholinergic deficits in senile dementia
7. Alzheimer's disease and senile dementia: Loss of neurons in the basal forebrain
8. Neurotransmitter enzyme abnormalities in senile dementia. Choline acetyltransferase and glutamic acid decarboxylase activities in necropsy brain tissue
9. Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia
10. Pre- and postsynaptic neurochemical alterations in Alzheimer's disease
11. Neurotransmitter-related enzymes in senile dementia of Alzheimer type
12. Choline acetyltransferase activity and histopathology of frontal neocortex from biopsies of demented patients
13. A post-mortem study of the cholinergic and GABA systems in senile dementia
14. Cholinergic enzymes in neocortex, hippocampus and basal forebrain of non-neurological and senile dementia of Alzheimer-type patients
15. Presynaptic cholinergic dysfunction in patients with dementia
16. Amino acid release from biopsy samples of temporal neocortex from patients with Alzheimer's disease
17. Laminar organization of cholinergic circuits in human frontal cortex in Alzheimer's disease and aging
18. Neurochemical studies of early-onset Alzheimer's disease: Possible influence on treatment
19. Alzheimer's disease: A correlative study
20. Differential alteration of various cholinergic markers in cortical and subscortical regions of human brain in Alzheimer's disease
21. Topographical distribution of neurochemical changes in Alzheimer's disease
22. Cortical biopsy in Alzheimer's disease: Diagnostic accuracy and neurochemical, neuropathological and cogntive correlations
23. A new rating scale for Alzheimer's disease
24. The Clinical Dementia Rating (CDR): Current version and scoring rules
25. Cholinergic markers in elderly patients with early signs of Alzheimer's disease
26. Preservation of nucleus basalis neurons containing choline acetyltransferase and the vesicular acetylcholine transporter in the elderly with mild cognitive impairment and early Alzheimer's disease
27. Mild cognitive impairment
28. Mild cognitive impairment represents early-stage Alzheimer disease
29. Entorhinal cortex beta-amyloid load in individuals with mild cognitive impairment
30. Loss of nucleus basalis neurons containing trkA immunoreactivity in individuals with mild cognitive impairment and early Alzheimer's disease
31. Loss and atrophy of layer II entorhinal cortex neurons in elderly people with mild cognitive impairment
32. Metric properties of nurses' ratings of parkinsonian signs with a modified Unified Parkinson's disease rating scale
33. Dimensionality of parkinsonian signs in aging and Alzheimer's disease
34. Interrater reliability of the NIH stroke scale
35. Reliability of the national institutes of health stroke scale. Extension to non-neurologists in the context of a clinical trial
36. Mini-mental state: A practical method grading the cognitive state of patients for the clinician
37. The consortium to establish a registry for Alzheimer's disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer's disease
38. Around the WORLD backward: An algorithm for scoring the MMSE WORLD item
39. Diagnosis of dementia in a heterogeneous population. A comparison of paradigmbased diagnosis and physician's diagnosis
40. Linguistic ability in early life and cognitive function and Alzheimer's disease in late life. Findings from the Nun study
41. Clinical diagnosis of Alzheimer's disease: Report of health and human services task force on Alzheimer's disease
42. Use of brief cognitive tests to identify individuals in the community with clinically diagnosed Alzheimer's disease
43. Questionable dementia: Clinical course and predictors of outcome
44. Mild cognitive impairment in the elderly: Predictors of dementia
45. Very mild senile dementia of the Alzheimer type I. Clinical assessment
46. Neuron number in the entorhinal cortex and CA1 in preclinical Alzheimer's disease
47. Severe panencephalic Pick's disease with Alzheimer's disease-like neuropil threads and synaptophysin immunoreactiviry
48. The consortium to establish a registry for Alzheimer's disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease
49. Neuropathological staging of Alzheimer's disease
50. Consensus recommendations for the postmortem diagnosis of AD
51. Diagnosis of Alzheimer's disease
52. A rapid radiochemical method for the determination of choline aectyltransferase
53. Reinnervation of the hippocampal perforant pathway zone in Alzheimer's disease
54. Plasticity of hippocampal circuitry in Alzheimer's disease
55. Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease
56. Synaptic rearrangement in the dentate gyrus: Histochemical evidence of adjustments after lesions in immature and adult rats
57. Some connections of the entorhinal (area 28) and perirhinal (area 35) cortices in the rhesus monkey. II. Entorhinal cortex efferents
58. Alzheimer's disease: Cell-specific pathology isolates the hippocampal formation
59. Perforant pathway changes and memory impairment of Alzheimer's disease
60. Entorhinal cortex pathology in Alzheimer's disease
61. Loss of nerve growth factor receptor-containing neurons in Alzheimer's disease: A quantitative analysis across subregions of the basal forebrain
62. Cell loss and shrinkage in the nucleus basalis Meynert complex in Alzheimer's disease
63. Loss of nerve growth factor receptor-containing neurons in Alzheimer's disease: A quantitative analysis across regions of basal forebrain
64. Clinical, pathological and neurochemical changes in dementia: A subgroup with preserved mental status and numerous neocortical plaques
65. Antioxidants and reduced functional capacity in the elderly: Findings from the Nun Study
66. Do psychological risk factors contribute to Alzheimer's disease?
67. Staging of Alzheimer-related cortical destruction
68. The decline in synapses and cholinergic activity is asynchronous in Alzheimer's disease