The synthesis of parasitic cysteine protease and trypanothione reductase inhibitors

Current Medicinal Chemistry

Volumn 10, Issue 18, 2003, Pages 1863-1889

  Chibale, Kelly ^a   Musonda, Chitalu C ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

Cruzain; Falcipain 2; Inhibitors and synthesis; Rhodesain; Trypanothione reductase

Indexed keywords

ACRIDINE DERIVATIVE; AJOENE; ALLICIN; ANTILEISHMANIAL AGENT; ANTIMALARIAL AGENT; ANTIPARASITIC AGENT; ANTITRYPANOSOMAL AGENT; CHALCONE DERIVATIVE; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; GAMMA LACTAM DERIVATIVE; HYDRAZIDE DERIVATIVE; ISOQUINOLINE DERIVATIVE; KETONE DERIVATIVE; MALEIMIDE DERIVATIVE; NIFURTIMOX; NITROFURAN; PHENOTHIAZINE DERIVATIVE; PIPERAZINE DERIVATIVE; POLYAMINE DERIVATIVE; PROMAZINE; SPERMIDINE DERIVATIVE; SPERMINE DERIVATIVE; SUCCINIC ACID DERIVATIVE; SULFONE DERIVATIVE; THIOSEMICARBAZONE DERIVATIVE; THIOUREA DERIVATIVE; TRYPANOTHIONE REDUCTASE; TRYPANOTHIONE REDUCTASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

COMBINATORIAL CHEMISTRY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; HUMAN; LEISHMANIA; LEISHMANIASIS; MALARIA FALCIPARUM; METHODOLOGY; MOLECULAR WEIGHT; NONHUMAN; PARASITOSIS; PLASMODIUM FALCIPARUM; REVIEW; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA; TRYPANOSOMIASIS;

ANIMALS; ANTIPROTOZOAL AGENTS; CYSTEINE PROTEINASE INHIBITORS; ENZYME INHIBITORS; HUMANS; LEISHMANIA; MODELS, CHEMICAL; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; NADH, NADPH OXIDOREDUCTASES; TRYPANOSOMA;

EID: 0041921188     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/0929867033456963     Document Type: Review

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