Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors

Structure

Volumn 7, Issue 1, 1999, Pages 81-89

  Bond, Charles S ^a,d   Zhang, Yihong ^a,e   Berriman, Matthew ^b   Cunningham, Mark L ^c,f   Fairlamb, Alan H ^b   Hunter, William N ^b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

^c LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^d UNIVERSITY OF SYDNEY   (Australia)

^e NATIONAL INSTITUTES OF HEALTH   (United States)

^f WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cadabacine; Chagas' disease; Lunarine; Oxidoreductase; Trypanothione reductase

Indexed keywords

GLUTATHIONE; GLUTATHIONE REDUCTASE; NATURAL PRODUCT; POLYAMINE; TRYPANOTHIONE REDUCTASE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL INTERACTION; DISULFIDE BOND; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; HUMAN; HUMAN TISSUE; MOLECULAR INTERACTION; MOLECULAR MODEL; PARASITE VIRULENCE; POLYAMINE SYNTHESIS; PRIORITY JOURNAL; STRUCTURE ANALYSIS; TRYPANOSOMA CRUZI;

EID: 0033555451     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(99)80011-2     Document Type: Article

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