Ajoene is an inhibitor and subversive substrate of human glutathione reductase and Trypanosoma cruzi trypanothione reductase: Crystallographic, kinetic, and spectroscopic studies

Journal of Medicinal Chemistry

Volumn 42, Issue 3, 1999, Pages 364-372

  Gallwitz, Helge ^a   Bonse, Susanne ^a,b   Martinez Cruz, Alfonso ^b   Schlichting, Ilme ^c   Schumacher, Karin ^d   Krauth Siegel, R Luise ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

^c MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^d HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4,8,9,13 TETRATHIAHEXADECA 1,6,10,15 TETRAENE; AJOENE; ANTIOXIDANT; CYTOCHROME C; DEOXYAJOENE; DISULFIDE; DRUG METABOLITE; FLAVOPROTEIN; GLUTATHIONE REDUCTASE; NATURAL PRODUCT; OXIDOREDUCTASE; SUPEROXIDE; TRYPANOTHIONE REDUCTASE; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; CYTOSTASIS; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME SUBSTRATE; GARLIC; HUMAN; NONHUMAN; OXIDATIVE STRESS; SPECTROSCOPY; TRYPANOSOMA CRUZI;

ANIMALS; BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; DISULFIDES; ENZYME INHIBITORS; GLUTATHIONE REDUCTASE; HUMANS; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; NADH, NADPH OXIDOREDUCTASES; OXIDATION-REDUCTION; PLANT EXTRACTS; TRYPANOSOMA CRUZI;

EID: 0033048630     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980471k     Document Type: Article

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