Synthesis and antitrypanosomal evaluation of E-isomers of 5-nitro-2- furaldehyde and 5-nitrothtophene-2-carboxaldehyde de semicarbazone derivatives. Structure-activity relationships

European Journal of Medicinal Chemistry

Volumn 35, Issue 3, 2000, Pages 343-350

  Cerecetto, Hugo ^a   Di Maio, Rossanna ^a   González, Mercedes ^b   Risso, Mariela ^a   Sagrera, Gabriel ^b   Seoane, Gustavo ^a   Denicola, Ana ^b   Peluffo, Gonzalo ^c   Quijano, Celia ^b,c   Stoppani, Andrés O M ^d   Paulino, Margot ^b   Olea Azar, Claudio ^e   Basombrío, Miguel Angel ^f  

^a UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^b UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^c DEPARTAMENTO DE BIOQUÍMICA   (Uruguay)

^d UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^e UNIVERSITY OF CHILE   (Chile)

^f UNIVERSIDAD NACIONAL DE SALTA   (Argentina)

Author keywords

5 nitrofurfural and 5 nitrothiophene 2 carboxaldehyde semicarbazones; Antitrypanosomal activity; In vivo evaluation

Indexed keywords

5 NITROTHIOPHENE 2 CARBOXALDEHYDE SEMICARBAZONE; BENZNIDAZOLE; NIFURTIMOX; NITROFURAL; SEMICARBAZONE DERIVATIVE; SPERMIDINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHAGAS DISEASE; CONTROLLED STUDY; DRUG EFFICACY; DRUG SOLUBILITY; DRUG SYNTHESIS; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; NUCLEAR OVERHAUSER EFFECT; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA CRUZI; TRYPANOSOMIASIS; TRYPOMASTIGOTE;

EID: 0342293303     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(00)00131-8     Document Type: Article

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