Crystal structure of the Trypanosoma cruzi trypanothione reductase·mepacrine complex

Proteins: Structure, Function and Genetics

Volumn 24, Issue 1, 1996, Pages 73-80

  Jacoby, Elke M ^a,b   Schlichting, Ilme ^b,c   Lantwin, Christina B ^b   Kabsch, Wolfgang ^b   Krauth Siegel, R Luise ^a,d  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

^c MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^d Institut fur Biochemie I   (Germany)

Author keywords

drug target; flavoenzyme; Trypanosoma cruzi; X ray crystallography

Indexed keywords

MEPACRINE; OXIDOREDUCTASE; TRYPANOTHIONE;

AMINO ACID SEQUENCE; ANTIPROTOZOAL ACTIVITY; ARTICLE; BINDING COMPETITION; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ANALYSIS; TRYPANOSOMA CRUZI; X RAY CRYSTALLOGRAPHY;

ACRIDINES; ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; KINETICS; MODELS, MOLECULAR; NADH, NADPH OXIDOREDUCTASES; PROTEIN CONFORMATION; QUINACRINE; SUBSTRATE SPECIFICITY; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 0030057025     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0134(199601)24:1<73::AID-PROT5>3.0.CO;2-P     Document Type: Article

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