Structure-based design, synthesis and evaluation of conformationally constrained cysteine protease inhibitors

Bioorganic and Medicinal Chemistry

Volumn 6, Issue 12, 1998, Pages 2477-2494

  Scheidt, Karl A ^a,b   Roush, William R ^a,b   McKerrow, James H ^c   Selzer, Paul M ^c   Hansell, Elizabeth ^c   Rosenthal, Philip J ^c  

^a INDIANA UNIVERSITY   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Conformationally constrained peptidyl aldehydes; Cysteine protease inhibitors; Peptidyl vinyl sulfones

Indexed keywords

CRUZIPAIN; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR;

AMINO ACID COMPOSITION; ARTICLE; CRYSTALLOGRAPHY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IN VITRO STUDY; LEISHMANIA MAJOR; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION;

LEISHMANIA MAJOR; PLASMODIUM FALCIPARUM; TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 0032436499     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(98)80022-9     Document Type: Article

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