Parallel synthesis of a library of 1,4-Naphthoquinones and automated screening of potential inhibitors of trypanothione reductase from Trypanosoma cruzi

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 7, 2000, Pages 631-635

  Salmon Chemin, Laurence ^a   Lemaire, Anick ^a   De Freitas, Stéphanie ^a   Deprez, Benoît ^a,b   Sergheraert, Christian ^a   Davioud Charvet, Elisabeth ^a  

^a UNIV LILLE   (France)

^b DEVGEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; JUGLONE; MENADIONE; PEPTIDE LIBRARY; PLUMBAGIN; TRYPANOTHIONE REDUCTASE;

ARTICLE; DRUG DESIGN; DRUG INHIBITION; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; NONHUMAN; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA CRUZI;

ANIMALS; ANTIPROTOZOAL AGENTS; AUTOMATION; DRUG EVALUATION, PRECLINICAL; INHIBITORY CONCENTRATION 50; NADH, NADPH OXIDOREDUCTASES; NAPHTHOQUINONES; QUALITY CONTROL; TRYPANOSOMA CRUZI;

PROTOZOA; TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 0034599953     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00056-1     Document Type: Article

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