Aryl ureas represent a new class of anti-trypanosomal agents

Chemistry and Biology

Volumn 7, Issue 9, 2000, Pages 733-742

  Du, Xiaohui ^a   Hansell, Elizabeth ^b   Engel, Juan C ^b   Caffrey, Conor R ^b   Cohen, Fred E ^a,b   McKerrow, James H ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cysteine protease; DOCK; Structure based drug design; Thiourea; Trypanosomal disease; Urea

Indexed keywords

ANTITRYPANOSOMAL AGENT; CRUZAIN, TRYPANOSOMA CRUZI; CYSTEINE PROTEINASE; DRUG DERIVATIVE; ENZYME INHIBITOR; IMIDAZOLE DERIVATIVE; PROTOZOAL PROTEIN; SULFONAMIDE; THIOUREA;

ANIMAL; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; DRUG DESIGN; DRUG EFFECT; ENZYMOLOGY; HUMAN; METABOLISM; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI;

ANIMALS; CYSTEINE ENDOPEPTIDASES; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTOZOAN PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; THIOUREA; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMA CRUZI;

ANIMALIA; TRYPANOSOMA; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI;

EID: 0033830860     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(00)00018-1     Document Type: Article

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