Phenothiazine inhibitors of trypanothione reductase as potential antitrypanosomal and antileishmanial drugs

Journal of Medicinal Chemistry

Volumn 41, Issue 2, 1998, Pages 148-156

  Chan, Cecil ^a   Yin, Hong ^a   Garforth, Jacqui ^a   McKie, James H ^a   Jaouhari, Rabih ^a   Speers, Peter ^a   Douglas, Kenneth T ^a   Rock, Peter J ^b   Yardley, Vanessa ^b   Croft, Simon L ^b   Fairlamb, Alan H ^c  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLPROMAZINE; CHLORPROMAZINE DERIVATIVE; GLUTATHIONE; GLUTATHIONE REDUCTASE; OXIDOREDUCTASE; PHENOTHIAZINE DERIVATIVE; PROMAZINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TRIFLUOPERAZINE; TRYPANOTHIONE; TRYPANOTHIONE REDUCTASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG DESIGN; LEISHMANIA DONOVANI; LEISHMANIASIS; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI; TRYPANOSOMIASIS;

ANIMALS; ANTIPROTOZOAL AGENTS; BINDING SITES; CRITHIDIA FASCICULATA; ENZYME INHIBITORS; GLUTATHIONE DISULFIDE; GLUTATHIONE REDUCTASE; KINETICS; LEISHMANIA DONOVANI; MODELS, CHEMICAL; NADH, NADPH OXIDOREDUCTASES; NADP; PHENOTHIAZINES; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMA CRUZI;

EID: 15144347577     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960814j     Document Type: Article

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