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Volumn 2, Issue 23, 2000, Pages 3639-3642

Inhibition of trypanothione reductase by substrate analogues

Author keywords

[No Author keywords available]

Indexed keywords

DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; ENZYME INHIBITOR; GLUTATHIONE REDUCTASE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; OXIDOREDUCTASE; TRYPANOTHIONE REDUCTASE;

EID: 0034676618     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol0065423     Document Type: Article
Times cited : (34)

References (39)
  • 25
    • 85037492429 scopus 로고    scopus 로고
    • TR amino acid residue numbering is that of the T. cruzi enzyme
    • TR amino acid residue numbering is that of the T. cruzi enzyme.
  • 26
    • 85037519526 scopus 로고    scopus 로고
    • One TR-selective covalent inhibitor was recently reported; see ref 4a.
    • One TR-selective covalent inhibitor was recently reported; see ref 4a.
  • 28
    • 0026714017 scopus 로고
    • This synthesis was inspired by Jurgens' asymmetric synthesis or a diaminopimelic acid derivative, see: Jurgens, A. R. Tetrahedon Lett. 1992, 33, 4727-4730.
    • (1992) Tetrahedon Lett. , vol.33 , pp. 4727-4730
    • Jurgens, A.R.1
  • 29
    • 85037507238 scopus 로고    scopus 로고
    • CH=CH = 15.6 Hz). No trans isomer was observed in the NMR spectrum of this compound
    • CH=CH = 15.6 Hz). No trans isomer was observed in the NMR spectrum of this compound.
  • 33
    • 85037496236 scopus 로고    scopus 로고
    • Our low yield in this normally high-yielding Fmoc deprotection reaction was the result of accidental loss of material during purification
    • Our low yield in this normally high-yielding Fmoc deprotection reaction was the result of accidental loss of material during purification.
  • 39
    • 0018735516 scopus 로고
    • We also attempted to fit the data to the uncompetitive and noncompetitive inhibition models using Cleland's UNCOMP and NCOMP programs. As expected, the data for each inhibitor either failed to fit these models or gave a fit significantly worse than that obtained with the competitive model. Cleland, W. W. Methods Enzymol. 1979, 63, 103-138.
    • (1979) Methods Enzymol. , vol.63 , pp. 103-138
    • Cleland, W.W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.