Trypanothione reductase inhibition/trypanocidal activity relationships in a 1,4-bis(3-aminopropyl)piperazine series

Bioorganic and Medicinal Chemistry

Volumn 8, Issue 1, 2000, Pages 95-103

  Bonnet, B Éatrice ^a   Soullez, David ^a   Girault, Sophie ^a   Maes, Louis ^b   Landry, Valérie ^a   Davioud Charvet, Elisabeth ^a   Sergheraert, Christian ^a  

^a CNRS   (France)

^b JANSSEN RESEARCH FOUNDATION   (Belgium)

Author keywords

Antiparasitics; Chemotherapy; Enzyme inhibitors; Polycyclic heterocyclic compounds

Indexed keywords

1,4 BIS(3 AMINOPROPYL)PIPERAZINE; ANTITRYPANOSOMAL AGENT; PIPERAZINE DERIVATIVE; TRYPANOTHIONE REDUCTASE; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REACTION ANALYSIS; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI;

ANIMALS; CELL LINE; CELL SURVIVAL; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; NADH, NADPH OXIDOREDUCTASES; PIPERAZINES; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

TRYPANOSOMA; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI;

EID: 0034101748     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00268-0     Document Type: Article

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