Polyamine derivatives as inhibitors of trypanothione reductase and assessment of their trypanocidal activities

Bioorganic and Medicinal Chemistry

Volumn 5, Issue 12, 1997, Pages 2145-2155

  O'Sullivan, Mary C ^a   Zhou, Qibing ^a   Li, Zhili ^a   Durham, Timothy B ^a   Rattendi, Donna ^b   Lane, Schennella ^b   Bacchi, Cyrus J ^b  

^a INDIANA STATE UNIVERSITY   (United States)

^b PACE UNIVERSITY   (United States)

Author keywords

Polyamine; Spermidine; Spermine; Trypanosome; Trypanothione reductase

Indexed keywords

ANTITRYPANOSOMAL AGENT; POLYAMINE DERIVATIVE; SPERMIDINE DERIVATIVE; TRYPANOTHIONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG ACTIVITY; DRUG SYNTHESIS; INTRAPERITONEAL DRUG ADMINISTRATION; LEISHMANIA; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARASITEMIA; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA;

ANIMALS; ENZYME INHIBITORS; FEMALE; MICE; MODELS, CHEMICAL; NADH, NADPH OXIDOREDUCTASES; SPERMIDINE; SPERMINE; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

EID: 0031451002     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(97)00157-0     Document Type: Article

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