Rational drug design using trypanothione reductase as a target for anti-trypanosomal and anti-leishmanial drug leads

Drug Design and Discovery

Volumn 16, Issue 1, 1999, Pages 5-23

  Austin, Susan E ^a   Khan, M Omar F ^a   Douglas, Kenneth T ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Chagas' disease; Glutathione; Imipramines; NADPH; Phenothiazines; Reductase; Trypanothione

Indexed keywords

ANTILEISHMANIAL AGENT; ANTITRYPANOSOMAL AGENT; BENZNIDAZOLE; CHLORPROMAZINE; CRYSTAL VIOLET; EFLORNITHINE; IMIPRAMINE; MEGLUMINE ANTIMONATE; MELARSOPROL; MEPACRINE; NIFURTIMOX; OXIDOREDUCTASE; PENTAMIDINE; PHENOTHIAZINE DERIVATIVE; STIBOGLUCONATE SODIUM;

COMPETITIVE INHIBITION; COMPUTER MODEL; DRUG ACTIVITY; DRUG DESIGN; DRUG STRUCTURE; DRUG TARGETING; DRUG TOXICITY; ENZYME STRUCTURE; HUMAN; LEISHMANIASIS; NONHUMAN; REVIEW; SIDE EFFECT; TRYPANOSOMIASIS;

ADRENERGIC UPTAKE INHIBITORS; ANTIPARASITIC AGENTS; DRUG DESIGN; ENZYME INHIBITORS; GLUTATHIONE; IMIPRAMINE; LEISHMANIASIS; MASTIGOPHORA INFECTIONS; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; OXIDOREDUCTASES; PHENOTHIAZINES; SEQUENCE HOMOLOGY, AMINO ACID; SPECIES SPECIFICITY; SPERMIDINE; TRYPANOSOMIASIS;

EID: 0032866917     PISSN: 10559612     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

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