메뉴 건너뛰기




Volumn 3, Issue 3, 2003, Pages 193-203

Taxanes: Microtubule and centrosome targets, and cell cycle dependent mechanisms of action

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TUBULIN; ANTINEOPLASTIC AGENT; BACCATIN III; BETA TUBULIN; COLCHICINE; CRYPTOPHYCIN DERIVATIVE; CYTOTOXIC AGENT; DISCODERMOLIDE; DOCETAXEL; ELEUTHEROBIN; EPOTHILONE DERIVATIVE; FLUORESCENT DYE; LAULIMALIDE; PACLITAXEL; PROTEIN BCL 2; PROTEIN P53; TAXANE DERIVATIVE; VINCA ALKALOID;

EID: 0038216623     PISSN: 15680096     EISSN: None     Source Type: Journal    
DOI: 10.2174/1568009033481967     Document Type: Review
Times cited : (340)

References (152)
  • 1
    • 0034743675 scopus 로고    scopus 로고
    • Structural insight into microtubule function
    • Nogales, E. Structural Insight into Microtubule Function. Annu. Rev. Biophys. Biomol. Struct. 2001, 30, 397-420.
    • (2001) Annu. Rev. Biophys. Biomol. Struct. , vol.30 , pp. 397-420
    • Nogales, E.1
  • 2
    • 0024527982 scopus 로고
    • Role of nucleotide hydrolysis in the dynamics of actin filaments and microtubules
    • Carlier, M. F. Role of Nucleotide Hydrolysis in the Dynamics of Actin Filaments and Microtubules. Int. Rev. Cytol. 1989, 115, 139-170.
    • (1989) Int. Rev. Cytol. , vol.115 , pp. 139-170
    • Carlier, M.F.1
  • 4
    • 0028879986 scopus 로고
    • Nucleation of microtubule assembly by a gamma-tubulin-containing ring complex
    • Zheng, Y.; Wong, M. L.; Alberts, B.; Mitchison, T. Nucleation of Microtubule Assembly by a Gamma-Tubulin-Containing Ring Complex. Nature 1995, 378, 578-583.
    • (1995) Nature , vol.378 , pp. 578-583
    • Zheng, Y.1    Wong, M.L.2    Alberts, B.3    Mitchison, T.4
  • 5
    • 0018147902 scopus 로고
    • Kinetic analysis of cooperativity in tubulin polymerization in the presence of guanosine Di- or triphosphate nucleotides
    • Carlier, M. F.; Pantaloni, D. Kinetic Analysis of Cooperativity in Tubulin Polymerization in the Presence of Guanosine Di- or Triphosphate Nucleotides. Biochemistry 1978, 17, 1908-1915.
    • (1978) Biochemistry , vol.17 , pp. 1908-1915
    • Carlier, M.F.1    Pantaloni, D.2
  • 6
    • 0032191054 scopus 로고    scopus 로고
    • Microtubule treadmilling: What goes around comes around
    • Margolis, R. L.; Wilson, L. Microtubule Treadmilling: What Goes Around Comes Around. Bioessays 1998, 20, 830-836.
    • (1998) Bioessays , vol.20 , pp. 830-836
    • Margolis, R.L.1    Wilson, L.2
  • 7
    • 0031172760 scopus 로고    scopus 로고
    • Microtubule dynamics: Treadmilling comes around again
    • Waterman-Storer, C. M.; Salmon, E. D. Microtubule Dynamics: Treadmilling Comes around Again. Curr. Biol. 1997, 7, R369-R372.
    • (1997) Curr. Biol. , vol.7
    • Waterman-Storer, C.M.1    Salmon, E.D.2
  • 8
    • 0021686169 scopus 로고
    • Dynamic instability of microtubule growth
    • Mitchison, T.; Kirschner, M. Dynamic Instability of Microtubule Growth. Nature 1984, 312, 237-42.
    • (1984) Nature , vol.312 , pp. 237-242
    • Mitchison, T.1    Kirschner, M.2
  • 9
    • 0033214537 scopus 로고    scopus 로고
    • A structural view of microtubule dynamics
    • Nogales, E. A Structural View of Microtubule Dynamics. Cell Mol. Life Sci. 1999, 56, 133-142.
    • (1999) Cell Mol. Life Sci. , vol.56 , pp. 133-142
    • Nogales, E.1
  • 10
    • 0030059247 scopus 로고    scopus 로고
    • Morphogenetic properties of microtubules and mitotic spindle assembly
    • Hyman, A. A.; Karsenti, E. Morphogenetic Properties of Microtubules and Mitotic Spindle Assembly. Cell 1996, 84, 401-410.
    • (1996) Cell , vol.84 , pp. 401-410
    • Hyman, A.A.1    Karsenti, E.2
  • 11
    • 0028241003 scopus 로고
    • Dynamic instability of microtubules as an efficient way to search in space
    • Holy, T. E.; Leibler, S. Dynamic Instability of Microtubules as an Efficient Way to Search in Space. Proc. Natl. Acad. Sci. USA 1994, 91, 5682-5685.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 5682-5685
    • Holy, T.E.1    Leibler, S.2
  • 12
    • 0030048731 scopus 로고    scopus 로고
    • Identification of a protein that interacts with tubulin dimers and increases the catastrophe rate of microtubules
    • Belmont, L. D.; Mitchison, T. J. Identification of a Protein That Interacts with Tubulin Dimers and Increases the Catastrophe Rate of Microtubules. Cell 1996, 84, 623-631.
    • (1996) Cell , vol.84 , pp. 623-631
    • Belmont, L.D.1    Mitchison, T.J.2
  • 13
    • 0036468982 scopus 로고    scopus 로고
    • The oncoprotein 18/stathmin family of microtubule destabilizers
    • Cassimeris, L. The Oncoprotein 18/Stathmin Family of Microtubule Destabilizers. Curr. Opin. Cell Biol. 2002, 14, 18-24.
    • (2002) Curr. Opin. Cell Biol. , vol.14 , pp. 18-24
    • Cassimeris, L.1
  • 14
    • 0030031999 scopus 로고    scopus 로고
    • Xkcm1: A xenopus kinesin-related protein that regulates microtubule dynamics during mitotic spindle assembly
    • Walczak, C. E.; Mitchison, T. J.; Desai, A. Xkcm1: A Xenopus Kinesin-Related Protein That Regulates Microtubule Dynamics During Mitotic Spindle Assembly. Cell 1996, 84, 37-47.
    • (1996) Cell , vol.84 , pp. 37-47
    • Walczak, C.E.1    Mitchison, T.J.2    Desai, A.3
  • 15
    • 0028062756 scopus 로고
    • Xmap from xenopus eggs promotes rapid plus end assembly of microtubules and rapid microtubule polymer turnover
    • Vasquez, R. J.; Gard, D. L.; Cassimeris, L. Xmap from Xenopus Eggs Promotes Rapid Plus End Assembly of Microtubules and Rapid Microtubule Polymer Turnover. J. Cell Biol. 1994, 127, 985-993.
    • (1994) J. Cell Biol. , vol.127 , pp. 985-993
    • Vasquez, R.J.1    Gard, D.L.2    Cassimeris, L.3
  • 16
    • 0033280668 scopus 로고    scopus 로고
    • The road less traveled: Emerging principles of kinesin motor utilization
    • Goldstein, L. S.; Philp, A. V. The Road Less Traveled: Emerging Principles of Kinesin Motor Utilization. Annu. Rev. Cell Dev. Bio. 1999, 15, 141-183.
    • (1999) Annu. Rev. Cell Dev. Bio. , vol.15 , pp. 141-183
    • Goldstein, L.S.1    Philp, A.V.2
  • 17
    • 0034677929 scopus 로고    scopus 로고
    • The dynein microtubule motor
    • King, S. M. The Dynein Microtubule Motor. Biochim. Biophys. Acta 2000, 1496, 60-75.
    • (2000) Biochim. Biophys. Acta , vol.1496 , pp. 60-75
    • King, S.M.1
  • 19
    • 13144251122 scopus 로고    scopus 로고
    • A model for the proposed roles of different microtubule-based motor proteins in establishing spindle bipolarity
    • Walczak, C. E.; Vernos, I.; Mitchison, T. J.; Karsenti, E.; Heald, R. A Model for the Proposed Roles of Different Microtubule-Based Motor Proteins in Establishing Spindle Bipolarity. Curr. Biol. 1998, 8, 903-913.
    • (1998) Curr. Biol. , vol.8 , pp. 903-913
    • Walczak, C.E.1    Vernos, I.2    Mitchison, T.J.3    Karsenti, E.4    Heald, R.5
  • 20
    • 0033003162 scopus 로고    scopus 로고
    • Numa is a component of an insoluble matrix at mitotic spindle poles
    • Dionne, M. A.; Howard, L.; Compton, D. A. Numa Is a Component of an Insoluble Matrix at Mitotic Spindle Poles. Cell Motil. Cytoskeleton 1999, 42, 189-203.
    • (1999) Cell Motil. Cytoskeleton , vol.42 , pp. 189-203
    • Dionne, M.A.1    Howard, L.2    Compton, D.A.3
  • 21
    • 0031709688 scopus 로고    scopus 로고
    • The centrosome - A tiny organelle with big potential
    • Doxsey, S. The Centrosome - a Tiny Organelle with Big Potential. Nat. Genet. 1998, 20, 104-106.
    • (1998) Nat. Genet. , vol.20 , pp. 104-106
    • Doxsey, S.1
  • 22
    • 0030910037 scopus 로고    scopus 로고
    • p53 and ATM: Cell cycle, cell death, and cancer
    • Morgan, S. E.; Kastan, M. B. p53 and ATM: Cell Cycle, Cell Death, and Cancer. Adv. Cancer Res. 1997, 71, 1-25.
    • (1997) Adv. Cancer Res. , vol.71 , pp. 1-25
    • Morgan, S.E.1    Kastan, M.B.2
  • 23
    • 0031040149 scopus 로고    scopus 로고
    • The development and clinical utility of the taxane class of antimicrotubule chemotherapy agents
    • Rowinsky, E. K. The Development and Clinical Utility of the Taxane Class of Antimicrotubule Chemotherapy Agents. Annu. Rev. Med. 1997, 48, 353-374.
    • (1997) Annu. Rev. Med. , vol.48 , pp. 353-374
    • Rowinsky, E.K.1
  • 24
    • 0032006059 scopus 로고    scopus 로고
    • Microtubules and actin filaments: Dynamic targets for cancer chemotherapy
    • Jordan, M. A.; Wilson, L. Microtubules and Actin Filaments: Dynamic Targets for Cancer Chemotherapy. Curr. Opin. Cell Biol. 1998, 10, 123-130.
    • (1998) Curr. Opin. Cell Biol. , vol.10 , pp. 123-130
    • Jordan, M.A.1    Wilson, L.2
  • 28
    • 0034518173 scopus 로고    scopus 로고
    • Structural basis for the interaction of tubulin with proteins and drugs that affect microtubule dynamics
    • Downing, K. H. Structural Basis for the Interaction of Tubulin with Proteins and Drugs That Affect Microtubule Dynamics. Annu. Rev. Cell Dev. Biol. 2000, 16, 89-111.
    • (2000) Annu. Rev. Cell Dev. Biol. , vol.16 , pp. 89-111
    • Downing, K.H.1
  • 29
    • 0033083045 scopus 로고    scopus 로고
    • Laulimalide and isolaulimalide, new paclitaxel-like microtubule-stabilizing agents
    • Mooberry, S. L.; Tien, G.; Hernandez, A. H.; Plubrukarn, A.; Davidson, B. S. Laulimalide and Isolaulimalide, New Paclitaxel-Like Microtubule-Stabilizing Agents. Cancer Res. 1999, 59, 653-660.
    • (1999) Cancer Res. , vol.59 , pp. 653-660
    • Mooberry, S.L.1    Tien, G.2    Hernandez, A.H.3    Plubrukarn, A.4    Davidson, B.S.5
  • 30
    • 18444400213 scopus 로고    scopus 로고
    • The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for activity
    • Pryor, D. E.; O'Brate, A.; Bilcer, G.; Diaz, J. F.; Wang, Y.; Kabaki, M.; Jung, M. K.; Andreu, J. M.; Ghosh, A. K.; Giannakakou, P.; Hamel, E. The Microtubule Stabilizing Agent Laulimalide Does Not Bind in the Taxoid Site, Kills Cells Resistant to Paclitaxel and Epothilones, and May Not Require Its Epoxide Moiety for Activity. Biochemistry 2002, 41, 9109-9115.
    • (2002) Biochemistry , vol.41 , pp. 9109-9115
    • Pryor, D.E.1    O'Brate, A.2    Bilcer, G.3    Diaz, J.F.4    Wang, Y.5    Kabaki, M.6    Jung, M.K.7    Andreu, J.M.8    Ghosh, A.K.9    Giannakakou, P.10    Hamel, E.11
  • 31
    • 0034041275 scopus 로고    scopus 로고
    • Recent advances in the chemistry of taxol
    • Kingston, D. G. Recent Advances in the Chemistry of Taxol. J. Nat. Prod. 2000, 63, 726-734.
    • (2000) J. Nat. Prod. , vol.63 , pp. 726-734
    • Kingston, D.G.1
  • 32
    • 0001318007 scopus 로고
    • Relationships between the structures of taxol and baccatine III. Derivatives and their in vitro action on the disassembly of mammalian brain and physarum amoebal microtubules
    • Lataste, H.; Senilh, V.; Wright, M.; Guenard, D.; Potier, P. Relationships between the Structures of Taxol and Baccatine III. Derivatives and Their in Vitro Action on the Disassembly of Mammalian Brain and Physarum Amoebal Microtubules. Proc. Natl. Acad. Sci. USA 1984, 81, 4090-4.
    • (1984) Proc. Natl. Acad. Sci. USA , vol.81 , pp. 4090-4094
    • Lataste, H.1    Senilh, V.2    Wright, M.3    Guenard, D.4    Potier, P.5
  • 33
    • 0028605783 scopus 로고
    • Is taxol a surrogate for a universal regulator of mitosis?
    • Suffness, M. Is Taxol a Surrogate for a Universal Regulator of Mitosis? In Vivo 1994, 8, 867-878.
    • (1994) In Vivo , vol.8 , pp. 867-878
    • Suffness, M.1
  • 34
    • 0034636084 scopus 로고    scopus 로고
    • A common pharmacophore for taxol the epothilones based on the biological activity of a taxane molecule lacking a C-13 side chain
    • He, L.; Jagtap, P. G.; Kingston, D. G.; Shen, H. J.; Orr, G. A.; Horwitz, S. B. A Common Pharmacophore for Taxol and the Epothilones Based on the Biological Activity of a Taxane Molecule Lacking a C-13 Side Chain. Biochemistry 2000, 39, 3972-3978.
    • (2000) Biochemistry , vol.39 , pp. 3972-3978
    • He, L.1    Jagtap, P.G.2    Kingston, D.G.3    Shen, H.J.4    Orr, G.A.5    Horwitz, S.B.6
  • 35
    • 0032731664 scopus 로고    scopus 로고
    • Apoptotic cell death induced by baccatin Iii, a precursor of paclitaxel, may occur without G(2)/M arrest
    • Miller, M. C., 3rd; Johnson, K. R.; Willingham, M. C.; Fan, W. Apoptotic Cell Death Induced by Baccatin Iii, a Precursor of Paclitaxel, May Occur without G(2)/M Arrest. Cancer Chemother. Pharmacol. 1999, 44, 444-452.
    • (1999) Cancer Chemother. Pharmacol. , vol.44 , pp. 444-452
    • Miller M.C. III1    Johnson, K.R.2    Willingham, M.C.3    Fan, W.4
  • 38
    • 0033621479 scopus 로고    scopus 로고
    • Characterization of the taxol binding site on the microtubule. Identification of Arg(282) in beta-tubulin as the site of photoincorporation of a 7-benzophenone analogue of taxol
    • Rao, S.; He, L.; Chakravarty, S.; Ojima, I.; Orr, G. A.; Horwitz, S. B. Characterization of the Taxol Binding Site on the Microtubule. Identification of Arg(282) in Beta-Tubulin as the Site of Photoincorporation of a 7-Benzophenone Analogue of Taxol. J. Biol. Chem. 1999, 274, 37990-37994.
    • (1999) J. Biol. Chem. , vol.274 , pp. 37990-37994
    • Rao, S.1    He, L.2    Chakravarty, S.3    Ojima, I.4    Orr, G.A.5    Horwitz, S.B.6
  • 39
    • 0035942226 scopus 로고    scopus 로고
    • The binding conformation of taxol in beta-tubulin: A model based on electron crystallographic density
    • Snyder, J. P.; Nettles, J. H.; Cornett, B.; Downing, K. H.; Nogales, E. The Binding Conformation of Taxol in Beta-Tubulin: A Model Based on Electron Crystallographic Density. Proc. Natl. Acad. Sci. USA 2001, 98, 5312-5316.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 5312-5316
    • Snyder, J.P.1    Nettles, J.H.2    Cornett, B.3    Downing, K.H.4    Nogales, E.5
  • 40
    • 0035834034 scopus 로고    scopus 로고
    • The interaction of baccatin Iii with the taxol binding site of microtubules determined by a homogeneous assay with fluorescent taxoid
    • Andreu, J. M.; Barasoain, I. The Interaction of Baccatin Iii with the Taxol Binding Site of Microtubules Determined by a Homogeneous Assay with Fluorescent Taxoid. Biochemistry 2001, 40, 11975-11984.
    • (2001) Biochemistry , vol.40 , pp. 11975-11984
    • Andreu, J.M.1    Barasoain, I.2
  • 41
    • 0027360552 scopus 로고
    • Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations
    • Jordan, M. A.; Toso, R. J.; Thrower, D.; Wilson, L. Mechanism of Mitotic Block and Inhibition of Cell Proliferation by Taxol at Low Concentrations. Proc. Natl. Acad. Sci. USA 1993, 90, 9552-9556.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 9552-9556
    • Jordan, M.A.1    Toso, R.J.2    Thrower, D.3    Wilson, L.4
  • 42
    • 0032933622 scopus 로고    scopus 로고
    • Taxol suppresses dynamics of individual microtubules in living human tumor cells
    • Yvon, A. M.; Wadsworth, P.; Jordan, M. A. Taxol Suppresses Dynamics of Individual Microtubules in Living Human Tumor Cells. Mol. Biol. Cell 1999, 10, 947-959.
    • (1999) Mol. Biol. Cell , vol.10 , pp. 947-959
    • Yvon, A.M.1    Wadsworth, P.2    Jordan, M.A.3
  • 43
  • 44
    • 0030020158 scopus 로고    scopus 로고
    • Mitotic block induced in hela cells by low concentrations of paclitaxel (taxol) results in abnormal mitotic exit and apoptotic cell death
    • Jordan, M. A.; Wendell, K.; Gardiner, S.; Derry, W. B.; Copp, H.; Wilson, L. Mitotic Block Induced in Hela Cells by Low Concentrations of Paclitaxel (Taxol) Results in Abnormal Mitotic Exit and Apoptotic Cell Death. Cancer Res. 1996, 56, 816-825.
    • (1996) Cancer Res. , vol.56 , pp. 816-825
    • Jordan, M.A.1    Wendell, K.2    Gardiner, S.3    Derry, W.B.4    Copp, H.5    Wilson, L.6
  • 45
    • 0031762622 scopus 로고    scopus 로고
    • Submicromolar paclitaxel induces apoptosis in human gastric cancer cells at early G1 phase
    • Lin, H. L.; Chang, Y. F.; Liu, T. Y.; Wu, C. W.; Chi, C. W. Submicromolar Paclitaxel Induces Apoptosis in Human Gastric Cancer Cells at Early G1 Phase. Anticancer Res. 1998, 18, 3443-3449.
    • (1998) Anticancer Res. , vol.18 , pp. 3443-3449
    • Lin, H.L.1    Chang, Y.F.2    Liu, T.Y.3    Wu, C.W.4    Chi, C.W.5
  • 46
    • 0029328641 scopus 로고
    • Taxol-induced mitotic block triggers rapid onset of a P53-independent apoptotic pathway
    • Woods, C. M.; Zhu, J.; McQueney, P. A.; Bollag, D.; Lazarides, E. Taxol-Induced Mitotic Block Triggers Rapid Onset of a P53-Independent Apoptotic Pathway. Mol. Med. 1995, 1, 506-526.
    • (1995) Mol. Med. , vol.1 , pp. 506-526
    • Woods, C.M.1    Zhu, J.2    McQueney, P.A.3    Bollag, D.4    Lazarides, E.5
  • 49
    • 0007463081 scopus 로고
    • Taxol induces the assembly of free microtubules in living cells and blocks the organizing capacity of the centrosomes and kinetochores
    • De Brabander, M.; Geuens, G.; Nuydens, R.; Willebrords, R.; De Mey, J. Taxol Induces the Assembly of Free Microtubules in Living Cells and Blocks the Organizing Capacity of the Centrosomes and Kinetochores. Proc. Natl. Acad. Sci. USA 1981, 78, 5608-5612.
    • (1981) Proc. Natl. Acad. Sci. USA , vol.78 , pp. 5608-5612
    • De Brabander, M.1    Geuens, G.2    Nuydens, R.3    Willebrords, R.4    De Mey, J.5
  • 51
    • 0036531790 scopus 로고    scopus 로고
    • Differential mitotic responses to microtubule-stabilizing and -destabilizing drugs
    • Chen, J. G.; Horwitz, S. B. Differential Mitotic Responses to Microtubule-Stabilizing and -Destabilizing Drugs. Cancer Res. 2002, 62, 1935-1938.
    • (2002) Cancer Res. , vol.62 , pp. 1935-1938
    • Chen, J.G.1    Horwitz, S.B.2
  • 52
    • 0032529464 scopus 로고    scopus 로고
    • Mechanisms of taxol-induced cell death are concentration dependent
    • Torres, K.; Horwitz, S. B. Mechanisms of Taxol-Induced Cell Death Are Concentration Dependent. Cancer Res. 1998, 58, 3620-3626.
    • (1998) Cancer Res. , vol.58 , pp. 3620-3626
    • Torres, K.1    Horwitz, S.B.2
  • 55
    • 0028070358 scopus 로고
    • Paclitaxel inhibits progression of mitotic cells to G1 phase by interference with spindle formation without affecting other microtubule functions during anaphase and telephase
    • Long, B. H.; Fairchild, C. R. Paclitaxel Inhibits Progression of Mitotic Cells to G1 Phase by Interference with Spindle Formation without Affecting Other Microtubule Functions During Anaphase and Telephase. Cancer Res. 1994, 54, 4355-4361.
    • (1994) Cancer Res. , vol.54 , pp. 4355-4361
    • Long, B.H.1    Fairchild, C.R.2
  • 56
    • 0035854383 scopus 로고    scopus 로고
    • The mouse Mps1p-like kinase regulates centrosome duplication
    • Fisk, H. A.; Winey, M. The Mouse Mps1p-Like Kinase Regulates Centrosome Duplication. Cell 2001, 106, 95-104.
    • (2001) Cell , vol.106 , pp. 95-104
    • Fisk, H.A.1    Winey, M.2
  • 58
    • 0033200397 scopus 로고    scopus 로고
    • Components of an Scf ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle
    • Freed, E.; Lacey, K. R.; Huie, P.; Lyapina, S. A.; Deshaies, R. J.; Stearns, T.; Jackson, P. K. Components of an Scf Ubiquitin Ligase Localize to the Centrosome and Regulate the Centrosome Duplication Cycle. Genes Dev. 1999, 13, 2242-2257.
    • (1999) Genes Dev. , vol.13 , pp. 2242-2257
    • Freed, E.1    Lacey, K.R.2    Huie, P.3    Lyapina, S.A.4    Deshaies, R.J.5    Stearns, T.6    Jackson, P.K.7
  • 61
    • 0035072802 scopus 로고    scopus 로고
    • Polo kinase and Asp are needed to promote the mitotic organizing activity of centrosomes
    • do Carmo Avides, M.; Tavares, A.; Glover, D. M. Polo Kinase and Asp Are Needed to Promote the Mitotic Organizing Activity of Centrosomes. Nat. Cell Biol. 2001, 3, 421-424.
    • (2001) Nat. Cell Biol. , vol.3 , pp. 421-424
    • Do Carmo Avides, M.1    Tavares, A.2    Glover, D.M.3
  • 62
    • 0032518798 scopus 로고    scopus 로고
    • A centrosomal function for the human Nek2 protein kinase, a member of the nima family of cell cycle regulators
    • Fry, A. M.; Meraldi, P.; Nigg, E. A. A Centrosomal Function for the Human Nek2 Protein Kinase, a Member of the Nima Family of Cell Cycle Regulators. EMBO J. 1998, 17, 470-481.
    • (1998) EMBO J. , vol.17 , pp. 470-481
    • Fry, A.M.1    Meraldi, P.2    Nigg, E.A.3
  • 63
    • 0034678923 scopus 로고    scopus 로고
    • Nek2b, a novel maternal form of Nek2 kinase, is essential for the assembly or maintenance of centrosomes in early xenopus embryos
    • Uto, K.; Sagata, N. Nek2b, a Novel Maternal Form of Nek2 Kinase, Is Essential for the Assembly or Maintenance of Centrosomes in Early Xenopus Embryos. EMBO J. 2000, 19, 1816-1826.
    • (2000) EMBO J. , vol.19 , pp. 1816-1826
    • Uto, K.1    Sagata, N.2
  • 64
    • 0035090344 scopus 로고    scopus 로고
    • Ran-Gtp coordinates regulation of microtubule nucleation and dynamics during mitotic-spindle assembly
    • Carazo-Salas, R. E.; Gruss, O. J.; Mattaj, I. W.; Karsenti, E. Ran-Gtp Coordinates Regulation of Microtubule Nucleation and Dynamics During Mitotic-Spindle Assembly. Nat. Cell Biol. 2001, 3, 228-234.
    • (2001) Nat. Cell Biol. , vol.3 , pp. 228-234
    • Carazo-Salas, R.E.1    Gruss, O.J.2    Mattaj, I.W.3    Karsenti, E.4
  • 65
    • 0034564214 scopus 로고    scopus 로고
    • The centrosome-associated aurora/Ip1-like kinase family
    • Goepfert, T. M.; Brinkley, B. R. The Centrosome-Associated Aurora/Ip1-Like Kinase Family. Curr. Top. Dev. Biol. 2000, 49, 331-342.
    • (2000) Curr. Top. Dev. Biol. , vol.49 , pp. 331-342
    • Goepfert, T.M.1    Brinkley, B.R.2
  • 66
    • 0034645037 scopus 로고    scopus 로고
    • The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion
    • Mayor, T.; Stierhof, Y. D.; Tanaka, K.; Fry, A. M.; Nigg, E. A. The Centrosomal Protein C-Nap1 Is Required for Cell Cycle-Regulated Centrosome Cohesion. J. Cell Biol. 2000, 151, 837-846.
    • (2000) J. Cell Biol. , vol.151 , pp. 837-846
    • Mayor, T.1    Stierhof, Y.D.2    Tanaka, K.3    Fry, A.M.4    Nigg, E.A.5
  • 67
    • 0035478337 scopus 로고    scopus 로고
    • The centrosome in vertebrates: More than a microtubule-organizing center
    • Rieder, C. L.; Faruki, S.; Khodjakov, A. The Centrosome in Vertebrates: More Than a Microtubule-Organizing Center. Trends Cell Biol. 2001, 11, 413-419.
    • (2001) Trends Cell Biol. , vol.11 , pp. 413-419
    • Rieder, C.L.1    Faruki, S.2    Khodjakov, A.3
  • 69
    • 0033580430 scopus 로고    scopus 로고
    • Centrosome hyperamplification in human cancer: Chromosome instability induced by p53 mutation and/or Mdm2 overexpression
    • Carroll, P. E.; Okuda, M.; Horn, H. F.; Biddinger, P.; Stambrook, P. J.; Gleich, L. L.; Li, Y. Q.; Tarapore, P.; Fukasawa, K. Centrosome Hyperamplification in Human Cancer: Chromosome Instability Induced by p53 Mutation and/or Mdm2 Overexpression. Oncogene 1999, 18, 1935-1944.
    • (1999) Oncogene , vol.18 , pp. 1935-1944
    • Carroll, P.E.1    Okuda, M.2    Horn, H.F.3    Biddinger, P.4    Stambrook, P.J.5    Gleich, L.L.6    Li, Y.Q.7    Tarapore, P.8    Fukasawa, K.9
  • 70
    • 0033557572 scopus 로고    scopus 로고
    • P21(Cip-1/Waf-1) deficiency causes deformed nuclear architecture, centriole overduplication, polyploidy, and relaxed microtubule damage checkpoints in human hematopoietic cells
    • Mantel, C.; Braun, S. E.; Reid, S.; Henegariu, O.; Liu, L.; Hangoc, G.; Broxmeyer, H. E. P21(Cip-1/Waf-1) Deficiency Causes Deformed Nuclear Architecture, Centriole Overduplication, Polyploidy, and Relaxed Microtubule Damage Checkpoints in Human Hematopoietic Cells. Blood 1999, 93, 1390-1398.
    • (1999) Blood , vol.93 , pp. 1390-1398
    • Mantel, C.1    Braun, S.E.2    Reid, S.3    Henegariu, O.4    Liu, L.5    Hangoc, G.6    Broxmeyer, H.E.7
  • 72
    • 0033106326 scopus 로고    scopus 로고
    • Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in Brca1 exon 11 isoform-deficient cells
    • Xu, X.; Weaver, Z.; Linke, S. P.; Li, C.; Gotay, J.; Wang, X. W.; Harris, C. C.; Ried, T.; Deng, C. X. Centrosome Amplification and a Defective G2-M Cell Cycle Checkpoint Induce Genetic Instability in Brca1 Exon 11 Isoform-Deficient Cells. Mol. Cell. 1999, 3, 389-395.
    • (1999) Mol. Cell , vol.3 , pp. 389-395
    • Xu, X.1    Weaver, Z.2    Linke, S.P.3    Li, C.4    Gotay, J.5    Wang, X.W.6    Harris, C.C.7    Ried, T.8    Deng, C.X.9
  • 73
    • 0033533731 scopus 로고    scopus 로고
    • Absence of Brca2 causes genome instability by chromosome breakage and loss associated with centrosome amplification
    • Tutt, A.; Gabriel, A.; Bertwistle, D.; Connor, F.; Paterson, H.; Peacock, J.; Ross, G.; Ashworth, A. Absence of Brca2 Causes Genome Instability by Chromosome Breakage and Loss Associated with Centrosome Amplification. Curr. Biol. 1999, 9, 1107-1110.
    • (1999) Curr. Biol. , vol.9 , pp. 1107-1110
    • Tutt, A.1    Gabriel, A.2    Bertwistle, D.3    Connor, F.4    Paterson, H.5    Peacock, J.6    Ross, G.7    Ashworth, A.8
  • 75
    • 0032539548 scopus 로고    scopus 로고
    • Cell cycle-dependent subcellular localization of the Tsg101 protein and mitotic and nuclear abnormalities associated with Tsg101 deficiency
    • Xie, W.; Li, L.; Cohen, S. N. Cell Cycle-Dependent Subcellular Localization of the Tsg101 Protein and Mitotic and Nuclear Abnormalities Associated with Tsg101 Deficiency. Proc. Natl. Acad. Sci. USA 1998, 95, 1595-1600.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 1595-1600
    • Xie, W.1    Li, L.2    Cohen, S.N.3
  • 76
    • 0031714080 scopus 로고    scopus 로고
    • Tumour amplified kinase Stk15/Btak induces centrosome amplification, aneuploidy and transformation
    • Zhou, H.; Kuang, J.; Zhong, L.; Kuo, W. L.; Gray, J. W.; Sahin, A.; Brinkley, B. R.; Sen, S. Tumour Amplified Kinase Stk15/Btak Induces Centrosome Amplification, Aneuploidy and Transformation. Nat. Genet. 1998, 20, 189-193.
    • (1998) Nat. Genet. , vol.20 , pp. 189-193
    • Zhou, H.1    Kuang, J.2    Zhong, L.3    Kuo, W.L.4    Gray, J.W.5    Sahin, A.6    Brinkley, B.R.7    Sen, S.8
  • 77
    • 0037084163 scopus 로고    scopus 로고
    • Aurora-a overexpression reveals tetraploidization as a major route to centrosome amplification in P53-/-cells
    • Meraldi, P.; Honda, R.; Nigg, E. A. Aurora-a Overexpression Reveals Tetraploidization as a Major Route to Centrosome Amplification in P53-/- Cells. EMBO J. 2002, 21, 483-492.
    • (2002) EMBO J. , vol.21 , pp. 483-492
    • Meraldi, P.1    Honda, R.2    Nigg, E.A.3
  • 78
    • 0035188129 scopus 로고    scopus 로고
    • Managing the centrosome numbers game: From chaos to stability in cancer cell division
    • Brinkley, B. R. Managing the Centrosome Numbers Game: From Chaos to Stability in Cancer Cell Division. Trends Cell Biol. 2001, 11, 18-21.
    • (2001) Trends Cell Biol. , vol.11 , pp. 18-21
    • Brinkley, B.R.1
  • 79
    • 0035951482 scopus 로고    scopus 로고
    • Centrosome abnormalities, genomic instability and carcinogenic progression
    • Duensing, S.; Munger, K. Centrosome Abnormalities, Genomic Instability and Carcinogenic Progression. Biochim. Biophys. Acta 2001, 1471, M81-M8.
    • (2001) Biochim. Biophys. Acta , vol.1471
    • Duensing, S.1    Munger, K.2
  • 80
    • 0036099467 scopus 로고    scopus 로고
    • Centrosome replication, genomic instability and cancer
    • Kramer, A.; Neben, K.; Ho, A. D. Centrosome Replication, Genomic Instability and Cancer. Leukemia 2002, 16, 767-75.
    • (2002) Leukemia , vol.16 , pp. 767-775
    • Kramer, A.1    Neben, K.2    Ho, A.D.3
  • 81
    • 0034565159 scopus 로고    scopus 로고
    • The role of the centrosome in the development of malignant tumors
    • Lingle, W. L.; Salisbury, J. L. The Role of the Centrosome in the Development of Malignant Tumors. Curr. Top. Dev. Biol. 2000, 49, 313-329.
    • (2000) Curr. Top. Dev. Biol. , vol.49 , pp. 313-329
    • Lingle, W.L.1    Salisbury, J.L.2
  • 82
    • 0032872295 scopus 로고    scopus 로고
    • The mitotic machinery as a source of genetic instability in cancer
    • Pihan, G. A.; Doxsey, S. J. The Mitotic Machinery as a Source of Genetic Instability in Cancer. Semin. Cancer Biol. 1999, 9, 289-302.
    • (1999) Semin. Cancer Biol. , vol.9 , pp. 289-302
    • Pihan, G.A.1    Doxsey, S.J.2
  • 83
    • 0035266301 scopus 로고    scopus 로고
    • Centrosome defects can account for cellular and genetic changes that characterize prostate cancer progression
    • Pihan, G. A.; Purohit, A.; Wallace, J.; Malhotra, R.; Liotta, L.; Doxsey, S. J. Centrosome Defects Can Account for Cellular and Genetic Changes That Characterize Prostate Cancer Progression. Cancer Res. 2001, 61, 2212-2219.
    • (2001) Cancer Res. , vol.61 , pp. 2212-2219
    • Pihan, G.A.1    Purohit, A.2    Wallace, J.3    Malhotra, R.4    Liotta, L.5    Doxsey, S.J.6
  • 84
    • 0034938142 scopus 로고    scopus 로고
    • Stepwise progression of centrosome defects associated with local tumor growth and metastatic process of human pancreatic carcinoma cells transplanted orthotopically into nude mice
    • Shono, M.; Sato, N.; Mizumoto, K.; Maehara, N.; Nakamura, M.; Nagai, E.; Tanaka, M. Stepwise Progression of Centrosome Defects Associated with Local Tumor Growth and Metastatic Process of Human Pancreatic Carcinoma Cells Transplanted Orthotopically into Nude Mice. Lab. Invest. 2001, 81, 945-952.
    • (2001) Lab. Invest. , vol.81 , pp. 945-952
    • Shono, M.1    Sato, N.2    Mizumoto, K.3    Maehara, N.4    Nakamura, M.5    Nagai, E.6    Tanaka, M.7
  • 85
    • 0035936898 scopus 로고    scopus 로고
    • Requirement of a centrosomal activity for cell cycle progression through G1 into S phase
    • Hinchcliffe, E. H.; Miller, F. J.; Cham, M.; Khodjakov, A.; Sluder, G. Requirement of a Centrosomal Activity for Cell Cycle Progression through G1 into S Phase. Science 2001, 291, 1547-1550.
    • (2001) Science , vol.291 , pp. 1547-1550
    • Hinchcliffe, E.H.1    Miller, F.J.2    Cham, M.3    Khodjakov, A.4    Sluder, G.5
  • 86
    • 0035795415 scopus 로고    scopus 로고
    • Centrosomes enhance the fidelity of cytokinesis in vertebrates and are required for cell cycle progression
    • Khodjakov, A.; Rieder, C. L. Centrosomes Enhance the Fidelity of Cytokinesis in Vertebrates and Are Required for Cell Cycle Progression. J. Cell Biol. 2001, 153, 237-242.
    • (2001) J. Cell Biol. , vol.153 , pp. 237-242
    • Khodjakov, A.1    Rieder, C.L.2
  • 87
    • 0035936920 scopus 로고    scopus 로고
    • Centrosome-dependent exit of cytokinesis in animal cells
    • Piel, M.; Nordberg, J.; Euteneuer, U.; Bornens, M. Centrosome-Dependent Exit of Cytokinesis in Animal Cells. Science 2001, 291, 1550-3.
    • (2001) Science , vol.291 , pp. 1550-1553
    • Piel, M.1    Nordberg, J.2    Euteneuer, U.3    Bornens, M.4
  • 88
    • 0035870243 scopus 로고    scopus 로고
    • A mutator phenotype in cancer
    • Loeb, L. A. A Mutator Phenotype in Cancer. Cancer Res. 2001, 61, 3230-3239.
    • (2001) Cancer Res. , vol.61 , pp. 3230-3239
    • Loeb, L.A.1
  • 89
    • 0032883001 scopus 로고    scopus 로고
    • Molecular effects of paclitaxel: Myths and reality (a critical review)
    • Blagosklonny, M. V.; Fojo, T. Molecular Effects of Paclitaxel: Myths and Reality (a Critical Review). Int. J. Cancer 1999, 83, 151-156.
    • (1999) Int. J. Cancer , vol.83 , pp. 151-156
    • Blagosklonny, M.V.1    Fojo, T.2
  • 90
    • 0031687587 scopus 로고    scopus 로고
    • Bcl-2 overexpression is associated with resistance to paclitaxel, but not gemcitabine, in multiple myeloma cells
    • Gazitt, Y.; Rothenberg, M. L.; Hilsenbeck, S. G.; Fey, V.; Thomas, C.; Montegomrey, W. Bcl-2 Overexpression Is Associated with Resistance to Paclitaxel, but Not Gemcitabine, in Multiple Myeloma Cells. Int. J. Oncol. 1998, 13, 839-848.
    • (1998) Int. J. Oncol. , vol.13 , pp. 839-848
    • Gazitt, Y.1    Rothenberg, M.L.2    Hilsenbeck, S.G.3    Fey, V.4    Thomas, C.5    Montegomrey, W.6
  • 92
    • 0031595523 scopus 로고    scopus 로고
    • Bcl-XI is expressed in ovarian carcinoma and modulates chemotherapy-induced apoptosis
    • Liu, J. R.; Fletcher, B.; Page, C.; Hu, C.; Nunez, G.; Baker, V. Bcl-XI Is Expressed in Ovarian Carcinoma and Modulates Chemotherapy-Induced Apoptosis. Gynecol. Oncol. 1998, 70, 398-403.
    • (1998) Gynecol. Oncol. , vol.70 , pp. 398-403
    • Liu, J.R.1    Fletcher, B.2    Page, C.3    Hu, C.4    Nunez, G.5    Baker, V.6
  • 93
    • 0028979438 scopus 로고
    • Overexpression of Bcl-Xs sensitizes Mcf-7 cells to chemotherapy-induced apoptosis
    • Sumantran, V. N.; Ealovega, M. W.; Nunez, G.; Clarke, M. F.; Wicha, M. S. Overexpression of Bcl-Xs Sensitizes Mcf-7 Cells to Chemotherapy-Induced Apoptosis. Cancer Res. 1995, 55, 2507-2510.
    • (1995) Cancer Res. , vol.55 , pp. 2507-2510
    • Sumantran, V.N.1    Ealovega, M.W.2    Nunez, G.3    Clarke, M.F.4    Wicha, M.S.5
  • 94
    • 0031747118 scopus 로고    scopus 로고
    • Cisplatin- and paclitaxel-induced apoptosis of ovarian carcinoma cells and the relationship between Bax and Bak up-regulation and the functional status of P53
    • Jones, N. A.; Turner, J.; McIlwrath, A. J.; Brown, R.; Dive, C. Cisplatin- and Paclitaxel-Induced Apoptosis of Ovarian Carcinoma Cells and the Relationship between Bax and Bak up-Regulation and the Functional Status of P53. Mol. Pharmacol. 1998, 53, 819-826.
    • (1998) Mol. Pharmacol. , vol.53 , pp. 819-826
    • Jones, N.A.1    Turner, J.2    McIlwrath, A.J.3    Brown, R.4    Dive, C.5
  • 95
    • 0032511891 scopus 로고    scopus 로고
    • Bad partly reverses paclitaxel resistance in human ovarian cancer cells
    • Strobel, T.; Tai, Y. T.; Korsmeyer, S.; Cannistra, S. A. Bad Partly Reverses Paclitaxel Resistance in Human Ovarian Cancer Cells. Oncogene 1998, 17, 2419-2427.
    • (1998) Oncogene , vol.17 , pp. 2419-2427
    • Strobel, T.1    Tai, Y.T.2    Korsmeyer, S.3    Cannistra, S.A.4
  • 96
    • 0030462463 scopus 로고    scopus 로고
    • Bax enhances paclitaxel-induced apoptosis through a P53-independent pathway
    • Strobel, T.; Swanson, L.; Korsmeyer, S.; Cannistra, S. A. Bax Enhances Paclitaxel-Induced Apoptosis through a P53-Independent Pathway. Proc. Natl. Acad. Sci. USA 1996, 93, 14094-14099.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 14094-14099
    • Strobel, T.1    Swanson, L.2    Korsmeyer, S.3    Cannistra, S.A.4
  • 97
    • 0031671581 scopus 로고    scopus 로고
    • Microtubule-damaging drugs triggered Bcl2 phosphorylation-requirement of phosphorylation on both serine-70 and serine-87 residues of Bcl2 protein
    • Basu, A.; Haldar, S. Microtubule-Damaging Drugs Triggered Bcl2 Phosphorylation-Requirement of Phosphorylation on Both Serine-70 and Serine-87 Residues of Bcl2 Protein. Int. J. Oncol. 1998, 13, 659-664.
    • (1998) Int. J. Oncol. , vol.13 , pp. 659-664
    • Basu, A.1    Haldar, S.2
  • 98
    • 0034988898 scopus 로고    scopus 로고
    • Unwinding the loop of Bcl-2 phosphorylation
    • Blagosklonny, M. V. Unwinding the Loop of Bcl-2 Phosphorylation. Leukemia 2001, 15, 869-874.
    • (2001) Leukemia , vol.15 , pp. 869-874
    • Blagosklonny, M.V.1
  • 99
    • 0031035693 scopus 로고    scopus 로고
    • Bcl2 is the guardian of microtubule integrity
    • Haldar, S.; Basu, A.; Croce, C. M. Bcl2 Is the Guardian of Microtubule Integrity. Cancer Res. 1997, 57, 229-233.
    • (1997) Cancer Res. , vol.57 , pp. 229-233
    • Haldar, S.1    Basu, A.2    Croce, C.M.3
  • 100
    • 0032514914 scopus 로고    scopus 로고
    • Mitotic phosphorylation of Bcl-2 during normal cell cycle progression and taxol-induced growth arrest
    • Scatena, C. D.; Stewart, Z. A.; Mays, D.; Tang, L. J.; Keefer, C. J.; Leach, S. D.; Pietenpol, J. A. Mitotic Phosphorylation of Bcl-2 During Normal Cell Cycle Progression and Taxol-Induced Growth Arrest. J. Biol. Chem. 1998, 273, 30777-30784.
    • (1998) J. Biol. Chem. , vol.273 , pp. 30777-30784
    • Scatena, C.D.1    Stewart, Z.A.2    Mays, D.3    Tang, L.J.4    Keefer, C.J.5    Leach, S.D.6    Pietenpol, J.A.7
  • 101
    • 0032563202 scopus 로고    scopus 로고
    • Phosphorylation of Bcl-2 is a marker of M phase events and not a determinant of apoptosis
    • Ling, Y. H.; Tornos, C.; Perez-Soler, R. Phosphorylation of Bcl-2 Is a Marker of M Phase Events and Not a Determinant of Apoptosis. J. Biol. Chem. 1998, 273, 18984-18991.
    • (1998) J. Biol. Chem. , vol.273 , pp. 18984-18991
    • Ling, Y.H.1    Tornos, C.2    Perez-Soler, R.3
  • 103
    • 0031893985 scopus 로고    scopus 로고
    • Accumulation of cyclin B1, activation of cyclin B1-dependent kinase and induction of programmed cell death in human epidermoid carcinoma Kb cells treated with taxol
    • Ling, Y. H.; Consoli, U.; Tornos, C.; Andreeff, M.; Perez-Soler, R. Accumulation of Cyclin B1, Activation of Cyclin B1-Dependent Kinase and Induction of Programmed Cell Death in Human Epidermoid Carcinoma Kb Cells Treated with Taxol. Int. J. Cancer 1998, 75, 925-932.
    • (1998) Int. J. Cancer , vol.75 , pp. 925-932
    • Ling, Y.H.1    Consoli, U.2    Tornos, C.3    Andreeff, M.4    Perez-Soler, R.5
  • 105
    • 0029913172 scopus 로고    scopus 로고
    • Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves C-Raf-1 and represents a novel C-Raf-1 signal transduction pathway
    • Blagosklonny, M. V.; Schulte, T.; Nguyen, P.; Trepel, J.; Neckers, L. M. Taxol-Induced Apoptosis and Phosphorylation of Bcl-2 Protein Involves C-Raf-1 and Represents a Novel C-Raf-1 Signal Transduction Pathway. Cancer Res. 1996, 56, 1851-1854.
    • (1996) Cancer Res. , vol.56 , pp. 1851-1854
    • Blagosklonny, M.V.1    Schulte, T.2    Nguyen, P.3    Trepel, J.4    Neckers, L.M.5
  • 107
    • 0030615086 scopus 로고    scopus 로고
    • Bcl-X1 overexpression inhibits progression of molecular events leading to paclitaxel-induced apoptosis of human acute myeloid leukemia H1-60 cells
    • Ibrado, A. M.; Liu, L.; Bhalla, K. Bcl-X1 Overexpression Inhibits Progression of Molecular Events Leading to Paclitaxel-Induced Apoptosis of Human Acute Myeloid Leukemia H1-60 Cells. Cancer Res. 1997, 57, 1109-1115.
    • (1997) Cancer Res. , vol.57 , pp. 1109-1115
    • Ibrado, A.M.1    Liu, L.2    Bhalla, K.3
  • 108
    • 0034219421 scopus 로고    scopus 로고
    • Raf-1 kinase activity predicts for paclitaxel resistance in Tp53mut, but Not Tp53wt human ovarian cancer cells
    • Britten, R. A.; Perdue, S.; Eshpeter, A.; Merriam, D. Raf-1 Kinase Activity Predicts for Paclitaxel Resistance in Tp53mut, but Not Tp53wt Human Ovarian Cancer Cells. Oncol. Rep. 2000, 7, 821-825.
    • (2000) Oncol. Rep. , vol.7 , pp. 821-825
    • Britten, R.A.1    Perdue, S.2    Eshpeter, A.3    Merriam, D.4
  • 110
    • 0032776120 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase pathway is dispensable for microtubule-active drug-induced Raf-1/Bcl-2 phosphorylation and apoptosis in leukemia cells
    • Blagosklonny, M. V.; Chuman, Y.; Bergan, R. C.; Fojo, T. Mitogen-Activated Protein Kinase Pathway Is Dispensable for Microtubule-Active Drug-Induced Raf-1/Bcl-2 Phosphorylation and Apoptosis in Leukemia Cells. Leukemia 1999, 13, 1028-1036.
    • (1999) Leukemia , vol.13 , pp. 1028-1036
    • Blagosklonny, M.V.1    Chuman, Y.2    Bergan, R.C.3    Fojo, T.4
  • 111
    • 0034920013 scopus 로고    scopus 로고
    • Selective potentiation of paclitaxel (taxol)-induced cell death by mitogen-activated protein kinase kinase inhibition in human cancer cell lines
    • McDaid, H. M.; Horwitz, S. B. Selective Potentiation of Paclitaxel (Taxol)-Induced Cell Death by Mitogen-Activated Protein Kinase Kinase Inhibition in Human Cancer Cell Lines. Mol. Pharmacol. 2001, 60, 290-301.
    • (2001) Mol. Pharmacol. , vol.60 , pp. 290-301
    • McDaid, H.M.1    Horwitz, S.B.2
  • 112
    • 0034627879 scopus 로고    scopus 로고
    • Microtubule inhibitors elicit differential effects on map kinase (Jnk, Erk, and p38) signaling pathways in human Kb-3 carcinoma cells
    • Stone, A. A.; Chambers, T. C. Microtubule Inhibitors Elicit Differential Effects on Map Kinase (Jnk, Erk, and p38) Signaling Pathways in Human Kb-3 Carcinoma Cells. Exp. Cell Res. 2000, 254, 110-119.
    • (2000) Exp. Cell Res. , vol.254 , pp. 110-119
    • Stone, A.A.1    Chambers, T.C.2
  • 113
    • 0032561366 scopus 로고    scopus 로고
    • Paclitaxel (taxol)-induced gene expression and cell death are both mediated by the activation of C-Jun Nh2-terminal kinase (Jnk/Sapk)
    • Lee, L. F.; Li, G.; Templeton, D. J.; Ting, J. P. Paclitaxel (Taxol)-Induced Gene Expression and Cell Death Are Both Mediated by the Activation of C-Jun Nh2-Terminal Kinase (Jnk/Sapk). J. Biol. Chem. 1998, 273, 28253-28260.
    • (1998) J. Biol. Chem. , vol.273 , pp. 28253-28260
    • Lee, L.F.1    Li, G.2    Templeton, D.J.3    Ting, J.P.4
  • 114
    • 0032570594 scopus 로고    scopus 로고
    • Microtubule-interfering agents activate C-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways
    • Wang, T. H.; Wang, H. S.; Ichijo, H.; Giannakakou, P.; Foster, J. S.; Fojo, T.; Wimalasena, J. Microtubule-Interfering Agents Activate C-Jun N-Terminal Kinase/Stress-Activated Protein Kinase through Both Ras and Apoptosis Signal-Regulating Kinase Pathways. J. Biol. Chem. 1998, 273, 4928-4936.
    • (1998) J. Biol. Chem. , vol.273 , pp. 4928-4936
    • Wang, T.H.1    Wang, H.S.2    Ichijo, H.3    Giannakakou, P.4    Foster, J.S.5    Fojo, T.6    Wimalasena, J.7
  • 115
    • 0033499801 scopus 로고    scopus 로고
    • Bcl-2 is phosphorylated and inactivated by an Ask1/Jun N-terminal protein kinase pathway normally activated at G(2)/M
    • Yamamoto, K.; Ichijo, H.; Korsmeyer, S. J. Bcl-2 Is Phosphorylated and Inactivated by an Ask1/Jun N-Terminal Protein Kinase Pathway Normally Activated at G(2)/M. Mol. Cell Biol. 1999, 19, 8469-8478.
    • (1999) Mol. Cell Biol. , vol.19 , pp. 8469-8478
    • Yamamoto, K.1    Ichijo, H.2    Korsmeyer, S.J.3
  • 116
    • 0033583321 scopus 로고    scopus 로고
    • Microtubule dysfunction induced by paclitaxel initiates apoptosis through both C-Jun N-terminal kinase (Jnk)-dependent and -independent pathways in ovarian cancer cells
    • Wang, T. H.; Popp, D. M.; Wang, H. S.; Saitoh, M.; Mural, J. G.; Henley, D. C.; Ichijo, H.; Wimalasena, J. Microtubule Dysfunction Induced by Paclitaxel Initiates Apoptosis through Both C-Jun N-Terminal Kinase (Jnk)-Dependent and -Independent Pathways in Ovarian Cancer Cells. J. Biol. Chem. 1999, 274, 8208-8216.
    • (1999) J. Biol. Chem. , vol.274 , pp. 8208-8216
    • Wang, T.H.1    Popp, D.M.2    Wang, H.S.3    Saitoh, M.4    Mural, J.G.5    Henley, D.C.6    Ichijo, H.7    Wimalasena, J.8
  • 117
    • 0034748021 scopus 로고    scopus 로고
    • Inhibition of drug-induced Fas ligand transcription and apoptosis by Bcl-XI
    • Biswas, R. S.; Cha, H. J.; Hardwick, J. M.; Srivastava, R. K. Inhibition of Drug-Induced Fas Ligand Transcription and Apoptosis by Bcl-XI. Mol. Cell. Biochem. 2001, 225, 7-20.
    • (2001) Mol. Cell. Biochem. , vol.225 , pp. 7-20
    • Biswas, R.S.1    Cha, H.J.2    Hardwick, J.M.3    Srivastava, R.K.4
  • 118
    • 0036491526 scopus 로고    scopus 로고
    • Paclitaxel-induced FasL-independent apoptosis and slow (non-apoptotic) cell death
    • Blagosklonny, M. V.; Robey, R.; Sheikh, M. S.; Fojo, T. Paclitaxel-Induced FasL-Independent Apoptosis and Slow (Non-Apoptotic) Cell Death. Cancer Biol. Ther. 2002, 1, 113-117.
    • (2002) Cancer Biol. Ther. , vol.1 , pp. 113-117
    • Blagosklonny, M.V.1    Robey, R.2    Sheikh, M.S.3    Fojo, T.4
  • 120
    • 0032005132 scopus 로고    scopus 로고
    • P53 and Prb prevent rereplication in response to microtubule inhibitors by mediating a reversible G1 arrest
    • Khan, S. H.; Wahl, G. M. P53 and Prb Prevent Rereplication in Response to Microtubule Inhibitors by Mediating a Reversible G1 Arrest. Cancer Res. 1998, 58, 396-401.
    • (1998) Cancer Res. , vol.58 , pp. 396-401
    • Khan, S.H.1    Wahl, G.M.2
  • 121
    • 0031931414 scopus 로고    scopus 로고
    • Characterization of the P53-dependent postmitotic checkpoint following spindle disruption
    • Lanni, J. S.; Jacks, T. Characterization of the P53-Dependent Postmitotic Checkpoint Following Spindle Disruption. Mol. Cell Biol. 1998, 18, 1055-1064.
    • (1998) Mol. Cell Biol. , vol.18 , pp. 1055-1064
    • Lanni, J.S.1    Jacks, T.2
  • 122
  • 123
    • 0035963277 scopus 로고    scopus 로고
    • Low concentrations of paclitaxel induce cell type-dependent P53, P21 and G1/G2 arrest instead of mitotic arrest: Molecular determinants of paclitaxel-induced cytotoxicity
    • Giannakakou, P.; Robey, R.; Fojo, T.; Blagosklonny, M. V. Low Concentrations of Paclitaxel Induce Cell Type-Dependent P53, P21 and G1/G2 Arrest Instead of Mitotic Arrest: Molecular Determinants of Paclitaxel-Induced Cytotoxicity. Oncogene 2001, 20, 3806-3813.
    • (2001) Oncogene , vol.20 , pp. 3806-3813
    • Giannakakou, P.1    Robey, R.2    Fojo, T.3    Blagosklonny, M.V.4
  • 124
    • 0029807822 scopus 로고    scopus 로고
    • Differential taxol-dependent arrest of transformed and nontransformed cells in the G1 phase of the cell cycle, and specific-related mortality of transformed cells
    • Trielli, M. O.; Andreassen, P. R.; Lacroix, F. B.; Margolis, R. L. Differential Taxol-Dependent Arrest of Transformed and Nontransformed Cells in the G1 Phase of the Cell Cycle, and Specific-Related Mortality of Transformed Cells. J. Cell Biol. 1996, 135, 689-700.
    • (1996) J. Cell Biol. , vol.135 , pp. 689-700
    • Trielli, M.O.1    Andreassen, P.R.2    Lacroix, F.B.3    Margolis, R.L.4
  • 125
    • 0033169231 scopus 로고    scopus 로고
    • Defective G1-S cell cycle checkpoint function sensitizes cells to microtubule inhibitor-induced apoptosis
    • Stewart, Z. A.; Mays, D.; Pietenpol, J. A. Defective G1-S Cell Cycle Checkpoint Function Sensitizes Cells to Microtubule Inhibitor-Induced Apoptosis. Cancer Res. 1999, 59, 3831-3837.
    • (1999) Cancer Res. , vol.59 , pp. 3831-3837
    • Stewart, Z.A.1    Mays, D.2    Pietenpol, J.A.3
  • 126
    • 0031953822 scopus 로고    scopus 로고
    • Disruption of p53 function in immortalized human cells does not affect survival or apoptosis after taxol or vincristine treatment
    • Fan, S.; Cherney, B.; Reinhold, W.; Rucker, K.; O'Connor, P. M. Disruption of p53 Function in Immortalized Human Cells Does Not Affect Survival or Apoptosis after Taxol or Vincristine Treatment. Clin. Cancer Res. 1998, 4, 1047-1054.
    • (1998) Clin. Cancer Res. , vol.4 , pp. 1047-1054
    • Fan, S.1    Cherney, B.2    Reinhold, W.3    Rucker, K.4    O'Connor, P.M.5
  • 127
    • 0030886975 scopus 로고    scopus 로고
    • P53-independent apoptosis induced by paclitaxel through an indirect mechanism
    • Lanni, J. S.; Lowe, S. W.; Licitra, E. J.; Liu, J. O.; Jacks, T. P53-Independent Apoptosis Induced by Paclitaxel through an Indirect Mechanism. Proc. Natl. Acad. Sci. USA 1997, 94, 9679-9683.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 9679-9683
    • Lanni, J.S.1    Lowe, S.W.2    Licitra, E.J.3    Liu, J.O.4    Jacks, T.5
  • 128
    • 0035499794 scopus 로고    scopus 로고
    • A multistep model for paclitaxel-induced apoptosis in human breast cancer cell lines
    • Blajeski, A. L.; Kottke, T. J.; Kaufmann, S. H. A Multistep Model for Paclitaxel-Induced Apoptosis in Human Breast Cancer Cell Lines. Exp. Cell Res. 2001, 270, 277-288.
    • (2001) Exp. Cell Res. , vol.270 , pp. 277-288
    • Blajeski, A.L.1    Kottke, T.J.2    Kaufmann, S.H.3
  • 129
    • 0030021996 scopus 로고    scopus 로고
    • Inactivation of p53 enhances sensitivity to multiple chemotherapeutic agents
    • Hawkins, D. S.; Demers, G. W.; Galloway, D. A. Inactivation of p53 Enhances Sensitivity to Multiple Chemotherapeutic Agents. Cancer Res. 1996, 56, 892-898.
    • (1996) Cancer Res. , vol.56 , pp. 892-898
    • Hawkins, D.S.1    Demers, G.W.2    Galloway, D.A.3
  • 130
  • 131
    • 0032568221 scopus 로고    scopus 로고
    • The role of Map4 expression in the sensitivity to paclitaxel and resistance to vinca alkaloids in p53 mutant cells
    • Zhang, C. C.; Yang, J. M.; White, E.; Murphy, M.; Levine, A.; Hait, W. N. The Role of Map4 Expression in the Sensitivity to Paclitaxel and Resistance to Vinca Alkaloids in p53 Mutant Cells. Oncogene 1998, 16, 1617-1624.
    • (1998) Oncogene , vol.16 , pp. 1617-1624
    • Zhang, C.C.1    Yang, J.M.2    White, E.3    Murphy, M.4    Levine, A.5    Hait, W.N.6
  • 133
    • 0030865104 scopus 로고    scopus 로고
    • Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents
    • O'Connor, P. M.; Jackman, J.; Bae, I.; Myers, T. G.; Fan, S.; Mutoh, M.; Scudiero, D. A.; Monks, A.; Sausville, E. A.; Weinstein, J. N.; Friend, S.; Fornace, A. J., Jr.; Kohn, K. W. Characterization of the p53 Tumor Suppressor Pathway in Cell Lines of the National Cancer Institute Anticancer Drug Screen and Correlations with the Growth-Inhibitory Potency of 123 Anticancer Agents. Cancer Res. 1997, 57, 4285-4300.
    • (1997) Cancer Res. , vol.57 , pp. 4285-4300
    • O'Connor, P.M.1    Jackman, J.2    Bae, I.3    Myers, T.G.4    Fan, S.5    Mutoh, M.6    Scudiero, D.A.7    Monks, A.8    Sausville, E.A.9    Weinstein, J.N.10    Friend, S.11    Fornace A.J., Jr.12    Kohn, K.W.13
  • 135
    • 0028883179 scopus 로고
    • Tumor suppressor P53 is a direct transcriptional activator of the human Bax gene
    • Miyashita, T.; Reed, J. C. Tumor Suppressor P53 Is a Direct Transcriptional Activator of the Human Bax Gene. Cell 1995, 80, 293-299.
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 136
    • 0020578356 scopus 로고
    • Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines
    • Kartner, N.; Riordan, J. R.; Ling, V. Cell Surface P-Glycoprotein Associated with Multidrug Resistance in Mammalian Cell Lines. Science 1983, 221, 1285-1288.
    • (1983) Science , vol.221 , pp. 1285-1288
    • Kartner, N.1    Riordan, J.R.2    Ling, V.3
  • 137
    • 0035060238 scopus 로고    scopus 로고
    • Factors determining cellular mechanisms of resistance to antimitotic drugs
    • Cabral, F. Factors Determining Cellular Mechanisms of Resistance to Antimitotic Drugs. Drug Resist. Updat. 2001, 4, 3-8.
    • (2001) Drug Resist. Updat. , vol.4 , pp. 3-8
    • Cabral, F.1
  • 139
    • 0033052777 scopus 로고    scopus 로고
    • Mechanisms of action of and resistance to antitubulin agents: Microtubule dynamics, drug transport, and cell death
    • Dumontet, C.; Sikic, B. I. Mechanisms of Action of and Resistance to Antitubulin Agents: Microtubule Dynamics, Drug Transport, and Cell Death. J. Clin. Oncol. 1999, 17, 1061-1070.
    • (1999) J. Clin. Oncol. , vol.17 , pp. 1061-1070
    • Dumontet, C.1    Sikic, B.I.2
  • 140
    • 0035951505 scopus 로고    scopus 로고
    • The role of beta-tubulin isotypes in resistance to antimitotic drugs
    • Burkhart, C. A.; Kavallaris, M.; Band Horwitz, S. The Role of Beta-Tubulin Isotypes in Resistance to Antimitotic Drugs. Biochim. Biophys. Acta 2001, 1471, 1-9.
    • (2001) Biochim. Biophys. Acta , vol.1471 , pp. 1-9
    • Burkhart, C.A.1    Kavallaris, M.2    Band Horwitz, S.3
  • 141
    • 0030758777 scopus 로고    scopus 로고
    • Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization
    • Giannakakou, P.; Sackett, D. L.; Kang, Y. K.; Zhan, Z.; Buters, J. T.; Fojo, T.; Poruchynsky, M. S. Paclitaxel-Resistant Human Ovarian Cancer Cells Have Mutant Beta-Tubulins That Exhibit Impaired Paclitaxel-Driven Polymerization. J. Biol. Chem. 1997, 272, 17118-17125.
    • (1997) J. Biol. Chem. , vol.272 , pp. 17118-17125
    • Giannakakou, P.1    Sackett, D.L.2    Kang, Y.K.3    Zhan, Z.4    Buters, J.T.5    Fojo, T.6    Poruchynsky, M.S.7
  • 142
    • 0034887884 scopus 로고    scopus 로고
    • Cell cycle-mediated drug resistance: An emerging concept in cancer therapy
    • Shah, M. A.; Schwartz, G. K. Cell Cycle-Mediated Drug Resistance: An Emerging Concept in Cancer Therapy. Clin. Cancer Res. 2001, 7, 2168-2181.
    • (2001) Clin. Cancer Res. , vol.7 , pp. 2168-2181
    • Shah, M.A.1    Schwartz, G.K.2
  • 143
    • 0029665778 scopus 로고    scopus 로고
    • Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (Cdk) 2 and Cdk4 in human breast carcinoma cells
    • Carlson, B. A.; Dubay, M. M.; Sausville, E. A.; Brizuela, L.; Worland, P. J. Flavopiridol Induces G1 Arrest with Inhibition of Cyclin-Dependent Kinase (Cdk) 2 and Cdk4 in Human Breast Carcinoma Cells. Cancer Res. 1996, 56, 2973-2978.
    • (1996) Cancer Res. , vol.56 , pp. 2973-2978
    • Carlson, B.A.1    Dubay, M.M.2    Sausville, E.A.3    Brizuela, L.4    Worland, P.J.5
  • 144
    • 0032804733 scopus 로고    scopus 로고
    • Sequential dependent enhancement of caspase activation and apoptosis by flavopiridol on paclitaxel-treated human gastric and breast cancer cells
    • Motwani, M.; Delohery, T. M.; Schwartz, G. K. Sequential Dependent Enhancement of Caspase Activation and Apoptosis by Flavopiridol on Paclitaxel-Treated Human Gastric and Breast Cancer Cells. Clin. Cancer Res. 1999, 5, 1876-1883.
    • (1999) Clin. Cancer Res. , vol.5 , pp. 1876-1883
    • Motwani, M.1    Delohery, T.M.2    Schwartz, G.K.3
  • 145
    • 0030812207 scopus 로고    scopus 로고
    • Cytotoxic synergy between flavopiridol (Nsc 649890, L86-8275) and various antineoplastic agents: The importance of sequence of administration
    • Bible, K. C.; Kaufmann, S. H. Cytotoxic Synergy between Flavopiridol (Nsc 649890, L86-8275) and Various Antineoplastic Agents: The Importance of Sequence of Administration. Cancer Res. 1997, 57, 3375-3380.
    • (1997) Cancer Res. , vol.57 , pp. 3375-3380
    • Bible, K.C.1    Kaufmann, S.H.2
  • 146
    • 0031920710 scopus 로고    scopus 로고
    • Induction of apoptosis by taxol and cisplatin and effect on cell cycle-related proteins in cisplatin-sensitive and -resistant human ovarian cells
    • Zaffaroni, N.; Silvestrini, R.; Orlandi, L.; Bearzatto, A.; Gornati, D.; Villa, R. Induction of Apoptosis by Taxol and Cisplatin and Effect on Cell Cycle-Related Proteins in Cisplatin-Sensitive and -Resistant Human Ovarian Cells. Br. J. Cancer 1998, 77, 1378-1385.
    • (1998) Br. J. Cancer , vol.77 , pp. 1378-1385
    • Zaffaroni, N.1    Silvestrini, R.2    Orlandi, L.3    Bearzatto, A.4    Gornati, D.5    Villa, R.6
  • 147
    • 0033562991 scopus 로고    scopus 로고
    • Cisplatin inhibits paclitaxel-induced apoptosis in cisplatin-resistant ovarian cancer cell lines: Possible explanation for failure of combination therapy
    • Judson, P. L.; Watson, J. M.; Gehrig, P. A.; Fowler, W. C., Jr.; Haskill, J. S. Cisplatin Inhibits Paclitaxel-Induced Apoptosis in Cisplatin-Resistant Ovarian Cancer Cell Lines: Possible Explanation for Failure of Combination Therapy. Cancer Res. 1999, 59, 2425-2432.
    • (1999) Cancer Res. , vol.59 , pp. 2425-2432
    • Judson, P.L.1    Watson, J.M.2    Gehrig, P.A.3    Fowler W.C., Jr.4    Haskill, J.S.5
  • 148
    • 0029090720 scopus 로고
    • Sequence-dependent antitumor activity of paclitaxel (taxol) and cisplatin in vivo
    • Milross, C. G.; Peters, L. J.; Hunter, N. R.; Mason, K. A.; Milas, L. Sequence-Dependent Antitumor Activity of Paclitaxel (Taxol) and Cisplatin in Vivo. Int. J. Cancer 1995, 62, 599-604.
    • (1995) Int. J. Cancer , vol.62 , pp. 599-604
    • Milross, C.G.1    Peters, L.J.2    Hunter, N.R.3    Mason, K.A.4    Milas, L.5
  • 149
    • 0027501314 scopus 로고
    • Sequence-dependent cytotoxic effects due to combinations of cisplatin and the antimicrotubule agents taxol and vincristine
    • Rowinsky, E. K.; Citardi, M. J.; Noe, D. A.; Donehower, R. C. Sequence-Dependent Cytotoxic Effects Due to Combinations of Cisplatin and the Antimicrotubule Agents Taxol and Vincristine. J Cancer Res. Clin. Oncol. 1993, 119, 727-733.
    • (1993) J. Cancer Res. Clin. Oncol. , vol.119 , pp. 727-733
    • Rowinsky, E.K.1    Citardi, M.J.2    Noe, D.A.3    Donehower, R.C.4
  • 150
    • 0033997563 scopus 로고    scopus 로고
    • Pretreatment with DNA-damaging agents permits selective killing of checkpoint-deficient cells by microtubule-active drugs
    • Blagosklonny, M. V.; Robey, R.; Bates, S.; Fojo, T. Pretreatment with DNA-Damaging Agents Permits Selective Killing of Checkpoint-Deficient Cells by Microtubule-Active Drugs. J. Clin. Invest. 2000, 105, 533-539.
    • (2000) J. Clin. Invest. , vol.105 , pp. 533-539
    • Blagosklonny, M.V.1    Robey, R.2    Bates, S.3    Fojo, T.4
  • 151
    • 0037870053 scopus 로고    scopus 로고
    • Flavopiridol inversely affects p21(Waf1/Cip1) and p53 and protects p21-sensitive cells from paclitaxel
    • Blagosklonny, M. V.; Darzynkiewicz, Z.; Figg, W. D. Flavopiridol Inversely Affects p21(Waf1/Cip1) and p53 and Protects p21-Sensitive Cells from Paclitaxel. Cancer Biol. Ther. 2002, 1, 420-425.
    • (2002) Cancer Biol. Ther. , vol.1 , pp. 420-425
    • Blagosklonny, M.V.1    Darzynkiewicz, Z.2    Figg, W.D.3
  • 152
    • 0032880829 scopus 로고    scopus 로고
    • The effect of antimicrotubule agents on signal transduction pathways of apoptosis: A review
    • Wang, L. G.; Liu, X. M.; Kreis, W.; Budman, D. R. The Effect of Antimicrotubule Agents on Signal Transduction Pathways of Apoptosis: A Review. Cancer Chemother. Pharmacol. 1999, 44, 355-361.
    • (1999) Cancer Chemother. Pharmacol. , vol.44 , pp. 355-361
    • Wang, L.G.1    Liu, X.M.2    Kreis, W.3    Budman, D.R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.