The effect of antimicrotubule agents on signal transduction pathways of apoptosis: A review

Cancer Chemotherapy and Pharmacology

Volumn 44, Issue 5, 1999, Pages 355-361

  Wang, Long G ^a   Liu, Xiao M ^a   Kreis, Willi ^a   Budman, Daniel R ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antimicrotubule agents; Apoptosis; Bcl 2 phosphorylation; Protein kinases; Signal transduction pathways

Indexed keywords

ANTINEOPLASTIC AGENT; DOCETAXEL; ESTRAMUSTINE PHOSPHATE; MICROTUBULE PROTEIN; NAVELBINE; PACLITAXEL; PROTEIN BCL 2; PROTEIN KINASE; VINCRISTINE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; DRUG EFFECT; ENZYME PHOSPHORYLATION; GENE DISRUPTION; MICROTUBULE; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ASSEMBLY; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ESTRAMUSTINE; GENES, BCL-2; HUMANS; MICROTUBULES; MITOGEN-ACTIVATED PROTEIN KINASES; MULTIGENE FAMILY; PACLITAXEL; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION; TAXOIDS; TUMOR CELLS, CULTURED; VINBLASTINE; VINCRISTINE;

EID: 0032880829     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800050989     Document Type: Article

References (89)

1. 1. Ainsztein AM, Purich DL (1994) Stimulation of tubulin polymerization by MAP-2. Control by protein kinase C-mediated phosphorylation at specific sites in the microtubule-binding region. J Biol Chem 269(45): 28465
2. 2. Attalla H, Westberg JA, Andersson LC, Adlercreutz H, Makela TP (1998) 2-Methoxyestradiol-induced phosphorylation of bcl-2: uncoupling from JNK/SAPK activation. Biochem Biophys Res Commun 247: 616
3. 3. Avruch J, Zhang X, Kyriakis JM (1994) Raf meets Ras: completing the frame work of a signal transduction pathway. Trends Biochem Sci 19: 279
4. 4. Barboule N, Chadebech P, Baldin V, Vidal S, Valette A (1998) Involvement of p21 in mitotic exit after paclitaxel treatment in MCF-7 breast adenocarcinoma cell line. Oncogene 15(23): 2867
5. 5. Basu A, Haldar S (1998) Microtubule-damaging drugs triggered bcl-2 phosphorylation - requirement of phosphorylation on both serine-70 and serine-87 residues of bcl-2 protein. Int J Oncol 13(4): 659
6. 6. Blagosklonny MV, Schulte TW, Nguyen P, Mimnaugh EG, Trepel J, Neckers L (1995) Taxol induction of p21WAF1 and p53 requires c-raf-1. Cancer Res 55: 623
7. 7. Blagosklonny MV, Schulte T, Nguyen P, Trepel J, Neckers LM (1996) Taxol-induced apoptosis and phosphorylation of bcl-2 protein involves c-raf-1 and represents a novel c-raf-1 signal transduction pathway. Cancer Res 56(8): 1851
8. 8. Blagosklonny MV, Giannakakou P, el-Deiry WS, Kingston DG, Higgs PI, Neckers L, Fojo T (1997) Raf-1/bcl-2 phosphorylation: a step from microtubule damage to cell death. Cancer Res 57(1): 130
9. 9. Boise LH, Gonzalez-Garcia M, Postema CE, Ding L, Lindsten T, Turka LA, Mao X, Nunez G, Thompson CB (1993) bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 74(4): 597
10. 10. Boyd JM, Gallo GJ, Elangovan B, Houghton AB, Malstrom B, Avery BJ, Ebb RG, Subramanian T, Chittenden T, Lutz RJ, Chinnadurai G (1995) Bik, a novel death-inducing protein shares a distinct sequence motif with bcl-2 family proteins and interacts with viral and cellular survival promoting proteins. Oncogene 11: 1921
11. 11. Budman DR (1997) Vinorelbine (Navelbine): a third-generation vinca alkaloid. Cancer Invest 15(5): 475
12. 12. Chittenden T, Harrington EA, Connor R, Flemington C, Lutz RJ, Evan GI, Guild BC (1995) Induction of apoptosis by the Bcl-2 homologue Bak. Nature 374(6524): 733
13. 13. Cho-Chung YS (1990) Role of cyclic AMP receptor proteins in growth, differentiation, and suppression of malignancy: new approach to therapy. Cancer Res 50: 7093
14. 14. Cho-Chung YS, Nesterova M, Kondrashin A, Noguchi K, Srivastava RK, Pepe S (1997) Antisense-protein kinase A: a single-gene-based therapeutic approach. Antisense Nucleic Acid Drug Dev 7: 217
15. 15. Choi SS, Park IC, Yun JW, Sung YC, Hong SI, Shin HS (1995) A novel bcl-2 related gene, Bfl-1, is overexpressed in stomach cancer and preferentially expressed in bone marrow. Oncogene 11(9): 1693
16. 16. Correia JJ (1991) Effects of anti-mitotic agents on tubulin-nucleotide interactions. Pharmacol Ther 52: 127
17. 17. Craig RW (1995) The bcl-2 gene family. Semin Cancer Biol 6: 35
18. 18. Dahllof B, Billstrom A, Cabral F, Hartley-Asp B (1993) Estramustine depolymerizes microtubules by binding to tubulin. Cancer Res 53: 4573
19. 19. Das R, Reddy EP, Chatterjee D, Andrews DW (1996) Identification of a novel bcl-2 related gene, BRAG-1, in human glioma. Oncogene 12(5): 947
20. 20. Daum G, Eisenmann-Tappe I, Fries HW, Troppmair J, Rapp UR (1994) The ins and outs of Raf kinase. Trends Biochem Sci 19: 474
21. 21. Donaldson KL, Goolsby GL, Kiener PA, Wahl AF (1994) Activation of p34cdc2 coincident with Taxol-induced apoptosis. Cell Growth Differ 5: 1041
22. 22. Fernandez-Sarabia MJ, Bischoff J (1993) Bcl-2 associates with the ras-related protein R-ras p23. Nature 366: 274
23. 23. Gibson L, Holmgreen SP, Huang DC, Bernard O, Copeland NG, Jenkins NA, Sutherland GR, Baker E, Adams JM, Cory S (1996) bcl-W, a novel member of the bcl-2 family, promotes cell survival. Oncogene 13(4): 665
24. 24. Green MR (1993) New directions for chemotherapy in non-small-cell lung cancer. Chest 103(4) [Suppl]: 370S
25. 25. Haldar S, Beatty C, Tsujimoto Y, Croce CM (1989) The bcl-2 gene encodes a novel G protein. Nature 342: 195
26. 26. Haldar S, Jena N, Croce CM (1995) Inactivation of bcl-2 by phosphorylation. Proc Natl Acad Sci USA 92: 4507
27. 27. Haldar S, Chintapalli J, Croce CM (1996) Taxol induces bcl-2 phosphorylation and death of prostate cancer cells. Cancer Res 56(6): 1253
28. 28. Haldar S, Basu A, Croce CM (1997) Bcl-2 is the guardian of microtubule integrity. Cancer Res 57: 229
29. 29. Hamel E (1990) Interaction of tubulin with small ligands. In: Avila J (ed) Microtubule proteins. CRC Press, Boca Raton, pp 89-191
30. 30. Henderson S, Huen D, Rowe M, Dawson C, Johnson G, Rickinson A (1993) Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death. Proc Natl Acad Sci USA 90: 8479
31. 31. Hengartner MO (1998) Death cycle and Swiss army knives. Nature 391: 441
32. 32. Hengartner MO, Horvitz HR (1994) Celegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2. Cell 76: 665
33. 33. Hickman JA (1992) Apoptosis induced by anti-cancer drugs. Cancer Metastasis Rev 11: 121
34. 34. Hirokawa N (1994) Microtubule organization and dynamics dependent on microtubule-associated proteins. Curr Opin Cell Biol 6: 74
35. 35. Hockenbery D (1995) Defining apoptosis. Am J Pathol 146: 16
36. 36. Hsu YT, Youle RJ (1997) Nonionic detergents induce dimerization among members of the bcl-2 family. J Biol Chem 272(21): 13829
37. 37. Inohara N, Ding L, Chen S, Nunez G (1997) Harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins bcl-2 and bcl-X(L). EMBO J 16(7): 1686
38. 38. Jarpe MB, Widmann C, Knall C, Schlesinger TK, Gibson S, Yujiri T, Fanger GR, Gelfand EW, Johnson GL (1998) Anti-apoptotic versus pro-apoptotic signal transduction: checkpoints and stop signs along the road to death. Oncogene 17: 1475
39. 39. Jordan MA, Wilson L (1998) Microtubules and actin filaments: dynamic targets for cancer chemotherapy. Curr Opin Cell Biol 10(1): 123
40. 40. Joshi HC (1998) Microtubule dynamics in living cells. Curr Opin Cell Biol 10(1): 35
41. 41. Kenny JL, Guinness ME, Curiel T, Lacy J (1998) Antisense to the epstein-barr virus (EBV)-encoded latent membrane protein 1 (LMP-1) suppresses LMP-1 and bcl-2 expression and promotes apoptosis in EBV-immortalized B cells. Blood 92(5): 1721
42. 42. Kerkhoff E, Rapp UR (1998) Cell cycle targets of Ras/Raf signalling. Oncogene 17: 1457
43. 43. Knudson CM, Korsmeyer SJ (1997) Bcl-2 and bax function independently to regulate cell death. Nat Genet 16: 358
44. 44. Kolch W, Heidecker G, Lloyd P, Rapp UR (1991) Raf-1 protein kinase is required for growth of induced NIH/3T3 cells. Nature 349: 426
45. 45. Kozopas KM, Yang T, Buchan HL, Zhou P, Craig RW (1993) MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. Proc Natl Acad Sci USA 90: 3516
46. 46. Krebs EG, Beavo JA (1979) Phosphorylation-dephosphorylation of enzymes. Annu Rev Biochem 88: 923
47. 47. Kreis W (1995) Estramustine revisited. In: Muggia FM (ed) Concepts, mechanisms, and new targets for chemotherapy. Kluwer Academic Publishers, Boston, pp 163-182
48. 48. Kroemer G (1997) The proto-oncogene bcl-2 and its role in regulating apoptosis. Nat Med 3(6): 614
49. 49. Lanotte M, Riviere B, Hermouet S, Houge G, Wintermyr OK, Gjertsen BT, Doskeland SO (1991) Programmed cell death (apoptosis) is induced rapidly and with positive cooperativity by activation of cyclic adenosine monophosphate-kinase I in a myeloid leukemia cell line. J Cell Physiol 146: 73
50. 50. Lieu CH, Liu CC, et al (1998) Role of mitogen-activated protein kinase in Taxol-induced apoptosis in human leukemic U937 cells. Cell Growth Differ 9(9): 767
51. 51. Lin EY, Orlofsky A, Berger MS, Prystowsky MB (1993) Characterization of A1, a novel hemopoietic-specific early-response gene with sequence similarity to bcl-2. J Immunol 151: 1979
52. 52. Ling Y-H, Tornos C, Perez-Soler R (1998) Phosphorylation of bcl-2 is a marker of M phase events and not a determinant of apoptosis. J Biol Chem 273(30): 18984
53. 53. Marshall MS (1995) Ras target proteins in eukaryotic cells. FASEB J 9: 1311
54. 54. Martin V (1993) Overview of paclitaxel (TAXOL). Semin Oncol Nurs 9(4) [Suppl 2]: 2
55. 55. Morrison DK, Cutler RE (1997) The complexity of Raf-1 regulation. Curr Opin Cell Biol 9: 174
56. 56. Nagata S, Golstein P (1995) The Fas death factor. Science 267: 1449
57. 57. Neilan JG, Lu Z, Afonso CL, Kutish GF, Sussman MD, Rock DL (1993) An African swine fever virus gene with similarity to the proto-oncogene bcl-2 and the Epstein-Barr virus gene BHRF1. J Virol 67: 4391
58. 58. Nishio K, Arioka H, Ishida T, Fukumoto H, Kurokawa H, Sata M, Ohata M, Saijo N (1995) Enhanced interaction between tubulin and microtubule-associated protein 2 via inhibition of MAP kinase and CDC2 kinase by paclitaxel. Int J Cancer 63(5): 688
59. 59. Oltvai ZN, Korsmeyer SJ (1994) Checkpoints of dueling dimers foil death wishes. Cell 79: 189
60. 60. Oltvai ZN, Milliman CL, Korsmeyer SJ (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74: 609
61. 61. Pender MP (1998) Genetically determined failure of activation-induced apoptosis of autoreactive T cells as a cause of multiple sclerosis. Lancet 351(9107): 978
62. 62. Powell CT, Brittis NJ, Stec D, Hug H, Heston WD, Fair WR (1996) Persistent membrane translocation of protein kinase C alpha during 12-0-tetradecanoylphorbol-13-acetate-induced apoptosis of LNCaP human prostate cancer cells. Cell Growth Differ 7(4): 419
63. 63. Pronk LC, Stoter G, Verweij J (1995) Docetaxel (Taxotere): single agent activity, development of combination treatment and reducing side-effects. Cancer Treat Rev 21(5): 463
64. 64. Pumiglia KM, Decker SJ (1997) Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway. Proc Natl Acad Sci USA 94: 448
65. 65. Raffaelli N, Yamauchi PS, Purichi DL (1992) Microtubule-associated protein auto-phosphorylation alters in vitro microtubule dynamic instability. FEBS Lett 296: 21
66. 66. Rodriguez Viciana P, Warne PH, Vanhaesebroeck B, Waterfield MD, Downward J (1996) Activation of phosphoinositide 3-kinase by interaction with ras and by point mutation. EMBO J 15(10): 2442
67. 67. Rowinsky EK (1997) The development and clinical utility of the taxane class of antimicrotubule chemotherapy agents. Annu Rev Med 48: 353
68. 68. Sackett DL (1993) Podophyllotoxin, steganacin and combretastatin: natural products that bind at the colchicine site of tubulin. Pharmacol Ther 59(2): 163
69. 69. Samuels ML, McMahon M (1994) Inhibition of platelet-derived growth factor-and epidermal growth factor-mediated mitogenesis and signaling in 3T3 cells expressing delta Raf-1:ER an estradiol regulated form of Raf-1. Mol Cell Biol 14: 7855
70. 70. Schmid DS, Tite JP, Ruddle NH (1986) DNA fragmentation manifestation of target cell destruction mediated by cytoxic T-cell lines. Proc Natl Acad Sci USA 83: 1881
71. 71. Sewing A, Wiseman B, Lloyd AC, Land H (1997) High-intensity Raf signal causes cell cycle arrest mediated by p21Cip. Mol Cell Biol 17: 5588
72. 72. Srinivasula SM, Ahmad M, Guo Y, Zhan Y, Lazebnik Y, Fernandes-Alnemri T, Alnemri E (1999) Identification of an endogenous dominant-negative short isoform of caspase-9 that can regulate apoptosis. Cancer Res 59: 999
73. 73. Srivastava RK, Srivastava AR, Cho-Chung YS (1998) Synergistic effects of 8-Cl-cAMP and retinoic acid on induction of apoptosis in Ewing's sarcoma CHP-100 cells. Clin Cancer Res 4: 755
74. 74. Srivastava RK, Srivastava AR, Korsmeyer SJ, Nesterova M, Cho-Chung YS, Longo DL (1998) Involvement of microtubules in the regulation of bcl-2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase. Mol Cell Biol 18(6): 3509
75. 75. Symons M (1996) Rho family GTPases: the cytoskeleton and beyond. Trends Biochem Sci 21(5): 178
76. 76. Thompson CB (1995) Apoptosis in the pathogenesis and treatment of disease. Science 267: 1456
77. 77. Tortora G, Yokozaki H, Pepe S, Clair T, Cho-Chung YS (1997) Differentiation of HL-60 leukemia by type I regulatory subunit antisense oligodeoxynucleotide of cAMP-dependent protein kinase. Proc Natl Acad Sci USA 88: 2011
78. cdc2 protein kinase in human fibroblasts. J Biol Chem 28: 19018
79. 79. Vintermyr OK, Gjersten BT, Lanotte M, Doskeland SO (1993) Microinjected catalytic subunit of cAMP-dependent protein kinase induces apoptosis in myeloid leukemia (IPC-81) cells. Exp Cell Res 206: 157
80. 80. Wang HG, Miyashita T, Takayama S, Sato T, Torigoe T, Krajewski S, Tanaka S, Hovey L 3rd, Troppmair J, Rapp UR (1994) Apoptosis regulation by interaction of bcl-2 protein and raf-1 kinase. Oncogene 9(9): 2751
81. 81. Wang K, Yin XM, Chao DT, Milliman CL, Korsmeyer SJ (1996) BID: a novel BH3 domain-only death agonist. Genes Dev 10(22): 2859
82. 82. Wang LG, Liu XM, Kreis W, Budman DR (1999) Activation of MAP kinase during apoptosis mediated by vinorelbine in MCF-7 cells. Proc Am Assoc Cancer Res 40: 13
83. 83. Wang TH, Wang HS, Ichijo H, Giannakakou P, Foster JS, Fojo T, Wimalasena J (1998) Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways. J Biol Chem 273(9): 4928
84. 84. Wang X, Martindale JL, Liu Y, Holbrook NJ (1998) The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival. Biochem J 333(2): 291
85. 85. Weissinger EM, Eissner G, Grammer C, Fackler S, Haefner B, Yoon LS, Lu KS, Bazarov A, Sedivy JM, Mischak H, Kolch W (1997) Inhibition of the Raf-1 kinase by cyclic AMP agonists causes apoptosis of v-abl-transformed cells. Mol Cell Biol 17: 3229
86. 86. Wilson L, Jordan MA (1995) Microtubule dynamics: taking aim at a moving target. Chem Biol 2(9): 569
87. 87. Woods D, Parry D, Cherwinski H, Bosch E, Lees E, McMahon M (1997) Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1. Mol Cell Biol 17: 5598
88. 88. Yamada T, Yamaoka S, Goto T, Nakai M, Tsujimoto Y, Hatanaka M (1994) The human T-cell leukemia virus type I Tax protein induces apoptosis which is blocked by the Bcl-2 protein. J Virol 68(5): 3374
89. L and bcl-2, displaces bax and promotes cell death. Cell 80(2): 285