Paclitaxel-induced fasl-independent apoptosis and slow (non-apoptotic) cell death

Cancer Biology and Therapy

Volumn 1, Issue 2, 2002, Pages 113-117

  Blagosklonny, Mikhail V ^a,b   Robey, Robert ^a   Sheikh, M Saeed ^c   Fojo, Tito ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NEW YORK MEDICAL COLLEGE   (United States)

^c State University of New York Upstate Medical University: College of Medicine   (United States)

Author keywords

Caspases; Microtubule active drugs; Mitotic slippage; Multinucleation

Indexed keywords

ANTINEOPLASTIC AGENT; DOXORUBICIN; FAS LIGAND; FASLG PROTEIN, HUMAN; MEMBRANE PROTEIN; PACLITAXEL;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL DEATH; DRUG EFFECT; HUMAN; PHYSIOLOGY;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL DEATH; DOXORUBICIN; FAS LIGAND PROTEIN; HUMANS; MEMBRANE GLYCOPROTEINS; PACLITAXEL; TUMOR CELLS, CULTURED;

EID: 0036491526     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.53     Document Type: Article

References (24)

1. Solary E, Droin N, Bettaieb A, Corcos L, Dimanche-Boitrel MT, Garrido C. Positive and negative regulation of apoptotic pathways by cytotoxic agents in hematological malignancies. Leukemia 2000; 14:1833-49.
2. Bhalla K, Ibrado AM, Tourkina E, Tang C, Mahoney ME, Huang Y. Taxol induces internucleosomal DNA fragmentation associated with programmed cell death in human myeloid leukemia cells. Leukemia 1993; 7:563-8. (Pubitemid 23139860)
3. Ibrado AM, Liu L, Bhalla K. Bcl-xL overexpression inhibits progression of molecular events leading to paclitaxel-induced apoptosis of human AML HL-60 cells. Cancer Res 1997; 57:1109-15. (Pubitemid 27138610)
4. Kottke TJ, Blajeski AL, Martins LM, Mesner PW Jr, Davidson NE, Earnshaw WC, et al. Comparison of paclitaxel-, 5-fluoro-2'-deoxyuridine-, and epidermal growth factor (EGF)-induced apoptosis. Evidence for EGF-induced anoikis. J Biol Chem 1999; 274:15927-36.
5. Ashkenasi A, Dixit VM. Death receptors: signaling and modulation. Science 1998; 281:1305-8. (Pubitemid 28406815)
6. Srivastava RK, Sasaki CY, Hardwick JM, Longo DL. Bcl-2-mediated drug resistance: inhibition of apoptosis by blocking nuclear factor of activated T lymphocytes (NFAT)-induced Fas ligand transcription. J Exp Med 1999; 190:253-65. (Pubitemid 29354918)
7. An WG, Hwang SG, Trepel JB, Blagosklonny MV. Protease inhibitor-induced apoptosis: Accumulation wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition. Leukemia 2000; 14:1276-83.
8. Blagosklonny MV. Drug-resistance enables selective killing of resistant leukemia cells: exploiting of drug resistance instead of reversal. Leukemia 1999; 13:2031-35.
9. Green DR, Reed JC. Mitochondria and apoptosis. Science 1998; 281:1309-12. (Pubitemid 28406816)
10. Li H, Zhu H, Xu CJ, Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 1998; 21:491-501. (Pubitemid 28391865)
11. Ozoren N, Kim K, Burns TF, Dicker DT, Moscioni AD, El-Deiry WS. The caspase 9 inhibitor Z-LEHD-FMK protects human liver cells while permitting death od cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand. Cancer Res 2000; 60:6259-65.
12. Wesselborg S, Engels IH, Rossmann E, Los M, Schulze-Osthoff K. Anticancer drugs induce caspase-8/FLICE activation and apoptosis in the absence of CD95 receptor/ligand interaction. Blood 1999; 93:3053-63. (Pubitemid 29200798)
13. Ferreira CG, Span SW, Peters GJ, Kruyt FA, Giaccone G. Chemotherapy triggers apoptosis in a caspase-8-dependent and mitochondria-controlled manner in the non-small cell lung cancer cell line NCI-H460. Cancer Res 2000; 60:7133-41. (Pubitemid 32059195)
14. Los M, Herr I, Friesen C, Fulda S, Schulze-Osthoff K, Debatin KM. Cross-resistance of CD95- and drug-induced apoptosis as a consequence of deficient activation of caspases (ICE/Ced-3 proteases). Blood 1997; 90:3118-29. (Pubitemid 27444206)
15. Landowski TH, Shain KH, Oshiro MM, Buyuksal I, Painter JS, Dalton WS. Myeloma cells selected for resistance to CD95-mediated apoptosis are not cross-resistant to cytotoxic drugs: evidence for independent mechanisms of caspase activation. Blood 1999; 94:265-74. (Pubitemid 29300158)
16. Askew DJ, Kuscuoglu U, Brunner T, Green DR, Miesfeld RL. Characterization of Apt-cell lines exhibiting cross-resistance to glucocorticoid- and fas-mediated apoptosis. Cell Death Differ 1999; 6:796-804. (Pubitemid 29425391)
17. Panvichian R, Orth K, Day ML, Day KC, Pilat MJ, Pienta KJ. Paclitaxel-associated multimininucleation is permitted by the inhibition of caspase activation: a potential early step in drug resistance. Cancer Res 1998; 58:4667-72. (Pubitemid 28480633)
18. Blagosklonny MV. Cell death beyond apoptosis. Leukemia 2000; 14:1502-8. (Pubitemid 30601357)
19. Posovszky C, Friesen C, Herr I, Debatin KM. Chemotherapeutic drugs sensitize pre-B ALL cells for CD95- and cytotoxic T-lymphocyte-mediated apoptosis. Leukemia 1999; 13:400-9. (Pubitemid 29108079)
20. Roberts JR, Allison DC, Donehower RC, Rowinsky EK. Development of polyploidization in taxol resistant human leukemia cells in vitro. Cancer Res 1990; 50:710-16. (Pubitemid 20054203)
21. Merlin JL, Bour-Dill C, Marchal S, Bastien L, Gramain MP. Resistance to paclitaxel induces time-delayed multinucleation and DNA fragmentation into large fragments in MCF-7 human breast adenocarcinoma cells. Anti-Cancer Drugs 2000; 11:295-302. (Pubitemid 30416960)
22. Blagosklonny MV. Paradox of Bcl-2 (and p53): Why may apoptosis-regulating proteins be irrelevant to cell death. BioEssays 2001; 23:947-53. (Pubitemid 32972694)
23. Sperandio S, de Belle I, Bredesen DE. An alternative, nonapoptotic form of programmed cell death. Proc Natl Acad Sci USA 2000; 97:14376-81. (Pubitemid 32016583)
24. Wyllie AH, Golstein P. More than one way to go. Proc Natl Acad Sci USA 2001; 98:11-3. (Pubitemid 32095852)