The Road Less Traveled: Emerging principles of kinesin motor utilization

Annual Review of Cell and Developmental Biology

Volumn 15, Issue , 1999, Pages 141-183

  Goldstein, L S B ^a   Philp, A V ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Microtubules; Mitosis; Molecular motors; Organelle transport

Indexed keywords

KINESIN; POLYPEPTIDE;

ANIMAL CELL; CATALYSIS; CELL GROWTH; CELL MEMBRANE TRANSPORT; CELL ORGANELLE; CROSS LINKING; LYSOSOME; MICROTUBULE; MITOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; REVIEW; SIGNAL TRANSDUCTION; SYNAPSE VESICLE;

ANIMALS; BIOLOGICAL TRANSPORT; HUMANS; KINESIN; MOLECULAR MOTOR PROTEINS;

ANIMALIA; EUKARYOTA; HARNESS;

EID: 0033280668     PISSN: 10810706     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.cellbio.15.1.141     Document Type: Review

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66. With apologies to scheherazade: Tails of 1001 kinesin motors
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81. Kinesin associates with anterogradely transported membranous organelles in vivo
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83. Radial extension of macrophage tubular lysosomes supported by kinesin
84. Interaction of the Rho family small G proteins with kinectin, an anchoring protein of kinesin motor
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90. The Kar3p and Kip2p motors function antagonistically at the spindle poles to influence cytoplasmic microtubule numbers
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100. Separation of meiotic and mitotic effects of claret non-disjunctional on chromosome segregation in Drosophila
101. KIF3A is a new microtubule-based anterograde motor in the nerve axon
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103. A motility in the eukaryotic flagellum unrelated to flagellar beating
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106. Kinectin, an essential anchor for kinesin-driven vesicle motility
107. Characterization of a minus end-directed kinesin-like motor protein from cultured mammalian cells
108. Isolation of a 45-kDa fragment from the kinesin heavy chain with enhanced ATPase and microtubule-binding activities
109. Involvement of microtubule motors in basolateral and apical transport in kidney cells
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111. Phosphorylation of kinesin in vivo correlates with organelle association and neurite outgrowth
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113. Identification of a motor protein required for filamentous growth in Ustilago maydis
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115. Kinesin is a candidate for cross-bridging microtubules and intermediate filaments. Selective binding of kinesin to detyrosinated tubulin and vimentin
116. Suppression of a myosin defect by a kinesin-related gene
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120. Kinesin is the motor for microtubule-mediated Golgi-to-ER membrane traffic
121. Microtubule-dependent retrograde transport of proteins into the ER in the presence of brefeldin A suggests an ER recycling pathway
122. Microtubules are involved in the localization of tan mRNA in primary neuronal cell cultures
123. Antibodies to the kinesin motor domain and CENP-E inhibit microtubule depolymerization-dependent motion of chromosomes in vitro
124. Minus-end-directed motion of kinesincoated microspheres driven by microtubule depolymerization
125. Mitotic centromere-associated kinesin is important for anaphase chromosome segregation
126. Association of kinesin with the Golgi apparatus in rat hepatocytes
127. Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II
128. Anastral meiotic spindle morphogenesis: Role of the non-claret disjunctional kinesin-like protein
129. Organization and function of the cytoskeleton in polarized epithelial cells: A component of the protein sorting machinery
130. Identification and characterization of a gene encoding a kinesin-like protein in Drosophila
131. KAR3, a kinesin-related gene required for yeast nuclear fusion
132. Suppression of the expression of a pancreatic beta-cell form of the kinesin heavy chain by antisense oligonucleotides inhibits insulin secretion from primary cultures of mouse beta-cells
133. Unconventional myosins in cell movement, membrane traffic, and signal transduction
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135. The kinesin-related proteins, Kip2p and Kip3p, function differently in nuclear migration in yeast
136. A chromatinassociated kinesin-related protein required for normal mitotic chromosome segregation in Drosophila
137. Suppression of KIF2 in PC12 cells alters the distribution of a growth cone nonsynaptic membrane receptor and inhibits neurite extension
138. Isolation and characterization of rapid transport vesicle subtypes from rabbit optic nerve
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141. KIF3C and KIF3A form a novel neuronal heteromeric kinesin that associates with membrane vesicles
142. The kinesin motor KIF3A is a component of the presynaptic ribbon in vertebrate photoreceptors
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144. Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome
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146. Point mutation of adenosine triphosphate-binding motif generated rigor kinesin that selectively blocks anterograde lysosome membrane transport
147. KIF1B, a novel microtubule plus end-directed monomeric motor protein for transport of mitochondria
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149. The cytoskeleton in mRNA localization and cell differentiation
150. Cloning and localization of a conventional kinesin motor expressed exclusively in neurons
151. A plus-end-directed motor enzyme that moves antiparallel microtubules in vitro localizes to the interzone of mitotic spindles
152. The slow axonal transport of cytoskeletal proteins
153. KIF2 is a new microtubule-based anterograde motor that transports membranous organelles distinct from those carded by kinesin heavy chain or KIF3A/B
154. Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein
155. Suppression of the bimC4 mitotic spindle defect by deletion of klpA, a gene encoding a KAR3-related kinesin-like protein in Aspergillus nidulans
156. Mutation of a gene for a Drosophila kinesin-like protein. Klp38B, leads to failure of cytokinesis
157. The neuron-specific kinesin supeffamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursors
158. RNA localization: Different zipcodes, same postman?
159. The C. elegans unc-104 gene encodes a putative kinesin heavy chain-like protein
160. Cloning by insertional mutagenesis of a cDNA encoding Caenorhabditis elegans kinesin heavy chain
161. A dynein light chain is essential for the retrograde particle movement of intraflagellar transport (IFT)
162. Mitochondrial association of a plus end-directed microtubule motor expressed during mitosis in Drosophila
163. Microtubules are needed for dispersal of alphamyosin heavy chain mRNA in rat neonatal cardiac myocytes
164. Characterization of the KLP68D kinesin-like protein in Drosophila: Possible roles in axonal transport
165. Fission yeast pkll is a kinesin-related protein involved in mitotic spindle function
166. Transport of a novel complex in the cytoplasmic matrix of Chlamydomonas flagella
167. Inner dynein arms but not outer dynein arms require the activity of kinesin homologue protein KHPI(FLA10) to reach the distal part of flagella in Chlamydomonas
168. Microtubules mediate the localization of bicoid RNA during Drosophila oogenesis
169. Microtubules are a general component of mRNA localization systems in Drosophila oocytes
170. A nematode kinesin required for cleavage furrow advancement
171. Rapid movements of vimentin on microtubule tracks: Kinesin-dependent assembly of intermediate filament networks
172. Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins
173. Cytokinesis and midzone microtubule organization in Caenorhabditis elegans require the kinesin-like protein ZEN-4
174. The lethal(1)TW-6cs mutation of Drosophila melanogaster is a dominant antimorphic allele of nod and is associated with a single base change in the putative ATP-binding domain
175. A plant kinesin heavy chain-like protein is a calmodulin-binding protein
176. A novel plant calmodulin-binding protein with a kinesin heavy chain motor domain
177. Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2
178. Regulated bidirectional motility of melanophore pigment granules along microtubules in vitro
179. Role of the kinesin neck region in processive microtubule-based motility
180. Multiple kinesin-related proteins in yeast mitosis
181. Kinesin-related proteins required for assembly of the mitotic spindle
182. A Drosophila kinesin-like protein, Klp38B, functions during meiosis, mitosis, and segmentation
183. Direction determination in the minus-end-directed kinesin motor ncd
184. A kinetic study of the kinesin ATPase
185. KIFC2 is a novel neuron-specific C-terminal type kinesin superfamily motor for dendritic transport of multivesicular body-like organelles
186. KIF3C, a novel member of the kinesin supeffamily: Sequence, expression, and mapping to human chromosome 2 at 2p23
187. The Saccharomyces cerevisiae kinesin-related motor Kar3p acts at preanaphase spindle poles to limit the number and length of cytoplasmic microtubules
188. Mitotic spindle function in Saccharomyces cerevisiae requires a balance between different types of kinesin-related motors
189. Kinesin-related proteins required for structural integrity of the mitotic spindle
190. Saccharomyces cerevisiae kinesin- and dynein-related proteins required for anaphase chromosome segregation
191. Kinesin heavy chain is essential for viability and neuromuscular functions in Drosophila, but mutants show no defects in mitosis
192. CENP-E function at kinetochores is essential for chromosome alignment
193. Intracellular distribution of kinesin in chromaffin cells
194. Kinesin is essential for cell morphogenesis and polarized secretion in Neurospora crassa
195. A novel microtubule-based motor protein (KIF4) for organelle transports, whose expression is regulated developmentally
196. C. elegans osm-3 gene mediating osmotic avoidance behaviour encodes a kinesin-like protein
197. Expression of a kinesin-related motor protein induces Sf9 cells to form dendrite-like processes with nonuniform microtubule polarity orientation
198. Expression of a minus-end-directed motor protein induces Sf9 cells to form axon-like processes with uniform microtubule polarity orientation
199. The bipolar kinesin, KLP61F, cross-links microtubules within interpolar microtubule bundles of Drosophila embryonic mitotic spindles
200. Identification of a microtubule-associated motor protein essential for dendritic differentiation
201. Microtubule motor complexes moving membranous organelles
202. Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide
203. Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway
204. The carboxyl-terminal domain of kinesin heavy chain is important for membrane binding
205. Minus end-directed kinesin-like motor protein, Kcbp, localizes to anaphase spindle poles in Haemanthus endosperm
206. Optical trapping: Motor molecules in motion
207. How molecular motors work
208. A kinesin-like mechanoenzyme from the zygomycete Syncephalastrum racemosum shares biochemical similarities with conventional kinesin from Neurospora crassa
209. The Neurospora organelle motor: A distant relative of conventional kinesin with unconventional properties
210. Characterization of the biophysical and motility properties of kinesin from the fungus Neurospora crassa
211. Kinesin from the plant pathogenic fungus Ustilago maydis is involved in vacuole formation and cytoplasmic migration
212. Immunochemical analysis of kinesin light chain function
213. Direction of microtubule movement is an intrinsic property of the motor domains of kinesin heavy chain and Drosophila ncd protein
214. Time-lapse microscopy reveals unique roles for kinesins during anaphase in budding yeast
215. Exclusive expression of C. elegans osm-3 kinesin gene in chemosensory neurons open to the external environment
216. Targeted disruption of mouse conventional kinesin heavy chain, kif5B, results in abnormal perinuclear clustering of mitochondria
217. Mitotic HeLa cells contain a CENP-E-associated minus end-directed microtubule motor
218. Modulation of CENP-E organization at kinetochores by spindle microtubule attachment
219. Kid, a novel kinesin-like DNA binding protein, is localized to chromosomes and the mitotic spindle
220. Kinectin, a major kinesin-binding protein on ER
221. Microtubule polarity and distribution in teleost photoreceptors
222. The unusual microtubule polarity in teleost retinal pigment epithelial cells
223. Microtubule nucleation and organization in teleost photoreceptors: Microtubule recovery after elimination by cold
224. Heterotrimeric kinesin II is the microtubule motor protein responsible for pigment dispersion in xenopus melanophores
225. The design plan of kinesin motors
226. Formation of membrane networks in vitro by kinesin-driven microtubule movement
227. Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility
228. The kinesin-homologous protein encoded by the Chlamydomonas FLA10 gene is associated with basal bodies and centrioles
229. Taxol-induced microtubule asters in mitotic extracts of Xenopus eggs: Requirement for phosphorylated factors and cytoplasmic dynein
230. Light chain-dependent regulation of kinesin's interaction with microtubules
231. Xklp1, a chromosomal Xenopus kinesin-like protein essential for spindle organization and chromosome positioning
232. XKCMl: A Xenopus kinesin-related protein that regulates microtubule dynamics during mitotic spindle assembly
233. XCTK2: A kinesin-related protein that promotes mitotic spindle assembly in Xenopus laevis egg extracts
234. A model for the proposed roles of different microtubule-based motor proteins in establishing spindle bipolarity
235. The Drosophila claret segregation protein is a minus-end directed motor molecule
236. The Chlamydomonas FLA10 gene encodes a novel kinesin-homologous protein
237. Chromokinesin: A DNA-binding, kinesin-like nuclear protein
238. Expanding the role of HsEg5 within the mitotic and postmitotic phases of the cell cycle
239. Visualization of the peroxisomal compartment in living mammalian cells: Dynamic behavior and association with microtubules
240. The Drosophila kinesin-like protein KLP3A is a midbodyn component required for central spindle assembly and initiation of cytokinesis
241. Monastral bipolar spindles: Implications for dynamic centrosome organization
242. Localization of the kinesin-like protein Xklp2 to spindle poles requires a leucine zipper, a microtubule-associated protein, and dynein
243. CENP-E is a plus end-directed kinetochore motor required for metaphase chromosome alignment
244. Identification and partial characterization of mitotic centromere-associated kinesin, a kinesin-related protein that associates with centromeres during mitosis
245. Chromosomal localization reveals three kinesin heavy chain genes in mouse
246. The claret locus in Drosophila encodes products required for eyecolor and for meiotic chromosome segregation
247. Motoring along the hyphae: Molecular motors and the fungal cytoskeleton
248. KIF3A/B: A heterodimeric kinesin superfamily protein that works as a microtubule plus end-directed motor for membrane organelle transport
249. Cloning and characterization of KAP3: A novel kinesin supeffamily-associated protein of KIF3A/3B
250. Evidence that the head of kinesin is sufficient for force generation and motility in vitro
251. Characterization of the KIF3C neural kinesin-like motor from mouse
252. The microtubule-dependent motor centromere-associated protein E (CENP- E) is an integral component of kinetochore corona fibers that link centromeres to spindle microtubules
253. CENP-E is a putative kinetochore motor that accumulates just before mitosis
254. Defect in synaptic vesicle precursor transport and neuronal cell death in KIF1A motor protein-deficient mice
255. Motile properties of vimentin intermediate filament networks in living cells
256. Characterization of kinectin, a kinesin-binding protein: Primary sequence and N-terminal topogenic signal analysis
257. Kinesin and cytoplasmic dynein binding to brain microsomes
258. Inhibition of a mitotic motor compromises the formation of dendrite-like processes from neuroblastoma cells
259. A kinesin-like protein required for distributive chromosome segregation in Drosophila